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UniProtKB - A2AVA0 (SVEP1_MOUSE)

Entry version 103 (12 Aug 2020)
Sequence version 1 (05 Feb 2008)
Previous versions | rss
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Protein

Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

Gene

Svep1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the cell attachment process.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
Alternative name(s):
Polydom
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Svep1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1928849, Svep1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500005761618 – 3567Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1Add BLAST3550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi379 ↔ 421By similarity
Disulfide bondi407 ↔ 434By similarity
Disulfide bondi439 ↔ 481By similarity
Disulfide bondi467 ↔ 494By similarity
Disulfide bondi499 ↔ 544By similarity
Disulfide bondi530 ↔ 559By similarity
Disulfide bondi727 ↔ 769By similarity
Disulfide bondi753 ↔ 787By similarity
Disulfide bondi1196 ↔ 1207By similarity
Disulfide bondi1201 ↔ 1216By similarity
Disulfide bondi1218 ↔ 1227By similarity
Disulfide bondi1234 ↔ 1245By similarity
Disulfide bondi1239 ↔ 1254By similarity
Disulfide bondi1256 ↔ 1265By similarity
Disulfide bondi1272 ↔ 1283By similarity
Disulfide bondi1277 ↔ 1292By similarity
Disulfide bondi1294 ↔ 1303By similarity
Disulfide bondi1310 ↔ 1321By similarity
Disulfide bondi1315 ↔ 1330By similarity
Disulfide bondi1332 ↔ 1341By similarity
Disulfide bondi1348 ↔ 1359By similarity
Disulfide bondi1353 ↔ 1368By similarity
Disulfide bondi1370 ↔ 1379By similarity
Disulfide bondi1386 ↔ 1397By similarity
Disulfide bondi1391 ↔ 1406By similarity
Disulfide bondi1408 ↔ 1417By similarity
Disulfide bondi1630 ↔ 1671By similarity
Disulfide bondi1657 ↔ 1684By similarity
Disulfide bondi1689 ↔ 1729By similarity
Disulfide bondi1715 ↔ 1742By similarity
Disulfide bondi1748 ↔ 1760By similarity
Disulfide bondi1754 ↔ 1769By similarity
Disulfide bondi1771 ↔ 1782By similarity
Disulfide bondi1788 ↔ 1828By similarity
Disulfide bondi1814 ↔ 1841By similarity
Disulfide bondi1846 ↔ 1886By similarity
Disulfide bondi1872 ↔ 1899By similarity
Disulfide bondi1904 ↔ 1944By similarity
Disulfide bondi1930 ↔ 1957By similarity
Disulfide bondi1962 ↔ 2002By similarity
Disulfide bondi1988 ↔ 2015By similarity
Disulfide bondi2020 ↔ 2060By similarity
Disulfide bondi2046 ↔ 2077By similarity
Disulfide bondi2082 ↔ 2125By similarity
Disulfide bondi2111 ↔ 2140By similarity
Disulfide bondi2145 ↔ 2185By similarity
Disulfide bondi2171 ↔ 2198By similarity
Disulfide bondi2203 ↔ 2244By similarity
Disulfide bondi2230 ↔ 2258By similarity
Disulfide bondi2263 ↔ 2303By similarity
Disulfide bondi2289 ↔ 2317By similarity
Disulfide bondi2322 ↔ 2362By similarity
Disulfide bondi2348 ↔ 2375By similarity
Disulfide bondi2380 ↔ 2421By similarity
Disulfide bondi2407 ↔ 2434By similarity
Disulfide bondi2439 ↔ 2479By similarity
Disulfide bondi2465 ↔ 2492By similarity
Disulfide bondi2497 ↔ 2537By similarity
Disulfide bondi2523 ↔ 2550By similarity
Disulfide bondi2555 ↔ 2595By similarity
Disulfide bondi2581 ↔ 2607By similarity
Disulfide bondi2682 ↔ 2709By similarity
Disulfide bondi2714 ↔ 2754By similarity
Disulfide bondi2740 ↔ 2767By similarity
Disulfide bondi2772 ↔ 2812By similarity
Disulfide bondi2798 ↔ 2825By similarity
Disulfide bondi2830 ↔ 2870By similarity
Disulfide bondi2856 ↔ 2883By similarity
Disulfide bondi2888 ↔ 2928By similarity
Disulfide bondi2914 ↔ 2941By similarity
Disulfide bondi2946 ↔ 2986By similarity
Disulfide bondi2972 ↔ 2999By similarity
Disulfide bondi3004 ↔ 3043By similarity
Disulfide bondi3029 ↔ 3055By similarity
Disulfide bondi3060 ↔ 3100By similarity
Disulfide bondi3086 ↔ 3113By similarity
Disulfide bondi3118 ↔ 3159By similarity
Disulfide bondi3144 ↔ 3172By similarity
Disulfide bondi3177 ↔ 3217By similarity
Disulfide bondi3203 ↔ 3232By similarity
Disulfide bondi3237 ↔ 3277By similarity
Disulfide bondi3263 ↔ 3290By similarity
Disulfide bondi3295 ↔ 3335By similarity
Disulfide bondi3321 ↔ 3348By similarity
Disulfide bondi3353 ↔ 3394By similarity
Disulfide bondi3380 ↔ 3407By similarity
Disulfide bondi3412 ↔ 3452By similarity
Disulfide bondi3438 ↔ 3464By similarity
Disulfide bondi3500 ↔ 3510By similarity
Disulfide bondi3504 ↔ 3516By similarity
Disulfide bondi3518 ↔ 3527By similarity
Disulfide bondi3532 ↔ 3542By similarity
Disulfide bondi3536 ↔ 3548By similarity
Disulfide bondi3550 ↔ 3559By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A2AVA0

MaxQB - The MaxQuant DataBase

More...MaxQBi		A2AVA0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2AVA0

PRoteomics IDEntifications database

More...PRIDEi		A2AVA0

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		A2AVA0, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A2AVA0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A2AVA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in stromal osteogenic cells. Expressed at much higher level in stromal osteogenic cells at low density compared to cells grown at higher densities (at protein level). Highly expressed in lung and placenta. Also expressed in bone and periosteum, but not in cartilage and skeletal muscle. Weakly or not expressed in other tissues.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from 11 dpc to 17 dpc in embryos.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000028369, Expressed in uterus and 197 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A2AVA0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		211104, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000045856

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A2AVA0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A2AVA0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini84 – 265VWFAPROSITE-ProRule annotationAdd BLAST182
Domaini377 – 436Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini437 – 496Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini497 – 561Sushi 3PROSITE-ProRule annotationAdd BLAST65
Domaini560 – 644HYR 1PROSITE-ProRule annotationAdd BLAST85
Domaini645 – 724HYR 2PROSITE-ProRule annotationAdd BLAST80
Domaini725 – 789Sushi 4PROSITE-ProRule annotationAdd BLAST65
Domaini1192 – 1228EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini1230 – 1266EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1268 – 1304EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1306 – 1342EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1344 – 1380EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1382 – 1418EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1423 – 1627Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST205
Domaini1628 – 1686Sushi 5PROSITE-ProRule annotationAdd BLAST59
Domaini1687 – 1744Sushi 6PROSITE-ProRule annotationAdd BLAST58
Domaini1744 – 1783EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1780 – 1843Sushi 7PROSITE-ProRule annotationAdd BLAST64
Domaini1844 – 1901Sushi 8PROSITE-ProRule annotationAdd BLAST58
Domaini1902 – 1959Sushi 9PROSITE-ProRule annotationAdd BLAST58
Domaini1960 – 2017Sushi 10PROSITE-ProRule annotationAdd BLAST58
Domaini2018 – 2079Sushi 11PROSITE-ProRule annotationAdd BLAST62
Domaini2080 – 2142Sushi 12PROSITE-ProRule annotationAdd BLAST63
Domaini2143 – 2200Sushi 13PROSITE-ProRule annotationAdd BLAST58
Domaini2201 – 2260Sushi 14PROSITE-ProRule annotationAdd BLAST60
Domaini2261 – 2319Sushi 15PROSITE-ProRule annotationAdd BLAST59
Domaini2320 – 2377Sushi 16PROSITE-ProRule annotationAdd BLAST58
Domaini2378 – 2436Sushi 17PROSITE-ProRule annotationAdd BLAST59
Domaini2437 – 2494Sushi 18PROSITE-ProRule annotationAdd BLAST58
Domaini2495 – 2552Sushi 19PROSITE-ProRule annotationAdd BLAST58
Domaini2553 – 2609Sushi 20PROSITE-ProRule annotationAdd BLAST57
Domaini2660 – 2711Sushi 21PROSITE-ProRule annotationAdd BLAST52
Domaini2712 – 2769Sushi 22PROSITE-ProRule annotationAdd BLAST58
Domaini2770 – 2827Sushi 23PROSITE-ProRule annotationAdd BLAST58
Domaini2828 – 2885Sushi 24PROSITE-ProRule annotationAdd BLAST58
Domaini2886 – 2943Sushi 25PROSITE-ProRule annotationAdd BLAST58
Domaini2944 – 3001Sushi 26PROSITE-ProRule annotationAdd BLAST58
Domaini3002 – 3057Sushi 27PROSITE-ProRule annotationAdd BLAST56
Domaini3058 – 3115Sushi 28PROSITE-ProRule annotationAdd BLAST58
Domaini3116 – 3174Sushi 29PROSITE-ProRule annotationAdd BLAST59
Domaini3175 – 3234Sushi 30PROSITE-ProRule annotationAdd BLAST60
Domaini3235 – 3292Sushi 31PROSITE-ProRule annotationAdd BLAST58
Domaini3293 – 3350Sushi 32PROSITE-ProRule annotationAdd BLAST58
Domaini3351 – 3409Sushi 33PROSITE-ProRule annotationAdd BLAST59
Domaini3410 – 3466Sushi 34PROSITE-ProRule annotationAdd BLAST57
Domaini3496 – 3528EGF-like 8PROSITE-ProRule annotationAdd BLAST33
Domaini3529 – 3560EGF-like 9PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1217, Eukaryota
KOG4297, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156061

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000343_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2AVA0

KEGG Orthology (KO)

More...KOi		K17495

Identification of Orthologs from Complete Genome Data

More...OMAi		LCQPNGL

Database of Orthologous Groups

More...OrthoDBi		46968at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2AVA0

TreeFam database of animal gene trees

More...TreeFami		TF342247

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 33 hits
cd00152, PTX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR003410, HYR_dom
IPR001759, Pentraxin-related
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR011641, Tyr-kin_ephrin_A/B_rcpt-like
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00008, EGF, 5 hits
PF07645, EGF_CA, 2 hits
PF07699, Ephrin_rec_like, 4 hits
PF12661, hEGF, 1 hit
PF02494, HYR, 2 hits
PF00354, Pentaxin, 1 hit
PF00084, Sushi, 33 hits
PF00092, VWA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00895, PENTAXIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 34 hits
SM00181, EGF, 12 hits
SM00179, EGF_CA, 8 hits
SM01411, Ephrin_rec_like, 4 hits
SM00159, PTX, 1 hit
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899, SSF49899, 1 hit
SSF53300, SSF53300, 1 hit
SSF57184, SSF57184, 3 hits
SSF57535, SSF57535, 33 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 6 hits
PS00022, EGF_1, 9 hits
PS01186, EGF_2, 11 hits
PS50026, EGF_3, 9 hits
PS01187, EGF_CA, 6 hits
PS50825, HYR, 2 hits
PS51828, PTX_2, 1 hit
PS50923, SUSHI, 34 hits
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A2AVA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWSRLAFCCW ALALVSGWTN FQPVAPSLNF SFRLFPEASP GALGRLAVPP 
        60         70         80         90        100
ASSEEEAAGS KVERLGRAFR SRVRRLRELS GSLELVFLVD ESSSVGQTNF 
       110        120        130        140        150
LNELKFVRKL LSDFPVVSTA TRVAIVTFSS KNNVVARVDY ISTSRAHQHK 
       160        170        180        190        200
CALLSREIPA ITYRGGGTYT KGAFQQAAQI LRHSRENSTK VIFLITDGYS 
       210        220        230        240        250
NGGDPRPIAA SLRDFGVEIF TFGIWQGNIR ELNDMASTPK EEHCYLLHSF 
       260        270        280        290        300
EEFEALARRA LHEDLPSGSF IQEDMARCSY LCEAGKDCCD RMASCKCGTH 
       310        320        330        340        350
TGQFECICEK GYYGKGLQHE CTACPSGTYK PEASPGGIST CIPCPDVSHT 
       360        370        380        390        400
SPPGSTSPED CVCREGYQRS GQTCEVVHCP ALKPPENGFF IQNTCKNHFN 
       410        420        430        440        450
AACGVRCRPG FDLVGSSIHL CQPNGLWSGT ESFCRVRTCP HLRQPKHGHI 
       460        470        480        490        500
SCSTAEMSYN TLCLVTCNEG YRLEGSTRLT CQGNAQWDGP EPRCVERHCA 
       510        520        530        540        550
TFQKPKGVII SPPSCGKQPA RPGMTCQLSC RQGYILSGVR EVRCATSGKW 
       560        570        580        590        600
SAKVQTAVCK DVEAPQISCP NDIEAKTGEQ QDSANVTWQV PTAKDNSGEK 
       610        620        630        640        650
VSVHVHPAFT PPYLFPIGDV AITYTATDSS GNQASCTFYI KVIDVEPPVI 
       660        670        680        690        700
DWCRSPPPIQ VVEKEHPASW DEPQFSDNSG AELVITSSHT QGDMFPHGET 
       710        720        730        740        750
VVWYTATDPS GNNRTCDIHI VIKGSPCEVP FTPVNGDFIC AQDSAGVNCS 
       760        770        780        790        800
LSCKEGYDFT EGSTEKYYCA FEDGIWRPPY STEWPDCAIK RFANHGFKSF 
       810        820        830        840        850
EMLYKTTRCD DMDLFKKFSA AFETTLGNMV PSFCNDADDI DCRLEDLTKK 
       860        870        880        890        900
YCIEYNYNYE NGFAIGPGGW GAGNRLDYSY DHFLDVVQET PTDVGKARSS 
       910        920        930        940        950
RIKRTVPLSD PKIQLIFNIT ASVPLPEERN DTLELENQQR LIKTLETITN 
       960        970        980        990       1000
RLKSTLNKEP MYSFQLASET VVADSNSLET EKAFLFCRPG SVLRGRMCVN 
      1010       1020       1030       1040       1050
CPLGTSYSLE HSTCESCLMG SYQDEEGQLE CKLCPPRTHT EYLHSRSVSE 
      1060       1070       1080       1090       1100
CKAQCKQGTY SSSGLETCES CPLGTYQPEF GSRSCLLCPE TTTTVKRGAV 
      1110       1120       1130       1140       1150
DISACGVPCP VGEFSRSGLT PCYPCPRDYY QPNAGKSFCL ACPFYGTTTI 
      1160       1170       1180       1190       1200
TGATSITDCS SFSSTFSAAE ESIVPLVAPG HSQNKYEVSS QVFHECFLNP 
      1210       1220       1230       1240       1250
CHNSGTCQQL GRGYVCLCPP GYTGLKCETD IDECSSLPCL NGGICRDQVG 
      1260       1270       1280       1290       1300
GFTCECSLGY SGQICEENIN ECISSPCLNK GTCTDGLASY RCTCVKGYMG 
      1310       1320       1330       1340       1350
VHCETDVNEC QSSPCLNNAV CKDQVGGFSC KCPPGFLGTR CEKNVDECLS 
      1360       1370       1380       1390       1400
QPCQNGATCK DGANSFRCQC PAGFTGTHCE LNINECQSNP CRNQATCVDE 
      1410       1420       1430       1440       1450
LNSYSCKCQP GFSGHRCETE QPSGFNLDFE VSGIYGYVLL DGVLPTLHAI 
      1460       1470       1480       1490       1500
TCAFWMKSSD VINYGTPISY ALEDDKDNTF LLTDYNGWVL YVNGKEKITN 
      1510       1520       1530       1540       1550
CPSVNDGIWH HIAITWTSTG GAWRVYIDGE LSDGGTGLSI GKAIPGGGAL 
      1560       1570       1580       1590       1600
VLGQEQDKKG EGFNPAESFV GSISQLNLWD YVLSPQQVKL LASSCPEELS 
      1610       1620       1630       1640       1650
RGNVLAWPDF LSGITGKVKV DSSSMFCSDC PSLEGSVPHL RPASGNRKPG 
      1660       1670       1680       1690       1700
SKVSLFCDPG FQMVGNPVQY CLNQGQWTQP LPHCERIRCG LPPALENGFY 
      1710       1720       1730       1740       1750
SAEDFHAGST VTYQCTSGYY LLGDSRMFCT DNGSWNGISP SCLDVDECAV 
      1760       1770       1780       1790       1800
GSDCSEHASC LNTNGSYVCS CNPPYTGDGK NCAEPVKCKA PENPENGHSS 
      1810       1820       1830       1840       1850
GEIYTVGTAV TFSCDEGHEL VGVSTITCLE TGEWDRLRPS CEAISCGVPP 
      1860       1870       1880       1890       1900
VPENGGVDGS AFTYGSKVVY RCDKGYTLSG DEESACLASG SWSHSSPVCE 
      1910       1920       1930       1940       1950
LVKCSQPEDI NNGKYILSGL TYLSIASYSC ENGYSLQGPS LLECTASGSW 
      1960       1970       1980       1990       2000
DRAPPSCQLV SCGEPPIVKD AVITGSNFTF GNTVAYTCKE GYTLAGPDTI 
      2010       2020       2030       2040       2050
VCQANGKWNS SNHQCLAVSC DEPPNVDHAS PETAHRLFGD TAFYYCADGY 
      2060       2070       2080       2090       2100
SLADNSQLIC NAQGNWVPPA GQAVPRCIAH FCEKPPSVSY SILESVSKAK 
      2110       2120       2130       2140       2150
FAAGSVVSFK CMEGFVLNTS AKIECLRGGE WSPSPLSVQC IPVRCGEPPS 
      2160       2170       2180       2190       2200
IANGYPSGTN YSFGAVVAYS CHKGFYIKGE KKSTCEATGQ WSKPTPTCHP 
      2210       2220       2230       2240       2250
VSCNEPPKVE NGFLEHTTGR TFESEARFQC NPGYKAAGSP VFVCQANRHW 
      2260       2270       2280       2290       2300
HSDAPLSCTP LNCGKPPPIQ NGFLKGESFE VGSKVQFVCN EGYELVGDNS 
      2310       2320       2330       2340       2350
WTCQKSGKWS KKPSPKCVPT KCAEPPLLEN QLVLKELASE VGVMTISCKE 
      2360       2370       2380       2390       2400
GHALQGPSVL KCLPSGQWNG SFPICKMVLC PSPPLIPFGV PASSGALHFG 
      2410       2420       2430       2440       2450
STVKYLCVDG FFLRGSPTIL CQADSTWSSP LPECVPVECP QPEEILNGII 
      2460       2470       2480       2490       2500
HVQGLAYLST TLYTCKPGFE LVGNATTLCG ENGQWLGGKP MCKPIECPEP 
      2510       2520       2530       2540       2550
KEILNGQFSS VSFQYGQTIT YFCDRGFRLE GPKSLTCLET GDWDMDPPSC 
      2560       2570       2580       2590       2600
DAIHCSDPQP IENGFVEGAD YRYGAMIIYS CFPGFQVLGH AMQTCEESGW 
      2610       2620       2630       2640       2650
SSSSPTCVPI DCGLPPHIDF GDCTKVRDGQ GHFDQEDDMM EVPYLAHPQH 
      2660       2670       2680       2690       2700
LEATAKALEN TKESPASHAS HFLYGTMVSY SCEPGYELLG IPVLICQEDG 
      2710       2720       2730       2740       2750
TWNGTAPSCI SIECDLPVAP ENGFLHFTQT TMGSAAQYSC KPGHILEGSH 
      2760       2770       2780       2790       2800
LRLCLQNKQW SGTVPRCEAI SCSKPNPLWN GSIKGDDYSY LGVLYYECDS 
      2810       2820       2830       2840       2850
GYILNGSKKR TCQENRDWDG HEPMCIPVDC GSPPVPTNGR VKGEEYTFQK 
      2860       2870       2880       2890       2900
EITYSCREGF ILEGARSRIC LTNGSWSGAT PSCMPVRCPA PPQVPNGVAD 
      2910       2920       2930       2940       2950
GLDYGFKKEV AFHCLEGYVL QGAPRLTCQS NGTWDAEVPV CKPATCGPPA 
      2960       2970       2980       2990       3000
DLPQGFPNGF SFYHGGHIQY QCFTGYKLHG NPSRRCLPNG SWSGSSPSCL 
      3010       3020       3030       3040       3050
PCRCSTPIIQ QGTINATDLG CGKTVQIECF KGFKLLGLSE ITCDANGQWS 
      3060       3070       3080       3090       3100
DVPLCEHAQC GPLPTIPNAI VLEGSLSEDN VVTYSCRPGY TMQGSSDLIC 
      3110       3120       3130       3140       3150
TEKAIWSQPY PTCEPLSCGP PPTVANAVAT GEAHTYESKV KLRCLEGYVM 
      3160       3170       3180       3190       3200
DSDTDTFTCQ QDGHWVPERI TCSPKKCPVP SNMTRIRFHG DDFQVNRQVS 
      3210       3220       3230       3240       3250
VSCAEGFTHE GVNWSTCQPD GTWEPPFSDE SCIPVVCGHP ESPAHGSVVG 
      3260       3270       3280       3290       3300
NKHSFGSTIV YQCDPGYKLE GNRERICQEN RQWSGEVAVC RENRCETPAE 
      3310       3320       3330       3340       3350
FPNGKAVLEN TTSGPSLLFS CHRGYTLEGS PEAHCTANGT WNHLTPLCKP 
      3360       3370       3380       3390       3400
NPCPVPFVIP ENAVLSEKEF YVDQNVSIKC REGFLLKGNG VITCSPDETW 
      3410       3420       3430       3440       3450
THTNARCEKI SCGPPSHVEN AIARGVYYQY GDMITYSCYS GYMLEGSLRS 
      3460       3470       3480       3490       3500
VCLENGTWTP SPVCRAVCRF PCQNGGVCQR PNACSCPDGW MGRLCEEPIC 
      3510       3520       3530       3540       3550
ILPCLNGGRC VAPYQCDCPT GWTGSRCHTA TCQSPCLNGG KCIRPNRCHC 
      3560 
LSAWTGHDCS RKRRAGL
Length:3,567
Mass (Da):387,457
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E10297DFB8392EE
GO
Isoform 2 (identifier: A2AVA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-440: VRTCP → GMESG
     441-3567: Missing.

Show »
Length:440
Mass (Da):48,188
Checksum:i9DE9289BC257C955
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1480F → S in AAG32160 (PubMed:11062057).Curated1
Sequence conflicti1528D → N in AAG32160 (PubMed:11062057).Curated1
Sequence conflicti3143R → K in BAB29505 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031629436 – 440VRTCP → GMESG in isoform 2. 1 Publication5
Alternative sequenceiVSP_031630441 – 3567Missing in isoform 2. 1 PublicationAdd BLAST3127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF206329 mRNA Translation: AAG32160.1
AK052699 mRNA Translation: BAC35103.1
AK014693 mRNA Translation: BAB29505.1
AK035333 mRNA Translation: BAC29036.1
AL805969 Genomic DNA No translation available.
AL929406 Genomic DNA No translation available.
BC008135 mRNA Translation: AAH08135.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS18209.1 [A2AVA0-1]

NCBI Reference Sequences

More...RefSeqi		NP_073725.2, NM_022814.2 [A2AVA0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000042850; ENSMUSP00000045856; ENSMUSG00000028369 [A2AVA0-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64817

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:64817

UCSC genome browser

More...UCSCi		uc008syr.1, mouse [A2AVA0-1]
uc008sys.1, mouse [A2AVA0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF206329 mRNA Translation: AAG32160.1
AK052699 mRNA Translation: BAC35103.1
AK014693 mRNA Translation: BAB29505.1
AK035333 mRNA Translation: BAC29036.1
AL805969 Genomic DNA No translation available.
AL929406 Genomic DNA No translation available.
BC008135 mRNA Translation: AAH08135.1
CCDSiCCDS18209.1 [A2AVA0-1]
RefSeqiNP_073725.2, NM_022814.2 [A2AVA0-1]

3D structure databases

SMRiA2AVA0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi211104, 1 interactor
STRINGi10090.ENSMUSP00000045856

PTM databases

GlyGeniA2AVA0, 1 site
iPTMnetiA2AVA0
PhosphoSitePlusiA2AVA0

Proteomic databases

jPOSTiA2AVA0
MaxQBiA2AVA0
PaxDbiA2AVA0
PRIDEiA2AVA0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7229, 19 antibodies

Genome annotation databases

EnsembliENSMUST00000042850; ENSMUSP00000045856; ENSMUSG00000028369 [A2AVA0-1]
GeneIDi64817
KEGGimmu:64817
UCSCiuc008syr.1, mouse [A2AVA0-1]
uc008sys.1, mouse [A2AVA0-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79987
MGIiMGI:1928849, Svep1

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
KOG4297, Eukaryota
GeneTreeiENSGT00940000156061
HOGENOMiCLU_000343_0_0_1
InParanoidiA2AVA0
KOiK17495
OMAiLCQPNGL
OrthoDBi46968at2759
PhylomeDBiA2AVA0
TreeFamiTF342247

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64817, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Svep1, mouse

Protein Ontology

More...PROi		PR:A2AVA0
RNActiA2AVA0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000028369, Expressed in uterus and 197 other tissues
GenevisibleiA2AVA0, MM

Family and domain databases

CDDicd00033, CCP, 33 hits
cd00152, PTX, 1 hit
Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR003410, HYR_dom
IPR001759, Pentraxin-related
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR011641, Tyr-kin_ephrin_A/B_rcpt-like
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF00008, EGF, 5 hits
PF07645, EGF_CA, 2 hits
PF07699, Ephrin_rec_like, 4 hits
PF12661, hEGF, 1 hit
PF02494, HYR, 2 hits
PF00354, Pentaxin, 1 hit
PF00084, Sushi, 33 hits
PF00092, VWA, 1 hit
PRINTSiPR00895, PENTAXIN
SMARTiView protein in SMART
SM00032, CCP, 34 hits
SM00181, EGF, 12 hits
SM00179, EGF_CA, 8 hits
SM01411, Ephrin_rec_like, 4 hits
SM00159, PTX, 1 hit
SM00327, VWA, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
SSF53300, SSF53300, 1 hit
SSF57184, SSF57184, 3 hits
SSF57535, SSF57535, 33 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 6 hits
PS00022, EGF_1, 9 hits
PS01186, EGF_2, 11 hits
PS50026, EGF_3, 9 hits
PS01187, EGF_CA, 6 hits
PS50825, HYR, 2 hits
PS51828, PTX_2, 1 hit
PS50923, SUSHI, 34 hits
PS50234, VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSVEP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AVA0
Secondary accession number(s): Q8C720
, Q8CBT2, Q922H0, Q9CUT3, Q9ES77
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 5, 2008
Last modified: August 12, 2020
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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