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Entry version 93 (26 Feb 2020)
Sequence version 2 (20 May 2008)
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Protein

Collagen alpha-4(VI) chain

Gene

Col6a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Collagen VI acts as a cell-binding protein.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-4(VI) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col6a4
Synonyms:Dvwa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1915803 Col6a4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500021419723 – 2309Collagen alpha-4(VI) chainAdd BLAST2287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi754N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1114N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AX52

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AX52

PRoteomics IDEntifications database

More...
PRIDEi
A2AX52

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AX52

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AX52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In newborn, it is expressed in lung, kidney, brain, intestine, skin, sternum and, at weak level, calvaria. In adult, it is almost absent with some weak expression in ovary and very weak expression in spleen, lung, uterus and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032572 Expressed in uterus and 92 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AX52 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AX52 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
212923, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000112472

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A2AX52 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AX52

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 206VWFA 1PROSITE-ProRule annotationAdd BLAST173
Domaini235 – 413VWFA 2PROSITE-ProRule annotationAdd BLAST179
Domaini430 – 653VWFA 3PROSITE-ProRule annotationAdd BLAST224
Domaini634 – 811VWFA 4PROSITE-ProRule annotationAdd BLAST178
Domaini849 – 1018VWFA 5PROSITE-ProRule annotationAdd BLAST170
Domaini1030 – 1199VWFA 6PROSITE-ProRule annotationAdd BLAST170
Domaini1776 – 1957VWFA 7PROSITE-ProRule annotationAdd BLAST182
Domaini1982 – 2187VWFA 8PROSITE-ProRule annotationAdd BLAST206

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni21 – 1410Nonhelical regionAdd BLAST1390
Regioni1411 – 1744Triple-helical regionAdd BLAST334
Regioni1745 – 2309Nonhelical regionAdd BLAST565

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1527 – 1529Cell attachment siteSequence analysis3
Motifi2208 – 2210Cell attachment siteSequence analysis3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type VI collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410ZT70 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163168

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000182_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AX52

KEGG Orthology (KO)

More...
KOi
K06238

Identification of Orthologs from Complete Genome Data

More...
OMAi
VHQYLIV

Database of Orthologous Groups

More...
OrthoDBi
1049829at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AX52

TreeFam database of animal gene trees

More...
TreeFami
TF337483

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 1 hit
PF00092 VWA, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00327 VWA, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234 VWFA, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AX52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTWKTFWLI ISLAAGLGFV KSQRIVCREA SVGDIVFLVH NSINPQHAHS
60 70 80 90 100
VRNFLYILAN SLQVGRDNIR VGLAQYSDTP TSEFLLSVYH RKGDVLKHIR
110 120 130 140 150
GLQFKPGGNR MGQALQFILE HHFREGAGSR ASQGVPQVAV VVSSGLTEDH
160 170 180 190 200
IREPAEALRR AGILVYAIGV KDASQAELRE ISSSPKDNFT FFVPNFPGLP
210 220 230 240 250
GLAQKLRPEL CSTLGKAAQY TERESPACSE ASPADIVFLV DSSTSIGLQN
260 270 280 290 300
FQKVKHFLHS VVSGLDVRSD QVQVGLVQYS DNIYPAFPLK QSSLKSAVLD
310 320 330 340 350
RIRNLPYSMG GTSTGSALEF IRANSLTEMS GSRAKDGVPQ IVVLVTDGES
360 370 380 390 400
SDEVQDVADQ LKRDGVFVFV VGINIQDVQE LQKIANEPFE EFLFTTENFS
410 420 430 440 450
ILQALSGTLL QALCSTVERQ MKKSTKTYAD VVFLIDTSQG TSQASFQWMQ
460 470 480 490 500
NFISRIIGIL EVGQDKYQIG LAQYSDQGHT EFLFNTHKTR NEMVAHIHEL
510 520 530 540 550
LVFQGGSRKT GQGLRFLHRT FFQEAAGSRL LQGVPQYVVV ITSGKSEDEV
560 570 580 590 600
GEVAQILRKR GVDIVSVGLQ DFDRAELEGI GPVVLVSDLQ GEDRIRQLML
610 620 630 640 650
DVNMFIQGSP KPPRVMTDVA KDAVEECLVP VPADLVFLVE DFSSARQPNF
660 670 680 690 700
QRVVHFLTTT VHSLNIHPDT TRVSLVFYSE KPRLEFSLDM YQSAAQVLRH
710 720 730 740 750
LDRLTFRARR GRAKAGAALD FLRKEVFLPE KGSRPHRGVQ QIAVVIIESP
760 770 780 790 800
SLDNVSTPAS YLRRAGVTIY AAGTQPASES KDLEKIVTYP PWKHAIRLES
810 820 830 840 850
FLQLSVVGNK LKKKLCPEML SGMPPLMSFI PESTRQSTQE GCESVEKADI
860 870 880 890 900
YFLIDGSGSI KPNDFIEMKD FMKEVIKMFH IGPDRVRFGV VQYSDKIISQ
910 920 930 940 950
FFLTQYASMA GLSAAIDNIQ QVGGGTTTGK ALSKMVPVFQ NTARIDVARY
960 970 980 990 1000
LIVITDGQST DPVAEAAQGL RDIGVNIYAI GVRDANTTEL EEIASKKMFF
1010 1020 1030 1040 1050
IYEFDSLKSI HQEVIRDICS SENCKSQKAD IIFLIDGSES IAPKDFEKMK
1060 1070 1080 1090 1100
DFMERMVNQS NIGADEIQIG LLQFSSNPQE EFRLNRYSSK VDMCRAILSV
1110 1120 1130 1140 1150
QQMSDGTHTG KALNFTLPFF DSSRGGRPRV HQYLIVITDG VSQDNVAPPA
1160 1170 1180 1190 1200
KALRDRNIII FAIGVGNVQR AQLLEITNDQ DKVFQEENFE SLQSLEKEIL
1210 1220 1230 1240 1250
SEVCSSQGCN IDLSVGVDTS TSSERAQQEL RRLLPELMQQ LAFLSNISCE
1260 1270 1280 1290 1300
APGQMEPRFR YVVPGSSDQP VFDSGFEKYS DETIQKFLVH QGSVNNRMDV
1310 1320 1330 1340 1350
DFLQSLGETA IHLSLAKVKV LLVFTDGLDE DLERLRRTSE FLRSRGLSGL
1360 1370 1380 1390 1400
LLIGLGGAHK LEELQELEFG RGFAYRQPLS SSLPSLPSVL LKQLDTIVER
1410 1420 1430 1440 1450
TCCNMYAKCY GDDGIRGEPG SRGEQGERGL DGLPGHPGEE GDHGQRGPRG
1460 1470 1480 1490 1500
LPGLRGEEGC PGVRGPKGAR GFSGEKGNPG EEGVGGLDGE QGDRGAAGPS
1510 1520 1530 1540 1550
GEKGSSGSRG LTGLPGPAGP RGEPGLRGDP GDPGIDNLIQ GPKGEKGRRG
1560 1570 1580 1590 1600
HQGSPGFHGP LGEAGSVGPR GSLGRHGLPG LKGVLGETGE LGSRGEPGHP
1610 1620 1630 1640 1650
GPQGPRGRQG PPGFFGQKGD PGTQGNPGLP GPSGSKGPDG PRGLKGEVGP
1660 1670 1680 1690 1700
AGERGPRGQQ GPRGQPGLFG PDGHGYPGRK GRKGEPGFPG YPGVQGEDGN
1710 1720 1730 1740 1750
PGRGGEKGAK GIRGKRGNSG FPGLAGTPGD QGPPGKMGTK GSKGLADRTP
1760 1770 1780 1790 1800
CEIVDFVRGN CPCSTGISRC PAFPTEVVFT LDMSNDVAPS DFERMRNILL
1810 1820 1830 1840 1850
SLLMKLEMCE SNCPTGARVA IVSYNTRTDY LVRLSDHRGK AALLQAVRKI
1860 1870 1880 1890 1900
PLERSSGSRN LGATMRFVAR HVFKRVRSGL LVRKVAVFFQ AGRNYDTASV
1910 1920 1930 1940 1950
STATLELHAA DIATAVVTFT EEHNLPEAGL VDGPNEFHLF TWETEGQQDV
1960 1970 1980 1990 2000
ERLASCTLCY DKCRPALGCQ LRAPGPQKLD MDLVFLVDSS QGVSRDIYLG
2010 2020 2030 2040 2050
ALRLVDSVLK DLEVAAQPGT SWHGARAALL THTTPGFWPG VDQAPVLEYF
2060 2070 2080 2090 2100
HLTSHGHRTE MQRQIREAAS GLLQGGPALG HALEWTLENV LLTAVLPRRS
2110 2120 2130 2140 2150
RVLYAIVASE TSIWDREKLR TLSQEAKCKG IALFVLAVGP GVGAQELAEL
2160 2170 2180 2190 2200
AKVASAPWEQ HLLRLEGVSE AEVAYASRFT EAFLNLLNSG INQYPPPELV
2210 2220 2230 2240 2250
KECGGPNRGD TLLHFFTSAK RFSRSQSGTS AAFANDSEAL KSQGIFLGER
2260 2270 2280 2290 2300
KSRVASVALQ EALGSHGKDR ADTEDIDQET PAKGRHLGPT HGPCPMGPEE

GECLNYVLK
Length:2,309
Mass (Da):250,798
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31F0282FC77B0DE8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6K8A0A1W2P6K8_MOUSE
Collagen alpha-4(VI) chain
Col6a4
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77S → G in BAF95091 (Ref. 1) Curated1
Sequence conflicti147T → A in BAF95091 (Ref. 1) Curated1
Sequence conflicti215G → A in BAF95091 (Ref. 1) Curated1
Sequence conflicti223R → Q in BAF95091 (Ref. 1) Curated1
Sequence conflicti263S → L in BAF95091 (Ref. 1) Curated1
Sequence conflicti386N → S in BAF95091 (Ref. 1) Curated1
Sequence conflicti425T → N in BAF95091 (Ref. 1) Curated1
Sequence conflicti443Q → P in BAF95091 (Ref. 1) Curated1
Sequence conflicti468Q → R in BAF95091 (Ref. 1) Curated1
Sequence conflicti646R → G in BAF95091 (Ref. 1) Curated1
Sequence conflicti699R → S in BAF95091 (Ref. 1) Curated1
Sequence conflicti707R → Q in BAF95091 (Ref. 1) Curated1
Sequence conflicti713A → T in BAF95091 (Ref. 1) Curated1
Sequence conflicti747I → M in BAF95091 (Ref. 1) Curated1
Sequence conflicti774T → I in BAF95091 (Ref. 1) Curated1
Sequence conflicti822G → R in BAF95091 (Ref. 1) Curated1
Sequence conflicti922V → E in BAF95091 (Ref. 1) Curated1
Sequence conflicti945I → V in BAF95091 (Ref. 1) Curated1
Sequence conflicti1079Q → R in BAF95091 (Ref. 1) Curated1
Sequence conflicti1281 – 1283DET → NEI in BAF95091 (Ref. 1) Curated3
Sequence conflicti1353 – 1354IG → VS in BAF95091 (Ref. 1) Curated2
Sequence conflicti1434P → L in BAF95091 (Ref. 1) Curated1
Sequence conflicti1629L → P in BAF95091 (Ref. 1) Curated1
Sequence conflicti1703R → H in BAF95091 (Ref. 1) Curated1
Sequence conflicti1775T → M in BAF95091 (Ref. 1) Curated1
Sequence conflicti1780T → A in BAF95091 (Ref. 1) Curated1
Sequence conflicti1788A → S in BAF95091 (Ref. 1) Curated1
Sequence conflicti1809C → S in BAF95091 (Ref. 1) Curated1
Sequence conflicti1978K → D in BAF95091 (Ref. 1) Curated1
Sequence conflicti2222F → L in BAF95091 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB370265 mRNA Translation: BAF95091.1
AM231151 mRNA Translation: CAJ77150.1
AM231152 mRNA Translation: CAJ77151.1
AM231153 mRNA Translation: CAJ77152.1
AC120386 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS52907.1

NCBI Reference Sequences

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RefSeqi
NP_081039.2, NM_026763.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000121963; ENSMUSP00000112472; ENSMUSG00000032572

Database of genes from NCBI RefSeq genomes

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GeneIDi
68553

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:68553

UCSC genome browser

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UCSCi
uc012gzq.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB370265 mRNA Translation: BAF95091.1
AM231151 mRNA Translation: CAJ77150.1
AM231152 mRNA Translation: CAJ77151.1
AM231153 mRNA Translation: CAJ77152.1
AC120386 Genomic DNA No translation available.
CCDSiCCDS52907.1
RefSeqiNP_081039.2, NM_026763.2

3D structure databases

SMRiA2AX52
ModBaseiSearch...

Protein-protein interaction databases

BioGridi212923, 1 interactor
STRINGi10090.ENSMUSP00000112472

PTM databases

iPTMnetiA2AX52
PhosphoSitePlusiA2AX52

Proteomic databases

MaxQBiA2AX52
PaxDbiA2AX52
PRIDEiA2AX52

Genome annotation databases

EnsembliENSMUST00000121963; ENSMUSP00000112472; ENSMUSG00000032572
GeneIDi68553
KEGGimmu:68553
UCSCiuc012gzq.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
68553
MGIiMGI:1915803 Col6a4

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410ZT70 LUCA
GeneTreeiENSGT00940000163168
HOGENOMiCLU_000182_1_0_1
InParanoidiA2AX52
KOiK06238
OMAiVHQYLIV
OrthoDBi1049829at2759
PhylomeDBiA2AX52
TreeFamiTF337483

Miscellaneous databases

Protein Ontology

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PROi
PR:A2AX52
RNActiA2AX52 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032572 Expressed in uterus and 92 other tissues
ExpressionAtlasiA2AX52 baseline and differential
GenevisibleiA2AX52 MM

Family and domain databases

Gene3Di3.40.50.410, 8 hits
InterProiView protein in InterPro
IPR008160 Collagen
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 1 hit
PF00092 VWA, 8 hits
SMARTiView protein in SMART
SM00327 VWA, 9 hits
SUPFAMiSSF53300 SSF53300, 9 hits
PROSITEiView protein in PROSITE
PS50234 VWFA, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO6A4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AX52
Secondary accession number(s): A2AX53, A2AX54, A9CR35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: February 26, 2020
This is version 93 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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