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Protein

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Gene

Dhtkd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  • oxoglutarate dehydrogenase (succinyl-transferring) activity Source: GO_Central
  • thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandThiamine pyrophosphate

Enzyme and pathway databases

ReactomeiR-MMU-389661 Glyoxylate metabolism and glycine degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC:1.2.4.2)
Alternative name(s):
Dehydrogenase E1 and transketolase domain-containing protein 1
Gene namesi
Name:Dhtkd1
Synonyms:Kiaa1630
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2445096 Dhtkd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000307937? – 921Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184N6-succinyllysineCombined sources1
Modified residuei189N6-succinyllysineCombined sources1
Modified residuei801N6-succinyllysineCombined sources1
Modified residuei819N6-succinyllysineCombined sources1

Proteomic databases

MaxQBiA2ATU0
PaxDbiA2ATU0
PeptideAtlasiA2ATU0
PRIDEiA2ATU0

PTM databases

iPTMnetiA2ATU0
PhosphoSitePlusiA2ATU0
SwissPalmiA2ATU0

Expressioni

Gene expression databases

BgeeiENSMUSG00000025815 Expressed in 178 organ(s), highest expression level in liver
GenevisibleiA2ATU0 MM

Interactioni

Protein-protein interaction databases

BioGridi229102, 1 interactor
IntActiA2ATU0, 2 interactors
MINTiA2ATU0
STRINGi10090.ENSMUSP00000026924

Structurei

3D structure databases

ProteinModelPortaliA2ATU0
SMRiA2ATU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0450 Eukaryota
COG0567 LUCA
GeneTreeiENSGT00530000063092
HOGENOMiHOG000259586
HOVERGENiHBG001892
InParanoidiA2ATU0
KOiK15791
OMAiQGINQEC
OrthoDBiEOG091G043R
PhylomeDBiA2ATU0
TreeFamiTF314198

Family and domain databases

InterProiView protein in InterPro
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2ATU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAATVAAA GRALRRAVLL LRRGYQTERG VYGYRPRKAK SGEPRGDRAR
60 70 80 90 100
PSVDHGLARL VTVYCEHGHK AAQINPLFPG QALLDTVPEI QALVRTLQGP
110 120 130 140 150
FTTTGLLNLG KEAASLEEVL AYLNHIYCGP ISIETAQLQS QEERDWFARR
160 170 180 190 200
FEELKKETFT TEERKYLSKL LLESQEFDHF LATKFATVKR YGGEGAESMM
210 220 230 240 250
GFFHELLKLS AYGGITDIII GMPHRGRLNL LTGLLQLPPE LMFRKMRGLS
260 270 280 290 300
EFPENVATIG DVLSHLTSSV DLDFGAHQPL HVTMLPNPSH LEAVNPVAVG
310 320 330 340 350
KTRGRQQSRE DGDYSPNGSA QPGDKVICLQ VHGDASFCGQ GIVLETFTLS
360 370 380 390 400
NLPHFRIGGS IHLIVNNQLG YTTPAERGRS SLYSSDIGKL VGCAIIHVNG
410 420 430 440 450
DSPEEVVRAT RLAFEYQRQF RKDVIVDLLC YRQWGHNELD EPFFTNPVMY
460 470 480 490 500
KIIRARKSIP DTYAEHLIAS GLMTQEEVSD IKTSYYTKLN DHLANVAHYS
510 520 530 540 550
PPATNLQARW QGLVQPEACV TTWDTGVPLE LLRFIGVKSV EVPEELQVHS
560 570 580 590 600
HLLKMYVQSR MEKVKNGSGL DWATAETLAL GSLLAQGFNV RLSGQDVGRG
610 620 630 640 650
TFSQRHAMVV CQDTDDAYIP LNHMDPNQKG FLEVSNSPLS EEAVLGFEYG
660 670 680 690 700
MSIESPTLLP LWEAQFGDFF NGAQIIFDTF ISGGEAKWLL QSGLVILLPH
710 720 730 740 750
GYDGAGPEHS SCRIERFLQM CDSAEEGVDS DTVNMFVVHP TTPAQYFHLL
760 770 780 790 800
RRQMIRNFRK PLIVASPKML LRYPAAVSTL EEMAPGTAFK PVIGDSSVDP
810 820 830 840 850
KNVKTLIFCS GKHFYALLKQ RESLGTKKHD FAIIRLEELC PFPLDALQQE
860 870 880 890 900
MSKYKHVRDV IWSQEEPQNM GPWSFVSPRF EKQLACRLRL VSRPPLPAPA
910 920
VGIGTVHQQQ HEDILSKTFT Q
Length:921
Mass (Da):102,793
Last modified:February 20, 2007 - v1
Checksum:iE40170D7D26EED65
GO

Sequence cautioni

The sequence BAD32501 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24G → S in AAI17995 (PubMed:15489334).Curated1
Sequence conflicti436H → R in AAI17995 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928924 Genomic DNA No translation available.
BC117994 mRNA Translation: AAI17995.1
AK173223 mRNA Translation: BAD32501.1 Sequence problems.
AK050057 mRNA Translation: BAC34055.1
CCDSiCCDS38040.1
RefSeqiNP_001074600.1, NM_001081131.2
UniGeneiMm.222517

Genome annotation databases

EnsembliENSMUST00000026924; ENSMUSP00000026924; ENSMUSG00000025815
ENSMUST00000095147; ENSMUSP00000092769; ENSMUSG00000025815
GeneIDi209692
KEGGimmu:209692
UCSCiuc008iga.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928924 Genomic DNA No translation available.
BC117994 mRNA Translation: AAI17995.1
AK173223 mRNA Translation: BAD32501.1 Sequence problems.
AK050057 mRNA Translation: BAC34055.1
CCDSiCCDS38040.1
RefSeqiNP_001074600.1, NM_001081131.2
UniGeneiMm.222517

3D structure databases

ProteinModelPortaliA2ATU0
SMRiA2ATU0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229102, 1 interactor
IntActiA2ATU0, 2 interactors
MINTiA2ATU0
STRINGi10090.ENSMUSP00000026924

PTM databases

iPTMnetiA2ATU0
PhosphoSitePlusiA2ATU0
SwissPalmiA2ATU0

Proteomic databases

MaxQBiA2ATU0
PaxDbiA2ATU0
PeptideAtlasiA2ATU0
PRIDEiA2ATU0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026924; ENSMUSP00000026924; ENSMUSG00000025815
ENSMUST00000095147; ENSMUSP00000092769; ENSMUSG00000025815
GeneIDi209692
KEGGimmu:209692
UCSCiuc008iga.1 mouse

Organism-specific databases

CTDi55526
MGIiMGI:2445096 Dhtkd1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0450 Eukaryota
COG0567 LUCA
GeneTreeiENSGT00530000063092
HOGENOMiHOG000259586
HOVERGENiHBG001892
InParanoidiA2ATU0
KOiK15791
OMAiQGINQEC
OrthoDBiEOG091G043R
PhylomeDBiA2ATU0
TreeFamiTF314198

Enzyme and pathway databases

ReactomeiR-MMU-389661 Glyoxylate metabolism and glycine degradation

Miscellaneous databases

ChiTaRSiDhtkd1 mouse
PROiPR:A2ATU0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025815 Expressed in 178 organ(s), highest expression level in liver
GenevisibleiA2ATU0 MM

Family and domain databases

InterProiView protein in InterPro
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHTK1_MOUSE
AccessioniPrimary (citable) accession number: A2ATU0
Secondary accession number(s): Q0VFY3, Q69ZE3, Q8BWT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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