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Protein

Kelch-like protein 41

Gene

Klhl41

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells.3 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 41
Alternative name(s):
Kelch repeat and BTB domain-containing protein 10
Gene namesi
Name:Klhl41
Synonyms:Kbtbd10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2683854 Klhl41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004212521 – 606Kelch-like protein 41Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiA2AUC9
PaxDbiA2AUC9
PeptideAtlasiA2AUC9
PRIDEiA2AUC9

PTM databases

iPTMnetiA2AUC9
PhosphoSitePlusiA2AUC9

Expressioni

Tissue specificityi

Skeletal muscle. Localized between laterally fusing myofibrils in skeletal muscle (at protein level). Expressed at a lower level in the heart compared to skeletal muscle.2 Publications

Developmental stagei

Expressed in the myotome part of the mature somites in embryos from embryonic day 9.5 onwards. It is not expressed in the developing heart at these embryonic stages.1 Publication

Gene expression databases

BgeeiENSMUSG00000075307 Expressed in 110 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiA2AUC9 MM

Interactioni

Subunit structurei

Interacts with NRAP. Part of a complex that contains CUL3, RBX1 and KLHL41. Interacts with LASP1.By similarity

Protein-protein interaction databases

BioGridi230702, 3 interactors
STRINGi10090.ENSMUSP00000097627

Structurei

3D structure databases

ProteinModelPortaliA2AUC9
SMRiA2AUC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 100BTBPROSITE-ProRule annotationAdd BLAST68
Domaini135 – 237BACKAdd BLAST103
Repeati346 – 398Kelch 1Add BLAST53
Repeati399 – 447Kelch 2Add BLAST49
Repeati448 – 495Kelch 3Add BLAST48
Repeati497 – 542Kelch 4Add BLAST46
Repeati544 – 599Kelch 5Add BLAST56

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00930000150851
HOGENOMiHOG000231966
HOVERGENiHBG052215
InParanoidiA2AUC9
KOiK10473
OMAiFFQLDNV
OrthoDBiEOG091G0C3Y
PhylomeDBiA2AUC9
TreeFamiTF351653

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030571 KLHL41
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF146 PTHR24412:SF146, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 3 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 4 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

A2AUC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSQRELAEE LRLYQSTLLQ DGLKDLLEEK KFIDCTLKAG DKSFPCHRLI
60 70 80 90 100
LSACSPYFRE YFLSEIEEEK KKEVALDNVD PAILDLIIKY LYSASIDLND
110 120 130 140 150
GNVQDIFALS SRFQIPSVFT VCVSYLQKRL APGNCLAILR LGLLLDCPRL
160 170 180 190 200
AISAREFVSD RFVQICKEED FMQLSPQELI SVISNDSLNV EKEEVVFEAV
210 220 230 240 250
MKWVRTDKEN RAKNLSEVFD CIRFRLMAEK YFKDHVEKDD IIKSNPEVQK
260 270 280 290 300
KIKVLKDAFA GKLPEPSKNA EKAGAGEVNG DVGDEDLLPG YLNDIPRHGM
310 320 330 340 350
FVKDLILLVN DTAAVAYDPM ENECYLTALA EQIPRNHSSL VTQQNQVYVV
360 370 380 390 400
GGLYVDEENK DQPLQSYFFQ LDNVTSEWVG LPPLPSARCL FGLGEVDDKI
410 420 430 440 450
YVVAGKDLQT EASLDSVLCY DPVAAKWSEV KNLPIKVYGH NVISHNGMIY
460 470 480 490 500
CLGGKTDDKK CTNRVFIYNP KKGDWKDLAP MKTPRSMFGV AIHKGKIVIA
510 520 530 540 550
GGVTEDGLSA SVEAFDLKTN KWEVMTEFPQ ERSSISLVSL AGALYAIGGF
560 570 580 590 600
AMIQLESKEF APTEVNDIWK YEDDKKEWAG MLKEIRYASG ASCLATRLNL

FKLSKL
Length:606
Mass (Da):68,190
Last modified:February 20, 2007 - v1
Checksum:i952AEB63BBE84DDA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti404A → S in AAI50699 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929083 Genomic DNA Translation: CAM24293.1
CH466519 Genomic DNA Translation: EDL27039.1
BC150698 mRNA Translation: AAI50699.1
CCDSiCCDS38136.1
RefSeqiNP_001074556.1, NM_001081087.1
UniGeneiMm.178784

Genome annotation databases

EnsembliENSMUST00000100050; ENSMUSP00000097627; ENSMUSG00000075307
GeneIDi228003
KEGGimmu:228003
UCSCiuc008jyg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929083 Genomic DNA Translation: CAM24293.1
CH466519 Genomic DNA Translation: EDL27039.1
BC150698 mRNA Translation: AAI50699.1
CCDSiCCDS38136.1
RefSeqiNP_001074556.1, NM_001081087.1
UniGeneiMm.178784

3D structure databases

ProteinModelPortaliA2AUC9
SMRiA2AUC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230702, 3 interactors
STRINGi10090.ENSMUSP00000097627

PTM databases

iPTMnetiA2AUC9
PhosphoSitePlusiA2AUC9

Proteomic databases

MaxQBiA2AUC9
PaxDbiA2AUC9
PeptideAtlasiA2AUC9
PRIDEiA2AUC9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100050; ENSMUSP00000097627; ENSMUSG00000075307
GeneIDi228003
KEGGimmu:228003
UCSCiuc008jyg.1 mouse

Organism-specific databases

CTDi10324
MGIiMGI:2683854 Klhl41

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00930000150851
HOGENOMiHOG000231966
HOVERGENiHBG052215
InParanoidiA2AUC9
KOiK10473
OMAiFFQLDNV
OrthoDBiEOG091G0C3Y
PhylomeDBiA2AUC9
TreeFamiTF351653

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:A2AUC9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075307 Expressed in 110 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiA2AUC9 MM

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030571 KLHL41
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF146 PTHR24412:SF146, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 3 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 4 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLH41_MOUSE
AccessioniPrimary (citable) accession number: A2AUC9
Secondary accession number(s): B2RWT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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