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Protein

Potassium voltage-gated channel subfamily G member 1

Gene

Kcng1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.By similarity

GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: UniProtKB
  • voltage-gated potassium channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv6.1
Gene namesi
Name:Kcng1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:3616086 Kcng1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 224CytoplasmicBy similarityAdd BLAST224
Transmembranei225 – 246Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini247 – 267ExtracellularBy similarityAdd BLAST21
Transmembranei268 – 289Helical; Name=Segment S2By similarityAdd BLAST22
Topological domaini290 – 300CytoplasmicBy similarityAdd BLAST11
Transmembranei301 – 321Helical; Name=Segment S3By similarityAdd BLAST21
Topological domaini322 – 338ExtracellularBy similarityAdd BLAST17
Transmembranei339 – 359Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini360 – 374CytoplasmicBy similarityAdd BLAST15
Transmembranei375 – 396Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini397 – 411ExtracellularBy similarityAdd BLAST15
Intramembranei412 – 423Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei424 – 431By similarity8
Topological domaini432 – 438ExtracellularBy similarity7
Transmembranei439 – 467Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini468 – 514CytoplasmicBy similarityAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003201061 – 514Potassium voltage-gated channel subfamily G member 1Add BLAST514

Proteomic databases

PaxDbiA2BDX4
PRIDEiA2BDX4

PTM databases

PhosphoSitePlusiA2BDX4

Expressioni

Gene expression databases

BgeeiENSMUSG00000074575 Expressed in 73 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiA2BDX4 baseline and differential
GenevisibleiA2BDX4 MM

Interactioni

Subunit structurei

Heterotetramer with KCNB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096668

Structurei

3D structure databases

ProteinModelPortaliA2BDX4
SMRiA2BDX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi424 – 429Selectivity filterBy similarity6

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231014
HOVERGENiHBG100172
InParanoidiA2BDX4
KOiK04900
OMAiGQCSQMC
OrthoDBiEOG091G05DD
PhylomeDBiA2BDX4
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003969 K_chnl_volt-dep_Kv6
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01492 KV6CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2BDX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLLPGDNSH YDYSALSCAS DTSFHPAFFP QRQAIKGVFY RRAQRLRPQD
60 70 80 90 100
DLHQSCSLGD RRRQIIINVG GIKYSLPWTT LDEFPLTRLG QLKACTNFDD
110 120 130 140 150
ILSVCDDYDV TCNEFFFDRN PGAFGTILTF LRAGKLRLLR EMCALSFQEE
160 170 180 190 200
LLYWGIAEDH LDGCCKRRYL QKIEEFAEMM EREEEEEPLD SEDQESEGPS
210 220 230 240 250
ASEGRLSRCM RRLRDMVERP HSGLPGKVFA CLSVLFVTVT AVNLSVSTLP
260 270 280 290 300
SLREEEEQGQ CSQMCHNVFI VESVCVGWFS LEFLLRFIQA PSKFAFLRSP
310 320 330 340 350
LTLIDLVAIL PYYVTLLVDG AASSRRKPST GNSYLDKVGL VLRVLRALRI
360 370 380 390 400
LYVMRLARHS LGLQTLGLTA RRCTREFGLL LLFLCVAIAL FAPLLYVIEN
410 420 430 440 450
EMADSPEFTS IPACYWWAVI TMTTVGYGDM VPRSTPGQVV ALSSILSGIL
460 470 480 490 500
LMAFPVTSIF HTFSRSYLEL KQEQERVLIR RAQYLIKTKS QLSGMSQDSD
510
ILFGSASSDT RDNN
Length:514
Mass (Da):58,176
Last modified:February 20, 2007 - v1
Checksum:i775318D70706A92A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2BDX5A2BDX5_MOUSE
Potassium voltage-gated channel sub...
Kcng1
48Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005039 Genomic DNA No translation available.
CCDSiCCDS38344.1
RefSeqiNP_001074603.1, NM_001081134.1
XP_006499601.1, XM_006499538.3
XP_006499602.1, XM_006499539.3
UniGeneiMm.425102

Genome annotation databases

EnsembliENSMUST00000099069; ENSMUSP00000096668; ENSMUSG00000074575
ENSMUST00000109191; ENSMUSP00000104815; ENSMUSG00000074575
GeneIDi241794
KEGGimmu:241794
UCSCiuc008oat.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005039 Genomic DNA No translation available.
CCDSiCCDS38344.1
RefSeqiNP_001074603.1, NM_001081134.1
XP_006499601.1, XM_006499538.3
XP_006499602.1, XM_006499539.3
UniGeneiMm.425102

3D structure databases

ProteinModelPortaliA2BDX4
SMRiA2BDX4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096668

PTM databases

PhosphoSitePlusiA2BDX4

Proteomic databases

PaxDbiA2BDX4
PRIDEiA2BDX4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099069; ENSMUSP00000096668; ENSMUSG00000074575
ENSMUST00000109191; ENSMUSP00000104815; ENSMUSG00000074575
GeneIDi241794
KEGGimmu:241794
UCSCiuc008oat.1 mouse

Organism-specific databases

CTDi3755
MGIiMGI:3616086 Kcng1

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231014
HOVERGENiHBG100172
InParanoidiA2BDX4
KOiK04900
OMAiGQCSQMC
OrthoDBiEOG091G05DD
PhylomeDBiA2BDX4
TreeFamiTF313103

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Miscellaneous databases

PROiPR:A2BDX4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074575 Expressed in 73 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiA2BDX4 baseline and differential
GenevisibleiA2BDX4 MM

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003969 K_chnl_volt-dep_Kv6
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01492 KV6CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCNG1_MOUSE
AccessioniPrimary (citable) accession number: A2BDX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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