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Entry version 96 (13 Feb 2019)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Cyclin H

Gene

ccnh

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclinUniRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-112382 Formation of RNA Pol II elongation complex
R-DRE-113418 Formation of the Early Elongation Complex
R-DRE-5696395 Formation of Incision Complex in GG-NER
R-DRE-674695 RNA Polymerase II Pre-transcription Events
R-DRE-6781823 Formation of TC-NER Pre-Incision Complex
R-DRE-6782135 Dual incision in TC-NER
R-DRE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DRE-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-DRE-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-DRE-72086 mRNA Capping
R-DRE-73762 RNA Polymerase I Transcription Initiation
R-DRE-73772 RNA Polymerase I Promoter Escape
R-DRE-73776 RNA Polymerase II Promoter Escape
R-DRE-73777 RNA Polymerase I Chain Elongation
R-DRE-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DRE-73863 RNA Polymerase I Transcription Termination
R-DRE-75953 RNA Polymerase II Transcription Initiation
R-DRE-75955 RNA Polymerase II Transcription Elongation
R-DRE-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-DRE-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-DRE-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cyclin HImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ccnhImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050320-13 ccnh

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000007657 Expressed in 23 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000120229

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 152CYCLINInterPro annotationAdd BLAST91

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2496 Eukaryota
COG5333 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008634

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232149

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050840

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYYLTIH

Database of Orthologous Groups

More...
OrthoDBi
1469819at2759

TreeFam database of animal gene trees

More...
TreeFami
TF101008

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00043 CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR031658 Cyclin_C_2
IPR006671 Cyclin_N
IPR027081 CyclinH/Ccl1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16899 Cyclin_C_2, 1 hit
PF00134 Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385 CYCLIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954 SSF47954, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00569 ccl1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2BGI0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYHNSSQKKF WTYDKEETLD KLRLEANQKF CSKALSSGKP GINESTLLNE
60 70 80 90 100
QEEKVLFKHY EKRLLDFCAV FKPVMPKSVV GTACMYFRRF YLNNSLMEYH
110 120 130 140 150
PRTIMLTCAY LSCKVDEFNV SSTQFVGNLQ ESPAGQERAV DQILEYELLL
160 170 180 190 200
IQQLNFHLVV HNPYRPLEGF LIDLKTRYPL LENPEMLRKS AEDFLNRATM
210 220 230 240 250
TDAGLLFSPS QIALTAVLNS AARAGLKMDV YLNECMGLKE DKETLSKMYE
260 270 280 290 300
SMRRMTSLVK AYELPKAEEV SICKQKLERI YAEFATNLKR KHGYEDDDHV
310
VKRQMVADEE WTDDDLDAL
Length:319
Mass (Da):37,031
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEEFB3D75BB62BFA5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX470189 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005165569.1, XM_005165512.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dr.95737

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000007057; ENSDARP00000004735; ENSDARG00000007657
ENSDART00000145665; ENSDARP00000120229; ENSDARG00000007657

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
541325

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470189 Genomic DNA No translation available.
RefSeqiXP_005165569.1, XM_005165512.3
UniGeneiDr.95737

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000120229

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000007057; ENSDARP00000004735; ENSDARG00000007657
ENSDART00000145665; ENSDARP00000120229; ENSDARG00000007657
GeneIDi541325

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
902
ZFINiZDB-GENE-050320-13 ccnh

Phylogenomic databases

eggNOGiKOG2496 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00390000008634
HOGENOMiHOG000232149
HOVERGENiHBG050840
OMAiNYYLTIH
OrthoDBi1469819at2759
TreeFamiTF101008

Enzyme and pathway databases

ReactomeiR-DRE-112382 Formation of RNA Pol II elongation complex
R-DRE-113418 Formation of the Early Elongation Complex
R-DRE-5696395 Formation of Incision Complex in GG-NER
R-DRE-674695 RNA Polymerase II Pre-transcription Events
R-DRE-6781823 Formation of TC-NER Pre-Incision Complex
R-DRE-6782135 Dual incision in TC-NER
R-DRE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DRE-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-DRE-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-DRE-72086 mRNA Capping
R-DRE-73762 RNA Polymerase I Transcription Initiation
R-DRE-73772 RNA Polymerase I Promoter Escape
R-DRE-73776 RNA Polymerase II Promoter Escape
R-DRE-73777 RNA Polymerase I Chain Elongation
R-DRE-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DRE-73863 RNA Polymerase I Transcription Termination
R-DRE-75953 RNA Polymerase II Transcription Initiation
R-DRE-75955 RNA Polymerase II Transcription Elongation
R-DRE-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-DRE-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-DRE-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Gene expression databases

BgeeiENSDARG00000007657 Expressed in 23 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR031658 Cyclin_C_2
IPR006671 Cyclin_N
IPR027081 CyclinH/Ccl1
PfamiView protein in Pfam
PF16899 Cyclin_C_2, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
TIGRFAMsiTIGR00569 ccl1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2BGI0_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2BGI0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: February 13, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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