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Protein

Centrosomal protein of 152 kDa

Gene

Cep152

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (By similarity). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (By similarity). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (PubMed:24240477). Overexpression of cep152 can drive amplification of centrioles.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 152 kDa
Short name:
Cep152
Gene namesi
Name:Cep152
Synonyms:Kiaa0912
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139083 Cep152

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004248201 – 1736Centrosomal protein of 152 kDaAdd BLAST1736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1277PhosphothreonineBy similarity1
Modified residuei1714N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiA2AUM9
MaxQBiA2AUM9
PaxDbiA2AUM9
PeptideAtlasiA2AUM9
PRIDEiA2AUM9

PTM databases

iPTMnetiA2AUM9
PhosphoSitePlusiA2AUM9

Expressioni

Gene expression databases

BgeeiENSMUSG00000068394 Expressed in 206 organ(s), highest expression level in ventricular system choroidal fissure
GenevisibleiA2AUM9 MM

Interactioni

Subunit structurei

Interacts (via N-terminus) with PLK4; the interaction is mutally exclusive with a PLK4:CEP192 interaction. Interacts (via C-terminus) with CENPJ (via-N-terminus). Interacts with CINP. Interacts with CDK5RAP2, WDR62, CEP63 and CEP131. CEP63, CDK5RAP2, CEP152, WDR62 are proposed to form a stepwise assembled complex at the centrosome forming a ring near parental centrioles (By similarity). Interacts with DEUP1; this interaction recruits CEP152 to the deuterosome. The interactions with CEP63 and DEUP1 are mutually exclusive (PubMed:24240477).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221186, 81 interactors
ComplexPortaliCPX-1160 CEP152-PLK4 complex
DIPiDIP-56915N
IntActiA2AUM9, 85 interactors
STRINGi10090.ENSMUSP00000087208

Structurei

3D structure databases

SMRiA2AUM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 60Interaction with PLK4By similarityAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili228 – 481Sequence analysisAdd BLAST254
Coiled coili552 – 651Sequence analysisAdd BLAST100
Coiled coili692 – 776Sequence analysisAdd BLAST85
Coiled coili835 – 868Sequence analysisAdd BLAST34
Coiled coili950 – 1075Sequence analysisAdd BLAST126
Coiled coili1205 – 1315Sequence analysisAdd BLAST111

Sequence similaritiesi

Belongs to the CEP152 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGHC Eukaryota
ENOG410XQAW LUCA
GeneTreeiENSGT00630000089915
HOGENOMiHOG000111522
HOVERGENiHBG096403
InParanoidiA2AUM9
KOiK16728
OMAiDDHRNKI
OrthoDBiEOG091G0PGF
TreeFamiTF332017

Family and domain databases

InterProiView protein in InterPro
IPR029598 Cep152
PANTHERiPTHR10337:SF6 PTHR10337:SF6, 1 hit

Sequencei

Sequence statusi: Complete.

A2AUM9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLEFGSVAL QTQNEDEEFD KEDFEREKEL QQLLTDLPHD MLDDELSSPE
60 70 80 90 100
RHDSDCSMDG RAAEPHPSEH LERKWIERDI LPKPHSMNCG NGWEENRSKT
110 120 130 140 150
EDQHLGYHPG EGGDEGGSGY SPPGKREQAD LYRLPEDFRP YTGGSKQAAS
160 170 180 190 200
VITFSDPQRD NFQQFGLSRG PSCGALEPYK AVYKPYRNSS VQKNSSPAQE
210 220 230 240 250
VAASDMFEGL QQQFLGANET DSAENIHIIQ LQVLNKAKER QLDSLVEKLK
260 270 280 290 300
DSERQVRYLS HQLLIVQDEK DGLALSLRES QQLFQNGKER EMQLEAQIAA
310 320 330 340 350
LEAQVEAFRV SEEKLTKKLR TTEITLESLK QQLVELHHSE SLQRAREHHE
360 370 380 390 400
SIVASLTQKH EEQVSSLQKN LDATITALQE QESICTRLKD HVQQLERNQE
410 420 430 440 450
AVRLEKTELI NRLTRSLEDS QKQCAHLLQS GSVQEVAQLQ LQLQQAQKAH
460 470 480 490 500
VLSESMNKAL QEELTELKDE ISLYESAAEL GVLPGDSEGD LSIELTESCV
510 520 530 540 550
DLGIKKVNWK QSKANRVTQQ ESPDEDPSKD ELILKLKTQV QRLLTSNSVK
560 570 580 590 600
RHLVSQLQSD LRECRETMEA FQQSKDGDSG METKTDTSEK TTKQLWLESS
610 620 630 640 650
EAINREDILQ LKNEVQVLQK QNQELKEAEE KLRSTNQDLC NQMRQMVQEF
660 670 680 690 700
DHDKQEAVAR CERTYQQHHE AMKAQIRESL LAKHAVEKQH LLEVYEGTQS
710 720 730 740 750
QLRSDLDKMN KEMAAVQECY LEVCREKDGL ESTLRKTMEK AQEQKRQLLE
760 770 780 790 800
AREEYVRKLK LELEEKYQET LKTERQSWLQ EQAAGATQQA EKESRQKLIQ
810 820 830 840 850
QLEKEWQSKL DDSLAAWRKT TSDRGSQTEQ VACPAAVSKA EAAAVLAEEQ
860 870 880 890 900
ARQVQQEKEL ATKEALRKPE VELELKYCEI IAQKVETAVQ NARSRWIQEL
910 920 930 940 950
PMLAEYKALL RAQQQEWAKQ QELAVAHRLS LALSEAKEKW KSELENMKPN
960 970 980 990 1000
VMSVKELEEK VHSLQKELEL KDEEVPVIVR AEVAKARTEW NKEKQEEIHK
1010 1020 1030 1040 1050
IQEQNEEDYR QFLEDHRNKI NEVLAAAKED FVKQKAELLL QKETEFQACL
1060 1070 1080 1090 1100
DQSRKEWTLQ EAQQTQVEIR QYEEDTLTVL AYLLKDTQLE YGGDSQDKQL
1110 1120 1130 1140 1150
LEAMSACSSK WISVQYFEKV KACIQKALHD MLSLLTDSVA SEQEKRKVVK
1160 1170 1180 1190 1200
SSADTVSWTS SEGDSAVPVP LPDSTSVRCA QSSAWLKAEA ETDKKICEIK
1210 1220 1230 1240 1250
GLRCGHCFQE LEKEKQECQD LRRKLEKCRR HLQHLERTHR AAVEKLGEEN
1260 1270 1280 1290 1300
SRVVEELIEE NHDMKNKLEA LRALCRTPPR SLSAGAAESA GPSCSRQALE
1310 1320 1330 1340 1350
ELRGQYIKAV RKIKRDMLRY IQESKERAAE MVKAEVLRER QETARKMRNY
1360 1370 1380 1390 1400
YLSCLQQILQ DNGKEEGAEK KIMSAASKLA TMAELLGTIA ESDCRVRCAQ
1410 1420 1430 1440 1450
AGRSVALPLA SEMLTGTERS ERSGVNHNIP HYVESKPNSG KTLPRSVCEQ
1460 1470 1480 1490 1500
LPGRKAAPRS QRRLEESKHR EMRPMASTAL PSDCRCGDAS CRHSGVLAKD
1510 1520 1530 1540 1550
VAPEFVPCQG EGGFDLHEKR DALGAGSEPL LYSAAHSFLG GAEKNSSPRC
1560 1570 1580 1590 1600
ISESRHTTLR SPSEMPRLKA LMCGSPTETD SIASEKSQGV GSQDSPVKDG
1610 1620 1630 1640 1650
VGPSSSPAWP SDSTLPCGSP AVLFLGDGSQ RTQEMLGDSV QWKQFSATSC
1660 1670 1680 1690 1700
HPDAQKSNMV CRSSHTLDLP KETLHSQQGK MGATLGHPSP QSTDMLKTDF
1710 1720 1730
KRLSGTGPSS LCQKPLIKLT APMPSQQDSG FDSPLE
Length:1,736
Mass (Da):196,534
Last modified:February 5, 2008 - v1
Checksum:i16D6433AFFDEBA14
GO

Sequence cautioni

The sequence BAD32338 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173060 mRNA Translation: BAD32338.1 Different initiation.
AL928930 Genomic DNA No translation available.
AL929166 Genomic DNA No translation available.
BX321866 Genomic DNA No translation available.
BC026366 mRNA Translation: AAH26366.1
CCDSiCCDS38229.1
RefSeqiNP_001074560.1, NM_001081091.1
UniGeneiMm.330545

Genome annotation databases

EnsembliENSMUST00000089776; ENSMUSP00000087208; ENSMUSG00000068394
GeneIDi99100
KEGGimmu:99100
UCSCiuc008mcs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173060 mRNA Translation: BAD32338.1 Different initiation.
AL928930 Genomic DNA No translation available.
AL929166 Genomic DNA No translation available.
BX321866 Genomic DNA No translation available.
BC026366 mRNA Translation: AAH26366.1
CCDSiCCDS38229.1
RefSeqiNP_001074560.1, NM_001081091.1
UniGeneiMm.330545

3D structure databases

SMRiA2AUM9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221186, 81 interactors
ComplexPortaliCPX-1160 CEP152-PLK4 complex
DIPiDIP-56915N
IntActiA2AUM9, 85 interactors
STRINGi10090.ENSMUSP00000087208

PTM databases

iPTMnetiA2AUM9
PhosphoSitePlusiA2AUM9

Proteomic databases

EPDiA2AUM9
MaxQBiA2AUM9
PaxDbiA2AUM9
PeptideAtlasiA2AUM9
PRIDEiA2AUM9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089776; ENSMUSP00000087208; ENSMUSG00000068394
GeneIDi99100
KEGGimmu:99100
UCSCiuc008mcs.1 mouse

Organism-specific databases

CTDi22995
MGIiMGI:2139083 Cep152
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGHC Eukaryota
ENOG410XQAW LUCA
GeneTreeiENSGT00630000089915
HOGENOMiHOG000111522
HOVERGENiHBG096403
InParanoidiA2AUM9
KOiK16728
OMAiDDHRNKI
OrthoDBiEOG091G0PGF
TreeFamiTF332017

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

PROiPR:A2AUM9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068394 Expressed in 206 organ(s), highest expression level in ventricular system choroidal fissure
GenevisibleiA2AUM9 MM

Family and domain databases

InterProiView protein in InterPro
IPR029598 Cep152
PANTHERiPTHR10337:SF6 PTHR10337:SF6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCE152_MOUSE
AccessioniPrimary (citable) accession number: A2AUM9
Secondary accession number(s): Q69ZV8, Q8R0X1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 11, 2013
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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