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Entry version 97 (08 May 2019)
Sequence version 1 (05 Feb 2008)
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Protein

Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

Gene

Svep1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the cell attachment process.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • chromatin binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
Alternative name(s):
Polydom
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Svep1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1928849 Svep1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500005761618 – 3567Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1Add BLAST3550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi379 ↔ 421By similarity
Disulfide bondi407 ↔ 434By similarity
Disulfide bondi439 ↔ 481By similarity
Disulfide bondi467 ↔ 494By similarity
Disulfide bondi499 ↔ 544By similarity
Disulfide bondi530 ↔ 559By similarity
Disulfide bondi727 ↔ 769By similarity
Disulfide bondi753 ↔ 787By similarity
Disulfide bondi1196 ↔ 1207By similarity
Disulfide bondi1201 ↔ 1216By similarity
Disulfide bondi1218 ↔ 1227By similarity
Disulfide bondi1234 ↔ 1245By similarity
Disulfide bondi1239 ↔ 1254By similarity
Disulfide bondi1256 ↔ 1265By similarity
Disulfide bondi1272 ↔ 1283By similarity
Disulfide bondi1277 ↔ 1292By similarity
Disulfide bondi1294 ↔ 1303By similarity
Disulfide bondi1310 ↔ 1321By similarity
Disulfide bondi1315 ↔ 1330By similarity
Disulfide bondi1332 ↔ 1341By similarity
Disulfide bondi1348 ↔ 1359By similarity
Disulfide bondi1353 ↔ 1368By similarity
Disulfide bondi1370 ↔ 1379By similarity
Disulfide bondi1386 ↔ 1397By similarity
Disulfide bondi1391 ↔ 1406By similarity
Disulfide bondi1408 ↔ 1417By similarity
Disulfide bondi1630 ↔ 1671By similarity
Disulfide bondi1657 ↔ 1684By similarity
Disulfide bondi1689 ↔ 1729By similarity
Disulfide bondi1715 ↔ 1742By similarity
Disulfide bondi1748 ↔ 1760By similarity
Disulfide bondi1754 ↔ 1769By similarity
Disulfide bondi1771 ↔ 1782By similarity
Disulfide bondi1788 ↔ 1828By similarity
Disulfide bondi1814 ↔ 1841By similarity
Disulfide bondi1846 ↔ 1886By similarity
Disulfide bondi1872 ↔ 1899By similarity
Disulfide bondi1904 ↔ 1944By similarity
Disulfide bondi1930 ↔ 1957By similarity
Disulfide bondi1962 ↔ 2002By similarity
Disulfide bondi1988 ↔ 2015By similarity
Disulfide bondi2020 ↔ 2060By similarity
Disulfide bondi2046 ↔ 2077By similarity
Disulfide bondi2082 ↔ 2125By similarity
Disulfide bondi2111 ↔ 2140By similarity
Disulfide bondi2145 ↔ 2185By similarity
Disulfide bondi2171 ↔ 2198By similarity
Disulfide bondi2203 ↔ 2244By similarity
Disulfide bondi2230 ↔ 2258By similarity
Disulfide bondi2263 ↔ 2303By similarity
Disulfide bondi2289 ↔ 2317By similarity
Disulfide bondi2322 ↔ 2362By similarity
Disulfide bondi2348 ↔ 2375By similarity
Disulfide bondi2380 ↔ 2421By similarity
Disulfide bondi2407 ↔ 2434By similarity
Disulfide bondi2439 ↔ 2479By similarity
Disulfide bondi2465 ↔ 2492By similarity
Disulfide bondi2497 ↔ 2537By similarity
Disulfide bondi2523 ↔ 2550By similarity
Disulfide bondi2555 ↔ 2595By similarity
Disulfide bondi2581 ↔ 2607By similarity
Disulfide bondi2682 ↔ 2709By similarity
Disulfide bondi2714 ↔ 2754By similarity
Disulfide bondi2740 ↔ 2767By similarity
Disulfide bondi2772 ↔ 2812By similarity
Disulfide bondi2798 ↔ 2825By similarity
Disulfide bondi2830 ↔ 2870By similarity
Disulfide bondi2856 ↔ 2883By similarity
Disulfide bondi2888 ↔ 2928By similarity
Disulfide bondi2914 ↔ 2941By similarity
Disulfide bondi2946 ↔ 2986By similarity
Disulfide bondi2972 ↔ 2999By similarity
Disulfide bondi3004 ↔ 3043By similarity
Disulfide bondi3029 ↔ 3055By similarity
Disulfide bondi3060 ↔ 3100By similarity
Disulfide bondi3086 ↔ 3113By similarity
Disulfide bondi3118 ↔ 3159By similarity
Disulfide bondi3144 ↔ 3172By similarity
Disulfide bondi3177 ↔ 3217By similarity
Disulfide bondi3203 ↔ 3232By similarity
Disulfide bondi3237 ↔ 3277By similarity
Disulfide bondi3263 ↔ 3290By similarity
Disulfide bondi3295 ↔ 3335By similarity
Disulfide bondi3321 ↔ 3348By similarity
Disulfide bondi3353 ↔ 3394By similarity
Disulfide bondi3380 ↔ 3407By similarity
Disulfide bondi3412 ↔ 3452By similarity
Disulfide bondi3438 ↔ 3464By similarity
Disulfide bondi3500 ↔ 3510By similarity
Disulfide bondi3504 ↔ 3516By similarity
Disulfide bondi3518 ↔ 3527By similarity
Disulfide bondi3532 ↔ 3542By similarity
Disulfide bondi3536 ↔ 3548By similarity
Disulfide bondi3550 ↔ 3559By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2AVA0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AVA0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AVA0

PRoteomics IDEntifications database

More...
PRIDEi
A2AVA0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AVA0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AVA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in stromal osteogenic cells. Expressed at much higher level in stromal osteogenic cells at low density compared to cells grown at higher densities (at protein level). Highly expressed in lung and placenta. Also expressed in bone and periosteum, but not in cartilage and skeletal muscle. Weakly or not expressed in other tissues.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from 11 dpc to 17 dpc in embryos.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028369 Expressed in 182 organ(s), highest expression level in uterus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AVA0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000045856

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AVA0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini84 – 265VWFAPROSITE-ProRule annotationAdd BLAST182
Domaini377 – 436Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini437 – 496Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini497 – 561Sushi 3PROSITE-ProRule annotationAdd BLAST65
Domaini560 – 644HYR 1PROSITE-ProRule annotationAdd BLAST85
Domaini645 – 724HYR 2PROSITE-ProRule annotationAdd BLAST80
Domaini725 – 789Sushi 4PROSITE-ProRule annotationAdd BLAST65
Domaini1192 – 1228EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini1230 – 1266EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1268 – 1304EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1306 – 1342EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1344 – 1380EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1382 – 1418EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1423 – 1627Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST205
Domaini1628 – 1686Sushi 5PROSITE-ProRule annotationAdd BLAST59
Domaini1687 – 1744Sushi 6PROSITE-ProRule annotationAdd BLAST58
Domaini1744 – 1783EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1780 – 1843Sushi 7PROSITE-ProRule annotationAdd BLAST64
Domaini1844 – 1901Sushi 8PROSITE-ProRule annotationAdd BLAST58
Domaini1902 – 1959Sushi 9PROSITE-ProRule annotationAdd BLAST58
Domaini1960 – 2017Sushi 10PROSITE-ProRule annotationAdd BLAST58
Domaini2018 – 2079Sushi 11PROSITE-ProRule annotationAdd BLAST62
Domaini2080 – 2142Sushi 12PROSITE-ProRule annotationAdd BLAST63
Domaini2143 – 2200Sushi 13PROSITE-ProRule annotationAdd BLAST58
Domaini2201 – 2260Sushi 14PROSITE-ProRule annotationAdd BLAST60
Domaini2261 – 2319Sushi 15PROSITE-ProRule annotationAdd BLAST59
Domaini2320 – 2377Sushi 16PROSITE-ProRule annotationAdd BLAST58
Domaini2378 – 2436Sushi 17PROSITE-ProRule annotationAdd BLAST59
Domaini2437 – 2494Sushi 18PROSITE-ProRule annotationAdd BLAST58
Domaini2495 – 2552Sushi 19PROSITE-ProRule annotationAdd BLAST58
Domaini2553 – 2609Sushi 20PROSITE-ProRule annotationAdd BLAST57
Domaini2660 – 2711Sushi 21PROSITE-ProRule annotationAdd BLAST52
Domaini2712 – 2769Sushi 22PROSITE-ProRule annotationAdd BLAST58
Domaini2770 – 2827Sushi 23PROSITE-ProRule annotationAdd BLAST58
Domaini2828 – 2885Sushi 24PROSITE-ProRule annotationAdd BLAST58
Domaini2886 – 2943Sushi 25PROSITE-ProRule annotationAdd BLAST58
Domaini2944 – 3001Sushi 26PROSITE-ProRule annotationAdd BLAST58
Domaini3002 – 3057Sushi 27PROSITE-ProRule annotationAdd BLAST56
Domaini3058 – 3115Sushi 28PROSITE-ProRule annotationAdd BLAST58
Domaini3116 – 3174Sushi 29PROSITE-ProRule annotationAdd BLAST59
Domaini3175 – 3234Sushi 30PROSITE-ProRule annotationAdd BLAST60
Domaini3235 – 3292Sushi 31PROSITE-ProRule annotationAdd BLAST58
Domaini3293 – 3350Sushi 32PROSITE-ProRule annotationAdd BLAST58
Domaini3351 – 3409Sushi 33PROSITE-ProRule annotationAdd BLAST59
Domaini3410 – 3466Sushi 34PROSITE-ProRule annotationAdd BLAST57
Domaini3496 – 3528EGF-like 8PROSITE-ProRule annotationAdd BLAST33
Domaini3529 – 3560EGF-like 9PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
KOG4297 Eukaryota
ENOG410XPJ1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156061

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154457

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AVA0

KEGG Orthology (KO)

More...
KOi
K17495

Identification of Orthologs from Complete Genome Data

More...
OMAi
DCPSVND

Database of Orthologous Groups

More...
OrthoDBi
46968at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AVA0

TreeFam database of animal gene trees

More...
TreeFami
TF342247

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 33 hits
cd00152 PTX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR003410 HYR_dom
IPR001759 Pentraxin-related
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 5 hits
PF07645 EGF_CA, 2 hits
PF07699 Ephrin_rec_like, 4 hits
PF12661 hEGF, 1 hit
PF02494 HYR, 2 hits
PF00354 Pentaxin, 1 hit
PF00084 Sushi, 33 hits
PF00092 VWA, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00895 PENTAXIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 34 hits
SM00181 EGF, 12 hits
SM00179 EGF_CA, 8 hits
SM01411 Ephrin_rec_like, 4 hits
SM00159 PTX, 1 hit
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 1 hit
SSF57184 SSF57184, 3 hits
SSF57535 SSF57535, 33 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 6 hits
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 6 hits
PS50825 HYR, 2 hits
PS51828 PTX_2, 1 hit
PS50923 SUSHI, 34 hits
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A2AVA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWSRLAFCCW ALALVSGWTN FQPVAPSLNF SFRLFPEASP GALGRLAVPP
60 70 80 90 100
ASSEEEAAGS KVERLGRAFR SRVRRLRELS GSLELVFLVD ESSSVGQTNF
110 120 130 140 150
LNELKFVRKL LSDFPVVSTA TRVAIVTFSS KNNVVARVDY ISTSRAHQHK
160 170 180 190 200
CALLSREIPA ITYRGGGTYT KGAFQQAAQI LRHSRENSTK VIFLITDGYS
210 220 230 240 250
NGGDPRPIAA SLRDFGVEIF TFGIWQGNIR ELNDMASTPK EEHCYLLHSF
260 270 280 290 300
EEFEALARRA LHEDLPSGSF IQEDMARCSY LCEAGKDCCD RMASCKCGTH
310 320 330 340 350
TGQFECICEK GYYGKGLQHE CTACPSGTYK PEASPGGIST CIPCPDVSHT
360 370 380 390 400
SPPGSTSPED CVCREGYQRS GQTCEVVHCP ALKPPENGFF IQNTCKNHFN
410 420 430 440 450
AACGVRCRPG FDLVGSSIHL CQPNGLWSGT ESFCRVRTCP HLRQPKHGHI
460 470 480 490 500
SCSTAEMSYN TLCLVTCNEG YRLEGSTRLT CQGNAQWDGP EPRCVERHCA
510 520 530 540 550
TFQKPKGVII SPPSCGKQPA RPGMTCQLSC RQGYILSGVR EVRCATSGKW
560 570 580 590 600
SAKVQTAVCK DVEAPQISCP NDIEAKTGEQ QDSANVTWQV PTAKDNSGEK
610 620 630 640 650
VSVHVHPAFT PPYLFPIGDV AITYTATDSS GNQASCTFYI KVIDVEPPVI
660 670 680 690 700
DWCRSPPPIQ VVEKEHPASW DEPQFSDNSG AELVITSSHT QGDMFPHGET
710 720 730 740 750
VVWYTATDPS GNNRTCDIHI VIKGSPCEVP FTPVNGDFIC AQDSAGVNCS
760 770 780 790 800
LSCKEGYDFT EGSTEKYYCA FEDGIWRPPY STEWPDCAIK RFANHGFKSF
810 820 830 840 850
EMLYKTTRCD DMDLFKKFSA AFETTLGNMV PSFCNDADDI DCRLEDLTKK
860 870 880 890 900
YCIEYNYNYE NGFAIGPGGW GAGNRLDYSY DHFLDVVQET PTDVGKARSS
910 920 930 940 950
RIKRTVPLSD PKIQLIFNIT ASVPLPEERN DTLELENQQR LIKTLETITN
960 970 980 990 1000
RLKSTLNKEP MYSFQLASET VVADSNSLET EKAFLFCRPG SVLRGRMCVN
1010 1020 1030 1040 1050
CPLGTSYSLE HSTCESCLMG SYQDEEGQLE CKLCPPRTHT EYLHSRSVSE
1060 1070 1080 1090 1100
CKAQCKQGTY SSSGLETCES CPLGTYQPEF GSRSCLLCPE TTTTVKRGAV
1110 1120 1130 1140 1150
DISACGVPCP VGEFSRSGLT PCYPCPRDYY QPNAGKSFCL ACPFYGTTTI
1160 1170 1180 1190 1200
TGATSITDCS SFSSTFSAAE ESIVPLVAPG HSQNKYEVSS QVFHECFLNP
1210 1220 1230 1240 1250
CHNSGTCQQL GRGYVCLCPP GYTGLKCETD IDECSSLPCL NGGICRDQVG
1260 1270 1280 1290 1300
GFTCECSLGY SGQICEENIN ECISSPCLNK GTCTDGLASY RCTCVKGYMG
1310 1320 1330 1340 1350
VHCETDVNEC QSSPCLNNAV CKDQVGGFSC KCPPGFLGTR CEKNVDECLS
1360 1370 1380 1390 1400
QPCQNGATCK DGANSFRCQC PAGFTGTHCE LNINECQSNP CRNQATCVDE
1410 1420 1430 1440 1450
LNSYSCKCQP GFSGHRCETE QPSGFNLDFE VSGIYGYVLL DGVLPTLHAI
1460 1470 1480 1490 1500
TCAFWMKSSD VINYGTPISY ALEDDKDNTF LLTDYNGWVL YVNGKEKITN
1510 1520 1530 1540 1550
CPSVNDGIWH HIAITWTSTG GAWRVYIDGE LSDGGTGLSI GKAIPGGGAL
1560 1570 1580 1590 1600
VLGQEQDKKG EGFNPAESFV GSISQLNLWD YVLSPQQVKL LASSCPEELS
1610 1620 1630 1640 1650
RGNVLAWPDF LSGITGKVKV DSSSMFCSDC PSLEGSVPHL RPASGNRKPG
1660 1670 1680 1690 1700
SKVSLFCDPG FQMVGNPVQY CLNQGQWTQP LPHCERIRCG LPPALENGFY
1710 1720 1730 1740 1750
SAEDFHAGST VTYQCTSGYY LLGDSRMFCT DNGSWNGISP SCLDVDECAV
1760 1770 1780 1790 1800
GSDCSEHASC LNTNGSYVCS CNPPYTGDGK NCAEPVKCKA PENPENGHSS
1810 1820 1830 1840 1850
GEIYTVGTAV TFSCDEGHEL VGVSTITCLE TGEWDRLRPS CEAISCGVPP
1860 1870 1880 1890 1900
VPENGGVDGS AFTYGSKVVY RCDKGYTLSG DEESACLASG SWSHSSPVCE
1910 1920 1930 1940 1950
LVKCSQPEDI NNGKYILSGL TYLSIASYSC ENGYSLQGPS LLECTASGSW
1960 1970 1980 1990 2000
DRAPPSCQLV SCGEPPIVKD AVITGSNFTF GNTVAYTCKE GYTLAGPDTI
2010 2020 2030 2040 2050
VCQANGKWNS SNHQCLAVSC DEPPNVDHAS PETAHRLFGD TAFYYCADGY
2060 2070 2080 2090 2100
SLADNSQLIC NAQGNWVPPA GQAVPRCIAH FCEKPPSVSY SILESVSKAK
2110 2120 2130 2140 2150
FAAGSVVSFK CMEGFVLNTS AKIECLRGGE WSPSPLSVQC IPVRCGEPPS
2160 2170 2180 2190 2200
IANGYPSGTN YSFGAVVAYS CHKGFYIKGE KKSTCEATGQ WSKPTPTCHP
2210 2220 2230 2240 2250
VSCNEPPKVE NGFLEHTTGR TFESEARFQC NPGYKAAGSP VFVCQANRHW
2260 2270 2280 2290 2300
HSDAPLSCTP LNCGKPPPIQ NGFLKGESFE VGSKVQFVCN EGYELVGDNS
2310 2320 2330 2340 2350
WTCQKSGKWS KKPSPKCVPT KCAEPPLLEN QLVLKELASE VGVMTISCKE
2360 2370 2380 2390 2400
GHALQGPSVL KCLPSGQWNG SFPICKMVLC PSPPLIPFGV PASSGALHFG
2410 2420 2430 2440 2450
STVKYLCVDG FFLRGSPTIL CQADSTWSSP LPECVPVECP QPEEILNGII
2460 2470 2480 2490 2500
HVQGLAYLST TLYTCKPGFE LVGNATTLCG ENGQWLGGKP MCKPIECPEP
2510 2520 2530 2540 2550
KEILNGQFSS VSFQYGQTIT YFCDRGFRLE GPKSLTCLET GDWDMDPPSC
2560 2570 2580 2590 2600
DAIHCSDPQP IENGFVEGAD YRYGAMIIYS CFPGFQVLGH AMQTCEESGW
2610 2620 2630 2640 2650
SSSSPTCVPI DCGLPPHIDF GDCTKVRDGQ GHFDQEDDMM EVPYLAHPQH
2660 2670 2680 2690 2700
LEATAKALEN TKESPASHAS HFLYGTMVSY SCEPGYELLG IPVLICQEDG
2710 2720 2730 2740 2750
TWNGTAPSCI SIECDLPVAP ENGFLHFTQT TMGSAAQYSC KPGHILEGSH
2760 2770 2780 2790 2800
LRLCLQNKQW SGTVPRCEAI SCSKPNPLWN GSIKGDDYSY LGVLYYECDS
2810 2820 2830 2840 2850
GYILNGSKKR TCQENRDWDG HEPMCIPVDC GSPPVPTNGR VKGEEYTFQK
2860 2870 2880 2890 2900
EITYSCREGF ILEGARSRIC LTNGSWSGAT PSCMPVRCPA PPQVPNGVAD
2910 2920 2930 2940 2950
GLDYGFKKEV AFHCLEGYVL QGAPRLTCQS NGTWDAEVPV CKPATCGPPA
2960 2970 2980 2990 3000
DLPQGFPNGF SFYHGGHIQY QCFTGYKLHG NPSRRCLPNG SWSGSSPSCL
3010 3020 3030 3040 3050
PCRCSTPIIQ QGTINATDLG CGKTVQIECF KGFKLLGLSE ITCDANGQWS
3060 3070 3080 3090 3100
DVPLCEHAQC GPLPTIPNAI VLEGSLSEDN VVTYSCRPGY TMQGSSDLIC
3110 3120 3130 3140 3150
TEKAIWSQPY PTCEPLSCGP PPTVANAVAT GEAHTYESKV KLRCLEGYVM
3160 3170 3180 3190 3200
DSDTDTFTCQ QDGHWVPERI TCSPKKCPVP SNMTRIRFHG DDFQVNRQVS
3210 3220 3230 3240 3250
VSCAEGFTHE GVNWSTCQPD GTWEPPFSDE SCIPVVCGHP ESPAHGSVVG
3260 3270 3280 3290 3300
NKHSFGSTIV YQCDPGYKLE GNRERICQEN RQWSGEVAVC RENRCETPAE
3310 3320 3330 3340 3350
FPNGKAVLEN TTSGPSLLFS CHRGYTLEGS PEAHCTANGT WNHLTPLCKP
3360 3370 3380 3390 3400
NPCPVPFVIP ENAVLSEKEF YVDQNVSIKC REGFLLKGNG VITCSPDETW
3410 3420 3430 3440 3450
THTNARCEKI SCGPPSHVEN AIARGVYYQY GDMITYSCYS GYMLEGSLRS
3460 3470 3480 3490 3500
VCLENGTWTP SPVCRAVCRF PCQNGGVCQR PNACSCPDGW MGRLCEEPIC
3510 3520 3530 3540 3550
ILPCLNGGRC VAPYQCDCPT GWTGSRCHTA TCQSPCLNGG KCIRPNRCHC
3560
LSAWTGHDCS RKRRAGL
Length:3,567
Mass (Da):387,457
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E10297DFB8392EE
GO
Isoform 2 (identifier: A2AVA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-440: VRTCP → GMESG
     441-3567: Missing.

Note: No experimental confirmation available.
Show »
Length:440
Mass (Da):48,188
Checksum:i9DE9289BC257C955
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1480F → S in AAG32160 (PubMed:11062057).Curated1
Sequence conflicti1528D → N in AAG32160 (PubMed:11062057).Curated1
Sequence conflicti3143R → K in BAB29505 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031629436 – 440VRTCP → GMESG in isoform 2. 1 Publication5
Alternative sequenceiVSP_031630441 – 3567Missing in isoform 2. 1 PublicationAdd BLAST3127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF206329 mRNA Translation: AAG32160.1
AK052699 mRNA Translation: BAC35103.1
AK014693 mRNA Translation: BAB29505.1
AK035333 mRNA Translation: BAC29036.1
AL805969 Genomic DNA No translation available.
AL929406 Genomic DNA No translation available.
BC008135 mRNA Translation: AAH08135.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18209.1 [A2AVA0-1]

NCBI Reference Sequences

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RefSeqi
NP_073725.2, NM_022814.2 [A2AVA0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000042850; ENSMUSP00000045856; ENSMUSG00000028369 [A2AVA0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64817

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:64817

UCSC genome browser

More...
UCSCi
uc008syr.1 mouse [A2AVA0-1]
uc008sys.1 mouse [A2AVA0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF206329 mRNA Translation: AAG32160.1
AK052699 mRNA Translation: BAC35103.1
AK014693 mRNA Translation: BAB29505.1
AK035333 mRNA Translation: BAC29036.1
AL805969 Genomic DNA No translation available.
AL929406 Genomic DNA No translation available.
BC008135 mRNA Translation: AAH08135.1
CCDSiCCDS18209.1 [A2AVA0-1]
RefSeqiNP_073725.2, NM_022814.2 [A2AVA0-1]

3D structure databases

SMRiA2AVA0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045856

PTM databases

iPTMnetiA2AVA0
PhosphoSitePlusiA2AVA0

Proteomic databases

jPOSTiA2AVA0
MaxQBiA2AVA0
PaxDbiA2AVA0
PRIDEiA2AVA0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042850; ENSMUSP00000045856; ENSMUSG00000028369 [A2AVA0-1]
GeneIDi64817
KEGGimmu:64817
UCSCiuc008syr.1 mouse [A2AVA0-1]
uc008sys.1 mouse [A2AVA0-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79987
MGIiMGI:1928849 Svep1

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
KOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00940000156061
HOGENOMiHOG000154457
InParanoidiA2AVA0
KOiK17495
OMAiDCPSVND
OrthoDBi46968at2759
PhylomeDBiA2AVA0
TreeFamiTF342247

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Svep1 mouse

Protein Ontology

More...
PROi
PR:A2AVA0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028369 Expressed in 182 organ(s), highest expression level in uterus
GenevisibleiA2AVA0 MM

Family and domain databases

CDDicd00033 CCP, 33 hits
cd00152 PTX, 1 hit
Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR003410 HYR_dom
IPR001759 Pentraxin-related
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00008 EGF, 5 hits
PF07645 EGF_CA, 2 hits
PF07699 Ephrin_rec_like, 4 hits
PF12661 hEGF, 1 hit
PF02494 HYR, 2 hits
PF00354 Pentaxin, 1 hit
PF00084 Sushi, 33 hits
PF00092 VWA, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00032 CCP, 34 hits
SM00181 EGF, 12 hits
SM00179 EGF_CA, 8 hits
SM01411 Ephrin_rec_like, 4 hits
SM00159 PTX, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 1 hit
SSF57184 SSF57184, 3 hits
SSF57535 SSF57535, 33 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 6 hits
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 6 hits
PS50825 HYR, 2 hits
PS51828 PTX_2, 1 hit
PS50923 SUSHI, 34 hits
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSVEP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AVA0
Secondary accession number(s): Q8C720
, Q8CBT2, Q922H0, Q9CUT3, Q9ES77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 5, 2008
Last modified: May 8, 2019
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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