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Protein

Ribosomal biogenesis protein LAS1L

Gene

Las1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • maturation of 5.8S rRNA Source: GO_Central
  • maturation of LSU-rRNA Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processrRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosomal biogenesis protein LAS1L
Alternative name(s):
Protein LAS1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Las1l
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923380 Las1l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003909981 – 776Ribosomal biogenesis protein LAS1LAdd BLAST776

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei425PhosphoserineBy similarity1
Modified residuei509PhosphoserineBy similarity1
Modified residuei658PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2BE28

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2BE28

PeptideAtlas

More...
PeptideAtlasi
A2BE28

PRoteomics IDEntifications database

More...
PRIDEi
A2BE28

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2BE28

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2BE28

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000057421 Expressed in 286 organ(s), highest expression level in placenta labyrinth

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2BE28 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
217980, 5 interactors

Protein interaction database and analysis system

More...
IntActi
A2BE28, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000078901

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAS1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2425 Eukaryota
ENOG411230Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014785

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232090

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080556

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2BE28

KEGG Orthology (KO)

More...
KOi
K16912

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPKSHKN

Database of Orthologous Groups

More...
OrthoDBi
1070386at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314042

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007174 Las1

The PANTHER Classification System

More...
PANTHERi
PTHR15002 PTHR15002, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04031 Las1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A2BE28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRVWRAWDG QSFKENQPES PSARGIVVSW LSRAEWEQVT VYLFCDDHKL
60 70 80 90 100
QQYALNRITV WRSRLGNELP LAVASTADLV RCKLIDAAGT LGTDELRLLY
110 120 130 140 150
GMALVRFVNL ISERKTKCSN LPLKYLAQEV NIPDWIVELR HNLTHKKMPH
160 170 180 190 200
INECRRGCYF VLNWLQKTYW SRQLEGSLKE TWELDEDQLD AEDPEEEERE
210 220 230 240 250
IIADDVLEEI PEPQDDDKDE ELAVEDDANT KGNEEVASHP EPSSRHKELY
260 270 280 290 300
EKARELLVSY EEEQFKVLEK HRHLLQAIKV WNNLSPRVQC ILEELKSISW
310 320 330 340 350
ENRDAVLDAF LDDGFLIPTF EQLAALQIEY EDGQTEVQKG EVTEPNSHKN
360 370 380 390 400
IDLNEVLVPK PFSQFWQPLL RGLHSQTFTQ ALLERMFSEL STVGSTGIRP
410 420 430 440 450
TYILRWTVEL IVANTKTGRN ARRFSASQWE ARKSWRLFNC SATLDWPQVI
460 470 480 490 500
ESCLGSPCWA SPQLLQVVFK AMGQVLPDEE QEKLLRVCSI YTQNGENGLA
510 520 530 540 550
KAIEGSSSSS TGKAPYTLDT LHEDLQPPGT NCESEESIQQ KEQGNLKDVK
560 570 580 590 600
QEEKKENEEE EKEEEEMEEE EEEEEEEKEE EEEEQEQEEH QEEEQEEEEE
610 620 630 640 650
EENQKVFQDQ MEADVEESDD VEEEEEVDDE EEDEDDDYDD DEEEDRMEVG
660 670 680 690 700
AFSLAQGSSV FENTRTTSRK REALQGSAWQ VSSEDVRWGT FPLGRLPGQT
710 720 730 740 750
EDPAELMLDN YDTMYLLDQP VIEHRLEPQK SKSSTLSLCC GGSNTNSSSS
760 770
SSSGNMEGLL WNQGQMHGLK AGLQLF
Length:776
Mass (Da):89,414
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6855167CD37D57EC
GO
Isoform 2 (identifier: A2BE28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-349: DGQTEVQKGEVTEPNSHK → E

Show »
Length:759
Mass (Da):87,578
Checksum:i93701CFEE32B2326
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038670332 – 349DGQTE…PNSHK → E in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX005184 Genomic DNA No translation available.
BC141155 mRNA Translation: AAI41156.1
AK052578 mRNA Translation: BAC35047.1
AK131142 mRNA Translation: BAD21392.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30287.1 [A2BE28-2]

NCBI Reference Sequences

More...
RefSeqi
NP_690035.2, NM_152822.3 [A2BE28-2]
XP_006528397.1, XM_006528334.2 [A2BE28-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.274318

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000079987; ENSMUSP00000078901; ENSMUSG00000057421 [A2BE28-2]
ENSMUST00000113864; ENSMUSP00000109495; ENSMUSG00000057421 [A2BE28-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
76130

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:76130

UCSC genome browser

More...
UCSCi
uc009tud.2 mouse [A2BE28-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005184 Genomic DNA No translation available.
BC141155 mRNA Translation: AAI41156.1
AK052578 mRNA Translation: BAC35047.1
AK131142 mRNA Translation: BAD21392.1
CCDSiCCDS30287.1 [A2BE28-2]
RefSeqiNP_690035.2, NM_152822.3 [A2BE28-2]
XP_006528397.1, XM_006528334.2 [A2BE28-1]
UniGeneiMm.274318

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

BioGridi217980, 5 interactors
IntActiA2BE28, 1 interactor
STRINGi10090.ENSMUSP00000078901

PTM databases

iPTMnetiA2BE28
PhosphoSitePlusiA2BE28

Proteomic databases

MaxQBiA2BE28
PaxDbiA2BE28
PeptideAtlasiA2BE28
PRIDEiA2BE28

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079987; ENSMUSP00000078901; ENSMUSG00000057421 [A2BE28-2]
ENSMUST00000113864; ENSMUSP00000109495; ENSMUSG00000057421 [A2BE28-1]
GeneIDi76130
KEGGimmu:76130
UCSCiuc009tud.2 mouse [A2BE28-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81887
MGIiMGI:1923380 Las1l

Phylogenomic databases

eggNOGiKOG2425 Eukaryota
ENOG411230Q LUCA
GeneTreeiENSGT00390000014785
HOGENOMiHOG000232090
HOVERGENiHBG080556
InParanoidiA2BE28
KOiK16912
OMAiDPKSHKN
OrthoDBi1070386at2759
TreeFamiTF314042

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2BE28

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000057421 Expressed in 286 organ(s), highest expression level in placenta labyrinth
GenevisibleiA2BE28 MM

Family and domain databases

InterProiView protein in InterPro
IPR007174 Las1
PANTHERiPTHR15002 PTHR15002, 1 hit
PfamiView protein in Pfam
PF04031 Las1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAS1L_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2BE28
Secondary accession number(s): A2BE30, Q6KAR5, Q8C742
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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