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Protein
Submitted name:

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Gene

Pfkfb3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 6-phosphofructo-2-kinase activity Source: MGI
  • ATP binding Source: InterPro
  • fructose-2,6-bisphosphate 2-phosphatase activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-70171 Glycolysis

Names & Taxonomyi

Protein namesi
Submitted name:
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3Imported
Gene namesi
Name:Pfkfb3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2181202 Pfkfb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiA2AUP1
PeptideAtlasiA2AUP1
PRIDEiA2AUP1

Expressioni

Gene expression databases

BgeeiENSMUSG00000026773 Expressed in 291 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiA2AUP1 baseline and differential
GenevisibleiA2AUP1 MM

Structurei

3D structure databases

ProteinModelPortaliA2AUP1
SMRiA2AUP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 2466PF2KInterPro annotationAdd BLAST221

Phylogenomic databases

GeneTreeiENSGT00390000018751
HOGENOMiHOG000181112
HOVERGENiHBG005628
TreeFamiTF313541

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR003094 6Pfruct_kin
IPR013079 6Phosfructo_kin
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR027417 P-loop_NTPase
IPR001345 PG/BPGM_mutase_AS
PANTHERiPTHR10606 PTHR10606, 1 hit
PfamiView protein in Pfam
PF01591 6PF2K, 1 hit
PF00300 His_Phos_1, 1 hit
PRINTSiPR00991 6PFRUCTKNASE
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

A2AUP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLELTQSRV QKIWVPVDHR PSLPRSCGPK LTNSPTVIVM VGLPARGKTY
60 70 80 90 100
ISKKLTRYLN WIGVPTKVFN VGEYRREAVK QYSSYNFFRP DNEEAMRVRK
110 120 130 140 150
QCALAALRDV KSYLTKEGGQ IAVFDATNTT RERRHMILNF AKENDFKAFF
160 170 180 190 200
IESVCDDPTV VASNIMEVKI SSPDYKDCNS AEAMDDFMKR INCYEASYQP
210 220 230 240 250
LDPDKCDRDL SLIKVIDVGR RFLVNRVQDH IQSRIVYYLM NIHVQPRTIY
260 270 280 290 300
LCRHGENEYN LQGKIGGDSG LSSRGKKFAN ALSKFVEEQN LKDLRVWTSQ
310 320 330 340 350
LKSTIQTAEA LRLPYEQWKA LNEIDAGVCE ELTYEEIRDT YPEEYALREQ
360 370 380 390 400
DKYYYRYPTG ESYQDLVQRL EPVIMELERQ ENVLVICHQA VLRCLLAYFL
410 420 430 440 450
DKSAEEMPYL KCPLHTVLKL TPVAYGCRVE SIYLNVESVS THRERSEDAK
460 470 480 490 500
KGPNPLMRRN SVTPLASPEP TKKPRINSFE ERVASTSAAL PSCLPPEVPT
510 520
QLPGQNMKSS RSGADSSQKH
Length:520
Mass (Da):59,671
Last modified:February 20, 2007 - v1
Checksum:i3958F42071A7D18D
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A7UAK5A7UAK5_MOUSE
6-phosphofructo-2-kinase/fructose-2...
Pfkfb3
555Annotation score:
A7UAK4A7UAK4_MOUSE
6-phosphofructo-2-kinase/fructose-2...
Pfkfb3
462Annotation score:
Q3U3S6Q3U3S6_MOUSE
6-phosphofructo-2-kinase/fructose-2...
Pfkfb3
549Annotation score:
A2AUP5A2AUP5_MOUSE
6-phosphofructo-2-kinase/fructose-2...
Pfkfb3
514Annotation score:
A7UAK8A7UAK8_MOUSE
6-phosphofructo-2-kinase/fructose-2...
Pfkfb3
543Annotation score:
Q7TS91Q7TS91_MOUSE
6-phosphofructo-2-kinase/fructose-2...
Pfkfb3
526Annotation score:
A0A0A6YY64A0A0A6YY64_MOUSE
6-phosphofructo-2-kinase/fructose-2...
Pfkfb3
500Annotation score:
A2AUP4A2AUP4_MOUSE
6-phosphofructo-2-kinase/fructose-2...
Pfkfb3
542Annotation score:
A2AUP3A2AUP3_MOUSE
6-phosphofructo-2-kinase/fructose-2...
Pfkfb3
513Annotation score:
A0A0A6YW89A0A0A6YW89_MOUSE
6-phosphofructo-2-kinase/fructose-2...
Pfkfb3
327Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831794 Genomic DNA No translation available.
AL929179 Genomic DNA No translation available.
RefSeqiNP_573495.2, NM_133232.3
UniGeneiMm.19669

Genome annotation databases

EnsembliENSMUST00000114846; ENSMUSP00000110495; ENSMUSG00000026773
GeneIDi170768
UCSCiuc008iie.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL831794 Genomic DNA No translation available.
AL929179 Genomic DNA No translation available.
RefSeqiNP_573495.2, NM_133232.3
UniGeneiMm.19669

3D structure databases

ProteinModelPortaliA2AUP1
SMRiA2AUP1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA2AUP1
PeptideAtlasiA2AUP1
PRIDEiA2AUP1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114846; ENSMUSP00000110495; ENSMUSG00000026773
GeneIDi170768
UCSCiuc008iie.2 mouse

Organism-specific databases

CTDi5209
MGIiMGI:2181202 Pfkfb3

Phylogenomic databases

GeneTreeiENSGT00390000018751
HOGENOMiHOG000181112
HOVERGENiHBG005628
TreeFamiTF313541

Enzyme and pathway databases

ReactomeiR-MMU-70171 Glycolysis

Miscellaneous databases

ChiTaRSiPfkfb3 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026773 Expressed in 291 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiA2AUP1 baseline and differential
GenevisibleiA2AUP1 MM

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR003094 6Pfruct_kin
IPR013079 6Phosfructo_kin
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR027417 P-loop_NTPase
IPR001345 PG/BPGM_mutase_AS
PANTHERiPTHR10606 PTHR10606, 1 hit
PfamiView protein in Pfam
PF01591 6PF2K, 1 hit
PF00300 His_Phos_1, 1 hit
PRINTSiPR00991 6PFRUCTKNASE
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2AUP1_MOUSE
AccessioniPrimary (citable) accession number: A2AUP1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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