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Entry version 85 (13 Feb 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Armadillo repeat-containing protein 3

Gene

Armc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Armadillo repeat-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Armc3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918132 Armc3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002844041 – 881Armadillo repeat-containing protein 3Add BLAST881

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AU72

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AU72

PRoteomics IDEntifications database

More...
PRIDEi
A2AU72

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AU72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037683 Expressed in 68 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AU72 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AU72 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000110287

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2AU72

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati15 – 54ARM 1Add BLAST40
Repeati57 – 96ARM 2Add BLAST40
Repeati98 – 138ARM 3Add BLAST41
Repeati140 – 179ARM 4Add BLAST40
Repeati181 – 220ARM 5Add BLAST40
Repeati222 – 262ARM 6Add BLAST41
Repeati264 – 304ARM 7Add BLAST41
Repeati306 – 345ARM 8Add BLAST40
Repeati346 – 385ARM 9Add BLAST40
Repeati388 – 427ARM 10Add BLAST40
Repeati429 – 468ARM 11Add BLAST40
Repeati470 – 509ARM 12Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi628 – 634Poly-Ser7

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITMR Eukaryota
ENOG410XPHA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157476

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231960

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG059366

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AU72

Identification of Orthologs from Complete Genome Data

More...
OMAi
GCQFERA

Database of Orthologous Groups

More...
OrthoDBi
206276at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AU72

TreeFam database of animal gene trees

More...
TreeFami
TF329738

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00514 Arm, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50176 ARM_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AU72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKKIKKEVE PPPKDVFDPI TIESKKAATV VLMLKSPEED ILAKACEAIY
60 70 80 90 100
KFALKGEENK ATLLELGAVE PLTKLLTHED KTVRRNAMMI FGILASNSDV
110 120 130 140 150
KKLLRELEVM NSVIAQLSPE EEVVIHEFAS LCLANMSVEY TGKVQIFEHG
160 170 180 190 200
GLEPLIRLLS SSDPDVKKNS IECIYNLVQD FQCRTTLQEL NAIPPILELL
210 220 230 240 250
RSEYPIIQLL ALKTLGVITC DKEARTMLKE NQGLDHLTKI LETKELNDLH
260 270 280 290 300
VEALSVIANC LEDMDTMVLM QQTGSLKKVL SFAESSTIPD IQKNAAKAIA
310 320 330 340 350
KAAYDPENRK VFHEQEVEKC LVTLLGSDSD GTKIAASQAI SALCENLSCK
360 370 380 390 400
EFFNTQGIPQ IVQLLRSDNE EVREAAALAL ANLTTSSPAN ANAAAEADAI
410 420 430 440 450
DPLINILSSK RDGAIANAAT VLTNMATQEP LRAIIQNHEI MHALLGPLHS
460 470 480 490 500
TNTLVQSTAA LTVAATACDV EARTQLRNCG GLVPLVGLLH SKNDEVRRHA
510 520 530 540 550
SWAVMVCAGD EPMAVELCRL GALNILEEIN RSLSRKNKFS EAAYNKLLNN
560 570 580 590 600
NLSLKYSQTG YLSSSNIISD GFYDYGRINP GTKLLSLKEL CLQELNDQRA
610 620 630 640 650
ILLVNNKSDT SPPPSMEDKS SDVGYGRSIS SSSSLRRGSK EKANAIFGSP
660 670 680 690 700
TEEKSEPASV RNTILSRAFT KEKGVSKKKS RLQLICSSYL LWKGKGKKEE
710 720 730 740 750
EKVKEEEEIL ALPKFTEGSP EKEWNPPPDP EFCVYVLEVT KSILPIVNLK
760 770 780 790 800
EQIEVLAKYV ADKMGGKIPK EKLADFSWEL HISELKFQLK SNVVPIGYIK
810 820 830 840 850
KGIFYHRALL FKALADKIGV GCSLVRGEYS RGWNEVKLVN EARKGMIGNL
860 870 880
PPPEEYIVDL MFHPGNLLKL RSKEADLYRF L
Note: Gene prediction based on EST data.
Length:881
Mass (Da):97,357
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6898CE3C8F2C10D7
GO
Isoform 2 (identifier: A2AU72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     644-644: N → NFRFS
     676-680: SKKKS → RKGKG
     681-881: Missing.

Note: No experimental confirmation available.
Show »
Length:684
Mass (Da):74,805
Checksum:i0B7A5AFE9665725F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AU71A2AU71_MOUSE
Armadillo repeat-containing protein...
Armc3
869Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024502644N → NFRFS in isoform 2. 1 Publication1
Alternative sequenceiVSP_024503676 – 680SKKKS → RKGKG in isoform 2. 1 Publication5
Alternative sequenceiVSP_024504681 – 881Missing in isoform 2. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK041744 mRNA Translation: BAC31050.1
AL929034 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38052.1 [A2AU72-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001074552.1, NM_001081083.2 [A2AU72-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.276696

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000114640; ENSMUSP00000110287; ENSMUSG00000037683 [A2AU72-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
70882

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:70882

UCSC genome browser

More...
UCSCi
uc008imd.2 mouse [A2AU72-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041744 mRNA Translation: BAC31050.1
AL929034 Genomic DNA No translation available.
CCDSiCCDS38052.1 [A2AU72-1]
RefSeqiNP_001074552.1, NM_001081083.2 [A2AU72-1]
UniGeneiMm.276696

3D structure databases

ProteinModelPortaliA2AU72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110287

PTM databases

PhosphoSitePlusiA2AU72

Proteomic databases

MaxQBiA2AU72
PaxDbiA2AU72
PRIDEiA2AU72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114640; ENSMUSP00000110287; ENSMUSG00000037683 [A2AU72-1]
GeneIDi70882
KEGGimmu:70882
UCSCiuc008imd.2 mouse [A2AU72-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
219681
MGIiMGI:1918132 Armc3

Phylogenomic databases

eggNOGiENOG410ITMR Eukaryota
ENOG410XPHA LUCA
GeneTreeiENSGT00940000157476
HOGENOMiHOG000231960
HOVERGENiHBG059366
InParanoidiA2AU72
OMAiGCQFERA
OrthoDBi206276at2759
PhylomeDBiA2AU72
TreeFamiTF329738

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2AU72

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037683 Expressed in 68 organ(s), highest expression level in testis
ExpressionAtlasiA2AU72 baseline and differential
GenevisibleiA2AU72 MM

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
PfamiView protein in Pfam
PF00514 Arm, 3 hits
SMARTiView protein in SMART
SM00185 ARM, 9 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARMC3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AU72
Secondary accession number(s): Q8BY67
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 20, 2007
Last modified: February 13, 2019
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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