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Protein

Lymphocyte expansion molecule

Gene

Lexm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Was reported to promote CD8+ T cell immunity through effects on mitochondrial respiration (PubMed:25883318). However, the corresponding article has been retracted (PubMed:27980177).

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte expansion molecule1 Publication
Gene namesi
Name:LexmImported
Synonyms:Lem1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2681853 Lexm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002975861 – 414Lymphocyte expansion moleculeAdd BLAST414

Proteomic databases

PaxDbiA2AVQ5
PRIDEiA2AVQ5

PTM databases

PhosphoSitePlusiA2AVQ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000054362 Expressed in 17 organ(s), highest expression level in testis
CleanExiMM_BC055111
ExpressionAtlasiA2AVQ5 baseline and differential

Interactioni

Protein-protein interaction databases

DIPiDIP-61652N
STRINGi10090.ENSMUSP00000066732

Structurei

3D structure databases

ProteinModelPortaliA2AVQ5
SMRiA2AVQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IG0F Eukaryota
ENOG410XYWM LUCA
GeneTreeiENSGT00390000015471
HOGENOMiHOG000007878
HOVERGENiHBG095692
InParanoidiA2AVQ5
OMAiGNPYTKL
OrthoDBiEOG091G0LV6
PhylomeDBiA2AVQ5
TreeFamiTF329164

Family and domain databases

InterProiView protein in InterPro
IPR033557 LEXM
PANTHERiPTHR34914 PTHR34914, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AVQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPRTHGAPP RNIMSTIPKW FKGAPFGVQS HRFDVSAVYP NQKKFSTFTE
60 70 80 90 100
APYSRHHSVE LSHIGPGTYN SKDTCFSKKF LEQKLGSGWS QAHEATRLTQ
110 120 130 140 150
LPHFHYQAIK KEKEQQVHKR GPGSYNIKDF ITELQKKPQS KRGLLSSGET
160 170 180 190 200
RFRGFIGNYY PGPGNYGEKG NPYTQLEEKA WNRSHSDGLM CRVSNKPPLF
210 220 230 240 250
HQGSGLGPGT YTIKSDLETF VKKSTGNRGP YDIFSGERSS PLPYGHYSVQ
260 270 280 290 300
KMKPKELTDY KSFLDEMNSQ HKKKQGVFSK YPRDPKHPTE RIFWTTLSQC
310 320 330 340 350
PKNMDIAGPG SWLPHETEQK HVNRPPFLLA SKRCGLKAYQ MILGTWNPVG
360 370 380 390 400
VGRYLNTTLM ESIDRRQRYR SLYMSEPKRY LQDLTRDRLM QKRITPITKG
410
KCRPTVDYNS DPTP
Length:414
Mass (Da):47,584
Last modified:February 20, 2007 - v1
Checksum:i251EF0F88B6E80C3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6X5R4F6X5R4_MOUSE
Lymphocyte expansion molecule
Lexm BC055111
59Annotation score:

Sequence cautioni

The sequence AAH55111 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165N → D in AAH55111 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929585 Genomic DNA No translation available.
BC055111 mRNA Translation: AAH55111.1 Different initiation.
CCDSiCCDS51252.1
RefSeqiNP_899005.2, NM_183182.3
UniGeneiMm.235591

Genome annotation databases

EnsembliENSMUST00000067387; ENSMUSP00000066732; ENSMUSG00000054362
ENSMUST00000106788; ENSMUSP00000102400; ENSMUSG00000054362
ENSMUST00000189032; ENSMUSP00000139868; ENSMUSG00000054362
GeneIDi242602
KEGGimmu:242602
UCSCiuc012dhz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929585 Genomic DNA No translation available.
BC055111 mRNA Translation: AAH55111.1 Different initiation.
CCDSiCCDS51252.1
RefSeqiNP_899005.2, NM_183182.3
UniGeneiMm.235591

3D structure databases

ProteinModelPortaliA2AVQ5
SMRiA2AVQ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61652N
STRINGi10090.ENSMUSP00000066732

PTM databases

PhosphoSitePlusiA2AVQ5

Proteomic databases

PaxDbiA2AVQ5
PRIDEiA2AVQ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067387; ENSMUSP00000066732; ENSMUSG00000054362
ENSMUST00000106788; ENSMUSP00000102400; ENSMUSG00000054362
ENSMUST00000189032; ENSMUSP00000139868; ENSMUSG00000054362
GeneIDi242602
KEGGimmu:242602
UCSCiuc012dhz.1 mouse

Organism-specific databases

CTDi163747
MGIiMGI:2681853 Lexm

Phylogenomic databases

eggNOGiENOG410IG0F Eukaryota
ENOG410XYWM LUCA
GeneTreeiENSGT00390000015471
HOGENOMiHOG000007878
HOVERGENiHBG095692
InParanoidiA2AVQ5
OMAiGNPYTKL
OrthoDBiEOG091G0LV6
PhylomeDBiA2AVQ5
TreeFamiTF329164

Miscellaneous databases

PROiPR:A2AVQ5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054362 Expressed in 17 organ(s), highest expression level in testis
CleanExiMM_BC055111
ExpressionAtlasiA2AVQ5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR033557 LEXM
PANTHERiPTHR34914 PTHR34914, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLEXM_MOUSE
AccessioniPrimary (citable) accession number: A2AVQ5
Secondary accession number(s): A2AVQ4, Q7TPM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 20, 2007
Last modified: September 12, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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