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Protein

Rab GTPase-activating protein 1

Gene

Rabgap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei603Arginine fingerBy similarity1
Sitei644Glutamine fingerBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • activation of GTPase activity Source: GO_Central
  • cell cycle Source: UniProtKB-KW
  • intracellular protein transport Source: GO_Central
  • regulation of GTPase activity Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
Biological processCell cycle

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.1.23 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8854214 TBC/RABGAPs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab GTPase-activating protein 1
Alternative name(s):
GAP and centrosome-associated protein
Rab6 GTPase-activating protein GAPCenA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rabgap1Imported
Synonyms:Kiaa4104Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2385139 Rabgap1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002987801 – 1064Rab GTPase-activating protein 1Add BLAST1064

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei42PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Modified residuei991PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2AWA9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AWA9

PeptideAtlas

More...
PeptideAtlasi
A2AWA9

PRoteomics IDEntifications database

More...
PRIDEi
A2AWA9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AWA9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AWA9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035437 Expressed in 273 organ(s), highest expression level in dorsal pancreas

CleanEx database of gene expression profiles

More...
CleanExi
MM_RABGAP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A2AWA9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AWA9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB6A and tubulin gamma.By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A2AWA9, 2 interactors

Molecular INTeraction database

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MINTi
A2AWA9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000061624

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2AWA9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AWA9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini137 – 293PIDPROSITE-ProRule annotationAdd BLAST157
Domaini561 – 747Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST187

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili805 – 1038Sequence analysisAdd BLAST234

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1102 Eukaryota
COG5210 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157216

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007923

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG063892

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2AWA9

KEGG Orthology (KO)

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KOi
K20284

Identification of Orthologs from Complete Genome Data

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OMAi
PTFQSYM

Database of Orthologous Groups

More...
OrthoDBi
191811at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AWA9

TreeFam database of animal gene trees

More...
TreeFami
TF317184

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022164 Kinesin-like
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR033185 RabGAP1

The PANTHER Classification System

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PANTHERi
PTHR22957:SF205 PTHR22957:SF205, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12473 DUF3694, 1 hit
PF00640 PID, 1 hit
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462 PTB, 1 hit
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01179 PID, 1 hit
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: A2AWA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDKASVGKI SVSSDSVSTL NSEDFVLVSR QGDETPSTNN GSDDEKTGLK
60 70 80 90 100
IVGNGSEQQL QKELADVLMD PPMDDQPGER SQLDGEGDGP LSNQLSASST
110 120 130 140 150
INPVPLVGLP KPEMSLPVKP GQGDSEVSSP FTPVADEDSV VFNKLTYLGC
160 170 180 190 200
ASVNAPRSEV EALRMMSILR SQCQISLDVT LSVPNVSEGT VRLLDPQTNT
210 220 230 240 250
EIANYPIYKI LFCVRGHDGT PESDCFAFTE SHYNAELFRI HVFRCEIQEA
260 270 280 290 300
VSRILYSFAT AFRRSAKQTP LSATAAPQTP DSDIFTFSVS LEIKEDDGKG
310 320 330 340 350
YFSAVPKDKD RQCFKLRQGI DKKIVICVQQ TANKELAIER CFGLLLSPGK
360 370 380 390 400
DVRNSDMHLL DLESMGKSSD GKSYVITGSW NPKSPHFQVV NEETPKDKVL
410 420 430 440 450
FMTTAVDLVI TEVQEPVRFL LETKVRVCSP NERLFWPFSK RSTTENFFLK
460 470 480 490 500
LKQIKQKEKK NNADTLYEVV CLESESERER RKTTASPSVR LPQSGSQSSM
510 520 530 540 550
IPSPPEDDEE EDNDEPLLSG FGDVSKECAE KILETWGELL SKWHLNLSVR
560 570 580 590 600
PKQLSSLVRS GVPEALRGEV WQLLAGCHNN DHLVEKYRIL ITKESPQDSA
610 620 630 640 650
ITRDINRTFP AHDYFKDTGG DGQDSLYKIC KAYSVYDEEI GYCQGQSFLA
660 670 680 690 700
AVLLLHMPEE QAFSVLVKIM FDYGLRELFK QNFEDLHCKF YQLERLMQEY
710 720 730 740 750
IPDLYNHFLD ISLEAHMYAS QWFLTLFTAK FPLYMVFHII DLLLCEGISV
760 770 780 790 800
IFNVALGLLK TSKDDLLLTD FEGALKFFRV QLPKRYRSEE NAKRLMELAC
810 820 830 840 850
NTKISQKKLK KFEKEYHTMR EQQAQQEDPI ERFERENRRL QEANMRLEQE
860 870 880 890 900
NDDLAHELVT SKIALRKDLD NAEEKADALN KELLMTKQKL IDAEDEKRRL
910 920 930 940 950
EEESAQLKEM CRRELDKAES EIKKNSSIIG DYKQICSQLS ERLEKQQTAN
960 970 980 990 1000
KVEIEKIRQK VDDCDRCRDF FNKEGRVKGI SSAKGVSDED TDEEKETLKN
1010 1020 1030 1040 1050
QLREMELELA QTKLQLVEAE CKIQDLEHHL GLALSEVQAA KKTWFNRTLS
1060
SIKTATGVQG KETC
Note: No experimental confirmation available.Curated
Length:1,064
Mass (Da):120,798
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AFAB7C7827F0040
GO
Isoform 21 Publication (identifier: A2AWA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     804-809: ISQKKL → VQQRLL
     810-1064: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:809
Mass (Da):91,083
Checksum:i04E42DFEA2161061
GO
Isoform 31 Publication (identifier: A2AWA9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.
     19-30: TLNSEDFVLVSR → MGLSSLSANKPW
     363-384: ESMGKSSDGKSYVITGSWNPKS → VRFCCCCCCGLFWLWLVFIRNL
     385-1064: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:366
Mass (Da):40,303
Checksum:i016708AC6D659B18
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AWA7A2AWA7_MOUSE
Rab GTPase-activating protein 1
Rabgap1
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AWB0A2AWB0_MOUSE
Rab GTPase-activating protein 1
Rabgap1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH26862 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH31714 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC34703 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD90509 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti646Q → E in BAC34703 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0525161 – 18Missing in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_05251719 – 30TLNSE…VLVSR → MGLSSLSANKPW in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_052518363 – 384ESMGK…WNPKS → VRFCCCCCCGLFWLWLVFIR NL in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_052519385 – 1064Missing in isoform 3. 1 PublicationAdd BLAST680
Alternative sequenceiVSP_052520804 – 809ISQKKL → VQQRLL in isoform 2. 1 Publication6
Alternative sequenceiVSP_052521810 – 1064Missing in isoform 2. 1 PublicationAdd BLAST255

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK031315 mRNA Translation: BAC27344.1
AK044346 mRNA Translation: BAC31880.1
AK051644 mRNA Translation: BAC34703.1 Different initiation.
AK220489 mRNA Translation: BAD90509.1 Different initiation.
AL953890 Genomic DNA No translation available.
BC026862 mRNA Translation: AAH26862.1 Different initiation.
BC031714 mRNA Translation: AAH31714.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16002.1 [A2AWA9-1]
CCDS16003.1 [A2AWA9-2]

NCBI Reference Sequences

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RefSeqi
NP_001029132.1, NM_001033960.1 [A2AWA9-2]
NP_666233.2, NM_146121.2 [A2AWA9-1]
XP_006498057.1, XM_006497994.3
XP_017172964.1, XM_017317475.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.383192

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000061179; ENSMUSP00000061624; ENSMUSG00000035437 [A2AWA9-1]
ENSMUST00000066055; ENSMUSP00000068835; ENSMUSG00000035437 [A2AWA9-2]
ENSMUST00000112920; ENSMUSP00000108542; ENSMUSG00000035437 [A2AWA9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
227800

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:227800

UCSC genome browser

More...
UCSCi
uc008jmw.1 mouse [A2AWA9-3]
uc008jmx.1 mouse [A2AWA9-1]
uc008jmy.1 mouse [A2AWA9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK031315 mRNA Translation: BAC27344.1
AK044346 mRNA Translation: BAC31880.1
AK051644 mRNA Translation: BAC34703.1 Different initiation.
AK220489 mRNA Translation: BAD90509.1 Different initiation.
AL953890 Genomic DNA No translation available.
BC026862 mRNA Translation: AAH26862.1 Different initiation.
BC031714 mRNA Translation: AAH31714.1 Different initiation.
CCDSiCCDS16002.1 [A2AWA9-1]
CCDS16003.1 [A2AWA9-2]
RefSeqiNP_001029132.1, NM_001033960.1 [A2AWA9-2]
NP_666233.2, NM_146121.2 [A2AWA9-1]
XP_006498057.1, XM_006497994.3
XP_017172964.1, XM_017317475.1
UniGeneiMm.383192

3D structure databases

ProteinModelPortaliA2AWA9
SMRiA2AWA9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2AWA9, 2 interactors
MINTiA2AWA9
STRINGi10090.ENSMUSP00000061624

PTM databases

iPTMnetiA2AWA9
PhosphoSitePlusiA2AWA9

Proteomic databases

EPDiA2AWA9
PaxDbiA2AWA9
PeptideAtlasiA2AWA9
PRIDEiA2AWA9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061179; ENSMUSP00000061624; ENSMUSG00000035437 [A2AWA9-1]
ENSMUST00000066055; ENSMUSP00000068835; ENSMUSG00000035437 [A2AWA9-2]
ENSMUST00000112920; ENSMUSP00000108542; ENSMUSG00000035437 [A2AWA9-1]
GeneIDi227800
KEGGimmu:227800
UCSCiuc008jmw.1 mouse [A2AWA9-3]
uc008jmx.1 mouse [A2AWA9-1]
uc008jmy.1 mouse [A2AWA9-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23637
MGIiMGI:2385139 Rabgap1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG1102 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00940000157216
HOGENOMiHOG000007923
HOVERGENiHBG063892
InParanoidiA2AWA9
KOiK20284
OMAiPTFQSYM
OrthoDBi191811at2759
PhylomeDBiA2AWA9
TreeFamiTF317184

Enzyme and pathway databases

BRENDAi2.3.1.23 3474
ReactomeiR-MMU-8854214 TBC/RABGAPs

Miscellaneous databases

Protein Ontology

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PROi
PR:A2AWA9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000035437 Expressed in 273 organ(s), highest expression level in dorsal pancreas
CleanExiMM_RABGAP1
ExpressionAtlasiA2AWA9 baseline and differential
GenevisibleiA2AWA9 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR022164 Kinesin-like
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR033185 RabGAP1
PANTHERiPTHR22957:SF205 PTHR22957:SF205, 1 hit
PfamiView protein in Pfam
PF12473 DUF3694, 1 hit
PF00640 PID, 1 hit
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBGP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AWA9
Secondary accession number(s): Q5DTN1
, Q8BQ32, Q8C8W3, Q8CD74, Q8R312
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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