Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BPI fold-containing family B member 4

Gene

Bpifb4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).By similarity

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 4
Alternative name(s):
Long palate, lung and nasal epithelium carcinoma-associated protein 41 Publication
Gene namesi
Name:Bpifb4
Synonyms:Gm1006Imported, Lplunc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2685852 Bpifb4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000035558918 – 617BPI fold-containing family B member 4Add BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi297 ↔ 334By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA2BGH0
PRIDEiA2BGH0

PTM databases

PhosphoSitePlusiA2BGH0

Expressioni

Gene expression databases

BgeeiENSMUSG00000074665 Expressed in 11 organ(s), highest expression level in female gonad

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105379

Structurei

3D structure databases

ProteinModelPortaliA2BGH0
SMRiA2BGH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 228Gly-richSequence analysisAdd BLAST72

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00730000110772
HOGENOMiHOG000231741
HOVERGENiHBG108092
InParanoidiA2BGH0
OMAiCPLIIRI
OrthoDBiEOG091G048N
PhylomeDBiA2BGH0
TreeFamiTF315617

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A2BGH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWTAWCVAAL SVAAVCGIRQ DTTTVLRVTK DVLGNAISGT IQKSDAFRSA
60 70 80 90 100
LREVPVGVGG VPYNDFHVRE PPPKYTNGRQ LGGNYKYGHI KANDNRAQLG
110 120 130 140 150
GKYRYGEILD SDGSLRDLRH EDYRPPDSAY HRGSGRYRSA ADSSSVGRLY
160 170 180 190 200
RRELRPGEIP AGVATGALGP GGLLGTGGML ANEGILAGQG GLLGGGGLLG
210 220 230 240 250
DGGLLGGGGV LGVLGEGGIL STVQGITGLR IVELTLPRVS VRLLPGVGVY
260 270 280 290 300
LSLYTRVAIN GRSLIGFLDI AVEVNITAKV RLTMDRTGYP RLVIERCDTL
310 320 330 340 350
LGGIKVKLLR GLLPNLVDNL VNRVLANVLP DLLCPIVDVV LGLVNDQLGL
360 370 380 390 400
VDSLVPLGIL GSVQYTFSSL PLVTGEFLEL DLNTLVGEAG GDLIDYPLGR
410 420 430 440 450
PAILPRPQMP ELPPMGDNTN SQLAISANFL SSVLTMLQKQ GAMDIDITDG
460 470 480 490 500
MFEDLPPLTT STLGALIPKV FQQYPESRPL TIRIQVPNPP TVTLQKDKAL
510 520 530 540 550
VKVFATSEVV VSQPNDVETT ICLIDVDTDL LASFSVEGDK LMIDAKLDKT
560 570 580 590 600
SLNLRTSNVG NFDVFILEML VEKIFDLAFM PAMNAILGSG VPLPKILNID
610
FSNADIDVLE DLLVLST
Note: Gene prediction based on EST data.Curated
Length:617
Mass (Da):65,723
Last modified:February 20, 2007 - v1
Checksum:i7601EB15E01F73C1
GO
Isoform 22 Publications (identifier: A2BGH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-214: Missing.
     215-228: GEGGILSTVQGITG → MAAVASSSLLTACR

Show »
Length:403
Mass (Da):43,598
Checksum:i7FCCA14BE38448EF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0529851 – 214Missing in isoform 2. 2 PublicationsAdd BLAST214
Alternative sequenceiVSP_052986215 – 228GEGGI…QGITG → MAAVASSSLLTACR in isoform 2. 2 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143420 mRNA Translation: BAE25370.1
BX470156 Genomic DNA No translation available.
BC147610 mRNA Translation: AAI47611.1
BC147625 mRNA Translation: AAI47626.1
CCDSiCCDS16922.2 [A2BGH0-1]
RefSeqiNP_001030047.2, NM_001034875.3 [A2BGH0-1]
XP_006499887.1, XM_006499824.1 [A2BGH0-1]
UniGeneiMm.315572

Genome annotation databases

EnsembliENSMUST00000099181; ENSMUSP00000096786; ENSMUSG00000074665 [A2BGH0-2]
ENSMUST00000109757; ENSMUSP00000105379; ENSMUSG00000074665 [A2BGH0-1]
ENSMUST00000109759; ENSMUSP00000105381; ENSMUSG00000074665 [A2BGH0-1]
GeneIDi381399
KEGGimmu:381399
UCSCiuc008niq.1 mouse [A2BGH0-2]
uc012cgs.1 mouse [A2BGH0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143420 mRNA Translation: BAE25370.1
BX470156 Genomic DNA No translation available.
BC147610 mRNA Translation: AAI47611.1
BC147625 mRNA Translation: AAI47626.1
CCDSiCCDS16922.2 [A2BGH0-1]
RefSeqiNP_001030047.2, NM_001034875.3 [A2BGH0-1]
XP_006499887.1, XM_006499824.1 [A2BGH0-1]
UniGeneiMm.315572

3D structure databases

ProteinModelPortaliA2BGH0
SMRiA2BGH0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105379

PTM databases

PhosphoSitePlusiA2BGH0

Proteomic databases

PaxDbiA2BGH0
PRIDEiA2BGH0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099181; ENSMUSP00000096786; ENSMUSG00000074665 [A2BGH0-2]
ENSMUST00000109757; ENSMUSP00000105379; ENSMUSG00000074665 [A2BGH0-1]
ENSMUST00000109759; ENSMUSP00000105381; ENSMUSG00000074665 [A2BGH0-1]
GeneIDi381399
KEGGimmu:381399
UCSCiuc008niq.1 mouse [A2BGH0-2]
uc012cgs.1 mouse [A2BGH0-1]

Organism-specific databases

CTDi149954
MGIiMGI:2685852 Bpifb4

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00730000110772
HOGENOMiHOG000231741
HOVERGENiHBG108092
InParanoidiA2BGH0
OMAiCPLIIRI
OrthoDBiEOG091G048N
PhylomeDBiA2BGH0
TreeFamiTF315617

Enzyme and pathway databases

ReactomeiR-MMU-6803157 Antimicrobial peptides

Miscellaneous databases

PROiPR:A2BGH0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074665 Expressed in 11 organ(s), highest expression level in female gonad

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiBPIB4_MOUSE
AccessioniPrimary (citable) accession number: A2BGH0
Secondary accession number(s): Q3UPM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again