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Entry version 81 (08 May 2019)
Sequence version 2 (13 Nov 2007)
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Protein

Methyltransferase-like protein 8

Gene

Mettl8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable methyltransferase (By similarity). Isoform 5 overexpression in lung progenitor cells stimulates smooth muscle-specific gene expression and suppresses adipogenic gene expression. Isoform 4 and isoform 7 stimulate adipogenesis.By similarity2 Publications

Caution

According to PubMed:15992539 and PubMed:18710950, contains a SANT domain but this domain is not detected by any prediction tool.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histone acetyltransferase activity Source: MGI
  • mRNA methyltransferase activity Source: MGI
  • tRNA (cytosine-3-)-methyltransferase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methyltransferase-like protein 8 (EC:2.1.1.-)
Alternative name(s):
Tension-induced/inhibited protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mettl8
Synonyms:Tip
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2385142 Mettl8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003112921 – 281Methyltransferase-like protein 8Add BLAST281

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2AUU0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AUU0

PRoteomics IDEntifications database

More...
PRIDEi
A2AUU0

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AUU0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 5 is absent in undifferentiated embryonic lung mesenchymal cells, but expression is induced by stretch. Isoform 4 is expressed in undifferentiated progenitor cells, while its expression is inhibited by stretch. Isoform 2 is absent in embryonic lung but is induced in a fibroblast cell line by stretch. Isoform 7 is expressed in mature adipose tissue.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 5 is induced in stretched embryonic lung mesenchymal cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000041975 Expressed in 281 organ(s), highest expression level in limb

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AUU0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AUU0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EP300.1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000107804

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2361 Eukaryota
ENOG410YAN4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159683

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AUU0

Identification of Orthologs from Complete Genome Data

More...
OMAi
EQVKYES

Database of Orthologous Groups

More...
OrthoDBi
987359at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AUU0

TreeFam database of animal gene trees

More...
TreeFami
TF323232

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041698 Methyltransf_25
IPR026113 MeTrfase
IPR029063 SAM-dependent_MTases

The PANTHER Classification System

More...
PANTHERi
PTHR22809 PTHR22809, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13649 Methyltransf_25, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037755 Mettl2_prd, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AUU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNVIWRSCIC RLRQGKVPHR CQSGVHPVAP LGSRILTDPA KVFEHNMWDH
60 70 80 90 100
MQWSKEEEDA ARKKVEENSA TRVAPEEQVK FESDANKYWD IFYQTHKNKF
110 120 130 140 150
FKNRNWLLRE FPEILPVNQN TKEKVGESSW DQVGSSISRT QGTETHCQES
160 170 180 190 200
FVSPEPGSRG RSAPDPDLEE YSKGPGKTEP FPGSNATFRI LEVGCGAGNS
210 220 230 240 250
VFPILNTLQN IPGSFLYCCD FASEAVELVK SHESYSEAQC SAFIHDVCDD
260 270 280
GLAYPFPDGI LDVVLLVFVL SSIHPDRALF I
Note: Gene prediction based on similarity to human ortholog.
Length:281
Mass (Da):31,670
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B6DD620DA56FBFB
GO
Isoform 2 (identifier: A2AUU0-2) [UniParc]FASTAAdd to basket
Also known as: TIP-2

The sequence of this isoform differs from the canonical sequence as follows:
     278-281: ALFI → QVPPCLPNRTCDFYKMSQPPGRGYRPA

Show »
Length:304
Mass (Da):34,287
Checksum:i3E305C84AF58A734
GO
Isoform 3 (identifier: A2AUU0-3) [UniParc]FASTAAdd to basket
Also known as: TIP-4

The sequence of this isoform differs from the canonical sequence as follows:
     278-281: ALFI → MQAVAHRLSR...PSPWTPQSGN

Show »
Length:388
Mass (Da):44,337
Checksum:i330B0C33D6CC0D5A
GO
Isoform 4 (identifier: A2AUU0-4) [UniParc]FASTAAdd to basket
Also known as: TIP-3

The sequence of this isoform differs from the canonical sequence as follows:
     278-281: ALFI → MQAVAHRLSR...SKIWLIIACK

Show »
Length:358
Mass (Da):40,433
Checksum:i0F6F24A7787AAB23
GO
Isoform 5 (identifier: A2AUU0-5) [UniParc]FASTAAdd to basket
Also known as: TIP-1

The sequence of this isoform differs from the canonical sequence as follows:
     193-281: VGCGAGNSVF...SIHPDRALFI → EHSRILSLLLRLCL

Show »
Length:206
Mass (Da):23,753
Checksum:i3DC0134B9FF30A17
GO
Isoform 6 (identifier: A2AUU0-6) [UniParc]FASTAAdd to basket
Also known as: TIP-5

The sequence of this isoform differs from the canonical sequence as follows:
     79-154: Missing.
     278-281: ALFI → MQAVAHRLSR...PSPWTPQSGN

Show »
Length:312
Mass (Da):35,341
Checksum:i5364FE73A0F38FB1
GO
Isoform 7 (identifier: A2AUU0-7)
Also known as: TIP-6
Sequence is not available
Length:
Mass (Da):
Isoform 8 (identifier: A2AUU0-8)
Also known as: TIP-7
Sequence is not available
Length:
Mass (Da):
Isoform 9 (identifier: A2AUU0-9)
Also known as: TIP-8
Sequence is not available
Length:
Mass (Da):

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0R0U1B0R0U1_MOUSE
Methyltransferase-like protein
Mettl8
341Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8CA70Q8CA70_MOUSE
Methyltransferase-like protein 8
Mettl8 BC004636
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q7P7F6Q7P7_MOUSE
Methyltransferase-like protein 8
Mettl8
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6W103F6W103_MOUSE
Methyltransferase-like protein 8
Mettl8
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH04636 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH57960 differs from that shown. Sequence differs from the displayed sequence in the N-terminal region.Curated
The sequence AAZ04166 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAZ04167 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti91I → T in ABB54392 (PubMed:18710950).Curated1
Sequence conflicti91I → T in AAH04636 (PubMed:15489334).Curated1
Sequence conflicti91I → T in AAH57960 (PubMed:15489334).Curated1
Sequence conflicti161R → W in AAZ04166 (PubMed:15992539).Curated1
Sequence conflicti161R → W in AAZ04167 (PubMed:15992539).Curated1
Sequence conflicti161R → W in ABB54392 (PubMed:18710950).Curated1
Sequence conflicti161R → W in ABB54393 (PubMed:18710950).Curated1
Sequence conflicti161R → W in AAH04636 (PubMed:15489334).Curated1
Sequence conflicti161R → W in AAH57960 (PubMed:15489334).Curated1
Sequence conflicti233E → K in AAZ04167 (PubMed:15992539).Curated1
Sequence conflicti233E → K in ABB54392 (PubMed:18710950).Curated1
Sequence conflicti233E → K in ABB54393 (PubMed:18710950).Curated1
Sequence conflicti233E → K in AAH04636 (PubMed:15489334).Curated1
Sequence conflicti233E → K in AAH57960 (PubMed:15489334).Curated1
Sequence conflicti238A → T in AAZ04167 (PubMed:15992539).Curated1
Sequence conflicti238A → T in ABB54392 (PubMed:18710950).Curated1
Sequence conflicti238A → T in ABB54393 (PubMed:18710950).Curated1
Sequence conflicti238A → T in AAH04636 (PubMed:15489334).Curated1
Sequence conflicti238A → T in AAH57960 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03711179 – 154Missing in isoform 6. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_029515193 – 281VGCGA…RALFI → EHSRILSLLLRLCL in isoform 5. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_029516278 – 281ALFI → QVPPCLPNRTCDFYKMSQPP GRGYRPA in isoform 2. 2 Publications4
Alternative sequenceiVSP_029517278 – 281ALFI → MQAVAHRLSRLLKPGGMLLF RDHGRYDNAQLRFKKGRCLS ENFYVRGDGTRAYFFTKGEI RRMFCEAGLHEKQNLVDHRL QVNRKKQVQMHRVWIQGKFQ KPSPWTPQSGN in isoform 3 and isoform 6. 2 Publications4
Alternative sequenceiVSP_029518278 – 281ALFI → MQAVAHRLSRLLKPGGMLLF RDHGRYDNAQLRFKKGRCLS ENFYVRGDGPELISLQKGKS AVCSARLDYTKSKIWLIIAC K in isoform 4. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ093357 mRNA Translation: AAZ04166.1 Different initiation.
DQ093358 mRNA Translation: AAZ04167.1 Different initiation.
DQ230973 mRNA Translation: ABB54392.1
DQ230974 mRNA Translation: ABB54393.1
AL929228 Genomic DNA No translation available.
BC004636 mRNA Translation: AAH04636.1 Different initiation.
BC057960 mRNA Translation: AAH57960.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50600.1 [A2AUU0-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001103982.1, NM_001110512.1 [A2AUU0-6]
NP_663499.2, NM_145524.3 [A2AUU0-3]
XP_006499258.1, XM_006499195.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000112179; ENSMUSP00000107800; ENSMUSG00000041975 [A2AUU0-5]
ENSMUST00000112186; ENSMUSP00000107804; ENSMUSG00000041975 [A2AUU0-3]
ENSMUST00000121586; ENSMUSP00000113642; ENSMUSG00000041975 [A2AUU0-1]
ENSMUST00000148876; ENSMUSP00000115855; ENSMUSG00000041975 [A2AUU0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
228019

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:228019

UCSC genome browser

More...
UCSCi
uc008jzw.3 mouse [A2AUU0-6]
uc008jzx.3 mouse [A2AUU0-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ093357 mRNA Translation: AAZ04166.1 Different initiation.
DQ093358 mRNA Translation: AAZ04167.1 Different initiation.
DQ230973 mRNA Translation: ABB54392.1
DQ230974 mRNA Translation: ABB54393.1
AL929228 Genomic DNA No translation available.
BC004636 mRNA Translation: AAH04636.1 Different initiation.
BC057960 mRNA Translation: AAH57960.1 Sequence problems.
CCDSiCCDS50600.1 [A2AUU0-3]
RefSeqiNP_001103982.1, NM_001110512.1 [A2AUU0-6]
NP_663499.2, NM_145524.3 [A2AUU0-3]
XP_006499258.1, XM_006499195.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107804

PTM databases

PhosphoSitePlusiA2AUU0

Proteomic databases

jPOSTiA2AUU0
PaxDbiA2AUU0
PRIDEiA2AUU0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112179; ENSMUSP00000107800; ENSMUSG00000041975 [A2AUU0-5]
ENSMUST00000112186; ENSMUSP00000107804; ENSMUSG00000041975 [A2AUU0-3]
ENSMUST00000121586; ENSMUSP00000113642; ENSMUSG00000041975 [A2AUU0-1]
ENSMUST00000148876; ENSMUSP00000115855; ENSMUSG00000041975 [A2AUU0-2]
GeneIDi228019
KEGGimmu:228019
UCSCiuc008jzw.3 mouse [A2AUU0-6]
uc008jzx.3 mouse [A2AUU0-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79828
MGIiMGI:2385142 Mettl8

Phylogenomic databases

eggNOGiKOG2361 Eukaryota
ENOG410YAN4 LUCA
GeneTreeiENSGT00940000159683
InParanoidiA2AUU0
OMAiEQVKYES
OrthoDBi987359at2759
PhylomeDBiA2AUU0
TreeFamiTF323232

Miscellaneous databases

Protein Ontology

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PROi
PR:A2AUU0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000041975 Expressed in 281 organ(s), highest expression level in limb
ExpressionAtlasiA2AUU0 baseline and differential
GenevisibleiA2AUU0 MM

Family and domain databases

InterProiView protein in InterPro
IPR041698 Methyltransf_25
IPR026113 MeTrfase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR22809 PTHR22809, 1 hit
PfamiView protein in Pfam
PF13649 Methyltransf_25, 1 hit
PIRSFiPIRSF037755 Mettl2_prd, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMETL8_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AUU0
Secondary accession number(s): A2AUU3
, Q2XV35, Q2XV36, Q4FCR9, Q4FCS0, Q6PEN9, Q99KI7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 8, 2019
This is version 81 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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