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Entry version 89 (16 Jan 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Maestro heat-like repeat-containing protein family member 7

Gene

Mroh7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Maestro heat-like repeat-containing protein family member 7
Alternative name(s):
HEAT repeat-containing protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mroh7
Synonyms:Gm1027, Heatr8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685873 Mroh7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Transmembranei722 – 742HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002868671 – 1279Maestro heat-like repeat-containing protein family member 7Add BLAST1279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei356PhosphoserineBy similarity1
Glycosylationi541N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2AVR2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AVR2

PRoteomics IDEntifications database

More...
PRIDEi
A2AVR2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AVR2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AVR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000047502 Expressed in 18 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AVR2 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2AVR2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati913 – 950HEAT 1Add BLAST38
Repeati992 – 1029HEAT 2Add BLAST38
Repeati1035 – 1072HEAT 3Add BLAST38
Repeati1080 – 1117HEAT 4Add BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi125 – 341Ser-richAdd BLAST217

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2032 Eukaryota
ENOG410XQE8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161775

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107563

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AVR2

Identification of Orthologs from Complete Genome Data

More...
OMAi
GKDSGEM

Database of Orthologous Groups

More...
OrthoDBi
31329at2759

TreeFam database of animal gene trees

More...
TreeFami
TF337538

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2AVR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSRGTSLI LHEDPEKIPS PNSCEVPGIM SNTTPRPTPD LALAPPPEHA
60 70 80 90 100
LALTPALHPA LSPDPEGVSG PVSNDIPSHN ASGATTPSST QINTVDTADQ
110 120 130 140 150
GLNHTSGPDA AGTLCPDSQP ARIPSSTQAN VLSPENSSRP CSEDVSKSFS
160 170 180 190 200
SKVFGLGQSN SNPSRPEPNL YIKALSREAL VRSHNISRQG SQVPLLLPSN
210 220 230 240 250
TSLDRLHSGN ISKVNLGIAP NSNEAITLTS HTIFASISKE ALSAPWNTGS
260 270 280 290 300
KGSINGTSTI QPRSGLNVTV THASHVSMIP GSSEGLSLQS SARVPNSTLS
310 320 330 340 350
PSSCMTLIMD SESPSMDSSF LVTDTSTLTL SSHRDYSEDN SIRTMPLEEN
360 370 380 390 400
LGKWDSLQGV TALQSPPEGT SEDVKVNEAE KRNHDNKAAL VANIITYQKN
410 420 430 440 450
QEMVEMKEEK EATVKMMMRQ IQEEPLDSLL SPARRQAMEI LAQLSHTKPI
460 470 480 490 500
LSVRERVELV NTCVRSVFSL PSVQAMQEKD ESKAEVIQIL YYQTLDSLQK
510 520 530 540 550
LLNALFIEDP TPTGLKSILE PLGPWMNSGK AHERARAVNS NVSVLNHTLV
560 570 580 590 600
TLPFLISSGF PTLGLLLGRL LLRIGDPDEE IGREALDGIT ILYTILDLQK
610 620 630 640 650
RTKNKEDTNK KELYENNKRF LGPYNPVSPC QNILRVIAEF GDFLGPQQVR
660 670 680 690 700
DLLLAALEGL KGISETQGKD SGEMMQLASE VMLSSVLEWY RHRALEVIPE
710 720 730 740 750
IMQGIYMQLT HIQEPRAREV ALLPISFLAS SFMTEVVVAL LMCPLPLDSN
760 770 780 790 800
GAEMWRQLIL RKPSCDVRDL LDLLLTSLKE KPVTKKGRAS IVPLAAASGL
810 820 830 840 850
CELLSVNSCV GRVRRIYPQL LLALLIQVHY HIGLNLPSRM APRKDSKDDT
860 870 880 890 900
QPPLFIPVRW MVKVVKTLLL KMGCSYESAF LEEQGGWELM GQAESHYRGV
910 920 930 940 950
SLLARAMVHY SCQELCRILY LLIPLLERGD ERHKITATAF FVELFRMEQV
960 970 980 990 1000
RRIPEEYSLG RMVEGLSHRD PIMNVLSIRG LVILACKSEK MAKVQSLLPS
1010 1020 1030 1040 1050
MVKSLKNMDG MLVVEAVHDL KRIFKGQGKK LTDSAVYVEM LQILLPHFTD
1060 1070 1080 1090 1100
AREMVRASCI NVYGKVVKKL QTPRTQAMEE QLTSTLMPLL FIIQEGNAKV
1110 1120 1130 1140 1150
SQKCVKTLVC CSSFMNWELP KKAYSQKPWD NQQLTVTKIC KYLVSSHRDN
1160 1170 1180 1190 1200
VFTFLNQSLE YAKNSRASLR KSSVIFIGSL VPCMENMMTE ERLNEVKATL
1210 1220 1230 1240 1250
EILRHDPEAS VCICAAQAQD QIMATCWRNS WPLLYGDSWV CDPSSMHRWS
1260 1270
PSCENLPTSH QRRSWIMQAL ASWKMSLKQ
Length:1,279
Mass (Da):141,710
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i651202D41142A38D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8Y5T7A8Y5T7_MOUSE
Maestro heat-like repeat-containing...
Mroh7 Heatr8
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AVR3A2AVR3_MOUSE
Maestro heat-like repeat-containing...
Mroh7 Heatr8
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL929585 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51253.1

NCBI Reference Sequences

More...
RefSeqi
NP_001119959.1, NM_001126487.1
XP_006503264.1, XM_006503201.1
XP_011238863.1, XM_011240561.2
XP_011238864.1, XM_011240562.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.318201

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000106770; ENSMUSP00000102382; ENSMUSG00000047502

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
381538

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:381538

UCSC genome browser

More...
UCSCi
uc012dia.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929585 Genomic DNA No translation available.
CCDSiCCDS51253.1
RefSeqiNP_001119959.1, NM_001126487.1
XP_006503264.1, XM_006503201.1
XP_011238863.1, XM_011240561.2
XP_011238864.1, XM_011240562.1
UniGeneiMm.318201

3D structure databases

ProteinModelPortaliA2AVR2
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA2AVR2
PhosphoSitePlusiA2AVR2

Proteomic databases

jPOSTiA2AVR2
PaxDbiA2AVR2
PRIDEiA2AVR2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106770; ENSMUSP00000102382; ENSMUSG00000047502
GeneIDi381538
KEGGimmu:381538
UCSCiuc012dia.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
374977
MGIiMGI:2685873 Mroh7

Phylogenomic databases

eggNOGiKOG2032 Eukaryota
ENOG410XQE8 LUCA
GeneTreeiENSGT00940000161775
HOVERGENiHBG107563
InParanoidiA2AVR2
OMAiGKDSGEM
OrthoDBi31329at2759
TreeFamiTF337538

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2AVR2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000047502 Expressed in 18 organ(s), highest expression level in testis
ExpressionAtlasiA2AVR2 baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMROH7_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AVR2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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