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UniProtKB - A2BFV8 (A2BFV8_DANRE)
Protein
Annexin
Gene
anxa1a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: GO_Central
- calcium ion binding Source: GO_Central
- phospholipase A2 inhibitor activity Source: GO_Central
GO - Biological processi
- actin cytoskeleton reorganization Source: GO_Central
- alpha-beta T cell differentiation Source: GO_Central
- arachidonic acid secretion Source: GO_Central
- cell surface receptor signaling pathway Source: GO_Central
- cellular response to glucocorticoid stimulus Source: GO_Central
- cellular response to hydrogen peroxide Source: GO_Central
- cellular response to vascular endothelial growth factor stimulus Source: GO_Central
- DNA duplex unwinding Source: GO_Central
- endocrine pancreas development Source: GO_Central
- fin regeneration Source: ZFIN
- gliogenesis Source: GO_Central
- granulocyte chemotaxis Source: GO_Central
- hepatocyte differentiation Source: GO_Central
- inflammatory response Source: GO_Central
- insulin secretion Source: GO_Central
- keratinocyte differentiation Source: GO_Central
- myoblast migration involved in skeletal muscle regeneration Source: GO_Central
- negative regulation of exocytosis Source: GO_Central
- negative regulation of phospholipase A2 activity Source: GO_Central
- negative regulation of T-helper 2 cell differentiation Source: GO_Central
- neutrophil clearance Source: GO_Central
- positive regulation of cell migration involved in sprouting angiogenesis Source: GO_Central
- positive regulation of G1/S transition of mitotic cell cycle Source: GO_Central
- positive regulation of interleukin-2 production Source: GO_Central
- positive regulation of neutrophil apoptotic process Source: GO_Central
- positive regulation of prostaglandin biosynthetic process Source: GO_Central
- positive regulation of T cell proliferation Source: GO_Central
- positive regulation of T-helper 1 cell differentiation Source: GO_Central
- positive regulation of vesicle fusion Source: GO_Central
- positive regulation of wound healing Source: GO_Central
- regulation of cell shape Source: GO_Central
- regulation of hormone secretion Source: GO_Central
- regulation of inflammatory response Source: GO_Central
- regulation of interleukin-1 production Source: GO_Central
- regulation of leukocyte migration Source: GO_Central
- response to estradiol Source: GO_Central
- response to interleukin-1 Source: GO_Central
- response to peptide hormone Source: GO_Central
- response to X-ray Source: GO_Central
Keywordsi
Molecular function | Phospholipase A2 inhibitorARBA annotation |
Ligand | Calcium, Calcium/phospholipid-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: AnnexinUniRule annotation |
Gene namesi | Name:anxa1aImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030131-6664, anxa1a |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Plasma membrane
- Basolateral cell membrane ARBA annotation
- Cell membrane ARBA annotation
- Lateral cell membrane ARBA annotation
Nucleus
- Nucleus ARBA annotation
Other locations
Extracellular region or secreted
- extracellular space Source: GO_Central
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB-SubCell
- lateral plasma membrane Source: UniProtKB-SubCell
- plasma membrane Source: GO_Central
Other locations
Keywords - Cellular componenti
Cell membraneARBA annotation, Cell projection, CiliumARBA annotation, CytoplasmARBA annotation, Membrane, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000026726, Expressed in caudal fin and 35 other tissues |
ExpressionAtlasi | A2BFV8, baseline and differential |
Structurei
Family & Domainsi
Domaini
A pair of annexin repeats may form one binding site for calcium and phospholipid.UniRule annotation
Sequence similaritiesi
Keywords - Domaini
AnnexinUniRule annotationARBA annotation, RepeatUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155221 |
HOGENOMi | CLU_025300_2_0_1 |
OMAi | TVIVKCA |
Family and domain databases
Gene3Di | 1.10.220.10, 3 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR002388, ANX1 |
PANTHERi | PTHR10502:SF17, PTHR10502:SF17, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 3 hits |
PRINTSi | PR00196, ANNEXIN |
SMARTi | View protein in SMART SM00335, ANX, 2 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 2 hits PS51897, ANNEXIN_2, 3 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A2BFV8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFVSSFLEQ LAYQGMQETT VQDITEVQGT VKPYAQFNAA ADAAVLDKAI
60 70 80 90 100
KAKGVDEPTI IDTLVHRSNA QRQQIKAAYQ QATSKPLDVA LKNALKGELE
110 120 130 140 150
DVVLGLLMTP AQYDAFQLKY AMKGAGTTED TLIEILASRT NKEIGDIKQV
160 170 180 190 200
YKQEYKKDLE ADIKSDTSGD FRNALLSLCK ATRSEDNIVK DDLADKDARA
210 220 230
LYEAGEKRKG TDCSVFIDIL TSRNGPHLRK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ804H2 | Q804H2_DANRE | Annexin | anxa1a | 340 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 230 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX296526 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000145353; ENSDARP00000119317; ENSDARG00000026726 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX296526 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A2BFV8 |
PRIDEi | A2BFV8 |
Genome annotation databases
Ensembli | ENSDART00000145353; ENSDARP00000119317; ENSDARG00000026726 |
Organism-specific databases
ZFINi | ZDB-GENE-030131-6664, anxa1a |
Phylogenomic databases
GeneTreei | ENSGT00940000155221 |
HOGENOMi | CLU_025300_2_0_1 |
OMAi | TVIVKCA |
Gene expression databases
Bgeei | ENSDARG00000026726, Expressed in caudal fin and 35 other tissues |
ExpressionAtlasi | A2BFV8, baseline and differential |
Family and domain databases
Gene3Di | 1.10.220.10, 3 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR002388, ANX1 |
PANTHERi | PTHR10502:SF17, PTHR10502:SF17, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 3 hits |
PRINTSi | PR00196, ANNEXIN |
SMARTi | View protein in SMART SM00335, ANX, 2 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 2 hits PS51897, ANNEXIN_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A2BFV8_DANRE | |
Accessioni | A2BFV8Primary (citable) accession number: A2BFV8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | January 19, 2022 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |