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Entry version 102 (08 May 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Calcium-binding mitochondrial carrier protein SCaMC-2

Gene

Slc25a25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi60 – 711PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP transmembrane transporter activity Source: GO_Central
  • calcium ion binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-2
Alternative name(s):
Small calcium-binding mitochondrial carrier protein 2
Solute carrier family 25 member 25
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc25a25
Synonyms:Kiaa1896, Scamc2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1915913 Slc25a25

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 189Mitochondrial intermembraneSequence analysisAdd BLAST189
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei190 – 207Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini208 – 244Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei245 – 264Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini265 – 287Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei288 – 301Helical; Name=3Sequence analysisAdd BLAST14
Topological domaini302 – 337Mitochondrial matrixSequence analysisAdd BLAST36
Transmembranei338 – 357Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini358 – 380Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei381 – 398Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini399 – 437Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei438 – 457Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini458 – 469Mitochondrial intermembraneSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003176031 – 469Calcium-binding mitochondrial carrier protein SCaMC-2Add BLAST469

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A2ASZ8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2ASZ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2ASZ8

PRoteomics IDEntifications database

More...
PRIDEi
A2ASZ8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2ASZ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2ASZ8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A2ASZ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026819 Expressed in 229 organ(s), highest expression level in retina

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A2ASZ8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2ASZ8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A2ASZ8, 1 interactor

Molecular INTeraction database

More...
MINTi
A2ASZ8

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000028160

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A2ASZ8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 80EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini78 – 113EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini114 – 149EF-hand 3PROSITE-ProRule annotationAdd BLAST36
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati184 – 270Solcar 1Add BLAST87
Repeati278 – 363Solcar 2Add BLAST86
Repeati375 – 463Solcar 3Add BLAST89

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0036 Eukaryota
ENOG410XQ4P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157207

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2ASZ8

KEGG Orthology (KO)

More...
KOi
K14684

Identification of Orthologs from Complete Genome Data

More...
OMAi
YEYSSRA

Database of Orthologous Groups

More...
OrthoDBi
442523at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2ASZ8

TreeFam database of animal gene trees

More...
TreeFami
TF313492

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
PF00153 Mito_carr, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00928 GRAVESDC
PR00926 MITOCARRIER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 3 hits
PS50920 SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2ASZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLCLCLYVPI AGAAQTEFQY FESKGLPAEL KSIFKLSVFI PSQEFSTYRQ
60 70 80 90 100
WKQKIVQAGD KDLDGQLDFE EFVHYLQDHE KKLRLVFKSL DKKNDGRIDA
110 120 130 140 150
QEIMQSLRDL GVKISEQQAE KILKSMDKNG TMTIDWNEWR DYHLLHPVEN
160 170 180 190 200
IPEIILYWKH STIFDVGENL TVPDEFTVEE RQTGMWWRHL VAGGGAGAVS
210 220 230 240 250
RTCTAPLDRL KVLMQVHASR SNNMCIVGGF TQMIREGGAK SLWRGNGINV
260 270 280 290 300
LKIAPESAIK FMAYEQMKRL VGSDQETLRI HERLVAGSLA GAIAQSSIYP
310 320 330 340 350
MEVLKTRMAL RKTGQYSGML DCARRILAKE GVAAFYKGYI PNMLGIIPYA
360 370 380 390 400
GIDLAVYETL KNTWLQRYAV NSADPGVFVL LACGTISSTC GQLASYPLAL
410 420 430 440 450
VRTRMQAQAS IEGAPEVTMS SLFKQILRTE GAFGLYRGLA PNFMKVIPAV
460
SISYVVYENL KITLGVQSR
Length:469
Mass (Da):52,621
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFB0CC840738B63B
GO
Isoform 2 (identifier: A2ASZ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MLCLCLYVPI...EFSTYRQWKQ → MVSSVLCRCV...GLHRTEGELR

Show »
Length:502
Mass (Da):55,288
Checksum:i21ABC9B940B361FE
GO
Isoform 3 (identifier: A2ASZ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MLCLCLYVPI...EFSTYRQWKQ → MVSSVLCRCV...GLHRTEGELR
     125-125: S → RIRTGHFWGPVTY

Show »
Length:514
Mass (Da):56,773
Checksum:i46A493F31D98299F
GO
Isoform 4 (identifier: A2ASZ8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MLCLCLYVPI...EFSTYRQWKQ → MLQTLWHFLS...VVGPAEQFPK

Show »
Length:489
Mass (Da):54,593
Checksum:i922EFB5FAF79FBC4
GO
Isoform 5 (identifier: A2ASZ8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MLCLCLYVPI...EFSTYRQWKQ → MLQTLWHFLS...VVGPAEQFPK
     125-125: S → RIRTGHFWGPVTY

Show »
Length:501
Mass (Da):56,078
Checksum:i7FCC4FB5B8977778
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YLR9Z4YLR9_MOUSE
Calcium-binding mitochondrial carri...
Slc25a25
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWC1A0A0A6YWC1_MOUSE
Calcium-binding mitochondrial carri...
Slc25a25
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RC04F6RC04_MOUSE
Calcium-binding mitochondrial carri...
Slc25a25
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH19978 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH22114 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65850 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM18798 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM18799 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0310711 – 53MLCLC…RQWKQ → MVSSVLCRCVASPPPDAAAT ASSSASSPASVGDPCGGAVC GGPDHQLRLWSLFQTLDVNR DGGLCVNDLAVGLRRLGLHR TEGELR in isoform 2 and isoform 3. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_0310721 – 53MLCLC…RQWKQ → MLQTLWHFLSSFLPRAECQD SREGIDHGVRGTQAPARGDQ MSTFLGKQNGRAEATEKRPT ILLVVGPAEQFPK in isoform 4 and isoform 5. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_031073125S → RIRTGHFWGPVTY in isoform 3 and isoform 5. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK122568 mRNA Translation: BAC65850.1 Different initiation.
AK049392 mRNA Translation: BAC33730.1
AK082756 mRNA Translation: BAC38604.1
AK132204 mRNA Translation: BAE21031.1
AL928710 Genomic DNA Translation: CAM18795.1
AL928710 Genomic DNA Translation: CAM18796.1
AL928710 Genomic DNA Translation: CAM18797.1
AL928710 Genomic DNA Translation: CAM18798.1 Sequence problems.
AL928710 Genomic DNA Translation: CAM18799.1 Sequence problems.
AL928710 Genomic DNA Translation: CAM18800.1
AL928710 Genomic DNA Translation: CAM18801.1
BC004720 mRNA Translation: AAH04720.1
BC019978 mRNA Translation: AAH19978.1 Different initiation.
BC022114 mRNA Translation: AAH22114.1 Different initiation.
BC037109 mRNA Translation: AAH37109.1
BC066998 mRNA Translation: AAH66998.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15915.1 [A2ASZ8-3]
CCDS50567.1 [A2ASZ8-5]
CCDS50568.1 [A2ASZ8-2]
CCDS71028.1 [A2ASZ8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001157829.1, NM_001164357.1 [A2ASZ8-2]
NP_001157830.1, NM_001164358.1 [A2ASZ8-5]
NP_001277487.1, NM_001290558.1 [A2ASZ8-1]
NP_666230.2, NM_146118.3 [A2ASZ8-3]
XP_006498017.1, XM_006497954.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000028160; ENSMUSP00000028160; ENSMUSG00000026819 [A2ASZ8-3]
ENSMUST00000052119; ENSMUSP00000060581; ENSMUSG00000026819 [A2ASZ8-5]
ENSMUST00000113307; ENSMUSP00000108932; ENSMUSG00000026819 [A2ASZ8-1]
ENSMUST00000113308; ENSMUSP00000108933; ENSMUSG00000026819 [A2ASZ8-4]
ENSMUST00000113310; ENSMUSP00000108936; ENSMUSG00000026819 [A2ASZ8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
227731

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:227731

UCSC genome browser

More...
UCSCi
uc008jfn.2 mouse [A2ASZ8-1]
uc008jfo.2 mouse [A2ASZ8-5]
uc008jfp.2 mouse [A2ASZ8-3]
uc008jfq.2 mouse [A2ASZ8-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122568 mRNA Translation: BAC65850.1 Different initiation.
AK049392 mRNA Translation: BAC33730.1
AK082756 mRNA Translation: BAC38604.1
AK132204 mRNA Translation: BAE21031.1
AL928710 Genomic DNA Translation: CAM18795.1
AL928710 Genomic DNA Translation: CAM18796.1
AL928710 Genomic DNA Translation: CAM18797.1
AL928710 Genomic DNA Translation: CAM18798.1 Sequence problems.
AL928710 Genomic DNA Translation: CAM18799.1 Sequence problems.
AL928710 Genomic DNA Translation: CAM18800.1
AL928710 Genomic DNA Translation: CAM18801.1
BC004720 mRNA Translation: AAH04720.1
BC019978 mRNA Translation: AAH19978.1 Different initiation.
BC022114 mRNA Translation: AAH22114.1 Different initiation.
BC037109 mRNA Translation: AAH37109.1
BC066998 mRNA Translation: AAH66998.1
CCDSiCCDS15915.1 [A2ASZ8-3]
CCDS50567.1 [A2ASZ8-5]
CCDS50568.1 [A2ASZ8-2]
CCDS71028.1 [A2ASZ8-1]
RefSeqiNP_001157829.1, NM_001164357.1 [A2ASZ8-2]
NP_001157830.1, NM_001164358.1 [A2ASZ8-5]
NP_001277487.1, NM_001290558.1 [A2ASZ8-1]
NP_666230.2, NM_146118.3 [A2ASZ8-3]
XP_006498017.1, XM_006497954.1

3D structure databases

SMRiA2ASZ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2ASZ8, 1 interactor
MINTiA2ASZ8
STRINGi10090.ENSMUSP00000028160

PTM databases

iPTMnetiA2ASZ8
PhosphoSitePlusiA2ASZ8
SwissPalmiA2ASZ8

Proteomic databases

jPOSTiA2ASZ8
MaxQBiA2ASZ8
PaxDbiA2ASZ8
PRIDEiA2ASZ8

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
227731
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028160; ENSMUSP00000028160; ENSMUSG00000026819 [A2ASZ8-3]
ENSMUST00000052119; ENSMUSP00000060581; ENSMUSG00000026819 [A2ASZ8-5]
ENSMUST00000113307; ENSMUSP00000108932; ENSMUSG00000026819 [A2ASZ8-1]
ENSMUST00000113308; ENSMUSP00000108933; ENSMUSG00000026819 [A2ASZ8-4]
ENSMUST00000113310; ENSMUSP00000108936; ENSMUSG00000026819 [A2ASZ8-2]
GeneIDi227731
KEGGimmu:227731
UCSCiuc008jfn.2 mouse [A2ASZ8-1]
uc008jfo.2 mouse [A2ASZ8-5]
uc008jfp.2 mouse [A2ASZ8-3]
uc008jfq.2 mouse [A2ASZ8-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
114789
MGIiMGI:1915913 Slc25a25

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG0036 Eukaryota
ENOG410XQ4P LUCA
GeneTreeiENSGT00940000157207
InParanoidiA2ASZ8
KOiK14684
OMAiYEYSSRA
OrthoDBi442523at2759
PhylomeDBiA2ASZ8
TreeFamiTF313492

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Slc25a25 mouse

Protein Ontology

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PROi
PR:A2ASZ8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026819 Expressed in 229 organ(s), highest expression level in retina
ExpressionAtlasiA2ASZ8 baseline and differential
GenevisibleiA2ASZ8 MM

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits
PS50920 SOLCAR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCMC2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ASZ8
Secondary accession number(s): A2ASZ1
, A2ASZ5, A2ASZ9, Q6NXM8, Q80T78, Q8BHG0, Q8JZT8, Q8VBT4, Q99KD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 20, 2007
Last modified: May 8, 2019
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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