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Entry version 90 (13 Feb 2019)
Sequence version 1 (05 Feb 2008)
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Protein

Rho guanine nucleotide exchange factor 10-like protein

Gene

Arhgef10l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 10-like protein
Alternative name(s):
GrinchGEF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgef10l
Synonyms:Kiaa1626
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920004 Arhgef10l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003423621 – 1280Rho guanine nucleotide exchange factor 10-like proteinAdd BLAST1280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40PhosphoserineBy similarity1
Modified residuei131PhosphotyrosineCombined sources1
Modified residuei152PhosphotyrosineCombined sources1
Modified residuei279PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AWP8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AWP8

PeptideAtlas

More...
PeptideAtlasi
A2AWP8

PRoteomics IDEntifications database

More...
PRIDEi
A2AWP8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AWP8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AWP8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040964 Expressed in 138 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AWP8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AWP8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RHOA, RHOB and RHOC.By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A2AWP8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000040531

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2AWP8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A2AWP8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini314 – 501DHPROSITE-ProRule annotationAdd BLAST188

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3522 Eukaryota
KOG4305 Eukaryota
ENOG410ZJK1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153798

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050570

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2AWP8

KEGG Orthology (KO)

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KOi
K16727

Database of Orthologous Groups

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OrthoDBi
67600at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AWP8

TreeFam database of animal gene trees

More...
TreeFami
TF331430

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.130.10.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039919 ARHGEF10/ARHGEF17
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12877 PTHR12877, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AWP8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSNPPPQP AIGAPLAPSA PGPSPEVEED SGEAFEFDDS DEEEDTSSGL
60 70 80 90 100
VVPGLAPERD TEPSLICFDT VPGSDLDPAA APPQTEAPTV VSNGDAVGAA
110 120 130 140 150
ISGVRRSSWK RKSSRRIDRF TFPALEEDVI YDDVPCESPD AHQPGAERGL
160 170 180 190 200
VYEDVHRAGA PRETEDLGWS SSEFESYSED SGEETKPEAE PTKHRGSFQP
210 220 230 240 250
KLSPDLTRLK ERYVRTKRDI LALRVGGRDM QELKLKCDCK MTQLMKAAKS
260 270 280 290 300
GTRDGLEKTR MAVMRKVSFL HRKDVLGDSE EEDMGLLEVG VTDIKPPAPE
310 320 330 340 350
LGPMPDGLSP QQVVRRHILG SIVQSEGSYV ESLKRILQDY RNPLMEMEPK
360 370 380 390 400
ALSARKCQVV FFRVKEILHC HSMFQIALSS RVAEWDSTEK IGDLFVASFS
410 420 430 440 450
KSMVLDVYSD YVNNFTNAMS IIKKACLTKP AFLEFLKRRQ VCSTDRVTLY
460 470 480 490 500
GLMVKPVQRF PQFILLLQDM LKNTPRGHPD RLSLQLALTE LETLAEKLNE
510 520 530 540 550
QKRLADQVAE IQQLTKSVSD RSSLNKLLTS GQRQLLLCET LTETVYGDRG
560 570 580 590 600
QLIKSKERRV FLLNDMLVCA NINFKPSNHR GQLEISSLVP LGPKYVVKWN
610 620 630 640 650
TALPQVQVVE VGQDGGTYDK DNLLIQHAGA KKATAAGQAQ NKVYLGPPRL
660 670 680 690 700
FQELQDLQKD LAVVEQITLL ISTLHGTYQN LNMTVAQDWC LALQRLMRVK
710 720 730 740 750
EEEIHSANKC RLRLLLPGKP DKSGRPISFM VVFITPNPLS KISWVNRLHL
760 770 780 790 800
AKIGLREENQ PGWLCPDEDK KSKAPFWCPI LACCVPAFSS RTLSLQLGGL
810 820 830 840 850
VHSPVNSPLL GFSAVSTSLP QGYLWVGGGQ EGAGGQVEIF SLNRPSPRTV
860 870 880 890 900
KSFPVAAPVL CIEYIPDPEE EAEGAEESRA ATDPSVTVHP TVCLGLQDGS
910 920 930 940 950
ILLYGSVDTG TQCLATCKSP GPQPVLCLRH SPFYLLAGLQ DGTLAAYPRT
960 970 980 990 1000
SGDIPWDLES PPMCITVGPG PIRTLLSLED AAWASCGPRV TVLDAATLQT
1010 1020 1030 1040 1050
QQSFEAHQDE AVSVTHMVKA GSGVWMAFSS GSSIRLFHTE TLEHLQEINI
1060 1070 1080 1090 1100
ATRTTFLLPG QKHLCVTSLL ICQGLLWVGT DQGVIVLLPV PRLEGIPKIT
1110 1120 1130 1140 1150
GKGMVSLNGH CGPVAFLAVA MSILAPDILR SDQEEAEGPQ AEEDKPDGQA
1160 1170 1180 1190 1200
HETVPGPDSH TARELTRKKG ILLQYRLRST AHLPGPLLSV REPAPADGSA
1210 1220 1230 1240 1250
LEHSEEDGSI YEMADDPDVW VRSRPCARDA HRKEICSVAI ISGGQGYRHF
1260 1270 1280
GGAPGGLSGR AAPCSETDST LLIWQVPLAL
Length:1,280
Mass (Da):139,987
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A9C924B4D437252
GO
Isoform 2 (identifier: A2AWP8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-239: Missing.

Show »
Length:1,241
Mass (Da):135,386
Checksum:iBF08D9E93B2A2A0E
GO
Isoform 3 (identifier: A2AWP8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-239: Missing.
     576-580: Missing.

Show »
Length:1,236
Mass (Da):134,795
Checksum:iFBF0CE68F96DC823
GO
Isoform 4 (identifier: A2AWP8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     576-580: Missing.

Show »
Length:1,275
Mass (Da):139,395
Checksum:i22A892D801F32872
GO
Isoform 5 (identifier: A2AWP8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-215: Missing.
     216-276: TKRDILALRV...VSFLHRKDVL → MLPSSSWGKR...SSSSSSVSCS
     399-468: Missing.
     576-580: Missing.

Show »
Length:988
Mass (Da):107,747
Checksum:iE0F6129CDBB645A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AWP6A2AWP6_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef10l
1,040Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6S3V7F6S3V7_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef10l
611Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AWP4A2AWP4_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef10l
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AWP7A2AWP7_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef10l
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6ZH54F6ZH54_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef10l
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8Y5U3A8Y5U3_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef10l
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98218 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti280 – 281Missing in AAH59220 (PubMed:15489334).Curated2
Sequence conflicti453M → V in BAC26047 (PubMed:16141072).Curated1
Sequence conflicti850V → I in BAC98218 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0344271 – 215Missing in isoform 5. CuratedAdd BLAST215
Alternative sequenceiVSP_034428201 – 239Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_034429216 – 276TKRDI…RKDVL → MLPSSSWGKRKPRSQRLGWV RCDARGNMWARQEGLRQPHP HPHALIRCPSSSSSSVSCS in isoform 5. CuratedAdd BLAST61
Alternative sequenceiVSP_034430399 – 468Missing in isoform 5. CuratedAdd BLAST70
Alternative sequenceiVSP_034431576 – 580Missing in isoform 3, isoform 4 and isoform 5. 2 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK129408 mRNA Translation: BAC98218.1 Different initiation.
AK028648 mRNA Translation: BAC26047.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14356.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14358.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14359.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14360.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14361.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14469.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14471.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14472.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14473.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14474.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19324.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19327.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19328.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19329.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19330.1
BC021843 mRNA Translation: AAH21843.1
BC059220 mRNA Translation: AAH59220.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51342.1 [A2AWP8-3]
CCDS51343.1 [A2AWP8-2]
CCDS51344.1 [A2AWP8-4]
CCDS71507.1 [A2AWP8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001106193.1, NM_001112722.1 [A2AWP8-2]
NP_001106194.1, NM_001112723.1 [A2AWP8-3]
NP_001277732.1, NM_001290803.1 [A2AWP8-1]
NP_766003.3, NM_172415.3 [A2AWP8-4]
XP_006539264.1, XM_006539201.3 [A2AWP8-1]
XP_006539265.1, XM_006539202.1 [A2AWP8-1]
XP_011248639.1, XM_011250337.2 [A2AWP8-1]
XP_011248642.1, XM_011250340.2 [A2AWP8-3]
XP_017175885.1, XM_017320396.1 [A2AWP8-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.29329

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000039204; ENSMUSP00000040531; ENSMUSG00000040964 [A2AWP8-4]
ENSMUST00000069623; ENSMUSP00000066249; ENSMUSG00000040964 [A2AWP8-2]
ENSMUST00000097820; ENSMUSP00000095431; ENSMUSG00000040964 [A2AWP8-3]
ENSMUST00000105797; ENSMUSP00000101423; ENSMUSG00000040964 [A2AWP8-5]
ENSMUST00000105799; ENSMUSP00000101425; ENSMUSG00000040964 [A2AWP8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
72754

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:72754

UCSC genome browser

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UCSCi
uc008vmw.2 mouse [A2AWP8-4]
uc008vmx.2 mouse [A2AWP8-3]
uc008vmy.2 mouse [A2AWP8-2]
uc056zye.1 mouse [A2AWP8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129408 mRNA Translation: BAC98218.1 Different initiation.
AK028648 mRNA Translation: BAC26047.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14356.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14358.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14359.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14360.1
AL929073, AL954710, BX530090 Genomic DNA Translation: CAM14361.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14469.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14471.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14472.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14473.1
BX530090, AL929073, AL954710 Genomic DNA Translation: CAM14474.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19324.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19327.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19328.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19329.1
AL954710, AL929073, BX530090 Genomic DNA Translation: CAM19330.1
BC021843 mRNA Translation: AAH21843.1
BC059220 mRNA Translation: AAH59220.1
CCDSiCCDS51342.1 [A2AWP8-3]
CCDS51343.1 [A2AWP8-2]
CCDS51344.1 [A2AWP8-4]
CCDS71507.1 [A2AWP8-1]
RefSeqiNP_001106193.1, NM_001112722.1 [A2AWP8-2]
NP_001106194.1, NM_001112723.1 [A2AWP8-3]
NP_001277732.1, NM_001290803.1 [A2AWP8-1]
NP_766003.3, NM_172415.3 [A2AWP8-4]
XP_006539264.1, XM_006539201.3 [A2AWP8-1]
XP_006539265.1, XM_006539202.1 [A2AWP8-1]
XP_011248639.1, XM_011250337.2 [A2AWP8-1]
XP_011248642.1, XM_011250340.2 [A2AWP8-3]
XP_017175885.1, XM_017320396.1 [A2AWP8-1]
UniGeneiMm.29329

3D structure databases

ProteinModelPortaliA2AWP8
SMRiA2AWP8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2AWP8, 1 interactor
STRINGi10090.ENSMUSP00000040531

PTM databases

iPTMnetiA2AWP8
PhosphoSitePlusiA2AWP8

Proteomic databases

MaxQBiA2AWP8
PaxDbiA2AWP8
PeptideAtlasiA2AWP8
PRIDEiA2AWP8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039204; ENSMUSP00000040531; ENSMUSG00000040964 [A2AWP8-4]
ENSMUST00000069623; ENSMUSP00000066249; ENSMUSG00000040964 [A2AWP8-2]
ENSMUST00000097820; ENSMUSP00000095431; ENSMUSG00000040964 [A2AWP8-3]
ENSMUST00000105797; ENSMUSP00000101423; ENSMUSG00000040964 [A2AWP8-5]
ENSMUST00000105799; ENSMUSP00000101425; ENSMUSG00000040964 [A2AWP8-1]
GeneIDi72754
KEGGimmu:72754
UCSCiuc008vmw.2 mouse [A2AWP8-4]
uc008vmx.2 mouse [A2AWP8-3]
uc008vmy.2 mouse [A2AWP8-2]
uc056zye.1 mouse [A2AWP8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55160
MGIiMGI:1920004 Arhgef10l

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG3522 Eukaryota
KOG4305 Eukaryota
ENOG410ZJK1 LUCA
GeneTreeiENSGT00940000153798
HOVERGENiHBG050570
InParanoidiA2AWP8
KOiK16727
OrthoDBi67600at2759
PhylomeDBiA2AWP8
TreeFamiTF331430

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle

Miscellaneous databases

Protein Ontology

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PROi
PR:A2AWP8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040964 Expressed in 138 organ(s), highest expression level in heart
ExpressionAtlasiA2AWP8 baseline and differential
GenevisibleiA2AWP8 MM

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR039919 ARHGEF10/ARHGEF17
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR12877 PTHR12877, 1 hit
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARGAL_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AWP8
Secondary accession number(s): A2AWP5
, A2AWP9, A2AWQ0, A2AWQ1, Q6PCQ2, Q6ZPL3, Q8C1A1, Q8VDH5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 5, 2008
Last modified: February 13, 2019
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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