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UniProtKB - A2BGD5 (CACO1_DANRE)
Protein
Calcium-binding and coiled-coil domain-containing protein 1
Gene
calcoco1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
May function as a coactivator for aryl hydrocarbon and nuclear receptors.
By similarityGO - Molecular functioni
- transcription coactivator activity Source: GO_Central
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Enzyme and pathway databases
Reactomei | R-DRE-5357905, Regulation of TNFR1 signaling R-DRE-936440, Negative regulators of DDX58/IFIH1 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-binding and coiled-coil domain-containing protein 1 |
Gene namesi | Name:calcoco1 ORF Names:si:dkey-148f24.4 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030131-6911, calcoco1a |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308903 | 1 – 640 | Calcium-binding and coiled-coil domain-containing protein 1Add BLAST | 640 |
Proteomic databases
PaxDbi | A2BGD5 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000036695, Expressed in muscle organ and 31 other tissues |
ExpressionAtlasi | A2BGD5, baseline |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 262 – 288 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 519 – 640 | DisorderedSequence analysisAdd BLAST | 122 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 141 – 212 | Sequence analysisAdd BLAST | 72 | |
Coiled coili | 246 – 346 | Sequence analysisAdd BLAST | 101 | |
Coiled coili | 424 – 510 | Sequence analysisAdd BLAST | 87 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 539 – 555 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 575 – 594 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the CALCOCO family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QR9J, Eukaryota |
GeneTreei | ENSGT00950000183025 |
InParanoidi | A2BGD5 |
PhylomeDBi | A2BGD5 |
TreeFami | TF329501 |
Family and domain databases
InterProi | View protein in InterPro IPR012852, CALCOCO1-like IPR041611, SKICH |
Pfami | View protein in Pfam PF07888, CALCOCO1, 1 hit PF17751, SKICH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A2BGD5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKTWRVEFR NVGSCYFPQS RVDCHYTINP QHTWASNDWI GLFKVGWSSV
60 70 80 90 100
KEYHTFVWAV APSSYKEGTS VNCCVNFQAS YLPGPSAQQY QFVYVDGKGE
110 120 130 140 150
ICSCSAAFTF SAPKPLEELV TLEEEGQGEE VGEDMLLVIP RAQLLQSRLQ
160 170 180 190 200
ECLKERAELL QALEAADQNV EREKGRRERD RGSWEHTRKE LERKIDDLKE
210 220 230 240 250
EVREYREKVE DMKKKQKEVE DLGEALTEEK RALLAQKEAN EQRIRELEED
260 270 280 290 300
IKILTQRGLE RETDLERMRE RAKKSAAQKR EDEDEHKNLK LKMEQTEKEL
310 320 330 340 350
HSLSAEFQSL RSSLAQRDTH ALQLRDTITT LTHKLNSAHR KEAANELALN
360 370 380 390 400
ELRSVQERLN VSEHCVETLR GELRDMVAQR DSAHAELHQA RLQAAQLTLQ
410 420 430 440 450
LADASLALRE GRANWAQERE TLQQNAEIDK VRLERQNDEI QQKEEMLQKA
460 470 480 490 500
RMEREKAVVE LGREKDCNRE LKASLRVAQK EKEQLQTEIQ EVMEYSRQLE
510 520 530 540 550
RRLEVLSDCK WSETALLQSS RAESPLLSDS EDENPEALQD THSSGPLNHY
560 570 580 590 600
SLCEQPQSDL LLPATPPPSP RHPSTVVISQ PAPLSSPHQP SARSHTHSSE
610 620 630 640
SEEEYEAALS GGHSSGEETA LLLPDNRDTT LGELAESPLW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4IFJ0 | A0A0R4IFJ0_DANRE | Calcium-binding and coiled-coil dom... | calcoco1a | 651 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX465864 Genomic DNA Translation: CAM14487.1 |
RefSeqi | NP_001103636.1, NM_001110166.1 |
Genome annotation databases
Ensembli | ENSDART00000103150; ENSDARP00000093924; ENSDARG00000036695 |
GeneIDi | 334971 |
KEGGi | dre:334971 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX465864 Genomic DNA Translation: CAM14487.1 |
RefSeqi | NP_001103636.1, NM_001110166.1 |
3D structure databases
SMRi | A2BGD5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000093924 |
Proteomic databases
PaxDbi | A2BGD5 |
Genome annotation databases
Ensembli | ENSDART00000103150; ENSDARP00000093924; ENSDARG00000036695 |
GeneIDi | 334971 |
KEGGi | dre:334971 |
Organism-specific databases
CTDi | 334971 |
ZFINi | ZDB-GENE-030131-6911, calcoco1a |
Phylogenomic databases
eggNOGi | ENOG502QR9J, Eukaryota |
GeneTreei | ENSGT00950000183025 |
InParanoidi | A2BGD5 |
PhylomeDBi | A2BGD5 |
TreeFami | TF329501 |
Enzyme and pathway databases
Reactomei | R-DRE-5357905, Regulation of TNFR1 signaling R-DRE-936440, Negative regulators of DDX58/IFIH1 signaling |
Miscellaneous databases
PROi | PR:A2BGD5 |
Gene expression databases
Bgeei | ENSDARG00000036695, Expressed in muscle organ and 31 other tissues |
ExpressionAtlasi | A2BGD5, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR012852, CALCOCO1-like IPR041611, SKICH |
Pfami | View protein in Pfam PF07888, CALCOCO1, 1 hit PF17751, SKICH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CACO1_DANRE | |
Accessioni | A2BGD5Primary (citable) accession number: A2BGD5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | September 29, 2021 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families