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Protein

Fibrinogen C domain-containing protein 1

Gene

Fibcd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi391CalciumBy similarity1
Metal bindingi393CalciumBy similarity1
Sitei403Implicated in ligand bindingBy similarity1
Sitei413Implicated in ligand bindingBy similarity1
Sitei429Implicated in ligand bindingBy similarity1
Sitei430Implicated in ligand bindingBy similarity1

GO - Molecular functioni

Keywordsi

LigandCalcium, Chitin-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen C domain-containing protein 1
Gene namesi
Name:Fibcd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2138953 Fibcd1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini55 – 459ExtracellularSequence analysisAdd BLAST405

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943171 – 459Fibrinogen C domain-containing protein 1Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi242 ↔ 271PROSITE-ProRule annotation
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi399 ↔ 412PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA2AV25
PRIDEiA2AV25

PTM databases

iPTMnetiA2AV25
PhosphoSitePlusiA2AV25

Expressioni

Gene expression databases

BgeeiENSMUSG00000026841 Expressed in 72 organ(s), highest expression level in Ammon's horn
CleanExiMM_FIBCD1
GenevisibleiA2AV25 MM

Interactioni

Subunit structurei

Homotetramer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028188

Structurei

3D structure databases

ProteinModelPortaliA2AV25
SMRiA2AV25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 456Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST224

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150813
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiA2AV25
OMAiATYELHV
OrthoDBiEOG091G03M1
TreeFamiTF351983

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A2AV25-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVHERWKTVG SASQLEDRPR DKPQRASCSY VLCTVLLSLA VLLAVAVTGV
60 70 80 90 100
VLFLNHTHTP GTAPPPIVST GTAGANSALV TVERADSSHL SLLIDPRCPD
110 120 130 140 150
LTDSFARLEG IQASILRALS EHQAQPRLDG APELLDALAD QLPRLLTRAS
160 170 180 190 200
ELQAECAGLR KGHSLLGQGL STLQSEQGRL IQLLSESQGH MAHLVNSVSD
210 220 230 240 250
VLEALQRERG LGRPRVKADL QRAPSRGARP RGCANGSRPR DCLDVLLSGQ
260 270 280 290 300
QDDGVYSIFP THYPAGFQVY CDMRTDGGGW TVFQRREDGS VNFFRGWEAY
310 320 330 340 350
REGFGKLTGE HWLGLKRIHA LTTQAAYELH VDLEDFDNGT AYAHYGSFGV
360 370 380 390 400
GLFSVDPEED GYPLTVADYS GTAGDSLLKH SGMRFTTKDR DSDHSENNCA
410 420 430 440 450
AFYRGAWWYR NCHTSNLNGQ YLRGAHASYA DGVEWSSWTG WQYSLKFSEM

KIRPVREDR
Length:459
Mass (Da):50,602
Last modified:April 17, 2007 - v1
Checksum:i63D94371CB91A900
GO
Isoform 2 (identifier: A2AV25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-190: Missing.

Show »
Length:269
Mass (Da):30,357
Checksum:i7BE8B01596D23370
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti427A → V in BAC32685 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0266211 – 190Missing in isoform 2. 2 PublicationsAdd BLAST190

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046338 mRNA Translation: BAC32685.1
AK084379 mRNA Translation: BAC39169.1
AL929275 Genomic DNA No translation available.
BC060634 mRNA Translation: AAH60634.2
CCDSiCCDS50564.1 [A2AV25-1]
RefSeqiNP_849218.2, NM_178887.4 [A2AV25-1]
UniGeneiMm.32080

Genome annotation databases

EnsembliENSMUST00000028188; ENSMUSP00000028188; ENSMUSG00000026841 [A2AV25-1]
GeneIDi98970
KEGGimmu:98970
UCSCiuc008jee.2 mouse [A2AV25-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046338 mRNA Translation: BAC32685.1
AK084379 mRNA Translation: BAC39169.1
AL929275 Genomic DNA No translation available.
BC060634 mRNA Translation: AAH60634.2
CCDSiCCDS50564.1 [A2AV25-1]
RefSeqiNP_849218.2, NM_178887.4 [A2AV25-1]
UniGeneiMm.32080

3D structure databases

ProteinModelPortaliA2AV25
SMRiA2AV25
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028188

PTM databases

iPTMnetiA2AV25
PhosphoSitePlusiA2AV25

Proteomic databases

PaxDbiA2AV25
PRIDEiA2AV25

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028188; ENSMUSP00000028188; ENSMUSG00000026841 [A2AV25-1]
GeneIDi98970
KEGGimmu:98970
UCSCiuc008jee.2 mouse [A2AV25-1]

Organism-specific databases

CTDi84929
MGIiMGI:2138953 Fibcd1

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150813
HOGENOMiHOG000037127
HOVERGENiHBG001644
InParanoidiA2AV25
OMAiATYELHV
OrthoDBiEOG091G03M1
TreeFamiTF351983

Miscellaneous databases

PROiPR:A2AV25
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026841 Expressed in 72 organ(s), highest expression level in Ammon's horn
CleanExiMM_FIBCD1
GenevisibleiA2AV25 MM

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBCD1_MOUSE
AccessioniPrimary (citable) accession number: A2AV25
Secondary accession number(s): Q6P9R8, Q8BJE7, Q8BL54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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