Annexin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium-dependent phospholipid binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• calcium-dependent protein binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• calcium ion binding Source: InterPro
• DNA/DNA annealing activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• double-stranded DNA-dependent ATPase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• phospholipase A2 inhibitor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• protein binding, bridging Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• protein homodimerization activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• structural molecule activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

GO - Biological processⁱ

• actin cytoskeleton reorganization Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• alpha-beta T cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• arachidonic acid secretion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cell surface receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cellular response to glucocorticoid stimulus Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cellular response to hydrogen peroxide Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cellular response to vascular endothelial growth factor stimulus Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• endocrine pancreas development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• fin regeneration Source: ZFIN <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 22278371
• gliogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• granulocyte chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• hepatocyte differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• inflammatory response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• insulin secretion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• keratinocyte differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• monocyte chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• myoblast migration involved in skeletal muscle regeneration Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of exocytosis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of interleukin-8 secretion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of phospholipase A2 activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of T-helper 2 cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• neutrophil clearance Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• phagocytosis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of cell migration involved in sprouting angiogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of G1/S transition of mitotic cell cycle Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of interleukin-2 production Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of neutrophil apoptotic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of prostaglandin biosynthetic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of T cell proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of T-helper 1 cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of vesicle fusion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of wound healing Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• prostate gland development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• regulation of cell proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• regulation of cell shape Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• regulation of hormone secretion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• regulation of inflammatory response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• regulation of interleukin-1 production Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• regulation of leukocyte migration Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to drug Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to estradiol Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to interleukin-1 Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to peptide hormone Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to X-ray Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• calcium-dependent protein binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• protein binding, bridging Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• protein homodimerization activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSFVSSFLEQ LAYQGMQETT VQDITEVQGT VKPYAQFNAA ADAAVLDKAI 
        60         70         80         90        100
KAKGVDEPTI IDTLVHRSNA QRQQIKAAYQ QATSKPLDVA LKNALKGELE 
       110        120        130        140        150
DVVLGLLMTP AQYDAFQLKY AMKGAGTTED TLIEILASRT NKEIGDIKQV 
       160        170        180        190        200
YKQEYKKDLE ADIKSDTSGD FRNALLSLCK ATRSEDNIVK DDLADKDARA 
       210        220        230
LYEAGEKRKG TDCSVFIDIL TSRNGPHLRK                       

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ