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UniProtKB - A2BFQ2 (A2BFQ2_DANRE)
Protein
Submitted name:
Si:ch211-284e13.4
Gene
si:ch211-284e13.4
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- insulin receptor binding Source: GO_Central
- phosphatidylinositol 3-kinase binding Source: GO_Central
GO - Biological processi
- insulin receptor signaling pathway Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Si:ch211-284e13.4Imported |
Gene namesi | Name:si:ch211-284e13.4Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-060526-161, si:ch211-284e13.4 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSDARG00000060330, Expressed in swim bladder and 8 other tissues |
Interactioni
GO - Molecular functioni
- insulin receptor binding Source: GO_Central
- phosphatidylinositol 3-kinase binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000117614 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 116 | PHInterPro annotationAdd BLAST | 103 | |
Domaini | 139 – 243 | IRS-type PTBInterPro annotationAdd BLAST | 105 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 250 – 355 | DisorderedSequence analysisAdd BLAST | 106 | |
Regioni | 367 – 387 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 411 – 431 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 458 – 566 | DisorderedSequence analysisAdd BLAST | 109 | |
Regioni | 728 – 763 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 786 – 816 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 857 – 889 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 978 – 1002 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1023 – 1091 | DisorderedSequence analysisAdd BLAST | 69 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 250 – 269 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 282 – 315 | Polar residuesSequence analysisAdd BLAST | 34 | |
Compositional biasi | 325 – 348 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 411 – 428 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 470 – 485 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 519 – 548 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 736 – 761 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 864 – 878 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 985 – 1002 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1024 – 1038 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1056 – 1084 | Polar residuesSequence analysisAdd BLAST | 29 |
Phylogenomic databases
eggNOGi | ENOG502R1RX, Eukaryota |
GeneTreei | ENSGT00940000166953 |
HOGENOMi | CLU_004902_2_0_1 |
InParanoidi | A2BFQ2 |
OMAi | DGRHHQK |
PhylomeDBi | A2BFQ2 |
TreeFami | TF325994 |
Family and domain databases
CDDi | cd01204, PTB_IRS, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR039011, IRS IPR002404, IRS_PTB IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR10614, PTHR10614, 1 hit |
Pfami | View protein in Pfam PF02174, IRS, 1 hit PF00169, PH, 1 hit |
PRINTSi | PR00628, INSULINRSI |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00310, PTBI, 1 hit |
PROSITEi | View protein in PROSITE PS51064, IRS_PTB, 1 hit PS50003, PH_DOMAIN, 1 hit |
i Sequence
Sequence statusi: Fragment.
A2BFQ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESQAAMEQQ SYEDVRKSGY LRKQKSMHRR FFVLRAASEQ GPARLEYYEN
60 70 80 90 100
EKKFRSKSPV PKKAVNLDSC FNINKRADSK NKHMIVLYTR GESFAIAADT
110 120 130 140 150
EEVQNEWYQA MLDLQCKCKT PDECGSGGDC GLPSPGPAFK EVWQVKVWPK
160 170 180 190 200
GLGQARNLIG IYRLCLTDKT VNFVKLNSDV AAVVLQLMNV RRCGHSENFF
210 220 230 240 250
FIEVGRSAMT GPGEFWMQVE DSVVAQNMHE TLLEAMKALS EEFRQRSKSQ
260 270 280 290 300
TVGVSCGGGT ASNPISVPSR RHHPNLPPSQ VGFSRRARTE TPGVHNTNTS
310 320 330 340 350
PTPRHGFSRS RTASIGARTE DGGGRATALS TSPSLNGSSC STTPTLRPKP
360 370 380 390 400
TRAPTPAKIT LSLARYTPNP APSPAPSLSS SSGHGSECGL GGATFGAVPI
410 420 430 440 450
CTYARIPQRV SMSGSPSDYG SSDEYGSSPG EHSLLAAGLP AALVEGGASY
460 470 480 490 500
ILMGHREGSH KRVHGRRVLR RSSSRECEVE RRLLSKRASL PPTSTQGLVP
510 520 530 540 550
RRREEEEEDE EEYAVMSRSA SRESFTSRRG SGGSATTSLV QENSADKGVS
560 570 580 590 600
TKGGPEDSSI DSGYMSMLPG VTAPPASLSL AVSGSDAVPK GGDEYMAMTP
610 620 630 640 650
NNSVSPPQHI RLPISEGYMM MSPNSSCSPD LHGISGCIWG SRGSMESRAG
660 670 680 690 700
SDYMNMSPIS ARSACSTPPS HPEQQPLQPK MVYSYFSLPR SYKHATLSAR
710 720 730 740 750
FEDNLERVCM GRGEAAGKTG HSAYDCGGDT PVGSGGGGQL SLSSSSFSSS
760 770 780 790 800
SASSESLEDR SLSLSVGGVG RAARLSTGHR VRGAHPKITS QHHHQQSCGP
810 820 830 840 850
GVPKQGHLQT RKDKSSSYFV DMSKANTLPR VRETLLPTAS QSPGEYVSIV
860 870 880 890 900
YKGERGGHKG RTAVESGNSR TQGHQRAFHR PQPCQGGSAN LPRSFSAPLA
910 920 930 940 950
TSISLSSEYV NMDLGSSPSS LTPLSSFKPA PKVRDEISRV PLVEQEVDMG
960 970 980 990 1000
LRKSKVTGLT PTDVAAAPFT DYTEMKFGLG GDSTSKSPKP GQTPLPSSME
1010 1020 1030 1040 1050
QEHTMNFSSP KAFSNVDQGA RVVRAESSAR RRHRSETFVA PPTHPLSPSA
1060 1070 1080 1090 1100
SPSPFPETPH SGLQRQQGLE GNLWSNNQPP SPKCASPGAA TLPAAQGSSL
1110 1120 1130 1140 1150
TLEQGLNYID LDLISKENQT SVDGPSGPHS FFSPVVGGLT GGLGGAGGNT
1160 1170
TSSINTYASI DFIKSDELRV HQSNRKDSK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1179 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX294181 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000131831; ENSDARP00000117614; ENSDARG00000060330 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX294181 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000117614 |
Proteomic databases
PaxDbi | A2BFQ2 |
Genome annotation databases
Ensembli | ENSDART00000131831; ENSDARP00000117614; ENSDARG00000060330 |
Organism-specific databases
ZFINi | ZDB-GENE-060526-161, si:ch211-284e13.4 |
Phylogenomic databases
eggNOGi | ENOG502R1RX, Eukaryota |
GeneTreei | ENSGT00940000166953 |
HOGENOMi | CLU_004902_2_0_1 |
InParanoidi | A2BFQ2 |
OMAi | DGRHHQK |
PhylomeDBi | A2BFQ2 |
TreeFami | TF325994 |
Gene expression databases
Bgeei | ENSDARG00000060330, Expressed in swim bladder and 8 other tissues |
Family and domain databases
CDDi | cd01204, PTB_IRS, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR039011, IRS IPR002404, IRS_PTB IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR10614, PTHR10614, 1 hit |
Pfami | View protein in Pfam PF02174, IRS, 1 hit PF00169, PH, 1 hit |
PRINTSi | PR00628, INSULINRSI |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00310, PTBI, 1 hit |
PROSITEi | View protein in PROSITE PS51064, IRS_PTB, 1 hit PS50003, PH_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2BFQ2_DANRE | |
Accessioni | A2BFQ2Primary (citable) accession number: A2BFQ2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | September 29, 2021 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |