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UniProtKB - A2BFP0 (A2BFP0_DANRE)

Entry version 99 (02 Jun 2021)
Sequence version 1 (20 Feb 2007)
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Protein
Submitted name:

Pleckstrin homology-like domain, family B, member 1a

Gene

phldb1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pleckstrin homology-like domain, family B, member 1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:phldb1aImported
Synonyms:phldb1Imported, si:dkey-252h13.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-060526-272, phldb1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		A2BFP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000061093, Expressed in muscle organ and 25 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2BFP0, baseline

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1255 – 1358PHInterPro annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni218 – 432DisorderedSequence analysisAdd BLAST215
Regioni448 – 547DisorderedSequence analysisAdd BLAST100
Regioni608 – 655DisorderedSequence analysisAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili553 – 573Sequence analysisAdd BLAST21
Coiled coili668 – 706Sequence analysisAdd BLAST39
Coiled coili714 – 751Sequence analysisAdd BLAST38
Coiled coili775 – 799Sequence analysisAdd BLAST25
Coiled coili825 – 845Sequence analysisAdd BLAST21
Coiled coili1140 – 1206Sequence analysisAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi234 – 424Polar residuesSequence analysisAdd BLAST191
Compositional biasi476 – 519Polar residuesSequence analysisAdd BLAST44
Compositional biasi520 – 547Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi626 – 655Basic and acidic residuesSequence analysisAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155231

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003180_0_0_1

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2BFP0

Family and domain databases

Conserved Domains Database

More...CDDi		cd00060, FHA, 1 hit
cd14673, PH_PHLDB1_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000253, FHA_dom
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037810, PHLDB1/2/3_PH
IPR008984, SMAD_FHA_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00169, PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879, SSF49879, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A2BFP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLNECEEMI DNSVDMDRMN RNVPEQGRQT HQVLQSTPLD LIETGKTLKV 
        60         70         80         90        100
QAERPHLVSL GSGRLSTAIT LLPLPEGKTT LGHGNTDINI QGPGVMSQHC 
       110        120        130        140        150
YIENVGAVIT LYPCGNQCSM DGLAVTKPVR LAQGCMLCFG QSSFFRFNHP 
       160        170        180        190        200
EEALRMKSLM PGGSPGFTNT YKNHSETHGQ LNGNHLPLHE RSRPGAGTLV 
       210        220        230        240        250
RSIEKDFQDI MNSLSMDDGQ AEHCKKARHP IPQSAMLNGS SRSLVSTPTS 
       260        270        280        290        300
PGALSVSSSY ENTSPPYSPL STPSMVSSPG ACLDSANTRS NSYTHTVQAP 
       310        320        330        340        350
VPQPRNFTSK NCSSNGGLKD QESARIQKAL TETPSSPGAN RRGDNTHGST 
       360        370        380        390        400
SGSSLVPGDL GRQVNTRFTS SSSASSSPRS SIGSSVQESS SSIQSLSRAL 
       410        420        430        440        450
LPPDSPQSSR RSVETSSIRE LPPLSPSTSR RGILGVPVLP VALPSVSLSS 
       460        470        480        490        500
RGRTVPDSPR LQRRTTAEEE VGNTRLHTRS PSPVSTLLKD QSGSKQKGGL 
       510        520        530        540        550
SSAVGSQTGV SPLTSPRNQR KASREARQVP PRTRERKNSI SEVSDKEEDL 
       560        570        580        590        600
LEYHRWQREE RMREQEMERL ERQRLETILN LCAEYNKSDP PVGVDAGRVC 
       610        620        630        640        650
LFPGMEEVSV RRPGPDPVSV PGQSSHRQRE SEEDNLKEEC SSTESQHQEH 
       660        670        680        690        700
EDTSVLGQQE RVYLEEERLR ILARVDELKT RVTDLEQQIQ ESRQEAEMER 
       710        720        730        740        750
ALLQGERRAE LDQVEAELEI INQLQLKLNE VENATQREKE KERAKVSAER 
       760        770        780        790        800
DVLARLKDSY SELKGQLHKC PESLREHLQE QLTRKVEALE SATKRFEDLE 
       810        820        830        840        850
FRQLERESGI EEEKETVGRQ LLQEKAEYHR NVAKRKEKMA ALEIQANQLG 
       860        870        880        890        900
LQAAQDCERM AKDRTLALQM LHKEKERLSS LEKRYQSLTG GKNFSKPTST 
       910        920        930        940        950
KEEYLKLSDV YKMYGNGCVP AQTASPNSLC LPLAVTSDTP REEYVTVSQL 
       960        970        980        990       1000
NQLFGMPKVD PYPTSSVQSF QAIDPAHSSH TSQCGSSQSL LVETQPAWSR 
      1010       1020       1030       1040       1050
PSIPRLDSER WYQEIMAAGQ PSHSCPPPLP AKCLSSRKPM QSLPDLSPAY 
      1060       1070       1080       1090       1100
LDIDSKRQLD LQSRGLYTCD DSRIRPMDHK LSHWGAPPSG APMVHHSILH 
      1110       1120       1130       1140       1150
HQAPPAGEST YDTLSLESSD SVETSVSTGN NSACSPESSN GLAGLRLEEM 
      1160       1170       1180       1190       1200
EKMLKEAQQE KARLVESRER EVQARKQMLE AERRRREEVE RRLLDETAHR 
      1210       1220       1230       1240       1250
QRLVEEEVKM REKQCSQARP MTRYLPIRKE EFDLRSHVES SGHSVDTCAY 
      1260       1270       1280       1290       1300
VIVTEKMCKG HLVKMGGKIK SWKKRWFVFD RLKRTFSYYV DKHETKLKGV 
      1310       1320       1330       1340       1350
IYFQAIEEVY YDHLRSATKS PNPSLTFCVK THDRLYFMVA PSPEAMRIWM 
      1360 
DVIVTGAEGY TQFMT
Length:1,365
Mass (Da):152,765
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF758E33FD2C842F6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7F1A4E7F1A4_DANRE
Pleckstrin homology-like domain, fa...
phldb1a
1,156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QUX6A0A2R8QUX6_DANRE
Pleckstrin homology-like domain, fa...
phldb1a
1,290Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QS69A0A2R8QS69_DANRE
Pleckstrin homology-like domain, fa...
phldb1a
1,455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QNM9A0A2R8QNM9_DANRE
Pleckstrin homology-like domain, fa...
phldb1a
1,412Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX294169 Genomic DNA No translation available.
BX294389 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000138464; ENSDARP00000122296; ENSDARG00000061093

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294169 Genomic DNA No translation available.
BX294389 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PeptideAtlasiA2BFP0

Genome annotation databases

EnsembliENSDART00000138464; ENSDARP00000122296; ENSDARG00000061093

Organism-specific databases

ZFINiZDB-GENE-060526-272, phldb1a

Phylogenomic databases

GeneTreeiENSGT00940000155231
HOGENOMiCLU_003180_0_0_1
PhylomeDBiA2BFP0

Gene expression databases

BgeeiENSDARG00000061093, Expressed in muscle organ and 25 other tissues
ExpressionAtlasiA2BFP0, baseline

Family and domain databases

CDDicd00060, FHA, 1 hit
cd14673, PH_PHLDB1_2, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000253, FHA_dom
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037810, PHLDB1/2/3_PH
IPR008984, SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00169, PH, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SUPFAMiSSF49879, SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2BFP0_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2BFP0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: June 2, 2021
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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