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Protein
Submitted name:

F-box/WD repeat-containing protein 2

Gene

Fbxw2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
F-box/WD repeat-containing protein 2Imported
Gene namesi
Name:Fbxw2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1353435 Fbxw2

PTM / Processingi

Proteomic databases

MaxQBiA2AUF9
PRIDEiA2AUF9

Expressioni

Gene expression databases

BgeeiENSMUSG00000035949 Expressed in 290 organ(s), highest expression level in thymus
ExpressionAtlasiA2AUF9 baseline and differential
GenevisibleiA2AUF9 MM

Structurei

3D structure databases

ProteinModelPortaliA2AUF9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 185WD_REPEATS_REGIONInterPro annotationAdd BLAST171
Repeati15 – 54WDPROSITE-ProRule annotationAdd BLAST40
Repeati93 – 134WDPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQD2 Eukaryota
ENOG410XP3H LUCA
GeneTreeiENSGT00930000151016
HOGENOMiHOG000231971
HOVERGENiHBG051593
OMAiCKQWNKV

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A2AUF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQLEDHEAF ETSSLIGHSA RVYALYYKDG LLCTGSDDLS AKLWDVSTGQ
60 70 80 90 100
CVYGIQTHTC AAVKFDEQKL VTGSFDNTVA CWEWSSGART QHFRGHTGAV
110 120 130 140 150
FSVDYSDELD ILVSGSADFA VKVWALSAGT CLNTLTGHTE WVTKVVLQKC
160 170 180 190 200
KVKSLLHSPG DYILLSADKY EIKIWPIGRE INCKCLKTLS VSEDRSICLQ
210 220 230 240 250
PRLHFDGKYI VCSSALGLYQ WDFASYDILR VIKTPEVANL ALLGFGDVFA
260 270 280 290 300
LLFDNHYLYI MDLRTESLIS RWPLPEYRKS KRGSSFLAGE ASWLNGLDGH
310 320
NDTGLVFATS MPDHSIHLVL WKEHC
Length:325
Mass (Da):36,367
Last modified:February 20, 2007 - v1
Checksum:i1C530A94801BB984
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q60584FBXW2_MOUSE
F-box/WD repeat-containing protein ...
Fbxw2
422Annotation score:
Q9QUH1Q9QUH1_MOUSE
F-box protein FWD2
Fbxw2 Fwd2
454Annotation score:
Q8BS25Q8BS25_MOUSE
F-box/WD repeat-containing protein ...
Fbxw2
359Annotation score:
A2AUG1A2AUG1_MOUSE
F-box/WD repeat-containing protein ...
Fbxw2
389Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929106 Genomic DNA No translation available.
RefSeqiNP_001158242.1, NM_001164770.1
XP_006498181.1, XM_006498118.3
UniGeneiMm.4465

Genome annotation databases

EnsembliENSMUST00000091020; ENSMUSP00000088541; ENSMUSG00000035949
GeneIDi30050
UCSCiuc008jiz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929106 Genomic DNA No translation available.
RefSeqiNP_001158242.1, NM_001164770.1
XP_006498181.1, XM_006498118.3
UniGeneiMm.4465

3D structure databases

ProteinModelPortaliA2AUF9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA2AUF9
PRIDEiA2AUF9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091020; ENSMUSP00000088541; ENSMUSG00000035949
GeneIDi30050
UCSCiuc008jiz.2 mouse

Organism-specific databases

CTDi26190
MGIiMGI:1353435 Fbxw2

Phylogenomic databases

eggNOGiENOG410IQD2 Eukaryota
ENOG410XP3H LUCA
GeneTreeiENSGT00930000151016
HOGENOMiHOG000231971
HOVERGENiHBG051593
OMAiCKQWNKV

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiFbxw2 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035949 Expressed in 290 organ(s), highest expression level in thymus
ExpressionAtlasiA2AUF9 baseline and differential
GenevisibleiA2AUF9 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2AUF9_MOUSE
AccessioniPrimary (citable) accession number: A2AUF9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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