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Entry version 124 (07 Oct 2020)
Sequence version 1 (20 Feb 2007)
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Protein

Regulator of nonsense transcripts 2

Gene

Upf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processNonsense-mediated mRNA decay

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of nonsense transcripts 2
Alternative name(s):
Nonsense mRNA reducing factor 2
Up-frameshift suppressor 2 homolog
Short name:
Upf2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Upf2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2449307, Upf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Knockout adult liver results in hepatosteatosis and disruption of liver homeostasis.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004486851 – 1269Regulator of nonsense transcripts 2Add BLAST1269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1085PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2AT37

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2AT37

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AT37

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AT37

PeptideAtlas

More...
PeptideAtlasi
A2AT37

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AT37

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AT37

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A2AT37

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Localized in male germ cells.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Weakly expressed in neonatal testes and expression increases during the development of spermatocytes and spermatids, in the late meiotic and postmeiotic stages of spermatogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000043241, Expressed in secondary oocyte and 285 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AT37, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a post-splicing messenger ribonucleoprotein (mRNP) complex (By similarity). Associates with the exon junction complex (EJC) (By similarity).

Interacts with SMG1, EST1A, UPF3A, UPF3B, EIF4A1 and EIF1 (By similarity).

Interacts with UPF1; interaction is promoted by TDRD6 (PubMed:27149095).

Interacts with DDX4 (PubMed:27149095).

By similarity1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A2AT37, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000058375

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A2AT37, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AT37

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini168 – 396MIF4G 1Sequence analysisAdd BLAST229
Domaini571 – 755MIF4G 2Sequence analysisAdd BLAST185
Domaini774 – 984MIF4G 3Sequence analysisAdd BLAST211

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili57 – 133Sequence analysisAdd BLAST77

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2051, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064318

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002633_2_1_1

KEGG Orthology (KO)

More...
KOi
K14327

Identification of Orthologs from Complete Genome Data

More...
OMAi
TRPQWKL

Database of Orthologous Groups

More...
OrthoDBi
653534at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AT37

TreeFam database of animal gene trees

More...
TreeFami
TF300543

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
IPR039762, Nmd2/UPF2
IPR007193, Upf2/Nmd2_C

The PANTHER Classification System

More...
PANTHERi
PTHR12839, PTHR12839, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02854, MIF4G, 3 hits
PF04050, Upf2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00543, MIF4G, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AT37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAERKKSAS MEEKESLLNN KEKDCSERRP VSSKEKPRDD LKVTAKKEVS
60 70 80 90 100
KVPEDKKKRL EEDKRKKEDK ERKKKEEEKV KAEEELKKKE EEEKKKQEEE
110 120 130 140 150
ERKKQEEQAK RQQEEAAAQL KEKEESLQLH QEAWERHQLR KELRSKNQNA
160 170 180 190 200
PDNRPEENFF SRLDSSLKKN TAFVKKLKTI TEQQRDSLSH DFNGLNLSKY
210 220 230 240 250
IAEAVASIVE AKLKLSDVNC AAHLCSLFHQ RYSDFAPSLL QVWKKHFEAR
260 270 280 290 300
KEEKTPNITK LRTDLRFIAE LTIVGIFTDK EGLSLIYEQL KSIINADRES
310 320 330 340 350
HTHVSVVISF CRHCGDDIAG LVPRKVKSAA EKFNLSFPPS EIISPEKQQP
360 370 380 390 400
FQNLLKEYFT SLTKHLKRDH RELQNTERQN RRILHSKGEL SEDRHKQYEE
410 420 430 440 450
FAMSYQKLLA NSQSLADLLD ENMPDLPQDK PTPEEHGPGI DIFTPGKPGE
460 470 480 490 500
YDLEGGIWED EDARNFYENL IDLKAFVPAI LFKDNEKSQN KDSNKDDSKE
510 520 530 540 550
AKEPKDNKEA SSPDDLELEL ENLEINDDTL ELEGADEAED LTKKLLDEQE
560 570 580 590 600
QEDEEASTGS HLKLIVDAFL QQLPNCVNRD LIDKAAMDFC MNMNTKANRK
610 620 630 640 650
KLVRALFIVP RQRLDLLPFY ARLVATLHPC MSDVAEDLCS MLRGDFRFHV
660 670 680 690 700
RKKDQINIET KNKTVRFIGE LTKFKMFTKN DTLHCLKMLL SDFSHHHIEM
710 720 730 740 750
ACTLLETCGR FLFRSPESHL RTSVLLEQMM RKKQAMHLDA RYVTMVENAY
760 770 780 790 800
YYCNPPPAEK TVRKKRPPLQ EYVRKLLYKD LSKVTTEKVL RQMRKLPWQD
810 820 830 840 850
QEVKDYVICC MINIWNVKYN SIHCVANLLA GLVLYQEDVG IHVVDGVLED
860 870 880 890 900
IRLGMEVNQP KFNQRRISSA KFLGELYNYR MVESAVIFRT LYSFTSFGVN
910 920 930 940 950
PDGSPSSLDP PEHLFRIRLV CTILDTCGQY FDRGSSKRKL DCFLVYFQRY
960 970 980 990 1000
VWWKKSLEVW TKDHPFPIDI DYMISDTLEL LRPKIKLCNS LEESIRQVQD
1010 1020 1030 1040 1050
LEREFLIKLG LVNDKESKDS MTEGENLEED EEEEEGGAET EEQSGNESEV
1060 1070 1080 1090 1100
NEPEEEEGSE EEEEGEEEEE ENTDYLTDSN KENETDEENA EVMIKGGGLK
1110 1120 1130 1140 1150
HVPCVEDEDF IQALDKMMLE NLQQRSGESV KVHQLDVAIP LHLKSQLRKG
1160 1170 1180 1190 1200
PPLGGGEGET ESADTMPFVM LTRKGNKQQF KILNVPMSSQ LAANHWNQQQ
1210 1220 1230 1240 1250
AEQEERMRMK KLTLDINERQ EQEDYQEMLQ SLAQRPAPAN TNRERRPRYQ
1260
HPKGAPNADL IFKTGGRRR
Length:1,269
Mass (Da):147,553
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE95314FDF923F01E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Q3G7F6Q3G7_MOUSE
Regulator of nonsense transcripts 2
Upf2
523Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL928735 Genomic DNA No translation available.
AL928924 Genomic DNA No translation available.
CR388026 Genomic DNA No translation available.
BC138358 mRNA Translation: AAI38359.1
BC138359 mRNA Translation: AAI38360.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38041.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074601.1, NM_001081132.1
XP_006497548.1, XM_006497485.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000060092; ENSMUSP00000058375; ENSMUSG00000043241

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
326622

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:326622

UCSC genome browser

More...
UCSCi
uc008igc.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928735 Genomic DNA No translation available.
AL928924 Genomic DNA No translation available.
CR388026 Genomic DNA No translation available.
BC138358 mRNA Translation: AAI38359.1
BC138359 mRNA Translation: AAI38360.1
CCDSiCCDS38041.1
RefSeqiNP_001074601.1, NM_001081132.1
XP_006497548.1, XM_006497485.3

3D structure databases

SMRiA2AT37
ModBaseiSearch...

Protein-protein interaction databases

IntActiA2AT37, 1 interactor
STRINGi10090.ENSMUSP00000058375

PTM databases

iPTMnetiA2AT37
PhosphoSitePlusiA2AT37
SwissPalmiA2AT37

Proteomic databases

EPDiA2AT37
jPOSTiA2AT37
MaxQBiA2AT37
PaxDbiA2AT37
PeptideAtlasiA2AT37

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24600, 162 antibodies

Genome annotation databases

EnsembliENSMUST00000060092; ENSMUSP00000058375; ENSMUSG00000043241
GeneIDi326622
KEGGimmu:326622
UCSCiuc008igc.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26019
MGIiMGI:2449307, Upf2

Phylogenomic databases

eggNOGiKOG2051, Eukaryota
GeneTreeiENSGT00530000064318
HOGENOMiCLU_002633_2_1_1
KOiK14327
OMAiTRPQWKL
OrthoDBi653534at2759
PhylomeDBiA2AT37
TreeFamiTF300543

Enzyme and pathway databases

ReactomeiR-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
326622, 6 hits in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Upf2, mouse
RNActiA2AT37, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000043241, Expressed in secondary oocyte and 285 other tissues
ExpressionAtlasiA2AT37, baseline and differential

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
IPR039762, Nmd2/UPF2
IPR007193, Upf2/Nmd2_C
PANTHERiPTHR12839, PTHR12839, 1 hit
PfamiView protein in Pfam
PF02854, MIF4G, 3 hits
PF04050, Upf2, 1 hit
SMARTiView protein in SMART
SM00543, MIF4G, 3 hits
SUPFAMiSSF48371, SSF48371, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRENT2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AT37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 11, 2019
Last sequence update: February 20, 2007
Last modified: October 7, 2020
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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