Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoinositide phospholipase C

Gene

Plcb4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei328UniRule annotation1
Active sitei375UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation, TransducerSAAS annotation
Biological processLipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-112043 PLC beta mediated events
R-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plcb4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107464 Plcb4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiA2AT91
PeptideAtlasiA2AT91
PRIDEiA2AT91

Expressioni

Gene expression databases

BgeeiENSMUSG00000039943 Expressed in 281 organ(s), highest expression level in saliva-secreting gland
ExpressionAtlasiA2AT91 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiA2AT91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini313 – 463PI-PLC X-boxInterPro annotationAdd BLAST151
Domaini577 – 693PI-PLC Y-boxInterPro annotationAdd BLAST117
Domaini700 – 798C2InterPro annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili490 – 510Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
GeneTreeiENSGT00760000118936
HOGENOMiHOG000232046
HOVERGENiHBG053609
OMAiERNIHHN

Family and domain databases

CDDicd13361 PH_PLC_beta, 1 hit
Gene3Di2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR016280 PLC-beta
IPR037862 PLC-beta_PH
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09279 EF-hand_like, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PIRSFiPIRSF000956 PLC-beta, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A2AT91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKPYEFNWQ KEVPSFLQEG AVFDRYEEES FVFEPNCLFK VDEFGFFLTW
60 70 80 90 100
KSEGKEGQVL ECSLINSIRQ AAIPKDPKIL AALEAVGKSE NDLEGRILCV
110 120 130 140 150
CSGTDLVNIG FTYMVAENPE VTKQWVEGLR SIIHNFRANN VSPMTCLKKH
160 170 180 190 200
WMKLAFLTNT TGKIPVRSIT RTFASGKTEK VIFQALKELG LPSGKNDEIE
210 220 230 240 250
PAAFTYEKFY ELTQKICPRT DIEDLFKKIN GDKTDYLTVD QLVSFLNEHQ
260 270 280 290 300
RDPRLNEILF PFYDAKRAMQ IIEMYEPDEE LKKKGLISSD GFCRYLMSDE
310 320 330 340 350
NAPVFLDRLE LYQEMDHPLA HYFISSSHNT YLTGRQFGGK SSVEMYRQVL
360 370 380 390 400
LAGCRCVELD CWDGKGEDQE PIITHGKAMC TDILFKDVIQ AIKETAFVTS
410 420 430 440 450
EYPVILSFEN HCSKYQQYKM SKYCEDLFGD LLLKQALESH PLEPGRPLPS
460 470 480 490 500
PNDLKRKILI KNKRLKPEVE KKQLEALKSM MEAGESAAPA SILEDDNEEE
510 520 530 540 550
IESADQEEEA HPEYKFGNEL SADDYSHKEA VANSVKKTSD DLEHENNKKG
560 570 580 590 600
LVTVEDEQAW MASYKYVGAT TNIHPYLSTM INYAQPVKFQ GFHVAEERNI
610 620 630 640 650
HYNMSSFNES VGLGYLKTHA IEFVNYNKRQ MSRIYPKGGR VDSSNYMPQI
660 670 680 690 700
FWNAGCQMVS LNYQTPDLAM QLNQGKFEYN GSCGYLLKPD FMRRPDRTFD
710 720 730 740 750
PFSETPVDGV IAATCSVQVI SGQFLSDKKI GTYVEVDMYG LPTDTIRKEF
760 770 780 790 800
RTRMVMNNGL NPVYNEESFV FRKVILPDLA VLRIAVYDDN NKLIGQRILP
810 820 830 840 850
LDGLQAGYRH ISLRNEGNKP LSLPTIFCNI VLKTYVPDGF GDIVDALSDP
860 870 880
KKFLSITEKR ADQMRAMGIE TSDIADVPSD TSK
Length:883
Mass (Da):100,651
Last modified:February 20, 2007 - v1
Checksum:i240286DCACF11AF6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q91UZ1Q91UZ1_MOUSE
1-phosphatidylinositol 4,5-bisphosp...
Plcb4
1,175Annotation score:
V9GXQ9V9GXQ9_MOUSE
Phosphoinositide phospholipase C
Plcb4
1,022Annotation score:
A2AT93A2AT93_MOUSE
Phospholipase C, beta 4
Plcb4
255Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei883Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928798 Genomic DNA No translation available.
AL929052 Genomic DNA No translation available.
AL935301 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000134310; ENSMUSP00000117638; ENSMUSG00000039943
UCSCiuc008mob.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928798 Genomic DNA No translation available.
AL929052 Genomic DNA No translation available.
AL935301 Genomic DNA No translation available.

3D structure databases

SMRiA2AT91
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA2AT91
PeptideAtlasiA2AT91
PRIDEiA2AT91

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000134310; ENSMUSP00000117638; ENSMUSG00000039943
UCSCiuc008mob.1 mouse

Organism-specific databases

MGIiMGI:107464 Plcb4

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
GeneTreeiENSGT00760000118936
HOGENOMiHOG000232046
HOVERGENiHBG053609
OMAiERNIHHN

Enzyme and pathway databases

ReactomeiR-MMU-112043 PLC beta mediated events
R-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

ChiTaRSiPlcb4 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039943 Expressed in 281 organ(s), highest expression level in saliva-secreting gland
ExpressionAtlasiA2AT91 baseline and differential

Family and domain databases

CDDicd13361 PH_PLC_beta, 1 hit
Gene3Di2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR016280 PLC-beta
IPR037862 PLC-beta_PH
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09279 EF-hand_like, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PIRSFiPIRSF000956 PLC-beta, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2AT91_MOUSE
AccessioniPrimary (citable) accession number: A2AT91
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again