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UniProtKB - A2BFQ2 (A2BFQ2_DANRE)

Entry version 89 (29 Sep 2021)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Si:ch211-284e13.4

Gene

si:ch211-284e13.4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Si:ch211-284e13.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:si:ch211-284e13.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-060526-161, si:ch211-284e13.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2BFQ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000060330, Expressed in swim bladder and 8 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000117614

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 116PHInterPro annotationAdd BLAST103
Domaini139 – 243IRS-type PTBInterPro annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni250 – 355DisorderedSequence analysisAdd BLAST106
Regioni367 – 387DisorderedSequence analysisAdd BLAST21
Regioni411 – 431DisorderedSequence analysisAdd BLAST21
Regioni458 – 566DisorderedSequence analysisAdd BLAST109
Regioni728 – 763DisorderedSequence analysisAdd BLAST36
Regioni786 – 816DisorderedSequence analysisAdd BLAST31
Regioni857 – 889DisorderedSequence analysisAdd BLAST33
Regioni978 – 1002DisorderedSequence analysisAdd BLAST25
Regioni1023 – 1091DisorderedSequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi250 – 269Polar residuesSequence analysisAdd BLAST20
Compositional biasi282 – 315Polar residuesSequence analysisAdd BLAST34
Compositional biasi325 – 348Polar residuesSequence analysisAdd BLAST24
Compositional biasi411 – 428Polar residuesSequence analysisAdd BLAST18
Compositional biasi470 – 485Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi519 – 548Polar residuesSequence analysisAdd BLAST30
Compositional biasi736 – 761Polar residuesSequence analysisAdd BLAST26
Compositional biasi864 – 878Polar residuesSequence analysisAdd BLAST15
Compositional biasi985 – 1002Polar residuesSequence analysisAdd BLAST18
Compositional biasi1024 – 1038Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1056 – 1084Polar residuesSequence analysisAdd BLAST29

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R1RX, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000166953

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004902_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2BFQ2

Identification of Orthologs from Complete Genome Data

More...OMAi		DGRHHQK

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2BFQ2

TreeFam database of animal gene trees

More...TreeFami		TF325994

Family and domain databases

Conserved Domains Database

More...CDDi		cd01204, PTB_IRS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039011, IRS
IPR002404, IRS_PTB
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...PANTHERi		PTHR10614, PTHR10614, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02174, IRS, 1 hit
PF00169, PH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00628, INSULINRSI

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit
SM00310, PTBI, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51064, IRS_PTB, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A2BFQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESQAAMEQQ SYEDVRKSGY LRKQKSMHRR FFVLRAASEQ GPARLEYYEN 
        60         70         80         90        100
EKKFRSKSPV PKKAVNLDSC FNINKRADSK NKHMIVLYTR GESFAIAADT 
       110        120        130        140        150
EEVQNEWYQA MLDLQCKCKT PDECGSGGDC GLPSPGPAFK EVWQVKVWPK 
       160        170        180        190        200
GLGQARNLIG IYRLCLTDKT VNFVKLNSDV AAVVLQLMNV RRCGHSENFF 
       210        220        230        240        250
FIEVGRSAMT GPGEFWMQVE DSVVAQNMHE TLLEAMKALS EEFRQRSKSQ 
       260        270        280        290        300
TVGVSCGGGT ASNPISVPSR RHHPNLPPSQ VGFSRRARTE TPGVHNTNTS 
       310        320        330        340        350
PTPRHGFSRS RTASIGARTE DGGGRATALS TSPSLNGSSC STTPTLRPKP 
       360        370        380        390        400
TRAPTPAKIT LSLARYTPNP APSPAPSLSS SSGHGSECGL GGATFGAVPI 
       410        420        430        440        450
CTYARIPQRV SMSGSPSDYG SSDEYGSSPG EHSLLAAGLP AALVEGGASY 
       460        470        480        490        500
ILMGHREGSH KRVHGRRVLR RSSSRECEVE RRLLSKRASL PPTSTQGLVP 
       510        520        530        540        550
RRREEEEEDE EEYAVMSRSA SRESFTSRRG SGGSATTSLV QENSADKGVS 
       560        570        580        590        600
TKGGPEDSSI DSGYMSMLPG VTAPPASLSL AVSGSDAVPK GGDEYMAMTP 
       610        620        630        640        650
NNSVSPPQHI RLPISEGYMM MSPNSSCSPD LHGISGCIWG SRGSMESRAG 
       660        670        680        690        700
SDYMNMSPIS ARSACSTPPS HPEQQPLQPK MVYSYFSLPR SYKHATLSAR 
       710        720        730        740        750
FEDNLERVCM GRGEAAGKTG HSAYDCGGDT PVGSGGGGQL SLSSSSFSSS 
       760        770        780        790        800
SASSESLEDR SLSLSVGGVG RAARLSTGHR VRGAHPKITS QHHHQQSCGP 
       810        820        830        840        850
GVPKQGHLQT RKDKSSSYFV DMSKANTLPR VRETLLPTAS QSPGEYVSIV 
       860        870        880        890        900
YKGERGGHKG RTAVESGNSR TQGHQRAFHR PQPCQGGSAN LPRSFSAPLA 
       910        920        930        940        950
TSISLSSEYV NMDLGSSPSS LTPLSSFKPA PKVRDEISRV PLVEQEVDMG 
       960        970        980        990       1000
LRKSKVTGLT PTDVAAAPFT DYTEMKFGLG GDSTSKSPKP GQTPLPSSME 
      1010       1020       1030       1040       1050
QEHTMNFSSP KAFSNVDQGA RVVRAESSAR RRHRSETFVA PPTHPLSPSA 
      1060       1070       1080       1090       1100
SPSPFPETPH SGLQRQQGLE GNLWSNNQPP SPKCASPGAA TLPAAQGSSL 
      1110       1120       1130       1140       1150
TLEQGLNYID LDLISKENQT SVDGPSGPHS FFSPVVGGLT GGLGGAGGNT 
      1160       1170 
TSSINTYASI DFIKSDELRV HQSNRKDSK
Length:1,179
Mass (Da):126,042
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i416B23339A51C068
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1179Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX294181 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000131831; ENSDARP00000117614; ENSDARG00000060330

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294181 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000117614

Proteomic databases

PaxDbiA2BFQ2

Genome annotation databases

EnsembliENSDART00000131831; ENSDARP00000117614; ENSDARG00000060330

Organism-specific databases

ZFINiZDB-GENE-060526-161, si:ch211-284e13.4

Phylogenomic databases

eggNOGiENOG502R1RX, Eukaryota
GeneTreeiENSGT00940000166953
HOGENOMiCLU_004902_2_0_1
InParanoidiA2BFQ2
OMAiDGRHHQK
PhylomeDBiA2BFQ2
TreeFamiTF325994

Gene expression databases

BgeeiENSDARG00000060330, Expressed in swim bladder and 8 other tissues

Family and domain databases

CDDicd01204, PTB_IRS, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039011, IRS
IPR002404, IRS_PTB
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR10614, PTHR10614, 1 hit
PfamiView protein in Pfam
PF02174, IRS, 1 hit
PF00169, PH, 1 hit
PRINTSiPR00628, INSULINRSI
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00310, PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064, IRS_PTB, 1 hit
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2BFQ2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2BFQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 29, 2021
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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