UniProtKB - A2AWE1 (A2AWE1_DANRE)
Protein
Peroxiredoxin-1
Gene
prdx1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.UniRule annotation
Catalytic activityi
- [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2OUniRule annotationEC:1.11.1.24UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 52 | Cysteine sulfenic acid (-SOH) intermediateUniRule annotation | 1 |
GO - Molecular functioni
- thioredoxin peroxidase activity Source: GO_Central
GO - Biological processi
- cell redox homeostasis Source: GO_Central
- leukocyte activation Source: ZFIN
- removal of superoxide radicals Source: GO_Central
- response to oxidative stress Source: GO_Central
Keywordsi
Molecular function | AntioxidantUniRule annotationARBA annotation, Oxidoreductase, PeroxidaseUniRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-DRE-3299685, Detoxification of Reactive Oxygen Species R-DRE-5628897, TP53 Regulates Metabolic Genes |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:prdx1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-050320-35, prdx1 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Other locations
- protein-containing complex Source: ZFIN
Expressioni
Gene expression databases
Bgeei | ENSDARG00000058734, Expressed in kidney and 39 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 165 | ThioredoxinInterPro annotationAdd BLAST | 160 |
Sequence similaritiesi
Belongs to the peroxiredoxin family.UniRule annotation
Keywords - Domaini
Redox-active centerUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0852, Eukaryota |
GeneTreei | ENSGT00940000154277 |
HOGENOMi | CLU_042529_21_1_1 |
OMAi | CDSEYSH |
OrthoDBi | 1326484at2759 |
TreeFami | TF105181 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A2AWE1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAGNAHIGK PAPDFTAKAV MPDGQFGDVR LSDYKGKYVV LFFYPLDFTF
60 70 80 90 100
VCPTEIIAFS DAAEEFRKIN CEIIGASVDS HFCHLAWTKT PRKQGGLGPM
110 120 130 140 150
NVPLVADTLR SISKDYGVLK EDEGIAYRGL FIIDDKGILR QITINDLPVG
160 170 180 190
RSIDETLRLV QAFQFTDKHG EVCPAGWKPG KDTIKPDVNQ SKDFFSKQN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL954171 Genomic DNA No translation available. CU467854 Genomic DNA No translation available. |
RefSeqi | NP_001013489.2, NM_001013471.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL954171 Genomic DNA No translation available. CU467854 Genomic DNA No translation available. |
RefSeqi | NP_001013489.2, NM_001013471.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000076104 |
Genome annotation databases
Organism-specific databases
CTDi | 5052 |
ZFINi | ZDB-GENE-050320-35, prdx1 |
Phylogenomic databases
eggNOGi | KOG0852, Eukaryota |
GeneTreei | ENSGT00940000154277 |
HOGENOMi | CLU_042529_21_1_1 |
OMAi | CDSEYSH |
OrthoDBi | 1326484at2759 |
TreeFami | TF105181 |
Enzyme and pathway databases
Reactomei | R-DRE-3299685, Detoxification of Reactive Oxygen Species R-DRE-5628897, TP53 Regulates Metabolic Genes |
Gene expression databases
Bgeei | ENSDARG00000058734, Expressed in kidney and 39 other tissues |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A2AWE1_DANRE | |
Accessioni | A2AWE1Primary (citable) accession number: A2AWE1 Secondary accession number(s): A0A0R4IYJ8, F1RA95 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | November 13, 2013 | |
Last modified: | December 2, 2020 | |
This is version 94 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |