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Protein

Proline-rich protein 5-like

Gene

Prr5l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (By similarity). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 5-like
Alternative name(s):
Protein observed with Rictor-2
Short name:
Protor-2
Gene namesi
Name:Prr5l
Synonyms:Protor2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919696 Prr5l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003327101 – 370Proline-rich protein 5-likeAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiA2AVJ5
PaxDbiA2AVJ5
PRIDEiA2AVJ5

PTM databases

iPTMnetiA2AVJ5
PhosphoSitePlusiA2AVJ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000032841 Expressed in 217 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiA2AVJ5 baseline and differential
GenevisibleiA2AVJ5 MM

Interactioni

Subunit structurei

Interacts with the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with RFFL. Interacts (via C-terminus) with ZFP36 (via C-terminus); this interaction may accelerate ZFP36-mediated mRNA decay during stress. Interacts with RICTOR.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042167

Structurei

3D structure databases

ProteinModelPortaliA2AVJ5
SMRiA2AVJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PROTOR family.Curated

Phylogenomic databases

eggNOGiENOG410IJB2 Eukaryota
ENOG410ZWNQ LUCA
GeneTreeiENSGT00530000063981
HOGENOMiHOG000290687
HOVERGENiHBG067971
InParanoidiA2AVJ5
OMAiDSELNCA
OrthoDBiEOG091G0VPK
PhylomeDBiA2AVJ5
TreeFamiTF314826

Family and domain databases

InterProiView protein in InterPro
IPR013745 Bit61/PRR5
PANTHERiPTHR32428 PTHR32428, 1 hit
PfamiView protein in Pfam
PF08539 HbrB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A2AVJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRGLAPLLP IEFHKMGSFR RPRPRFMSSP VLSELPRFQA ARQALQLSSN
60 70 80 90 100
SAWNSVQTAV INVFKGGGLQ SNELYALNES IRRLLKSELG SFITDYFQNQ
110 120 130 140 150
LLAKGLSFVE EKIKLCEGDN RIEVLAEVWD HFFTETLPTL QAIFYPVQGQ
160 170 180 190 200
ELTIRQISLL GFRDLVLLKV KLGDVLLLAQ SKLPSSVIQM LLILQSVHEP
210 220 230 240 250
TGPSEGYLQL EELVKQVVSP FLSISGDRSC SGPTYSLARR HSRVRPKVTV
260 270 280 290 300
LNYASLMTTV GRPLNEMVLT PLTEQEGEAY LEKCGSVRRH TVANAHSDIQ
310 320 330 340 350
LLAMATMMHS GLGEEAGGED KHLLLPPSFP PPHRQCSSEP SILDSPDELE
360 370
LEDVASGSQE DSELNCASLS
Length:370
Mass (Da):40,982
Last modified:February 20, 2007 - v1
Checksum:i2273461DCCA5D17F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0R105B0R105_MOUSE
Proline-rich protein 5-like
Prr5l
95Annotation score:
B0R106B0R106_MOUSE
Proline-rich protein 5-like
Prr5l
127Annotation score:
B0R103B0R103_MOUSE
Proline-rich protein 5-like
Prr5l
36Annotation score:
B0R102B0R102_MOUSE
Proline-rich protein 5-like
Prr5l
51Annotation score:
F6VRG5F6VRG5_MOUSE
Proline-rich protein 5-like
Prr5l
238Annotation score:

Sequence cautioni

The sequence AAH48394 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC25324 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE26803 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti293A → D in BAC25324 (PubMed:16141072).Curated1
Sequence conflicti317G → A in BAC25324 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011178 mRNA Translation: BAC25324.1 Different initiation.
AK145981 mRNA Translation: BAE26803.1 Different initiation.
AL929534, AL929571 Genomic DNA Translation: CAM19333.1
AL929571, AL929534 Genomic DNA Translation: CAM20506.1
BC048394 mRNA Translation: AAH48394.1 Different initiation.
BC172132 mRNA Translation: AAI72132.1
CCDSiCCDS38186.1
RefSeqiNP_001077279.1, NM_001083810.2
NP_001104319.1, NM_001110849.1
NP_780390.3, NM_175181.5
XP_006500301.1, XM_006500238.3
XP_006500303.1, XM_006500240.3
XP_006500304.1, XM_006500241.3
XP_017174768.1, XM_017319279.1
UniGeneiMm.24138

Genome annotation databases

EnsembliENSMUST00000043845; ENSMUSP00000042167; ENSMUSG00000032841
ENSMUST00000163762; ENSMUSP00000127530; ENSMUSG00000032841
ENSMUST00000171088; ENSMUSP00000130152; ENSMUSG00000032841
GeneIDi72446
KEGGimmu:72446
UCSCiuc008lho.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011178 mRNA Translation: BAC25324.1 Different initiation.
AK145981 mRNA Translation: BAE26803.1 Different initiation.
AL929534, AL929571 Genomic DNA Translation: CAM19333.1
AL929571, AL929534 Genomic DNA Translation: CAM20506.1
BC048394 mRNA Translation: AAH48394.1 Different initiation.
BC172132 mRNA Translation: AAI72132.1
CCDSiCCDS38186.1
RefSeqiNP_001077279.1, NM_001083810.2
NP_001104319.1, NM_001110849.1
NP_780390.3, NM_175181.5
XP_006500301.1, XM_006500238.3
XP_006500303.1, XM_006500240.3
XP_006500304.1, XM_006500241.3
XP_017174768.1, XM_017319279.1
UniGeneiMm.24138

3D structure databases

ProteinModelPortaliA2AVJ5
SMRiA2AVJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042167

PTM databases

iPTMnetiA2AVJ5
PhosphoSitePlusiA2AVJ5

Proteomic databases

MaxQBiA2AVJ5
PaxDbiA2AVJ5
PRIDEiA2AVJ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043845; ENSMUSP00000042167; ENSMUSG00000032841
ENSMUST00000163762; ENSMUSP00000127530; ENSMUSG00000032841
ENSMUST00000171088; ENSMUSP00000130152; ENSMUSG00000032841
GeneIDi72446
KEGGimmu:72446
UCSCiuc008lho.2 mouse

Organism-specific databases

CTDi79899
MGIiMGI:1919696 Prr5l

Phylogenomic databases

eggNOGiENOG410IJB2 Eukaryota
ENOG410ZWNQ LUCA
GeneTreeiENSGT00530000063981
HOGENOMiHOG000290687
HOVERGENiHBG067971
InParanoidiA2AVJ5
OMAiDSELNCA
OrthoDBiEOG091G0VPK
PhylomeDBiA2AVJ5
TreeFamiTF314826

Miscellaneous databases

PROiPR:A2AVJ5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032841 Expressed in 217 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiA2AVJ5 baseline and differential
GenevisibleiA2AVJ5 MM

Family and domain databases

InterProiView protein in InterPro
IPR013745 Bit61/PRR5
PANTHERiPTHR32428 PTHR32428, 1 hit
PfamiView protein in Pfam
PF08539 HbrB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRR5L_MOUSE
AccessioniPrimary (citable) accession number: A2AVJ5
Secondary accession number(s): B7ZWM2, Q80Y78, Q8BIT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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