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Protein

Histone deacetylase

Gene

Hdac5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi689ZincUniRule annotation1
Active sitei741UniRule annotation1
Sitei914Contributes to catalysisUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:Hdac5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1333784 Hdac5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

MaxQBiA2AWS5
PeptideAtlasiA2AWS5
PRIDEiA2AWS5

Expressioni

Gene expression databases

BgeeiENSMUSG00000008855 Expressed in 283 organ(s), highest expression level in cerebellum
ExpressionAtlasiA2AWS5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA2AWS5
SMRiA2AWS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 156HDAC4_GlnInterPro annotationAdd BLAST89
Domaini695 – 930Hist_deacetylInterPro annotationAdd BLAST236

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili118 – 169Sequence analysisAdd BLAST52
Coiled coili568 – 598Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00530000062809
HOGENOMiHOG000232065
HOVERGENiHBG057100

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR024643 Hist_deacetylase_Gln_rich_N
IPR017320 Histone_deAcase_II_euk
IPR030703 Histone_deacetylase_5
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 2 hits
PTHR10625:SF57 PTHR10625:SF57, 2 hits
PfamiView protein in Pfam
PF12203 HDAC4_Gln, 1 hit
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037911 HDAC_II_euk, 2 hits
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A2AWS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSPNESADG MSGREPSLEI LPRTPLHSIP VAVEVKPVLP GAMPSSMGGG
60 70 80 90 100
GGGSPSPVEL RGALAGPMDP ALREQQLQQE LLVLKQQQQL QKQLLFAEFQ
110 120 130 140 150
KQHDHLTRQH EVQLQKHLKQ QQEMLAAKRQ QELEQQRQRE QQRQEELEKQ
160 170 180 190 200
RLEQQLLILR NKEKSKESAI ASTEVKLRLQ EFLLSKSKEP TPGGLNHSLP
210 220 230 240 250
QHPKCWGAHH ASLDQSSPPQ SGPPGTPPSY KLPLLGPYDS RDDFPLRKTA
260 270 280 290 300
SEPNLKVRSR LKQKVAERRS SPLLRRKDGT VISTFKKRAV EITGTGPGVS
310 320 330 340 350
SVCNSAPGSG PSSPNSSHST IAENGFTGSV PNIPTEMIPQ HRALPLDSSP
360 370 380 390 400
NQFSLYTSPS LPNISLGLQA TVTVTNSHLT ASPKLSTQQE AERQALQSLR
410 420 430 440 450
QGGTLTGKFM STSSIPGCLL GVALEGDTSP HGHASLLQHV LLLEQARQQS
460 470 480 490 500
TLIAVPLHGQ SPLVTGERVA TSMRTVGKLP RHRPLSRTQS SPLPQSPQAL
510 520 530 540 550
QQLVMQQQHQ QFLEKQKQQQ MQLGKILTKT GELSRQPTTH PEETEEELTE
560 570 580 590 600
QQEALLGEGA LTIPREGSTE SESTQEDLEE EEEEEEEEEE DCIQVKDEDG
610 620 630 640 650
ESGPDEGPDL EESSAGYKKL FADAQQLQPL QVYQAPLSLA TVPHQALGRT
660 670 680 690 700
QSSPAAPGSM KSPTDQPTVV KHLFTTGPIS QKMYAMLPCG GIGVDSDTVW
710 720 730 740 750
NEMHSSSAVR MAVGCLVELA FKVAAGELKN GFAIIRPPGH HAEESTAMGF
760 770 780 790 800
CFFNSVAITA KLLQQKLSVG KVLIVDWDIH HGNGTQQAFY NDPSVLYISL
810 820 830 840 850
HRYDNGNFFP GSGAPEEVGG GPGVGYNVNV AWTGGVDPPI GDVEYLTAFR
860 870 880 890 900
TVVMPIAQEF SPDVVLVSAG FDAVEGHLSP LGGYSVTARC FGHLTRQLMT
910 920 930 940 950
LAGGRVVLAL EGGHDLTAIC DASEACVSAL LSVELQPLDE AVLQQKPSVN
960 970 980 990 1000
AVATLEKVIE IQSKHWSCVQ RFAAGLGCSL REAQTGEKEE AETVSAMALL
1010 1020 1030
SVGAEQAQAV ATQEHSPRPA EEPMEQEPAL
Length:1,030
Mass (Da):111,463
Last modified:February 20, 2007 - v1
Checksum:iBC08380109B0477B
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Z2V6HDAC5_MOUSE
Histone deacetylase 5
Hdac5
1,113Annotation score:
B7ZDF5B7ZDF5_MOUSE
Histone deacetylase
Hdac5
1,121Annotation score:
B7ZDF7B7ZDF7_MOUSE
Histone deacetylase
Hdac5
1,102Annotation score:
Q3UJF1Q3UJF1_MOUSE
Histone deacetylase
Hdac5
1,115Annotation score:
B7ZDF3B7ZDF3_MOUSE
Histone deacetylase 5
Hdac5
142Annotation score:
B7ZDF4B7ZDF4_MOUSE
Histone deacetylase 5
Hdac5
175Annotation score:
B7ZDF6B7ZDF6_MOUSE
Histone deacetylase 5
Hdac5
158Annotation score:
D6RH93D6RH93_MOUSE
Histone deacetylase 5
Hdac5
64Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954730 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000107151; ENSMUSP00000102769; ENSMUSG00000008855

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954730 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA2AWS5
SMRiA2AWS5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA2AWS5
PeptideAtlasiA2AWS5
PRIDEiA2AWS5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107151; ENSMUSP00000102769; ENSMUSG00000008855

Organism-specific databases

MGIiMGI:1333784 Hdac5

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00530000062809
HOGENOMiHOG000232065
HOVERGENiHBG057100

Miscellaneous databases

ChiTaRSiHdac5 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008855 Expressed in 283 organ(s), highest expression level in cerebellum
ExpressionAtlasiA2AWS5 baseline and differential

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR024643 Hist_deacetylase_Gln_rich_N
IPR017320 Histone_deAcase_II_euk
IPR030703 Histone_deacetylase_5
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 2 hits
PTHR10625:SF57 PTHR10625:SF57, 2 hits
PfamiView protein in Pfam
PF12203 HDAC4_Gln, 1 hit
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037911 HDAC_II_euk, 2 hits
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2AWS5_MOUSE
AccessioniPrimary (citable) accession number: A2AWS5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: September 12, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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