Si:ch211-284e13.4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• insulin receptor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• phosphatidylinositol 3-kinase binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

GO - Biological processⁱ

• insulin receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• insulin receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• phosphatidylinositol 3-kinase binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Fragment.

        10         20         30         40         50
MESQAAMEQQ SYEDVRKSGY LRKQKSMHRR FFVLRAASEQ GPARLEYYEN 
        60         70         80         90        100
EKKFRSKSPV PKKAVNLDSC FNINKRADSK NKHMIVLYTR GESFAIAADT 
       110        120        130        140        150
EEVQNEWYQA MLDLQCKCKT PDECGSGGDC GLPSPGPAFK EVWQVKVWPK 
       160        170        180        190        200
GLGQARNLIG IYRLCLTDKT VNFVKLNSDV AAVVLQLMNV RRCGHSENFF 
       210        220        230        240        250
FIEVGRSAMT GPGEFWMQVE DSVVAQNMHE TLLEAMKALS EEFRQRSKSQ 
       260        270        280        290        300
TVGVSCGGGT ASNPISVPSR RHHPNLPPSQ VGFSRRARTE TPGVHNTNTS 
       310        320        330        340        350
PTPRHGFSRS RTASIGARTE DGGGRATALS TSPSLNGSSC STTPTLRPKP 
       360        370        380        390        400
TRAPTPAKIT LSLARYTPNP APSPAPSLSS SSGHGSECGL GGATFGAVPI 
       410        420        430        440        450
CTYARIPQRV SMSGSPSDYG SSDEYGSSPG EHSLLAAGLP AALVEGGASY 
       460        470        480        490        500
ILMGHREGSH KRVHGRRVLR RSSSRECEVE RRLLSKRASL PPTSTQGLVP 
       510        520        530        540        550
RRREEEEEDE EEYAVMSRSA SRESFTSRRG SGGSATTSLV QENSADKGVS 
       560        570        580        590        600
TKGGPEDSSI DSGYMSMLPG VTAPPASLSL AVSGSDAVPK GGDEYMAMTP 
       610        620        630        640        650
NNSVSPPQHI RLPISEGYMM MSPNSSCSPD LHGISGCIWG SRGSMESRAG 
       660        670        680        690        700
SDYMNMSPIS ARSACSTPPS HPEQQPLQPK MVYSYFSLPR SYKHATLSAR 
       710        720        730        740        750
FEDNLERVCM GRGEAAGKTG HSAYDCGGDT PVGSGGGGQL SLSSSSFSSS 
       760        770        780        790        800
SASSESLEDR SLSLSVGGVG RAARLSTGHR VRGAHPKITS QHHHQQSCGP 
       810        820        830        840        850
GVPKQGHLQT RKDKSSSYFV DMSKANTLPR VRETLLPTAS QSPGEYVSIV 
       860        870        880        890        900
YKGERGGHKG RTAVESGNSR TQGHQRAFHR PQPCQGGSAN LPRSFSAPLA 
       910        920        930        940        950
TSISLSSEYV NMDLGSSPSS LTPLSSFKPA PKVRDEISRV PLVEQEVDMG 
       960        970        980        990       1000
LRKSKVTGLT PTDVAAAPFT DYTEMKFGLG GDSTSKSPKP GQTPLPSSME 
      1010       1020       1030       1040       1050
QEHTMNFSSP KAFSNVDQGA RVVRAESSAR RRHRSETFVA PPTHPLSPSA 
      1060       1070       1080       1090       1100
SPSPFPETPH SGLQRQQGLE GNLWSNNQPP SPKCASPGAA TLPAAQGSSL 
      1110       1120       1130       1140       1150
TLEQGLNYID LDLISKENQT SVDGPSGPHS FFSPVVGGLT GGLGGAGGNT 
      1160       1170 
TSSINTYASI DFIKSDELRV HQSNRKDSK                        

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ