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Protein

Ribosomal biogenesis protein LAS1L

Gene

Las1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processrRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal biogenesis protein LAS1L
Alternative name(s):
Protein LAS1 homolog
Gene namesi
Name:Las1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1923380 Las1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003909981 – 776Ribosomal biogenesis protein LAS1LAdd BLAST776

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei425PhosphoserineBy similarity1
Modified residuei509PhosphoserineBy similarity1
Modified residuei658PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2BE28
PaxDbiA2BE28
PeptideAtlasiA2BE28
PRIDEiA2BE28

PTM databases

iPTMnetiA2BE28
PhosphoSitePlusiA2BE28

Expressioni

Gene expression databases

BgeeiENSMUSG00000057421 Expressed in 286 organ(s), highest expression level in placenta labyrinth
GenevisibleiA2BE28 MM

Interactioni

Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.By similarity1 Publication

Protein-protein interaction databases

BioGridi217980, 5 interactors
IntActiA2BE28, 1 interactor
STRINGi10090.ENSMUSP00000078901

Family & Domainsi

Sequence similaritiesi

Belongs to the LAS1 family.Curated

Phylogenomic databases

eggNOGiKOG2425 Eukaryota
ENOG411230Q LUCA
GeneTreeiENSGT00390000014785
HOGENOMiHOG000232090
HOVERGENiHBG080556
InParanoidiA2BE28
KOiK16912
OMAiPFSQFWQ
OrthoDBiEOG091G04XI
TreeFamiTF314042

Family and domain databases

InterProiView protein in InterPro
IPR007174 Las1
PANTHERiPTHR15002 PTHR15002, 1 hit
PfamiView protein in Pfam
PF04031 Las1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A2BE28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRVWRAWDG QSFKENQPES PSARGIVVSW LSRAEWEQVT VYLFCDDHKL
60 70 80 90 100
QQYALNRITV WRSRLGNELP LAVASTADLV RCKLIDAAGT LGTDELRLLY
110 120 130 140 150
GMALVRFVNL ISERKTKCSN LPLKYLAQEV NIPDWIVELR HNLTHKKMPH
160 170 180 190 200
INECRRGCYF VLNWLQKTYW SRQLEGSLKE TWELDEDQLD AEDPEEEERE
210 220 230 240 250
IIADDVLEEI PEPQDDDKDE ELAVEDDANT KGNEEVASHP EPSSRHKELY
260 270 280 290 300
EKARELLVSY EEEQFKVLEK HRHLLQAIKV WNNLSPRVQC ILEELKSISW
310 320 330 340 350
ENRDAVLDAF LDDGFLIPTF EQLAALQIEY EDGQTEVQKG EVTEPNSHKN
360 370 380 390 400
IDLNEVLVPK PFSQFWQPLL RGLHSQTFTQ ALLERMFSEL STVGSTGIRP
410 420 430 440 450
TYILRWTVEL IVANTKTGRN ARRFSASQWE ARKSWRLFNC SATLDWPQVI
460 470 480 490 500
ESCLGSPCWA SPQLLQVVFK AMGQVLPDEE QEKLLRVCSI YTQNGENGLA
510 520 530 540 550
KAIEGSSSSS TGKAPYTLDT LHEDLQPPGT NCESEESIQQ KEQGNLKDVK
560 570 580 590 600
QEEKKENEEE EKEEEEMEEE EEEEEEEKEE EEEEQEQEEH QEEEQEEEEE
610 620 630 640 650
EENQKVFQDQ MEADVEESDD VEEEEEVDDE EEDEDDDYDD DEEEDRMEVG
660 670 680 690 700
AFSLAQGSSV FENTRTTSRK REALQGSAWQ VSSEDVRWGT FPLGRLPGQT
710 720 730 740 750
EDPAELMLDN YDTMYLLDQP VIEHRLEPQK SKSSTLSLCC GGSNTNSSSS
760 770
SSSGNMEGLL WNQGQMHGLK AGLQLF
Length:776
Mass (Da):89,414
Last modified:February 20, 2007 - v1
Checksum:i6855167CD37D57EC
GO
Isoform 2 (identifier: A2BE28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-349: DGQTEVQKGEVTEPNSHK → E

Show »
Length:759
Mass (Da):87,578
Checksum:i93701CFEE32B2326
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038670332 – 349DGQTE…PNSHK → E in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005184 Genomic DNA No translation available.
BC141155 mRNA Translation: AAI41156.1
AK052578 mRNA Translation: BAC35047.1
AK131142 mRNA Translation: BAD21392.1
CCDSiCCDS30287.1 [A2BE28-2]
RefSeqiNP_690035.2, NM_152822.3 [A2BE28-2]
XP_006528397.1, XM_006528334.2 [A2BE28-1]
UniGeneiMm.274318

Genome annotation databases

EnsembliENSMUST00000079987; ENSMUSP00000078901; ENSMUSG00000057421 [A2BE28-2]
ENSMUST00000113864; ENSMUSP00000109495; ENSMUSG00000057421 [A2BE28-1]
GeneIDi76130
KEGGimmu:76130
UCSCiuc009tud.2 mouse [A2BE28-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005184 Genomic DNA No translation available.
BC141155 mRNA Translation: AAI41156.1
AK052578 mRNA Translation: BAC35047.1
AK131142 mRNA Translation: BAD21392.1
CCDSiCCDS30287.1 [A2BE28-2]
RefSeqiNP_690035.2, NM_152822.3 [A2BE28-2]
XP_006528397.1, XM_006528334.2 [A2BE28-1]
UniGeneiMm.274318

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217980, 5 interactors
IntActiA2BE28, 1 interactor
STRINGi10090.ENSMUSP00000078901

PTM databases

iPTMnetiA2BE28
PhosphoSitePlusiA2BE28

Proteomic databases

MaxQBiA2BE28
PaxDbiA2BE28
PeptideAtlasiA2BE28
PRIDEiA2BE28

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079987; ENSMUSP00000078901; ENSMUSG00000057421 [A2BE28-2]
ENSMUST00000113864; ENSMUSP00000109495; ENSMUSG00000057421 [A2BE28-1]
GeneIDi76130
KEGGimmu:76130
UCSCiuc009tud.2 mouse [A2BE28-2]

Organism-specific databases

CTDi81887
MGIiMGI:1923380 Las1l

Phylogenomic databases

eggNOGiKOG2425 Eukaryota
ENOG411230Q LUCA
GeneTreeiENSGT00390000014785
HOGENOMiHOG000232090
HOVERGENiHBG080556
InParanoidiA2BE28
KOiK16912
OMAiPFSQFWQ
OrthoDBiEOG091G04XI
TreeFamiTF314042

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

PROiPR:A2BE28
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057421 Expressed in 286 organ(s), highest expression level in placenta labyrinth
GenevisibleiA2BE28 MM

Family and domain databases

InterProiView protein in InterPro
IPR007174 Las1
PANTHERiPTHR15002 PTHR15002, 1 hit
PfamiView protein in Pfam
PF04031 Las1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLAS1L_MOUSE
AccessioniPrimary (citable) accession number: A2BE28
Secondary accession number(s): A2BE30, Q6KAR5, Q8C742
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: February 20, 2007
Last modified: September 12, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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