Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 118 (16 Oct 2019)
Sequence version 1 (20 Feb 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

UPF2 regulator of nonsense transcripts homolog (Yeast)

Gene

Upf2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
UPF2 regulator of nonsense transcripts homolog (Yeast)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Upf2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2449307 Upf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000043241 Expressed in 269 organ(s), highest expression level in secondary oocyte

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A2AT37, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000058375

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini167 – 363MIF4GInterPro annotationAdd BLAST197
Domaini567 – 756MIF4GInterPro annotationAdd BLAST190
Domaini771 – 984MIF4GInterPro annotationAdd BLAST214

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 125DisorderedSequence analysisAdd BLAST125
Regioni143 – 162DisorderedSequence analysisAdd BLAST20
Regioni422 – 444DisorderedSequence analysisAdd BLAST23
Regioni487 – 518DisorderedSequence analysisAdd BLAST32
Regioni1017 – 1090DisorderedSequence analysisAdd BLAST74
Regioni1218 – 1269DisorderedSequence analysisAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili532 – 555Sequence analysisAdd BLAST24
Coiled coili984 – 1004Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi487 – 515PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1023 – 1075AcidicSequence analysisAdd BLAST53
Compositional biasi1076 – 1090PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2051 Eukaryota
ENOG410XQ1E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064318

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000180856

KEGG Orthology (KO)

More...
KOi
K14327

Identification of Orthologs from Complete Genome Data

More...
OMAi
TRPQWKL

Database of Orthologous Groups

More...
OrthoDBi
653534at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300543

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR039762 Nmd2/UPF2
IPR007193 Upf2/Nmd2_C

The PANTHER Classification System

More...
PANTHERi
PTHR12839 PTHR12839, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02854 MIF4G, 3 hits
PF04050 Upf2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00543 MIF4G, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AT37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAERKKSAS MEEKESLLNN KEKDCSERRP VSSKEKPRDD LKVTAKKEVS
60 70 80 90 100
KVPEDKKKRL EEDKRKKEDK ERKKKEEEKV KAEEELKKKE EEEKKKQEEE
110 120 130 140 150
ERKKQEEQAK RQQEEAAAQL KEKEESLQLH QEAWERHQLR KELRSKNQNA
160 170 180 190 200
PDNRPEENFF SRLDSSLKKN TAFVKKLKTI TEQQRDSLSH DFNGLNLSKY
210 220 230 240 250
IAEAVASIVE AKLKLSDVNC AAHLCSLFHQ RYSDFAPSLL QVWKKHFEAR
260 270 280 290 300
KEEKTPNITK LRTDLRFIAE LTIVGIFTDK EGLSLIYEQL KSIINADRES
310 320 330 340 350
HTHVSVVISF CRHCGDDIAG LVPRKVKSAA EKFNLSFPPS EIISPEKQQP
360 370 380 390 400
FQNLLKEYFT SLTKHLKRDH RELQNTERQN RRILHSKGEL SEDRHKQYEE
410 420 430 440 450
FAMSYQKLLA NSQSLADLLD ENMPDLPQDK PTPEEHGPGI DIFTPGKPGE
460 470 480 490 500
YDLEGGIWED EDARNFYENL IDLKAFVPAI LFKDNEKSQN KDSNKDDSKE
510 520 530 540 550
AKEPKDNKEA SSPDDLELEL ENLEINDDTL ELEGADEAED LTKKLLDEQE
560 570 580 590 600
QEDEEASTGS HLKLIVDAFL QQLPNCVNRD LIDKAAMDFC MNMNTKANRK
610 620 630 640 650
KLVRALFIVP RQRLDLLPFY ARLVATLHPC MSDVAEDLCS MLRGDFRFHV
660 670 680 690 700
RKKDQINIET KNKTVRFIGE LTKFKMFTKN DTLHCLKMLL SDFSHHHIEM
710 720 730 740 750
ACTLLETCGR FLFRSPESHL RTSVLLEQMM RKKQAMHLDA RYVTMVENAY
760 770 780 790 800
YYCNPPPAEK TVRKKRPPLQ EYVRKLLYKD LSKVTTEKVL RQMRKLPWQD
810 820 830 840 850
QEVKDYVICC MINIWNVKYN SIHCVANLLA GLVLYQEDVG IHVVDGVLED
860 870 880 890 900
IRLGMEVNQP KFNQRRISSA KFLGELYNYR MVESAVIFRT LYSFTSFGVN
910 920 930 940 950
PDGSPSSLDP PEHLFRIRLV CTILDTCGQY FDRGSSKRKL DCFLVYFQRY
960 970 980 990 1000
VWWKKSLEVW TKDHPFPIDI DYMISDTLEL LRPKIKLCNS LEESIRQVQD
1010 1020 1030 1040 1050
LEREFLIKLG LVNDKESKDS MTEGENLEED EEEEEGGAET EEQSGNESEV
1060 1070 1080 1090 1100
NEPEEEEGSE EEEEGEEEEE ENTDYLTDSN KENETDEENA EVMIKGGGLK
1110 1120 1130 1140 1150
HVPCVEDEDF IQALDKMMLE NLQQRSGESV KVHQLDVAIP LHLKSQLRKG
1160 1170 1180 1190 1200
PPLGGGEGET ESADTMPFVM LTRKGNKQQF KILNVPMSSQ LAANHWNQQQ
1210 1220 1230 1240 1250
AEQEERMRMK KLTLDINERQ EQEDYQEMLQ SLAQRPAPAN TNRERRPRYQ
1260
HPKGAPNADL IFKTGGRRR
Length:1,269
Mass (Da):147,553
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE95314FDF923F01E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Q3G7F6Q3G7_MOUSE
UPF2 regulator of nonsense transcri...
Upf2
523Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL928735 Genomic DNA No translation available.
AL928924 Genomic DNA No translation available.
CR388026 Genomic DNA No translation available.
BC138358 mRNA Translation: AAI38359.1
BC138359 mRNA Translation: AAI38360.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074601.1, NM_001081132.1
XP_006497548.1, XM_006497485.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000060092; ENSMUSP00000058375; ENSMUSG00000043241

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
326622

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:326622

UCSC genome browser

More...
UCSCi
uc008igc.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928735 Genomic DNA No translation available.
AL928924 Genomic DNA No translation available.
CR388026 Genomic DNA No translation available.
BC138358 mRNA Translation: AAI38359.1
BC138359 mRNA Translation: AAI38360.1
RefSeqiNP_001074601.1, NM_001081132.1
XP_006497548.1, XM_006497485.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiA2AT37, 1 interactor
STRINGi10090.ENSMUSP00000058375

Genome annotation databases

EnsembliENSMUST00000060092; ENSMUSP00000058375; ENSMUSG00000043241
GeneIDi326622
KEGGimmu:326622
UCSCiuc008igc.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26019
MGIiMGI:2449307 Upf2

Phylogenomic databases

eggNOGiKOG2051 Eukaryota
ENOG410XQ1E LUCA
GeneTreeiENSGT00530000064318
HOGENOMiHOG000180856
KOiK14327
OMAiTRPQWKL
OrthoDBi653534at2759
TreeFamiTF300543

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Upf2 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000043241 Expressed in 269 organ(s), highest expression level in secondary oocyte

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR039762 Nmd2/UPF2
IPR007193 Upf2/Nmd2_C
PANTHERiPTHR12839 PTHR12839, 1 hit
PfamiView protein in Pfam
PF02854 MIF4G, 3 hits
PF04050 Upf2, 1 hit
SMARTiView protein in SMART
SM00543 MIF4G, 3 hits
SUPFAMiSSF48371 SSF48371, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2AT37_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AT37
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 16, 2019
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again