UniProtKB - A2AWL7 (MGAP_MOUSE)
MAX gene-associated protein
Mga
Functioni
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 84 – 260 | T-boxPROSITE-ProRule annotationAdd BLAST | 177 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- cell fate specification Source: GO_Central
- cellular response to leukemia inhibitory factor Source: MGI
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-8953750, Transcriptional Regulation by E2F6 |
Names & Taxonomyi
Protein namesi | Recommended name: MAX gene-associated protein |
Gene namesi | Name:Mga Synonyms:Kiaa4252 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1352483, Mga |
VEuPathDBi | HostDB:ENSMUSG00000033943 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- MLL1 complex Source: UniProtKB
Other locations
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000342693 | 1 – 3003 | MAX gene-associated proteinAdd BLAST | 3003 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 4 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 178 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 323 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 329 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 348 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 431 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 458 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 463 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 480 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 531 | PhosphoserineBy similarity | 1 | |
Cross-linki | 567 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 604 | PhosphoserineBy similarity | 1 | |
Cross-linki | 610 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 651 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 782 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 788 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 814 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 823 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 848 | PhosphoserineBy similarity | 1 | |
Modified residuei | 921 | PhosphoserineBy similarity | 1 | |
Cross-linki | 925 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 987 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1088 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1136 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1158 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1194 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1202 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 1423 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1450 | PhosphoserineBy similarity | 1 | |
Cross-linki | 1454 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1495 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1937 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 1944 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 2060 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 2084 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 2104 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 2152 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 2179 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 2206 | Omega-N-methylarginineBy similarity | 1 | |
Cross-linki | 2225 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 2317 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 2352 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 2396 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 2471 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 2480 | PhosphoserineBy similarity | 1 | |
Cross-linki | 2568 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 2618 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 2724 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 2849 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2860 | PhosphoserineBy similarity | 1 | |
Cross-linki | 2979 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | A2AWL7 |
jPOSTi | A2AWL7 |
MaxQBi | A2AWL7 |
PaxDbi | A2AWL7 |
PeptideAtlasi | A2AWL7 |
PRIDEi | A2AWL7 |
ProteomicsDBi | 295896 [A2AWL7-1] 295897 [A2AWL7-2] 295898 [A2AWL7-3] 295899 [A2AWL7-4] |
PTM databases
iPTMneti | A2AWL7 |
PhosphoSitePlusi | A2AWL7 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000033943, Expressed in pineal body and 295 other tissues |
ExpressionAtlasi | A2AWL7, baseline and differential |
Genevisiblei | A2AWL7, MM |
Interactioni
Subunit structurei
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.
Interacts with ZMYND11 (By similarity).
Interacts with MAX. Requires heterodimerization with MAX for E-box binding.
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 205889, 23 interactors |
IntActi | A2AWL7, 6 interactors |
STRINGi | 10090.ENSMUSP00000106401 |
Miscellaneous databases
RNActi | A2AWL7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2362 – 2413 | bHLHPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 259 – 290 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 553 – 647 | DisorderedSequence analysisAdd BLAST | 95 | |
Regioni | 871 – 946 | DisorderedSequence analysisAdd BLAST | 76 | |
Regioni | 967 – 987 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1111 – 1130 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1186 – 1215 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 1246 – 1277 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1297 – 1323 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1376 – 1424 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 1476 – 1508 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 1722 – 1746 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1856 – 1885 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 1920 – 1954 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 1964 – 1983 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1988 – 2038 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 2087 – 2110 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 2207 – 2255 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 2515 – 2534 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 2629 – 2654 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 2877 – 2917 | DisorderedSequence analysisAdd BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 262 – 276 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 591 – 607 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 967 – 985 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1249 – 1272 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1304 – 1321 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1485 – 1506 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1924 – 1954 | Basic and acidic residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1964 – 1979 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 2003 – 2021 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 2240 – 2255 | Acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 2517 – 2534 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 2629 – 2650 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 2882 – 2897 | Polar residuesSequence analysisAdd BLAST | 16 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3585, Eukaryota |
GeneTreei | ENSGT00940000156269 |
HOGENOMi | CLU_000469_1_0_1 |
InParanoidi | A2AWL7 |
PhylomeDBi | A2AWL7 |
Family and domain databases
CDDi | cd00182, TBOX, 1 hit |
Gene3Di | 2.60.40.820, 1 hit 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR037935, MAX_gene-associated_protein IPR032060, MGA_dom IPR008967, p53-like_TF_DNA-bd IPR046360, T-box_DNA-bd IPR036960, T-box_sf IPR001699, TF_T-box IPR018186, TF_T-box_CS |
PANTHERi | PTHR11267, PTHR11267, 1 hit PTHR11267:SF32, PTHR11267:SF32, 1 hit |
Pfami | View protein in Pfam PF16059, DUF4801, 1 hit PF00010, HLH, 1 hit PF00907, T-box, 1 hit |
PRINTSi | PR00937, TBOX |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00425, TBOX, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS01264, TBOX_2, 1 hit PS50252, TBOX_3, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEKQQIILA NQDGGTVTGG APTFFVILKQ PGNGKTDQGI LVTNRDARAL
60 70 80 90 100
LSRESSPGKS KEKICLPADC TVGKITVTLD NNSMWNEFHN RSTEMILTKQ
110 120 130 140 150
GRRMFPYCRY WITGLDSNLK YILVMDISPV DSHRYKWNGR WWEPSGKAEP
160 170 180 190 200
HILGRVFIHP ESPSTGHYWM HQPVSFYKLK LTNNTLDQEG HIILHSMHRY
210 220 230 240 250
LPRLHLVPAE KATEVIQLNG PGVHTFTFPQ TEFFAVTAYQ NIQITQLKID
260 270 280 290 300
YNPFAKGFRD DGLSSKPQRE GKQRNSSDQE GNSVSSSPAH RVRLTEGEGS
310 320 330 340 350
EIHSGDFDPV LRGHEASSLS LEKAPHNVKQ DFLGFMNTDS THEVPQLKHE
360 370 380 390 400
ISESRIVNSF EDDSQISSPS NPNGNFNVVI KEEPLDDYDY ELGECPEGIT
410 420 430 440 450
VKQEETDEET DVYSNSDDDP ILEKQLKRHN KVDNLEADHP SYKWLPNSPG
460 470 480 490 500
VAKAKMFKLD AGKMPVVYLE PCAVTKSTVK ISELPDNMLS TSRKDKSMLA
510 520 530 540 550
ELEYLPAYIE NSDGTDFCLS KDSENSLRKH SPDLRIVQKY TLLKEPNWKY
560 570 580 590 600
PDILDNSSTE RIHDSSKGST AESFSGKEDL GKKRTTMLKM AIPSKTVTAS
610 620 630 640 650
HSASPNTPGK RGRPRKLRLS KAGRPPKNTG KSLTAAKNIP VGPGSTFPDV
660 670 680 690 700
KPDLEDVDGV LFVSFESKEA LDIHAVDGTT EEPSSLQTTT TNDSGCRTRI
710 720 730 740 750
SQLEKELIED LKSLRHKQVI HPALQEVGLK LNSVDPTVSI DLKYLGVQLP
760 770 780 790 800
LAPATSFPLW NVTGTNPASP DAGFPFVSRT GKTNDFTKIK GWRGKFQNAS
810 820 830 840 850
ASRNEGGNSE ASLKNRSAFC SDKLDEYLEN EGKLMETNIG FSSNAPTSPV
860 870 880 890 900
VYQLPTKSTS YVRTLDSVLK KQSTISPSTS HSVKPQSVTT ASRKTKAQNK
910 920 930 940 950
QTTLSGRTKS SYKSILPYPV SPKQKNSHVS QGDKITKNSL SSTSDNQVTN
960 970 980 990 1000
LVVPSVDENA FPKQISLRQA QQQHLQQQGT RPPGLSKSQV KLMDLEDCAL
1010 1020 1030 1040 1050
WEGKPRTYIT EERADVSLTT LLTAQASLKT KPIHTIIRKR APPCNNDFCR
1060 1070 1080 1090 1100
LGCVCSSLAL EKRQPAHCRR PDCMFGCTCL KRKVVLVKGG SKTKHFHKKA
1110 1120 1130 1140 1150
ANRDPLFYDT LGEEGREGGG VREDEEQLKE KKKRKKLEYT VCEAEPEQPV
1160 1170 1180 1190 1200
RHYPLWVKVE GEVDPEPVYI PTPSVIEPIK PLVLPQPDLS STTKGKLTPG
1210 1220 1230 1240 1250
IKPARTYTPK PNPVIREEDK DPVYLYFESM MTCARVRVYE RKKEEQRQLS
1260 1270 1280 1290 1300
PPLSPSSSFQ QQSSCYSSPE NRVTKELDSE QTLKQLICDL EDDSDKSQEK
1310 1320 1330 1340 1350
SWKSSCNEGE SSSTSYVHQR SPGGPTKLIE IISDCNWEED RNKILSILSQ
1360 1370 1380 1390 1400
HINSNMPQSL KVGSFIIELA SQRKCRGEKT PPVYSSRVKI SMPSSQDQDD
1410 1420 1430 1440 1450
MAEKSGSETP DGPLSPGKMD DISPVQTDAL DSVRERLHGG KGLPFYAGLS
1460 1470 1480 1490 1500
PSGKLVAYKR KPSSTTSGLI QVASNAKVAA SRKPRTLLPS TSNSKMASSG
1510 1520 1530 1540 1550
PATNRSGKNL KAFVPAKRPI AARPSPGGVF TQFVMSKVGA LQQKIPGVRT
1560 1570 1580 1590 1600
PQPLTGPQKF SIRPSPVMVV TPVVSSEQVQ VCSTVAAAVT TSPQVFLENV
1610 1620 1630 1640 1650
TAVPSLTANS DMGAKEATYS SSASTAGVVE ISETNNTTLV TSTQSTATVN
1660 1670 1680 1690 1700
LTKTTGITTS PVASVSFAKP LVASPTITLP VASTASTSIV MVTTAASSSV
1710 1720 1730 1740 1750
VTTPTSSLSS VPIILSGING SPPVSQRPEN APQIPVTTPQ ISSNNVKRTG
1760 1770 1780 1790 1800
PRLLHPNGQI VQLLPLHQIR GSNAQPSLQP VVFRNPGSMV GIRLPAPCKS
1810 1820 1830 1840 1850
SETPSSSASS SAFSVMSPVI QAVGSSPTVN VISQAPSLLS SGSSFVSQAG
1860 1870 1880 1890 1900
TLTLRISPPE TQNLASKTGS ESKITPSTGG QPVGTASLIP LQSGSFALLQ
1910 1920 1930 1940 1950
LPGQKPIPSS VLQHVASLQI KKESQSTDQK DETNSIKREE ETKKALPSKD
1960 1970 1980 1990 2000
KALDSEANIM KQNSGIIASE NTSNNSLDDG GDLLDEETLR EDARPYEYSY
2010 2020 2030 2040 2050
STGSHTDEDK DGDEDSGNKN QNSPKEKQTV PEVRAGSKNI DIMALQSIRS
2060 2070 2080 2090 2100
IRPQKCVKVK VEPQEGSDNP ENPDDFLVLS KDSKFELSGN QVKEQQSNSQ
2110 2120 2130 2140 2150
AEAKKDCEDS LGKDSLRERW RKHLKGPLTQ KYIGISQNFN KEANVQFFTE
2160 2170 2180 2190 2200
MKPCQENSEQ DISELLGKSG TIESGGVLKT EDGSWSGISS SAAFSIIPRR
2210 2220 2230 2240 2250
ATKGRRGSRH FQGHLLLPRE QMKPKQQTKD GRSSAADFTV LDLEDEDEED
2260 2270 2280 2290 2300
EKTDDSLDEI VDVVSGYQSE EVDVEKNNYV DYLEDDEQVD VETIEELSEE
2310 2320 2330 2340 2350
INFPYKKTTA THTQSFKQQC HSHISADEKA SEKSRKVSLI SSKLKDDCWG
2360 2370 2380 2390 2400
DKPHKETEAF AYYRRTHTAN ERRRRGEMRD LFEKLKITLG LLHSSKVSKS
2410 2420 2430 2440 2450
LILNRAFSEI QGLTDQADKL IGQKNLLSRK RSILIRKVSS LSGKTEEVVL
2460 2470 2480 2490 2500
KKLEYIYAKQ QALEAQKRKK KLGSDEFCVS PRIGTQLEGS SASSVDLGQM
2510 2520 2530 2540 2550
LMNNRRGKPL ILSRKRDQAT ENASPSDTPH SSANLVMTPQ GQLLTLKGPL
2560 2570 2580 2590 2600
FSGPVVAVSP ALLEGGLKPQ VASSTMSQSE NDDLFMMPRI VNVTSLAAEE
2610 2620 2630 2640 2650
DLGGMSGNKY RHEVPDGKPL DHLRDIAGSE ASSLKDTERI SSRGNHRDSR
2660 2670 2680 2690 2700
KALGPTQVLL ANKDSGFPHV ADVSTMQAAQ EFIPKNMSGD VRGHRYKWKE
2710 2720 2730 2740 2750
CELRGERLKS KESQFHKLKM KDLKDSSIEM ELRKVASAIE EAALHPSELL
2760 2770 2780 2790 2800
TNMEDEDDTD ETLTSLLNEI AFLNQQLNDD SGLAELSGSM DTEFSGDAQR
2810 2820 2830 2840 2850
AFISKLAPGN RSAFQVGHLG AGVKELPDVQ EESESISPLL LHLEDDDFSE
2860 2870 2880 2890 2900
NEKQLGDTAS EPDVLKIVID PEIKDSLVSH RKSSDGGQST SGLPAEPESV
2910 2920 2930 2940 2950
SSPPILHMKT GPENSNTDTL WRPMPKLAPL GLKVANPPSD ADGQSLKVMP
2960 2970 2980 2990 3000
ALAPIAAKVG SIGHKMNLAG IDQEGRGSKV MPTLAPVVPK LGNSGAPSSS
SGK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9QLG3 | E9QLG3_MOUSE | MAX gene-associated protein | Mga | 3,042 | Annotation score: | ||
H7BX50 | H7BX50_MOUSE | MAX gene-associated protein | Mga | 2,833 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | N → T in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 195 | H → Y in BAC27930 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 217 | Q → P in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 342 | H → P in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 346 | Q → P in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 349 | H → P in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 359 | S → R in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 403 | Q → P in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 458 | K → R in BAC32658 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 634 | T → P in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 666 | E → D in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 752 | A → G in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 757 | F → L in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 844 | N → D in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 873 | S → C in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 903 | T → A in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 1061 | E → D in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 1136 | K → E in BAD32240 (PubMed:15368895).Curated | 1 | |
Sequence conflicti | 1191 | S → ST in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 1593 | P → L in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 1753 – 1755 | LLH → FDVG in AAF24761 (PubMed:10601024).Curated | 3 | |
Sequence conflicti | 1763 | L → F in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 1826 | S → P in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 1845 | F → L in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2033 | V → A in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2043 | M → I in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2478 | C → G in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2800 – 2802 | RAF → ARLI in AAF24761 (PubMed:10601024).Curated | 3 | |
Sequence conflicti | 2809 | G → V in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2814 | F → Y in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2819 – 2821 | LGA → MGT in AAF24761 (PubMed:10601024).Curated | 3 | |
Sequence conflicti | 2830 | Q → L in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2835 | S → T in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2852 – 2853 | EK → VR in AAF24761 (PubMed:10601024).Curated | 2 | |
Sequence conflicti | 2865 | L → H in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2877 | L → R in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2928 | A → T in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2969 | A → T in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2971 | I → S in AAF24761 (PubMed:10601024).Curated | 1 | |
Sequence conflicti | 2998 | S → L in AAF24761 (PubMed:10601024).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034536 | 669 – 671 | EAL → VWL in isoform 4. 1 Publication | 3 | |
Alternative sequenceiVSP_034537 | 672 – 3003 | Missing in isoform 4. 1 PublicationAdd BLAST | 2332 | |
Alternative sequenceiVSP_034538 | 727 – 805 | Missing in isoform 3. 1 PublicationAdd BLAST | 79 | |
Alternative sequenceiVSP_034539 | 1214 | Missing in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_034540 | 1521 – 1728 | Missing in isoform 2. 1 PublicationAdd BLAST | 208 | |
Alternative sequenceiVSP_034541 | 1754 | L → LLIPVQQGSPTLRPIQNPQL QGQRMVLQPVRGPSGMNLFR in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_034542 | 2466 – 3003 | Missing in isoform 2. 1 PublicationAdd BLAST | 538 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF205935 mRNA Translation: AAF24761.1 AK032570 mRNA Translation: BAC27930.1 AK046252 mRNA Translation: BAC32658.1 AK133775 mRNA Translation: BAE21832.1 AK162302 mRNA Translation: BAE36840.1 AL954662 Genomic DNA No translation available. AK172962 mRNA Translation: BAD32240.1 Different initiation. |
RefSeqi | NP_038748.2, NM_013720.2 |
Genome annotation databases
Ensembli | ENSMUST00000046717; ENSMUSP00000043795; ENSMUSG00000033943 [A2AWL7-1] ENSMUST00000110773; ENSMUSP00000106400; ENSMUSG00000033943 [A2AWL7-3] ENSMUST00000156510; ENSMUSP00000119044; ENSMUSG00000033943 [A2AWL7-2] |
GeneIDi | 29808 |
KEGGi | mmu:29808 |
UCSCi | uc008lur.1, mouse [A2AWL7-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF205935 mRNA Translation: AAF24761.1 AK032570 mRNA Translation: BAC27930.1 AK046252 mRNA Translation: BAC32658.1 AK133775 mRNA Translation: BAE21832.1 AK162302 mRNA Translation: BAE36840.1 AL954662 Genomic DNA No translation available. AK172962 mRNA Translation: BAD32240.1 Different initiation. |
RefSeqi | NP_038748.2, NM_013720.2 |
3D structure databases
SMRi | A2AWL7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 205889, 23 interactors |
IntActi | A2AWL7, 6 interactors |
STRINGi | 10090.ENSMUSP00000106401 |
PTM databases
iPTMneti | A2AWL7 |
PhosphoSitePlusi | A2AWL7 |
Proteomic databases
EPDi | A2AWL7 |
jPOSTi | A2AWL7 |
MaxQBi | A2AWL7 |
PaxDbi | A2AWL7 |
PeptideAtlasi | A2AWL7 |
PRIDEi | A2AWL7 |
ProteomicsDBi | 295896 [A2AWL7-1] 295897 [A2AWL7-2] 295898 [A2AWL7-3] 295899 [A2AWL7-4] |
Protocols and materials databases
Antibodypediai | 6067, 84 antibodies from 16 providers |
DNASUi | 29808 |
Genome annotation databases
Ensembli | ENSMUST00000046717; ENSMUSP00000043795; ENSMUSG00000033943 [A2AWL7-1] ENSMUST00000110773; ENSMUSP00000106400; ENSMUSG00000033943 [A2AWL7-3] ENSMUST00000156510; ENSMUSP00000119044; ENSMUSG00000033943 [A2AWL7-2] |
GeneIDi | 29808 |
KEGGi | mmu:29808 |
UCSCi | uc008lur.1, mouse [A2AWL7-4] |
Organism-specific databases
CTDi | 23269 |
MGIi | MGI:1352483, Mga |
VEuPathDBi | HostDB:ENSMUSG00000033943 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG3585, Eukaryota |
GeneTreei | ENSGT00940000156269 |
HOGENOMi | CLU_000469_1_0_1 |
InParanoidi | A2AWL7 |
PhylomeDBi | A2AWL7 |
Enzyme and pathway databases
Reactomei | R-MMU-8953750, Transcriptional Regulation by E2F6 |
Miscellaneous databases
BioGRID-ORCSi | 29808, 9 hits in 76 CRISPR screens |
ChiTaRSi | Mga, mouse |
PROi | PR:A2AWL7 |
RNActi | A2AWL7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033943, Expressed in pineal body and 295 other tissues |
ExpressionAtlasi | A2AWL7, baseline and differential |
Genevisiblei | A2AWL7, MM |
Family and domain databases
CDDi | cd00182, TBOX, 1 hit |
Gene3Di | 2.60.40.820, 1 hit 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR037935, MAX_gene-associated_protein IPR032060, MGA_dom IPR008967, p53-like_TF_DNA-bd IPR046360, T-box_DNA-bd IPR036960, T-box_sf IPR001699, TF_T-box IPR018186, TF_T-box_CS |
PANTHERi | PTHR11267, PTHR11267, 1 hit PTHR11267:SF32, PTHR11267:SF32, 1 hit |
Pfami | View protein in Pfam PF16059, DUF4801, 1 hit PF00010, HLH, 1 hit PF00907, T-box, 1 hit |
PRINTSi | PR00937, TBOX |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00425, TBOX, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS01264, TBOX_2, 1 hit PS50252, TBOX_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MGAP_MOUSE | |
Accessioni | A2AWL7Primary (citable) accession number: A2AWL7 Secondary accession number(s): A2AWL6 Q9QXJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | February 20, 2007 | |
Last modified: | May 25, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot