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UniProtKB - A2BFP0 (A2BFP0_DANRE)
Protein
Submitted name:
Pleckstrin homology-like domain, family B, member 1a
Gene
phldb1a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Biological processi
- regulation of microtubule cytoskeleton organization Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Pleckstrin homology-like domain, family B, member 1aImported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-060526-272, phldb1a |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000061093, Expressed in muscle organ and 25 other tissues |
ExpressionAtlasi | A2BFP0, baseline |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1255 – 1358 | PHInterPro annotationAdd BLAST | 104 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 218 – 432 | DisorderedSequence analysisAdd BLAST | 215 | |
Regioni | 448 – 547 | DisorderedSequence analysisAdd BLAST | 100 | |
Regioni | 608 – 655 | DisorderedSequence analysisAdd BLAST | 48 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 553 – 573 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 668 – 706 | Sequence analysisAdd BLAST | 39 | |
Coiled coili | 714 – 751 | Sequence analysisAdd BLAST | 38 | |
Coiled coili | 775 – 799 | Sequence analysisAdd BLAST | 25 | |
Coiled coili | 825 – 845 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1140 – 1206 | Sequence analysisAdd BLAST | 67 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 234 – 424 | Polar residuesSequence analysisAdd BLAST | 191 | |
Compositional biasi | 476 – 519 | Polar residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 520 – 547 | Basic and acidic residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 626 – 655 | Basic and acidic residuesSequence analysisAdd BLAST | 30 |
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155231 |
HOGENOMi | CLU_003180_0_0_1 |
PhylomeDBi | A2BFP0 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd14673, PH_PHLDB1_2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR037810, PHLDB1/2/3_PH IPR008984, SMAD_FHA_dom_sf |
Pfami | View protein in Pfam PF00169, PH, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
A2BFP0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLNECEEMI DNSVDMDRMN RNVPEQGRQT HQVLQSTPLD LIETGKTLKV
60 70 80 90 100
QAERPHLVSL GSGRLSTAIT LLPLPEGKTT LGHGNTDINI QGPGVMSQHC
110 120 130 140 150
YIENVGAVIT LYPCGNQCSM DGLAVTKPVR LAQGCMLCFG QSSFFRFNHP
160 170 180 190 200
EEALRMKSLM PGGSPGFTNT YKNHSETHGQ LNGNHLPLHE RSRPGAGTLV
210 220 230 240 250
RSIEKDFQDI MNSLSMDDGQ AEHCKKARHP IPQSAMLNGS SRSLVSTPTS
260 270 280 290 300
PGALSVSSSY ENTSPPYSPL STPSMVSSPG ACLDSANTRS NSYTHTVQAP
310 320 330 340 350
VPQPRNFTSK NCSSNGGLKD QESARIQKAL TETPSSPGAN RRGDNTHGST
360 370 380 390 400
SGSSLVPGDL GRQVNTRFTS SSSASSSPRS SIGSSVQESS SSIQSLSRAL
410 420 430 440 450
LPPDSPQSSR RSVETSSIRE LPPLSPSTSR RGILGVPVLP VALPSVSLSS
460 470 480 490 500
RGRTVPDSPR LQRRTTAEEE VGNTRLHTRS PSPVSTLLKD QSGSKQKGGL
510 520 530 540 550
SSAVGSQTGV SPLTSPRNQR KASREARQVP PRTRERKNSI SEVSDKEEDL
560 570 580 590 600
LEYHRWQREE RMREQEMERL ERQRLETILN LCAEYNKSDP PVGVDAGRVC
610 620 630 640 650
LFPGMEEVSV RRPGPDPVSV PGQSSHRQRE SEEDNLKEEC SSTESQHQEH
660 670 680 690 700
EDTSVLGQQE RVYLEEERLR ILARVDELKT RVTDLEQQIQ ESRQEAEMER
710 720 730 740 750
ALLQGERRAE LDQVEAELEI INQLQLKLNE VENATQREKE KERAKVSAER
760 770 780 790 800
DVLARLKDSY SELKGQLHKC PESLREHLQE QLTRKVEALE SATKRFEDLE
810 820 830 840 850
FRQLERESGI EEEKETVGRQ LLQEKAEYHR NVAKRKEKMA ALEIQANQLG
860 870 880 890 900
LQAAQDCERM AKDRTLALQM LHKEKERLSS LEKRYQSLTG GKNFSKPTST
910 920 930 940 950
KEEYLKLSDV YKMYGNGCVP AQTASPNSLC LPLAVTSDTP REEYVTVSQL
960 970 980 990 1000
NQLFGMPKVD PYPTSSVQSF QAIDPAHSSH TSQCGSSQSL LVETQPAWSR
1010 1020 1030 1040 1050
PSIPRLDSER WYQEIMAAGQ PSHSCPPPLP AKCLSSRKPM QSLPDLSPAY
1060 1070 1080 1090 1100
LDIDSKRQLD LQSRGLYTCD DSRIRPMDHK LSHWGAPPSG APMVHHSILH
1110 1120 1130 1140 1150
HQAPPAGEST YDTLSLESSD SVETSVSTGN NSACSPESSN GLAGLRLEEM
1160 1170 1180 1190 1200
EKMLKEAQQE KARLVESRER EVQARKQMLE AERRRREEVE RRLLDETAHR
1210 1220 1230 1240 1250
QRLVEEEVKM REKQCSQARP MTRYLPIRKE EFDLRSHVES SGHSVDTCAY
1260 1270 1280 1290 1300
VIVTEKMCKG HLVKMGGKIK SWKKRWFVFD RLKRTFSYYV DKHETKLKGV
1310 1320 1330 1340 1350
IYFQAIEEVY YDHLRSATKS PNPSLTFCVK THDRLYFMVA PSPEAMRIWM
1360
DVIVTGAEGY TQFMT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7F1A4 | E7F1A4_DANRE | Pleckstrin homology-like domain, fa... | phldb1a | 1,156 | Annotation score: | ||
A0A2R8QUX6 | A0A2R8QUX6_DANRE | Pleckstrin homology-like domain, fa... | phldb1a | 1,290 | Annotation score: | ||
A0A2R8QS69 | A0A2R8QS69_DANRE | Pleckstrin homology-like domain, fa... | phldb1a | 1,455 | Annotation score: | ||
A0A2R8QNM9 | A0A2R8QNM9_DANRE | Pleckstrin homology-like domain, fa... | phldb1a | 1,412 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX294169 Genomic DNA No translation available. BX294389 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000138464; ENSDARP00000122296; ENSDARG00000061093 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX294169 Genomic DNA No translation available. BX294389 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A2BFP0 |
Genome annotation databases
Ensembli | ENSDART00000138464; ENSDARP00000122296; ENSDARG00000061093 |
Organism-specific databases
ZFINi | ZDB-GENE-060526-272, phldb1a |
Phylogenomic databases
GeneTreei | ENSGT00940000155231 |
HOGENOMi | CLU_003180_0_0_1 |
PhylomeDBi | A2BFP0 |
Gene expression databases
Bgeei | ENSDARG00000061093, Expressed in muscle organ and 25 other tissues |
ExpressionAtlasi | A2BFP0, baseline |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd14673, PH_PHLDB1_2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR037810, PHLDB1/2/3_PH IPR008984, SMAD_FHA_dom_sf |
Pfami | View protein in Pfam PF00169, PH, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2BFP0_DANRE | |
Accessioni | A2BFP0Primary (citable) accession number: A2BFP0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | June 2, 2021 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |