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Entry version 122 (18 Sep 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Titin

Gene

Ttn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Full activation of the protein kinase domain requires both phosphorylation of Tyr-33203, preventing it from blocking the catalytic aspartate residue, and binding of Ca/CALM to the C-terminal regulatory tail of the molecule which results in ATP binding to the kinase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei33069ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei33160Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi33046 – 33054ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-114608 Platelet degranulation
R-MMU-390522 Striated Muscle Contraction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Titin (EC:2.7.11.1)
Alternative name(s):
Connectin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TtnImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98864 Ttn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003116961 – 35213TitinAdd BLAST35213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei263Omega-N-methylarginineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei266PhosphothreonineCombined sources1
Modified residuei278Omega-N-methylarginineCombined sources1
Modified residuei286Omega-N-methylarginineCombined sources1
Modified residuei296Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei296Omega-N-methylarginine; alternateCombined sources1
Modified residuei299PhosphothreonineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei304Omega-N-methylarginineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1
Modified residuei756PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi967 ↔ 1018PROSITE-ProRule annotation
Modified residuei1251PhosphoserineCombined sources1
Modified residuei1415PhosphoserineCombined sources1
Modified residuei1420PhosphoserineCombined sources1
Modified residuei1424PhosphoserineCombined sources1
Modified residuei1429PhosphoserineCombined sources1
Modified residuei1434PhosphoserineCombined sources1
Disulfide bondi1730 ↔ 1783PROSITE-ProRule annotation
Modified residuei2078PhosphoserineCombined sources1
Modified residuei2080PhosphoserineCombined sources1
Disulfide bondi2202 ↔ 2252PROSITE-ProRule annotation
Disulfide bondi3265 ↔ 3317PROSITE-ProRule annotation
Modified residuei3516PhosphoserineCombined sources1
Modified residuei3784PhosphoserineCombined sources1
Disulfide bondi4365 ↔ 4416PROSITE-ProRule annotation
Disulfide bondi4460 ↔ 4511PROSITE-ProRule annotation
Disulfide bondi4553 ↔ 4604PROSITE-ProRule annotation
Disulfide bondi4647 ↔ 4698PROSITE-ProRule annotation
Disulfide bondi4740 ↔ 4791PROSITE-ProRule annotation
Disulfide bondi5022 ↔ 5073PROSITE-ProRule annotation
Disulfide bondi5209 ↔ 5260PROSITE-ProRule annotation
Disulfide bondi5584 ↔ 5635PROSITE-ProRule annotation
Disulfide bondi5771 ↔ 5822PROSITE-ProRule annotation
Disulfide bondi5864 ↔ 5915PROSITE-ProRule annotation
Disulfide bondi6146 ↔ 6197PROSITE-ProRule annotation
Disulfide bondi6333 ↔ 6384PROSITE-ProRule annotation
Disulfide bondi6426 ↔ 6477PROSITE-ProRule annotation
Disulfide bondi6709 ↔ 6760PROSITE-ProRule annotation
Disulfide bondi6988 ↔ 7039PROSITE-ProRule annotation
Disulfide bondi7084 ↔ 7135PROSITE-ProRule annotation
Disulfide bondi7180 ↔ 7231PROSITE-ProRule annotation
Disulfide bondi7274 ↔ 7325PROSITE-ProRule annotation
Disulfide bondi7367 ↔ 7418PROSITE-ProRule annotation
Disulfide bondi7650 ↔ 7701PROSITE-ProRule annotation
Disulfide bondi7929 ↔ 7980PROSITE-ProRule annotation
Disulfide bondi8025 ↔ 8076PROSITE-ProRule annotation
Disulfide bondi8121 ↔ 8172PROSITE-ProRule annotation
Disulfide bondi8215 ↔ 8266PROSITE-ProRule annotation
Disulfide bondi8308 ↔ 8359PROSITE-ProRule annotation
Modified residuei8387PhosphothreonineCombined sources1
Disulfide bondi8591 ↔ 8642PROSITE-ProRule annotation
Disulfide bondi8870 ↔ 8921PROSITE-ProRule annotation
Disulfide bondi8966 ↔ 9017PROSITE-ProRule annotation
Disulfide bondi9062 ↔ 9113PROSITE-ProRule annotation
Modified residuei9144PhosphoserineCombined sources1
Modified residuei9164PhosphoserineBy similarity1
Modified residuei9168PhosphothreonineBy similarity1
Disulfide bondi9255 ↔ 9306PROSITE-ProRule annotation
Modified residuei9459PhosphoserineCombined sources1
Disulfide bondi9654 ↔ 9704PROSITE-ProRule annotation
Modified residuei10281PhosphoserineCombined sources1
Modified residuei12869PhosphothreonineCombined sources1
Modified residuei12884PhosphoserineCombined sources1
Disulfide bondi12929 ↔ 12979PROSITE-ProRule annotation
Modified residuei12972PhosphoserineCombined sources1
Disulfide bondi13473 ↔ 13522PROSITE-ProRule annotation
Disulfide bondi13828 ↔ 13878PROSITE-ProRule annotation
Modified residuei13904PhosphoserineCombined sources1
Disulfide bondi14095 ↔ 14145PROSITE-ProRule annotation
Disulfide bondi14184 ↔ 14234PROSITE-ProRule annotation
Disulfide bondi14273 ↔ 14323PROSITE-ProRule annotation
Disulfide bondi14633 ↔ 14683PROSITE-ProRule annotation
Modified residuei21152PhosphoserineCombined sources1
Modified residuei21895PhosphoserineCombined sources1
Modified residuei21980PhosphoserineCombined sources1
Modified residuei22390PhosphoserineCombined sources1
Modified residuei23387PhosphoserineBy similarity1
Modified residuei23396PhosphothreonineBy similarity1
Modified residuei25920PhosphoserineCombined sources1
Disulfide bondi32343 ↔ 32394PROSITE-ProRule annotation
Modified residuei32870PhosphoserineCombined sources1
Modified residuei33203PhosphotyrosineBy similarity1
Disulfide bondi33378 ↔ 33430PROSITE-ProRule annotation
Modified residuei33859PhosphothreonineCombined sources1
Modified residuei33861PhosphoserineCombined sources1
Modified residuei33875PhosphoserineCombined sources1
Modified residuei33880PhosphoserineCombined sources1
Modified residuei33915PhosphoserineCombined sources1
Modified residuei34009PhosphoserineCombined sources1
Modified residuei34292PhosphoserineCombined sources1
Modified residuei34464PhosphoserineCombined sources1
Modified residuei34467PhosphothreonineCombined sources1
Modified residuei34470PhosphoserineCombined sources1
Modified residuei34476PhosphoserineCombined sources1
Modified residuei34481PhosphothreonineCombined sources1
Disulfide bondi34526 ↔ 34580PROSITE-ProRule annotation
Modified residuei34756PhosphoserineCombined sources1
Isoform 3 (identifier: A2ASS6-3)
Modified residuei3432PhosphoserineCombined sourcesCurated1
Modified residuei3636PhosphoserineCombined sourcesCurated1
Modified residuei3678PhosphoserineCombined sourcesCurated1
Modified residuei3763PhosphoserineCombined sourcesCurated1
Modified residuei3827PhosphoserineCombined sourcesCurated1
Modified residuei3836PhosphothreonineCombined sourcesCurated1
Modified residuei4672PhosphoserineCombined sourcesCurated1
Modified residuei4720PhosphoserineCombined sourcesCurated1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
A2ASS6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A2ASS6

MaxQB - The MaxQuant DataBase

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MaxQBi
A2ASS6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A2ASS6

PeptideAtlas

More...
PeptideAtlasi
A2ASS6

PRoteomics IDEntifications database

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PRIDEi
A2ASS6

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
A2ASS6

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2ASS6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2ASS6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in cardiac muscle from 8 dpc and in skeletal muscle from 9 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000051747 Expressed in 214 organ(s), highest expression level in diaphragm

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A2ASS6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2ASS6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYOM1, MYOM2, tropomyosin and myosin.

Interacts with actin, primarily via the PEVK domains and with MYPN.

Interacts with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B.

Interacts with TCAP/telethonin and/or ANK1 isoform Mu17/ank1.5, via the first two N-terminal immunoglobulin domains.

Interacts with TRIM63, TRIM55, ANKRD1, ANKRD2, ANKRD23, and CAPN3 through several Ig domains.

Interacts with NBR1 through the protein kinase domain (By similarity).

Interacts with CMYA5 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SynmQ70IV53EBI-9672947,EBI-9989763

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-127 Titin-Telethonin complex

Protein interaction database and analysis system

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IntActi
A2ASS6, 5 interactors

Molecular INTeraction database

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MINTi
A2ASS6

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000097561

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A2ASS6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 98Ig-like 1Sequence analysisAdd BLAST93
Domaini104 – 192Ig-like 2Sequence analysisAdd BLAST89
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati412 – 454Z-repeat 1Sequence analysisAdd BLAST43
Repeati463 – 504Z-repeat 2Sequence analysisAdd BLAST42
Repeati509 – 548Z-repeat 3Sequence analysisAdd BLAST40
Repeati553 – 594Z-repeat 4Sequence analysisAdd BLAST42
Repeati599 – 640Z-repeat 5Sequence analysisAdd BLAST42
Repeati645 – 686Z-repeat 6Sequence analysisAdd BLAST42
Domaini946 – 1034Ig-like 3Sequence analysisAdd BLAST89
Domaini1084 – 1174Ig-like 4Sequence analysisAdd BLAST91
Domaini1293 – 1384Ig-like 5Sequence analysisAdd BLAST92
Domaini1463 – 1552Ig-like 6Sequence analysisAdd BLAST90
Domaini1562 – 1652Ig-like 7Sequence analysisAdd BLAST91
Domaini1709 – 1799Ig-like 8Sequence analysisAdd BLAST91
Domaini1847 – 1934Ig-like 9Sequence analysisAdd BLAST88
Domaini2084 – 2173Ig-like 10Sequence analysisAdd BLAST90
Repeati2095 – 2128TPR 1Sequence analysisAdd BLAST34
Domaini2177 – 2268Ig-like 11Sequence analysisAdd BLAST92
Domaini2270 – 2356Ig-like 12Sequence analysisAdd BLAST87
Domaini2359 – 2449Ig-like 13Sequence analysisAdd BLAST91
Domaini2436 – 2535Ig-like 14Sequence analysisAdd BLAST100
Domaini2626 – 2709Ig-like 15Sequence analysisAdd BLAST84
Repeati2810 – 2844TPR 2Sequence analysisAdd BLAST35
Domaini2886 – 2971Ig-like 16Sequence analysisAdd BLAST86
Repeati3028 – 3068WD 1Sequence analysisAdd BLAST41
Domaini3064 – 3147Ig-like 17Sequence analysisAdd BLAST84
Repeati3208 – 3248WD 2Sequence analysisAdd BLAST41
Domaini3245 – 3333Ig-like 18Sequence analysisAdd BLAST89
Domaini3350 – 3438Ig-like 19Sequence analysisAdd BLAST89
Domaini3509 – 3599Ig-like 20Sequence analysisAdd BLAST91
Domaini3625 – 3716Ig-like 21Sequence analysisAdd BLAST92
Domaini4251 – 4337Ig-like 22Sequence analysisAdd BLAST87
Domaini4344 – 4432Ig-like 23Sequence analysisAdd BLAST89
Domaini4439 – 4527Ig-like 24Sequence analysisAdd BLAST89
Domaini4532 – 4620Ig-like 25Sequence analysisAdd BLAST89
Domaini4625 – 4716Ig-like 26Sequence analysisAdd BLAST92
Domaini4719 – 4807Ig-like 27Sequence analysisAdd BLAST89
Domaini4812 – 4897Ig-like 28Sequence analysisAdd BLAST86
Domaini4904 – 4993Ig-like 29Sequence analysisAdd BLAST90
Domaini5001 – 5089Ig-like 30Sequence analysisAdd BLAST89
Domaini5094 – 5182Ig-like 31Sequence analysisAdd BLAST89
Repeati5131 – 5164TPR 3Sequence analysisAdd BLAST34
Domaini5186 – 5276Ig-like 32Sequence analysisAdd BLAST91
Domaini5281 – 5369Ig-like 33Sequence analysisAdd BLAST89
Domaini5374 – 5462Ig-like 34Sequence analysisAdd BLAST89
Domaini5466 – 5555Ig-like 35Sequence analysisAdd BLAST90
Domaini5563 – 5651Ig-like 36Sequence analysisAdd BLAST89
Domaini5656 – 5744Ig-like 37Sequence analysisAdd BLAST89
Domaini5749 – 5838Ig-like 38Sequence analysisAdd BLAST90
Domaini5842 – 5931Ig-like 39Sequence analysisAdd BLAST90
Domaini5936 – 6024Ig-like 40Sequence analysisAdd BLAST89
Domaini6028 – 6117Ig-like 41Sequence analysisAdd BLAST90
Domaini6125 – 6213Ig-like 42Sequence analysisAdd BLAST89
Domaini6218 – 6308Ig-like 43Sequence analysisAdd BLAST91
Domaini6311 – 6401Ig-like 44Sequence analysisAdd BLAST91
Domaini6405 – 6493Ig-like 45Sequence analysisAdd BLAST89
Repeati6435 – 6468TPR 4Sequence analysisAdd BLAST34
Domaini6498 – 6587Ig-like 46Sequence analysisAdd BLAST90
Domaini6591 – 6682Ig-like 47Sequence analysisAdd BLAST92
Repeati6615 – 6653WD 3Sequence analysisAdd BLAST39
Domaini6688 – 6776Ig-like 48Sequence analysisAdd BLAST89
Domaini6781 – 6869Ig-like 49Sequence analysisAdd BLAST89
Domaini6873 – 6962Ig-like 50Sequence analysisAdd BLAST90
Domaini6966 – 7054Ig-like 51Sequence analysisAdd BLAST89
Domaini7063 – 7151Ig-like 52Sequence analysisAdd BLAST89
Domaini7159 – 7247Ig-like 53Sequence analysisAdd BLAST89
Domaini7252 – 7343Ig-like 54Sequence analysisAdd BLAST92
Domaini7346 – 7434Ig-like 55Sequence analysisAdd BLAST89
Domaini7439 – 7528Ig-like 56Sequence analysisAdd BLAST90
Domaini7532 – 7623Ig-like 57Sequence analysisAdd BLAST92
Domaini7629 – 7717Ig-like 58Sequence analysisAdd BLAST89
Domaini7722 – 7810Ig-like 59Sequence analysisAdd BLAST89
Domaini7814 – 7903Ig-like 60Sequence analysisAdd BLAST90
Domaini7907 – 7996Ig-like 61Sequence analysisAdd BLAST90
Domaini8004 – 8094Ig-like 62Sequence analysisAdd BLAST91
Domaini8099 – 8190Ig-like 63Sequence analysisAdd BLAST92
Domaini8193 – 8282Ig-like 64Sequence analysisAdd BLAST90
Domaini8287 – 8375Ig-like 65Sequence analysisAdd BLAST89
Domaini8380 – 8469Ig-like 66Sequence analysisAdd BLAST90
Domaini8473 – 8564Ig-like 67Sequence analysisAdd BLAST92
Domaini8570 – 8658Ig-like 68Sequence analysisAdd BLAST89
Domaini8663 – 8751Ig-like 69Sequence analysisAdd BLAST89
Domaini8755 – 8844Ig-like 70Sequence analysisAdd BLAST90
Domaini8849 – 8937Ig-like 71Sequence analysisAdd BLAST89
Domaini8945 – 9035Ig-like 72Sequence analysisAdd BLAST91
Domaini9040 – 9129Ig-like 73Sequence analysisAdd BLAST90
Domaini9137 – 9226Ig-like 74Sequence analysisAdd BLAST90
Repeati9145 – 9182TPR 5Sequence analysisAdd BLAST38
Domaini9233 – 9322Ig-like 75Sequence analysisAdd BLAST90
Domaini9331 – 9431Ig-like 76Sequence analysisAdd BLAST101
Domaini9621 – 9716Ig-like 77Sequence analysisAdd BLAST96
Repeati9662 – 9695TPR 6Sequence analysisAdd BLAST34
Domaini9721 – 9812Ig-like 78Sequence analysisAdd BLAST92
Repeati9865 – 9892PEVK 1Sequence analysisAdd BLAST28
Repeati9940 – 9963PEVK 2Sequence analysisAdd BLAST24
Repeati9991 – 10024TPR 7Sequence analysisAdd BLAST34
Repeati10001 – 10050Kelch 1Sequence analysisAdd BLAST50
Repeati10062 – 10085PEVK 3Sequence analysisAdd BLAST24
Repeati10091 – 10115PEVK 4Sequence analysisAdd BLAST25
Repeati10145 – 10169PEVK 5Sequence analysisAdd BLAST25
Repeati10170 – 10197PEVK 6Sequence analysisAdd BLAST28
Repeati10198 – 10225PEVK 7Sequence analysisAdd BLAST28
Repeati10227 – 10254PEVK 8Sequence analysisAdd BLAST28
Repeati10255 – 10281PEVK 9Sequence analysisAdd BLAST27
Repeati10282 – 10307PEVK 10Sequence analysisAdd BLAST26
Repeati10308 – 10332PEVK 11Sequence analysisAdd BLAST25
Repeati10333 – 10359PEVK 12Sequence analysisAdd BLAST27
Repeati10397 – 10431TPR 8Sequence analysisAdd BLAST35
Repeati10404 – 10427PEVK 13Sequence analysisAdd BLAST24
Repeati10451 – 10476PEVK 14Sequence analysisAdd BLAST26
Repeati10477 – 10504PEVK 15Sequence analysisAdd BLAST28
Repeati10505 – 10532PEVK 16Sequence analysisAdd BLAST28
Repeati10533 – 10560PEVK 17Sequence analysisAdd BLAST28
Repeati10561 – 10588PEVK 18Sequence analysisAdd BLAST28
Repeati10683 – 10707PEVK 19Sequence analysisAdd BLAST25
Repeati10709 – 10734PEVK 20Sequence analysisAdd BLAST26
Repeati10739 – 10764PEVK 21Sequence analysisAdd BLAST26
Repeati10765 – 10790PEVK 22Sequence analysisAdd BLAST26
Repeati10850 – 10877PEVK 23Sequence analysisAdd BLAST28
Repeati10878 – 10903PEVK 24Sequence analysisAdd BLAST26
Repeati10904 – 10931PEVK 25Sequence analysisAdd BLAST28
Repeati10932 – 10959PEVK 26Sequence analysisAdd BLAST28
Repeati10960 – 10987PEVK 27Sequence analysisAdd BLAST28
Repeati10988 – 11011PEVK 28Sequence analysisAdd BLAST24
Repeati11084 – 11109PEVK 29Sequence analysisAdd BLAST26
Repeati11111 – 11135PEVK 30Sequence analysisAdd BLAST25
Repeati11136 – 11160PEVK 31Sequence analysisAdd BLAST25
Repeati11161 – 11188PEVK 32Sequence analysisAdd BLAST28
Repeati11201 – 11225PEVK 33Sequence analysisAdd BLAST25
Repeati11226 – 11248PEVK 34Sequence analysisAdd BLAST23
Repeati11249 – 11272PEVK 35Sequence analysisAdd BLAST24
Repeati11273 – 11295PEVK 36Sequence analysisAdd BLAST23
Repeati11373 – 11400PEVK 37Sequence analysisAdd BLAST28
Repeati11401 – 11425PEVK 38Sequence analysisAdd BLAST25
Repeati11426 – 11453PEVK 39Sequence analysisAdd BLAST28
Repeati11454 – 11481PEVK 40Sequence analysisAdd BLAST28
Repeati11508 – 11533PEVK 41Sequence analysisAdd BLAST26
Repeati11562 – 11587PEVK 42Sequence analysisAdd BLAST26
Repeati11671 – 11698PEVK 43Sequence analysisAdd BLAST28
Repeati11700 – 11726PEVK 44Sequence analysisAdd BLAST27
Repeati11727 – 11754PEVK 45Sequence analysisAdd BLAST28
Repeati11755 – 11782PEVK 46Sequence analysisAdd BLAST28
Repeati11783 – 11810PEVK 47Sequence analysisAdd BLAST28
Repeati11811 – 11838PEVK 48Sequence analysisAdd BLAST28
Repeati11839 – 11866PEVK 49Sequence analysisAdd BLAST28
Repeati11867 – 11895PEVK 50Sequence analysisAdd BLAST29
Repeati11896 – 11923PEVK 51Sequence analysisAdd BLAST28
Repeati11924 – 11950PEVK 52Sequence analysisAdd BLAST27
Repeati11954 – 11977PEVK 53Sequence analysisAdd BLAST24
Repeati11979 – 11999PEVK 54Sequence analysisAdd BLAST21
Repeati12004 – 12026PEVK 55Sequence analysisAdd BLAST23
Repeati12051 – 12077PEVK 56Sequence analysisAdd BLAST27
Repeati12080 – 12104PEVK 57Sequence analysisAdd BLAST25
Repeati12105 – 12126PEVK 58Sequence analysisAdd BLAST22
Repeati12129 – 12154PEVK 59Sequence analysisAdd BLAST26
Repeati12155 – 12182PEVK 60Sequence analysisAdd BLAST28
Repeati12183 – 12210PEVK 61Sequence analysisAdd BLAST28
Repeati12211 – 12238PEVK 62Sequence analysisAdd BLAST28
Repeati12239 – 12266PEVK 63Sequence analysisAdd BLAST28
Repeati12267 – 12294PEVK 64Sequence analysisAdd BLAST28
Repeati12295 – 12322PEVK 65Sequence analysisAdd BLAST28
Repeati12323 – 12351PEVK 66Sequence analysisAdd BLAST29
Repeati12352 – 12379PEVK 67Sequence analysisAdd BLAST28
Repeati12380 – 12404PEVK 68Sequence analysisAdd BLAST25
Repeati12405 – 12430PEVK 69Sequence analysisAdd BLAST26
Repeati12431 – 12458PEVK 70Sequence analysisAdd BLAST28
Repeati12459 – 12486PEVK 71Sequence analysisAdd BLAST28
Repeati12491 – 12516PEVK 72Sequence analysisAdd BLAST26
Repeati12517 – 12542PEVK 73Sequence analysisAdd BLAST26
Repeati12543 – 12570PEVK 74Sequence analysisAdd BLAST28
Repeati12572 – 12598PEVK 75Sequence analysisAdd BLAST27
Repeati12599 – 12626PEVK 76Sequence analysisAdd BLAST28
Domaini12903 – 12995Ig-like 79Sequence analysisAdd BLAST93
Domaini13000 – 13084Ig-like 80Sequence analysisAdd BLAST85
Domaini13361 – 13446Ig-like 81Sequence analysisAdd BLAST86
Domaini13452 – 13534Ig-like 82Sequence analysisAdd BLAST83
Domaini13628 – 13712Ig-like 83Sequence analysisAdd BLAST85
Domaini13807 – 13894Ig-like 84Sequence analysisAdd BLAST88
Repeati13817 – 13850TPR 9Sequence analysisAdd BLAST34
Domaini13982 – 14068Ig-like 85Sequence analysisAdd BLAST87
Domaini14072 – 14157Ig-like 86Sequence analysisAdd BLAST86
Domaini14161 – 14246Ig-like 87Sequence analysisAdd BLAST86
Domaini14250 – 14335Ig-like 88Sequence analysisAdd BLAST86
Domaini14341 – 14424Ig-like 89Sequence analysisAdd BLAST84
Domaini14427 – 14517Ig-like 90Sequence analysisAdd BLAST91
Domaini14521 – 14610Ig-like 91Sequence analysisAdd BLAST90
Repeati14576 – 14615WD 4Sequence analysisAdd BLAST40
Domaini14611 – 14695Ig-like 92Sequence analysisAdd BLAST85
Domaini14789 – 14874Ig-like 93Sequence analysisAdd BLAST86
Domaini14881 – 14976Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Repeati14946 – 14998RCC1 1Sequence analysisAdd BLAST53
Domaini14982 – 15077Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Repeati15047 – 15100RCC1 2Sequence analysisAdd BLAST54
Domaini15083 – 15178Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini15279 – 15374Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini15379 – 15476Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST98
Domaini15477 – 15570Ig-like 94Sequence analysisAdd BLAST94
Domaini15575 – 15668Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST94
Domaini15674 – 15769Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Repeati15690 – 15738Kelch 2Sequence analysisAdd BLAST49
Domaini15775 – 15869Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Repeati15794 – 15839Kelch 3Sequence analysisAdd BLAST46
Repeati15848 – 15898Kelch 4Sequence analysisAdd BLAST51
Domaini15872 – 15969Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST98
Domaini15975 – 16069Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST95
Domaini16076 – 16172Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST97
Domaini16176 – 16264Ig-like 95Sequence analysisAdd BLAST89
Domaini16271 – 16365Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST95
Domaini16371 – 16466Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST96
Repeati16436 – 16492RCC1 3Sequence analysisAdd BLAST57
Domaini16470 – 16586Ig-like 96Sequence analysisAdd BLAST117
Domaini16593 – 16688Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST96
Domaini16694 – 16793Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST100
Domaini16794 – 16887Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST94
Domaini16988 – 17080Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST93
Repeati16996 – 17042WD 5Sequence analysisAdd BLAST47
Domaini17086 – 17180Fibronectin type-III 18PROSITE-ProRule annotationAdd BLAST95
Domaini17184 – 17282Ig-like 97Sequence analysisAdd BLAST99
Domaini17289 – 17384Fibronectin type-III 19PROSITE-ProRule annotationAdd BLAST96
Repeati17309 – 17355Kelch 5Sequence analysisAdd BLAST47
Domaini17390 – 17490Fibronectin type-III 20PROSITE-ProRule annotationAdd BLAST101
Domaini17496 – 17596Fibronectin type-III 21PROSITE-ProRule annotationAdd BLAST101
Domaini17589 – 17696Ig-like 98Sequence analysisAdd BLAST108
Domaini17703 – 17796Fibronectin type-III 22PROSITE-ProRule annotationAdd BLAST94
Domaini17803 – 17903Fibronectin type-III 23PROSITE-ProRule annotationAdd BLAST101
Domaini17906 – 18001Ig-like 99Sequence analysisAdd BLAST96
Domaini18009 – 18102Fibronectin type-III 24PROSITE-ProRule annotationAdd BLAST94
Domaini18108 – 18207Fibronectin type-III 25PROSITE-ProRule annotationAdd BLAST100
Domaini18210 – 18307Fibronectin type-III 26PROSITE-ProRule annotationAdd BLAST98
Domaini18311 – 18398Ig-like 100Sequence analysisAdd BLAST88
Domaini18407 – 18502Fibronectin type-III 27PROSITE-ProRule annotationAdd BLAST96
Domaini18508 – 18603Fibronectin type-III 28PROSITE-ProRule annotationAdd BLAST96
Repeati18573 – 18631RCC1 4Sequence analysisAdd BLAST59
Domaini18607 – 18696Ig-like 101Sequence analysisAdd BLAST90
Domaini18703 – 18797Fibronectin type-III 29PROSITE-ProRule annotationAdd BLAST95
Repeati18792 – 18831WD 6Sequence analysisAdd BLAST40
Domaini18803 – 18898Fibronectin type-III 30PROSITE-ProRule annotationAdd BLAST96
Repeati18868 – 18921RCC1 5Sequence analysisAdd BLAST54
Domaini18904 – 19001Fibronectin type-III 31PROSITE-ProRule annotationAdd BLAST98
Domaini19005 – 19090Ig-like 102Sequence analysisAdd BLAST86
Domaini19101 – 19195Fibronectin type-III 32PROSITE-ProRule annotationAdd BLAST95
Repeati19120 – 19165Kelch 6Sequence analysisAdd BLAST46
Repeati19165 – 19220RCC1 6Sequence analysisAdd BLAST56
Domaini19201 – 19293Fibronectin type-III 33PROSITE-ProRule annotationAdd BLAST93
Domaini19297 – 19388Ig-like 103Sequence analysisAdd BLAST92
Repeati19330 – 19363TPR 10Sequence analysisAdd BLAST34
Domaini19395 – 19494Fibronectin type-III 34PROSITE-ProRule annotationAdd BLAST100
Domaini19495 – 19589Fibronectin type-III 35PROSITE-ProRule annotationAdd BLAST95
Domaini19595 – 19691Fibronectin type-III 36PROSITE-ProRule annotationAdd BLAST97
Domaini19695 – 19786Ig-like 104Sequence analysisAdd BLAST92
Domaini19793 – 19887Fibronectin type-III 37PROSITE-ProRule annotationAdd BLAST95
Domaini19892 – 19986Fibronectin type-III 38PROSITE-ProRule annotationAdd BLAST95
Domaini19990 – 20081Ig-like 105Sequence analysisAdd BLAST92
Domaini20088 – 20183Fibronectin type-III 39PROSITE-ProRule annotationAdd BLAST96
Repeati20152 – 20208RCC1 7Sequence analysisAdd BLAST57
Domaini20187 – 20282Fibronectin type-III 40PROSITE-ProRule annotationAdd BLAST96
Repeati20252 – 20305RCC1 8Sequence analysisAdd BLAST54
Domaini20288 – 20389Fibronectin type-III 41PROSITE-ProRule annotationAdd BLAST102
Domaini20393 – 20479Ig-like 106Sequence analysisAdd BLAST87
Domaini20490 – 20584Fibronectin type-III 42PROSITE-ProRule annotationAdd BLAST95
Repeati20509 – 20554Kelch 7Sequence analysisAdd BLAST46
Domaini20590 – 20685Fibronectin type-III 43PROSITE-ProRule annotationAdd BLAST96
Domaini20688 – 20776Ig-like 107Sequence analysisAdd BLAST89
Domaini20783 – 20877Fibronectin type-III 44PROSITE-ProRule annotationAdd BLAST95
Domaini20880 – 20978Fibronectin type-III 45PROSITE-ProRule annotationAdd BLAST99
Domaini20981 – 21079Fibronectin type-III 46PROSITE-ProRule annotationAdd BLAST99
Domaini21082 – 21173Ig-like 108Sequence analysisAdd BLAST92
Domaini21180 – 21273Fibronectin type-III 47PROSITE-ProRule annotationAdd BLAST94
Domaini21279 – 21374Fibronectin type-III 48PROSITE-ProRule annotationAdd BLAST96
Domaini21380 – 21475Fibronectin type-III 49PROSITE-ProRule annotationAdd BLAST96
Domaini21578 – 21672Fibronectin type-III 50PROSITE-ProRule annotationAdd BLAST95
Domaini21675 – 21770Fibronectin type-III 51PROSITE-ProRule annotationAdd BLAST96
Domaini21868 – 21963Fibronectin type-III 52PROSITE-ProRule annotationAdd BLAST96
Repeati21887 – 21932Kelch 8Sequence analysisAdd BLAST46
Domaini21967 – 22062Fibronectin type-III 53PROSITE-ProRule annotationAdd BLAST96
Repeati22052 – 22093WD 7Sequence analysisAdd BLAST42
Domaini22065 – 22161Fibronectin type-III 54PROSITE-ProRule annotationAdd BLAST97
Repeati22084 – 22129Kelch 9Sequence analysisAdd BLAST46
Domaini22165 – 22257Ig-like 109Sequence analysisAdd BLAST93
Domaini22264 – 22357Fibronectin type-III 55PROSITE-ProRule annotationAdd BLAST94
Domaini22363 – 22458Fibronectin type-III 56PROSITE-ProRule annotationAdd BLAST96
Repeati22428 – 22482RCC1 9Sequence analysisAdd BLAST55
Domaini22464 – 22559Fibronectin type-III 57PROSITE-ProRule annotationAdd BLAST96
Domaini22659 – 22753Fibronectin type-III 58PROSITE-ProRule annotationAdd BLAST95
Domaini22756 – 22848Fibronectin type-III 59PROSITE-ProRule annotationAdd BLAST93
Domaini22950 – 23044Fibronectin type-III 60PROSITE-ProRule annotationAdd BLAST95
Domaini23050 – 23145Fibronectin type-III 61PROSITE-ProRule annotationAdd BLAST96
Domaini23148 – 23244Fibronectin type-III 62PROSITE-ProRule annotationAdd BLAST97
Repeati23168 – 23212Kelch 10Sequence analysisAdd BLAST45
Domaini23248 – 23339Ig-like 110Sequence analysisAdd BLAST92
Domaini23346 – 23440Fibronectin type-III 63PROSITE-ProRule annotationAdd BLAST95
Domaini23446 – 23541Fibronectin type-III 64PROSITE-ProRule annotationAdd BLAST96
Domaini23547 – 23643Fibronectin type-III 65PROSITE-ProRule annotationAdd BLAST97
Repeati23566 – 23612Kelch 11Sequence analysisAdd BLAST47
Domaini23647 – 23736Ig-like 111Sequence analysisAdd BLAST90
Domaini23743 – 23838Fibronectin type-III 66PROSITE-ProRule annotationAdd BLAST96
Domaini23840 – 23933Fibronectin type-III 67PROSITE-ProRule annotationAdd BLAST94
Repeati23903 – 23953RCC1 10Sequence analysisAdd BLAST51
Domaini23937 – 24025Ig-like 112Sequence analysisAdd BLAST89
Domaini24032 – 24126Fibronectin type-III 68PROSITE-ProRule annotationAdd BLAST95
Repeati24041 – 24087WD 8Sequence analysisAdd BLAST47
Domaini24132 – 24227Fibronectin type-III 69PROSITE-ProRule annotationAdd BLAST96
Domaini24230 – 24325Fibronectin type-III 70PROSITE-ProRule annotationAdd BLAST96
Domaini24330 – 24417Ig-like 113Sequence analysisAdd BLAST88
Domaini24428 – 24522Fibronectin type-III 71PROSITE-ProRule annotationAdd BLAST95
Repeati24513 – 24556WD 9Sequence analysisAdd BLAST44
Domaini24528 – 24623Fibronectin type-III 72PROSITE-ProRule annotationAdd BLAST96
Domaini24629 – 24725Fibronectin type-III 73PROSITE-ProRule annotationAdd BLAST97
Domaini24729 – 24816Ig-like 114Sequence analysisAdd BLAST88
Domaini24825 – 24919Fibronectin type-III 74PROSITE-ProRule annotationAdd BLAST95
Domaini24922 – 25015Fibronectin type-III 75PROSITE-ProRule annotationAdd BLAST94
Repeati24941 – 24986Kelch 12Sequence analysisAdd BLAST46
Domaini25019 – 25108Ig-like 115Sequence analysisAdd BLAST90
Domaini25114 – 25208Fibronectin type-III 76PROSITE-ProRule annotationAdd BLAST95
Repeati25123 – 25169WD 10Sequence analysisAdd BLAST47
Domaini25214 – 25308Fibronectin type-III 77PROSITE-ProRule annotationAdd BLAST95
Domaini25312 – 25408Fibronectin type-III 78PROSITE-ProRule annotationAdd BLAST97
Domaini25412 – 25503Ig-like 116Sequence analysisAdd BLAST92
Domaini25510 – 25604Fibronectin type-III 79PROSITE-ProRule annotationAdd BLAST95
Domaini25610 – 25705Fibronectin type-III 80PROSITE-ProRule annotationAdd BLAST96
Domaini25711 – 25807Fibronectin type-III 81PROSITE-ProRule annotationAdd BLAST97
Repeati25730 – 25778Kelch 13Sequence analysisAdd BLAST49
Repeati25891 – 25935WD 11Sequence analysisAdd BLAST45
Domaini25907 – 26002Fibronectin type-III 82PROSITE-ProRule annotationAdd BLAST96
Domaini26004 – 26097Fibronectin type-III 83PROSITE-ProRule annotationAdd BLAST94
Domaini26101 – 26187Ig-like 117Sequence analysisAdd BLAST87
Domaini26197 – 26290Fibronectin type-III 84PROSITE-ProRule annotationAdd BLAST94
Repeati26281 – 26324WD 12Sequence analysisAdd BLAST44
Domaini26296 – 26390Fibronectin type-III 85PROSITE-ProRule annotationAdd BLAST95
Domaini26394 – 26489Fibronectin type-III 86PROSITE-ProRule annotationAdd BLAST96
Domaini26494 – 26584Ig-like 118Sequence analysisAdd BLAST91
Domaini26593 – 26687Fibronectin type-III 87PROSITE-ProRule annotationAdd BLAST95
Domaini26693 – 26788Fibronectin type-III 88PROSITE-ProRule annotationAdd BLAST96
Domaini26794 – 26890Fibronectin type-III 89PROSITE-ProRule annotationAdd BLAST97
Domaini26894 – 26983Ig-like 119Sequence analysisAdd BLAST90
Domaini26990 – 27084Fibronectin type-III 90PROSITE-ProRule annotationAdd BLAST95
Domaini27087 – 27180Fibronectin type-III 91PROSITE-ProRule annotationAdd BLAST94
Domaini27168 – 27272Ig-like 120Sequence analysisAdd BLAST105
Domaini27279 – 27372Fibronectin type-III 92PROSITE-ProRule annotationAdd BLAST94
Repeati27363 – 27406WD 13Sequence analysisAdd BLAST44
Domaini27378 – 27475Fibronectin type-III 93PROSITE-ProRule annotationAdd BLAST98
Domaini27476 – 27572Fibronectin type-III 94PROSITE-ProRule annotationAdd BLAST97
Domaini27576 – 27663Ig-like 121Sequence analysisAdd BLAST88
Domaini27674 – 27768Fibronectin type-III 95PROSITE-ProRule annotationAdd BLAST95
Domaini27774 – 27869Fibronectin type-III 96PROSITE-ProRule annotationAdd BLAST96
Domaini27875 – 27969Fibronectin type-III 97PROSITE-ProRule annotationAdd BLAST95
Repeati27939 – 27989RCC1 11Sequence analysisAdd BLAST51
Domaini27963 – 28058Ig-like 122Sequence analysisAdd BLAST96
Domaini28069 – 28164Fibronectin type-III 98PROSITE-ProRule annotationAdd BLAST96
Repeati28133 – 28182RCC1 12Sequence analysisAdd BLAST50
Domaini28166 – 28259Fibronectin type-III 99PROSITE-ProRule annotationAdd BLAST94
Repeati28185 – 28230Kelch 14Sequence analysisAdd BLAST46
Domaini28361 – 28455Fibronectin type-III 100PROSITE-ProRule annotationAdd BLAST95
Domaini28461 – 28556Fibronectin type-III 101PROSITE-ProRule annotationAdd BLAST96
Domaini28559 – 28655Fibronectin type-III 102PROSITE-ProRule annotationAdd BLAST97
Domaini28659 – 28750Ig-like 123Sequence analysisAdd BLAST92
Repeati28669 – 28706TPR 11Sequence analysisAdd BLAST38
Domaini28757 – 28851Fibronectin type-III 103PROSITE-ProRule annotationAdd BLAST95
Domaini28857 – 28952Fibronectin type-III 104PROSITE-ProRule annotationAdd BLAST96
Repeati28923 – 28957TPR 12Sequence analysisAdd BLAST35
Domaini28958 – 29054Fibronectin type-III 105PROSITE-ProRule annotationAdd BLAST97
Domaini29058 – 29148Ig-like 124Sequence analysisAdd BLAST91
Domaini29157 – 29251Fibronectin type-III 106PROSITE-ProRule annotationAdd BLAST95
Domaini29254 – 29346Fibronectin type-III 107PROSITE-ProRule annotationAdd BLAST93
Domaini29350 – 29439Ig-like 125Sequence analysisAdd BLAST90
Domaini29445 – 29542Fibronectin type-III 108PROSITE-ProRule annotationAdd BLAST98
Repeati29468 – 29513Kelch 15Sequence analysisAdd BLAST46
Repeati29533 – 29576WD 14Sequence analysisAdd BLAST44
Domaini29548 – 29643Fibronectin type-III 109PROSITE-ProRule annotationAdd BLAST96
Domaini29646 – 29741Fibronectin type-III 110PROSITE-ProRule annotationAdd BLAST96
Domaini29745 – 29836Ig-like 126Sequence analysisAdd BLAST92
Domaini29844 – 29937Fibronectin type-III 111PROSITE-ProRule annotationAdd BLAST94
Domaini29943 – 30039Fibronectin type-III 112PROSITE-ProRule annotationAdd BLAST97
Domaini30045 – 30140Fibronectin type-III 113PROSITE-ProRule annotationAdd BLAST96
Domaini30144 – 30229Ig-like 127Sequence analysisAdd BLAST86
Domaini30240 – 30335Fibronectin type-III 114PROSITE-ProRule annotationAdd BLAST96
Domaini30337 – 30430Fibronectin type-III 115PROSITE-ProRule annotationAdd BLAST94
Repeati30399 – 30432TPR 13Sequence analysisAdd BLAST34
Domaini30430 – 30523Ig-like 128Sequence analysisAdd BLAST94
Domaini30532 – 30626Fibronectin type-III 116PROSITE-ProRule annotationAdd BLAST95
Domaini30632 – 30727Fibronectin type-III 117PROSITE-ProRule annotationAdd BLAST96
Domaini30730 – 30829Fibronectin type-III 118PROSITE-ProRule annotationAdd BLAST100
Domaini30833 – 30921Ig-like 129Sequence analysisAdd BLAST89
Domaini30932 – 31025Fibronectin type-III 119PROSITE-ProRule annotationAdd BLAST94
Domaini31028 – 31127Fibronectin type-III 120PROSITE-ProRule annotationAdd BLAST100
Domaini31133 – 31229Fibronectin type-III 121PROSITE-ProRule annotationAdd BLAST97
Domaini31233 – 31322Ig-like 130Sequence analysisAdd BLAST90
Domaini31329 – 31423Fibronectin type-III 122PROSITE-ProRule annotationAdd BLAST95
Domaini31426 – 31521Fibronectin type-III 123PROSITE-ProRule annotationAdd BLAST96
Domaini31525 – 31616Ig-like 131Sequence analysisAdd BLAST92
Domaini31623 – 31717Fibronectin type-III 124PROSITE-ProRule annotationAdd BLAST95
Domaini31723 – 31817Fibronectin type-III 125PROSITE-ProRule annotationAdd BLAST95
Repeati31742 – 31787Kelch 16Sequence analysisAdd BLAST46
Domaini31824 – 31920Fibronectin type-III 126PROSITE-ProRule annotationAdd BLAST97
Domaini31923 – 32012Ig-like 132Sequence analysisAdd BLAST90
Domaini32020 – 32116Fibronectin type-III 127PROSITE-ProRule annotationAdd BLAST97
Domaini32120 – 32216Fibronectin type-III 128PROSITE-ProRule annotationAdd BLAST97
Domaini32222 – 32317Fibronectin type-III 129PROSITE-ProRule annotationAdd BLAST96
Domaini32322 – 32410Ig-like 133Sequence analysisAdd BLAST89
Domaini32515 – 32610Fibronectin type-III 130PROSITE-ProRule annotationAdd BLAST96
Repeati32601 – 32644WD 15Sequence analysisAdd BLAST44
Domaini32616 – 32711Fibronectin type-III 131PROSITE-ProRule annotationAdd BLAST96
Domaini32717 – 32807Ig-like 134Sequence analysisAdd BLAST91
Repeati32754 – 32799WD 16Sequence analysisAdd BLAST46
Domaini32817 – 32908Ig-like 135Sequence analysisAdd BLAST92
Domaini32913 – 33006Fibronectin type-III 132PROSITE-ProRule annotationAdd BLAST94
Repeati32932 – 32977Kelch 17Sequence analysisAdd BLAST46
Domaini33040 – 33294Protein kinasePROSITE-ProRule annotationAdd BLAST255
Repeati33152 – 33189WD 17Sequence analysisAdd BLAST38
Domaini33358 – 33446Ig-like 136Sequence analysisAdd BLAST89
Repeati33366 – 33411Kelch 18Sequence analysisAdd BLAST46
Domaini33478 – 33571Ig-like 137Sequence analysisAdd BLAST94
Domaini33583 – 33672Ig-like 138Sequence analysisAdd BLAST90
Repeati34097 – 34130TPR 14Sequence analysisAdd BLAST34
Domaini34163 – 34253Ig-like 139Sequence analysisAdd BLAST91
Domaini34350 – 34438Ig-like 140Sequence analysisAdd BLAST89
Repeati34380 – 34413TPR 15Sequence analysisAdd BLAST34
Domaini34507 – 34596Ig-like 141Sequence analysisAdd BLAST90
Domaini34641 – 34729Ig-like 142Sequence analysisAdd BLAST89
Domaini34923 – 35011Ig-like 143Sequence analysisAdd BLAST89
Domaini35118 – 35209Ig-like 144Sequence analysisAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni252 – 340ZIS1By similarityAdd BLAST89
Regioni1412 – 1446ZIS5By similarityAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2031 – 2058Sequence analysisAdd BLAST28
Coiled coili9495 – 9538Sequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi390 – 397Poly-AlaSequence analysis8
Compositional biasi452 – 455Poly-ThrSequence analysis4
Compositional biasi9461 – 9464Poly-GluSequence analysis4
Compositional biasi9822 – 9909Pro-richSequence analysisAdd BLAST88
Compositional biasi9935 – 12793Glu-richSequence analysisAdd BLAST2859
Compositional biasi10170 – 12894Pro-richSequence analysisAdd BLAST2725
Compositional biasi33870 – 33874Poly-ArgSequence analysis5
Compositional biasi33988 – 33993Poly-GluSequence analysis6
Compositional biasi34050 – 34055Poly-SerSequence analysis6
Compositional biasi34059 – 34062Poly-ArgSequence analysis4
Compositional biasi35028 – 35106Ser-richSequence analysisAdd BLAST79

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1 could adopt a closed conformation which would block the TCAP-binding site (By similarity).By similarity
The PEVK region may serve as an entropic spring of a chain of structural folds and may also be an interaction site to other myofilament proteins to form interfilament connectivity in the sarcomere.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Kelch repeat, Repeat, TPR repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0613 Eukaryota
ENOG410XQFD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00960000186606

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000136636

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2ASS6

Database for complete collections of gene phylogenies

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PhylomeDBi
A2ASS6

TreeFam database of animal gene trees

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TreeFami
TF316477

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 132 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 194 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR011009 Kinase-like_dom_sf
IPR040849 MyBP-C_THB
IPR004168 PPAK_motif
IPR000719 Prot_kinase_dom
IPR015129 Titin_Z_rpt
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 132 hits
PF07679 I-set, 161 hits
PF00069 Pkinase, 1 hit
PF02818 PPAK, 11 hits
PF18362 THB, 1 hit
PF09042 Titin_Z, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 132 hits
SM00409 IG, 167 hits
SM00408 IGc2, 149 hits
SM00406 IGv, 23 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 167 hits
SSF49265 SSF49265, 74 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 132 hits
PS50835 IG_LIKE, 144 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 18 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2ASS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MTTQAPMFTQ PLQSVVVLEG STATFEAHVS GSPVPEVSWF RDGQVISTST
60 70 80 90 100
LPGVQISFSD GRARLMIPAV TKANSGRYSL RATNGSGQAT STAELLVTAE
110 120 130 140 150
TAPPNFSQRL QSMTVRQGSQ VRLQVRVTGI PTPVVKFYRD GAEIQSSLDF
160 170 180 190 200
QISQEGDLYS LLIAEAYPED SGTYSVNATN SVGRATSTAE LVVQGEEVVP
210 220 230 240 250
AKKTKTIVST AQISETRQTR IEKKIEAHFD ARSIATVEMV IDGATGQLPH
260 270 280 290 300
KTPPRIPPKP KSRSPTPPSI AAKAQLARQQ SPSPIRHSPS PVRHVRAPTP
310 320 330 340 350
SPVRSVSPAG RISTSPIRSV KSPLLIRKTQ TTTMATGPEV PPPWKQEGYV
360 370 380 390 400
ASSTEAEMRE TTMTSSTQIR REERWEGRYG VQEQVTISGA AAAAASASVS
410 420 430 440 450
SSFTAGAITT GTKEVKQETD KSAAVATVVA AVDMARVREP AISAVEQTAQ
460 470 480 490 500
RTTTTAVHIQ PAQEQARKEA EKTAVTKVVV AADKAKEQEL KSRTREVMVT
510 520 530 540 550
TQEQTHISHE QIRKETEKAF VPKVVISATK AKEQETRITG EITTKQEQKR
560 570 580 590 600
ITQETIRQET EEIAASMVVV ATAKSTKLEA AVGVQEETAI QQDQMHLTHE
610 620 630 640 650
QMMKETRKTV VPKVIVATPK IKEQDLVSRS REAITTKRDQ VQITQEKKRK
660 670 680 690 700
EVETTALSTI AVATAKAKEQ ETVLRSREAM ATRQEHIQVT HGQVGVGKKA
710 720 730 740 750
EAVATVVAAV DQARVREPRE PTHVEESHSQ QTTLEYGYKE HISTTKVPEQ
760 770 780 790 800
PRRPASEPHV VPQAVKPAVI QAPSETHIKT TDQMGMHISS QVKKTTDIST
810 820 830 840 850
ERLVHVDKRP RTASPHFTVS KISVPKTEHG YEASIAGSAI ATLQKELSAT
860 870 880 890 900
SSTQKITKSV KAPTVKPGET RVRAEPTPSP QFPFADMPPP DTYKSQAGIE
910 920 930 940 950
VKKEVGVSIS GSTVREEHFE VLRGREAKVT ETARVPAPAE VPVTPPTLVS
960 970 980 990 1000
GLKNVTVIEG ESVTLECHIS GYPSPKVTWY REDYQIESSI DFQITFQGGI
1010 1020 1030 1040 1050
ARLMIREAFA EDSGRFTCSA VNEAGTVSTS CYLAVQVSEE FDKETTLTEK
1060 1070 1080 1090 1100
FATEEKRFVE SRDVVMTDTS ITEEQAGPGE PAAPFFISKP VVQKLVEGGS
1110 1120 1130 1140 1150
VVFECQIGGN PKPHVYWKKS GVPLTTGYRY KVSYNKQTGE CRLVISMTFA
1160 1170 1180 1190 1200
DDAGEYTIVI RNKHGETSAS ASLLEEADYE ALVKTQQEML YQTQMSTFIQ
1210 1220 1230 1240 1250
EPKVGEIAPG FAYSEYEKEY EKEQALIRKK MAKDTVMVRT FVEDQEFHIS
1260 1270 1280 1290 1300
SFEERLIKEI EYRIIKTTLE ELLEEDGEEK MAVDISESEA IESGFDIRIK
1310 1320 1330 1340 1350
NYRILEGMGV TFHCKMSGYP LPKIAWYKDG KRIRHGERYQ MDFLQDGRAS
1360 1370 1380 1390 1400
LRIPVVLPED EGIYTAFASN IKGNAICSGK LYVEPAAPFS APTYMPTPEA
1410 1420 1430 1440 1450
VSRIRSVSPR SLSRSPIRMS PAMSPARMSP ARMSPARMSP ARMSPGRRLE
1460 1470 1480 1490 1500
ETDESQLERL YKPVFVLKPA SFKCLEGQTA RFDLKVVGRP MPETFWFHNG
1510 1520 1530 1540 1550
QQIVNDYTHK VVIKEDGTQS LIIVPASPSD SGEWTVVAQN RAGKSTISVT
1560 1570 1580 1590 1600
LTVEAVEHQI KPAFVEKLKN VNIKEGSRLE MKVRATGNPN PDIVWLKNSD
1610 1620 1630 1640 1650
IIVPHKYPRI RIEGTRGEAA LKIDSIISQD SAWYTATAIN KAGRDTTRCK
1660 1670 1680 1690 1700
VNVEVEFAEP EPERKLIIPR GTYRAKEIAA PELEPLHLRY GQEQWEEGDL
1710 1720 1730 1740 1750
YDKEKQQKPF FKKKLTSLRL KRFGPAHFEC RLTPIGDPTM VVEWLHDGKP
1760 1770 1780 1790 1800
LEAANRLRMI NEFGYCSLDY GAAYSRDSGV ITCRATNKYG TDHTSATLIV
1810 1820 1830 1840 1850
KDEKSLVEES QLPDGKKGLQ RIEELERMAH EGALTGVTTD QKEKQKPDIV
1860 1870 1880 1890 1900
LFPEPVRVLE GETARFRCRV TGYPQPKVNW YLNGQLIRKS KRFRVRYDGI
1910 1920 1930 1940 1950
HYLDIVDCKS YDTGEVKVTA ENPEGVTEHK VKLEIQQRED FRSVLRRAPE
1960 1970 1980 1990 2000
PKPEFHVHEP GKLQFEVQKV DRPVDTSETK EVVKLKRAER ITHEKVSEES
2010 2020 2030 2040 2050
EELRSKFKRR TEEGYYEAIT AVELKSRKKD ESYEELLKKT KDELLHWTKE
2060 2070 2080 2090 2100
LTEEEKKALA EEGKITIPTF KPERIELSPS MEAPKIFERI QSQTVGQGSD
2110 2120 2130 2140 2150
AHFRVRVVGK PDPECEWYKN GVKIERSDRI YWYWPEDNVC ELVIRDVTAE
2160 2170 2180 2190 2200
DSASIMVKAI NIAGETSSHA FLLVQAKQLI TFTQELQDVV AKEKDTMATF
2210 2220 2230 2240 2250
ECETSEPFIK VKWYKDGIEV HAGDKYRMHS DRKVHFLSVL TIDTSDAEDY
2260 2270 2280 2290 2300
SCVLVEDENI KTTAKLIVEG AVVEFVKELQ DIEVPESYSG ELECIISPEN
2310 2320 2330 2340 2350
IEGKWYHNDV ELKSNGKYSI TSRRGRQNLT VKDVTKEDQG EYSFVVDGKK
2360 2370 2380 2390 2400
TTCKLKMKPR PIAILQGLSD QKVCEGDIVQ LEVKVSLENV EGVWMKDGQE
2410 2420 2430 2440 2450
VQHSDRVHIV IDKQSHMLLI EDMTKEDAGN YSFTIPALGL STSGNVSVYS
2460 2470 2480 2490 2500
VDVITPLKDV NVIEGTKAVL ECKVSVPDVT SVKWYLNDEQ IKPDDRVQSI
2510 2520 2530 2540 2550
VKGTKQRLVI NRTHASDEGP YKLMVGRVET SCNLSVEKIK IIRGLRDLTC
2560 2570 2580 2590 2600
TETQNVVFEV ELSHSGIDVV WNFKGKEIKP SSKYKIEAHG KIYKLTVLNM
2610 2620 2630 2640 2650
MKDDEGEYAF YAGENTTSGK LTVAGGAIST PLTDQTVAES QEAVFECEVA
2660 2670 2680 2690 2700
NPESEGEWLK DGKHLALSNN FRGESDGHKR RLVIAAAKLD DAGEYTYKVA
2710 2720 2730 2740 2750
TSKTSAKLKV EAVKIKKTLR NLTVTETQDA VFSVELTHPD VKGVQWIKNG
2760 2770 2780 2790 2800
VVLDSNDKYE ISVKGTLYSL KIKNCAMADE SVYGFKLGRL GASARLHVET
2810 2820 2830 2840 2850
VKIIKKPKDV TALENATVTF EVSVSHDTVP VKWFHKNVEI KPSDKHRLVS
2860 2870 2880 2890 2900
ERKVHKLMLQ SISPSDAGEY TAMVGQLECK AKLFVETLHI TKTMKSIEVP
2910 2920 2930 2940 2950
ETKAASFECE VSHFNVPSMW LKNGVEIEMS EKFKIVVQGK LHQLIIMNTS
2960 2970 2980 2990 3000
TEDSAEYTFV CGNDQVSATL TVTPIMITSM LKDINAEEKD TITFEVTVNY
3010 3020 3030 3040 3050
EGISYKWLKN GVEIKSTDRC QMRTKKLTHS LNIRNVHFGD AADYTFVAGK
3060 3070 3080 3090 3100
ATSTATLYVE ARHIEFRKHI KDIKVLEKKR AMFECEVSEP DITVQWMKDG
3110 3120 3130 3140 3150
QELQIADRIK IQKEKYVHRL LIPSTRMSDA GKYTVVAGGN MSTANLFVEG
3160 3170 3180 3190 3200
RDVRIRSIKK EVQVIEKQRA VVEFEVNEDD VDAHWYKDGI EINFQVQERH
3210 3220 3230 3240 3250
QYVVERRIHR MFISETRHSD AGEYTFVAGR NRSSVTLYVN APEPPQVLQE
3260 3270 3280 3290 3300
LQPVTVQSGK PARFCAVISG RPQPKISWYK EEQLLSTGFK CKFLHDGQEY
3310 3320 3330 3340 3350
TLLLIEAFPE DAAVYTCEAK NDYGVATTSA SLSVEVPEVV SPDQEMPVYP
3360 3370 3380 3390 3400
PAIVTPLQDT VTSEGRPARF QCQVSGTDLK VSWYCKDKKI KPSRFFRMTQ
3410 3420 3430 3440 3450
FEDTYQLEIA EAYPEDEGTY AFVANNAVGQ VSSTATLRLE APESILHERI
3460 3470 3480 3490 3500
GQQIEMEMKE IASLLSAEED FQTYSSDLRL PNANETLELL SEPPARSTQF
3510 3520 3530 3540 3550
DSRQEGAAPV FIREISDVEI SVEDVAKLSV TVTGCPKPKI QWFFNGMLLT
3560 3570 3580 3590 3600
PSADYKFVFD GDTHSLIILF TRFQDEGEYT CLASNEYGKA VCSAHLRISP
3610 3620 3630 3640 3650
RGERSTEMES GEKKALEKPK GPCPPYFFKE LKPVHCGPGI PAVFEYSVHG
3660 3670 3680 3690 3700
EPAPTVLWFK EDMPLYTSVC YTIIHSPDGS GTFIVNDPQR GDSGLYLCKA
3710 3720 3730 3740 3750
QNLWGESTCA AELLVLPEDT DVPDASCKEE STLGVPGDFL ETSARGPLVQ
3760 3770 3780 3790 3800
GVDSRQEITA FAEGTISKAA LIAEETLQLS YERSVDDSEV GTGVTIGAQK
3810 3820 3830 3840 3850
LPPVVLSTPQ GTGELPSIDG AVHTQPGRGP PPTLNLQAVQ AQTTLPKEAT
3860 3870 3880 3890 3900
LQFEEPEGVF PGASSAAQVS PVTIKPLITL TAEPKGNYPQ SSTAAPDHAL
3910 3920 3930 3940 3950
LSSVAAETLQ LGEKKIPEVD KAQRALLLSQ SLAEGCVESL EVPDVAVSNM
3960 3970 3980 3990 4000
RSEPQVPFQH TCTEGKILMA SADTLKSTGQ DVALRTEEGK SLSFPLALEE
4010 4020 4030 4040 4050
KQVLLKEEQS EVVAVPTSQT SKSEKEPEAI KGVKEVREQE LLSKETLFPS
4060 4070 4080 4090 4100
MPEEQRLHLK TQVRRALQAA VAREQANLFS EWLRNIDKVE VTAVNFTQEP
4110 4120 4130 4140 4150
KRILCTYLIT SVSSLTEELT VTIEDIDPQM ANLETGLKDA LCSIVCEERN
4160 4170 4180 4190 4200
ILMAEDPRIH EEDKIDVQGG RDHLSDAQKV ETVIEAEADS KYLVSKEEVS
4210 4220 4230 4240 4250
WSKVESQLKD GDTNEVPQAE TLKLAEESGT QKTSTEMSQE EAEGTLADLC
4260 4270 4280 4290 4300
PAVLKHLVDT ISEEGDTVHL TSSISNAKEV HWYFKGNLVP SDGKFKCLKE
4310 4320 4330 4340 4350
QNAYTLVIEA VKTEDEGEYV CEASNDSGKA KTSAKLTVGE RAAPVIKRRI
4360 4370 4380 4390 4400
EPLEVALGHL AKFTCEIQGA PNVRFQWFKA GREIYESDKC SIRSSNYVSS
4410 4420 4430 4440 4450
LEILRTQVVD CGEYTCKASN EYGSVSCTAT LTVTEAYPPT FLSRPKALTT
4460 4470 4480 4490 4500
FVGKAAKFLC TVSGTPVIEI IWQKDGAALS PSPDCRVTDA DNKHSLELSN
4510 4520 4530 4540 4550
LTVQDRGIYS CKASNKFGAD ICQAELTIID KPHFIKELEA VQSAINKKIH
4560 4570 4580 4590 4600
LECQVDEDRK VTITWSKDGQ KLPAGKDYKI YFEDKIASLE IPLAKLKDSG
4610 4620 4630 4640 4650
TYTCTASNEA GSSSSSAAVA VREPPSFVKK VDPSYLMLPG ESARLHCKLK
4660 4670 4680 4690 4700
GSPVIQVTWF KNNKELSESN TVRMSFVNSE AILDITDVKV DDSGTYSCEA
4710 4720 4730 4740 4750
TNDVGSDSCS TEVVIKEPPS FIKTLEPADI VRGANALLQC EIAGTGPFEV
4760 4770 4780 4790 4800
NWFKDKKQIR SSKKYRLFTQ KTFVYLEISS FNSADVGDYE CVVANEVGKC
4810 4820 4830 4840 4850
GCVATHLLKE PPTFVKKVDD FTALAGQTVT LQAAVRGSEP ISVMWMKGQE
4860 4870 4880 4890 4900
VIKEDGKIKM SFSNGVAVLT IPDVQISLGG KYTCLAENEA GSQTSVGELI
4910 4920 4930 4940 4950
VKEPAKIIER AELIQVTAGD PATLEYTVSG TPELKPKWYK DGRPLVASKK
4960 4970 4980 4990 5000
YRISFKNNIA QLKFYSAELH DSGQYTFEIS NEVGSSSCET TFTVLDRDIA
5010 5020 5030 5040 5050
PLFTKPLRNV DSVVGGACRL DCKIAGSLPM RVSWFKDGKE LTASDRYQIA
5060 5070 5080 5090 5100
FVEGTASLEI SRVDMNDAGN FTCRATNSVG SKDSSGALIV QEPPSFVTKP
5110 5120 5130 5140 5150
GSRDVLPGSA VCLKSAFQGS APLTIKWFKG DKELVSGGSC YITKETSESS
5160 5170 5180 5190 5200
LELYAVKTSD SGTYTCKVSN VAGSVECSAD LFVKEPATFI EKLEPSQLLK
5210 5220 5230 5240 5250
KGDGTQLACK VTGTPPIKIT WFANDRELRE SSKHKMSFAE STAVLRLTDV
5260 5270 5280 5290 5300
AIEDSGEYMC EAQNEAGSDH CTGIVIVKES PYFTKEFKSI EVLKEYDVML
5310 5320 5330 5340 5350
LAEVAGTPPF EITWFKDNTT LRSGRKYKTF LQDQLVSLQV LKFVAADAGE
5360 5370 5380 5390 5400
YQCRVTNEVG SSTCSARVTL REPPSFIKKI EATSSLRGGT AAFQATLKGS
5410 5420 5430 5440 5450
LPITVTWLKD NDEITEDDNI RMTFENNVAS LYLSGIEVKH DGKYVCQAKN
5460 5470 5480 5490 5500
DAGIQRCSAL LSVKEPATIM EEAVSIDVTQ GDPATLQVKF SGTKEISAKW
5510 5520 5530 5540 5550
FKDGQELTLG PKYKISVTDT VSILKIISTE KKDSGEYTFE VQNDVGRSSC
5560 5570 5580 5590 5600
KASINVLDLI IPPSFTKKLR KMDSIKGSFI DLECIVAGSH PISIQWFKDD
5610 5620 5630 5640 5650
QEISASDKHK FSFHDNTAFL EISQLEGTDS GTYTCSATNK AGHSQCSGHL
5660 5670 5680 5690 5700
TVKEPPYFVE KPQSQDVNPG TRVQLKALVG GTAPMTIKWF KDNKELHPGA
5710 5720 5730 5740 5750
ARSVWKDDTS TILELFSAKA ADSGTYICQL SNDVGTTSSK ATIFVKEPPQ
5760 5770 5780 5790 5800
FIKKPSPVLV LRNGQSTTFE CQVTGTPEIR VSWYLDGNEI TDLRKYGISF
5810 5820 5830 5840 5850
VDGLATFQIS NARVENSGTY VCEARNDAGT ASCSIELKVK EPPIFIRELE
5860 5870 5880 5890 5900
PVEVVKDSDV ELECEVMGTT PFEVTWLKNN KEIRSGKKYT MSEKMSVFYL
5910 5920 5930 5940 5950
HITKCDPSDV GEYQCIIANE GGSCACSARV ALKEPPSFIK KIENVTTVLK
5960 5970 5980 5990 6000
SSATFQSTVA GSPPISITWL KDDQILEEND NVHISFEDSV ATLQVRSVDN
6010 6020 6030 6040 6050
GHSGRYTCQA KNESGIERCY AFLLVQEPAQ IIEKAKSVDV TEKDPVTLEC
6060 6070 6080 6090 6100
VVAGTPELKV KWLKDGKQIV PSRYFSMSFE NNVASFRIQS VMKQDSGQYT
6110 6120 6130 6140 6150
FKVENDFGSS SCDAYLRVLD QDIPPSFTKK LTKMDKVLGS SIHMECKVSG
6160 6170 6180 6190 6200
SLPISAQWFK DGKEISTSAK YRLVCHENTV SLEVSNLELE DTANYTCKVS
6210 6220 6230 6240 6250
NVAGDNACSG ILTVKEPPSF LVKPERQQAI PDSTVEFKAV LKGTPPFKIK
6260 6270 6280 6290 6300
WLKDDVELVS GPKCFIGLEG STSFLNLYSV DSSKTGQYTC QVTNDVGSDS
6310 6320 6330 6340 6350
CTTMLLVTEP PKFVKKLEAS KIIKAGDSAR LECKITGSPE IQVVWYRNEH
6360 6370 6380 6390 6400
ELTASDKYQM TFIDSVAVIQ MNSLGTEDSG DFICEAQNPA GSTSCSTKVI
6410 6420 6430 6440 6450
VKEPPVFSSF PPIVETLKNT EVSLECELSG TPPFEVVWYK DKRQLRSSKK
6460 6470 6480 6490 6500
YKVASKNFHA SIHILNVEST DIGEYHCKAQ NEVGSDACVC AVKLKEPPKF
6510 6520 6530 6540 6550
ISKLNSLTVV AGEPAELQAS IEGAQPISVQ WLKEKEEVIR ESENIRISFV
6560 6570 6580 6590 6600
NNVATLQFAK VEPANAGKYI CQVKNDGGVR ENMATLTVLE PAVIIEKAGS
6610 6620 6630 6640 6650
MTVTVGETCA LECKVAGTPE LSVEWYKDGK LLTSSQKHKF SFYNKISSLK
6660 6670 6680 6690 6700
ILSVEKEDAG TYTFQVQNNV GKSSCTAVVD VSDRMVPPSF TRRLKDTGGV
6710 6720 6730 6740 6750
LGTSCILECK VAGSSPISIA WFHEKTKIVS GAKYQTTFSD NVCTLQLNSL
6760 6770 6780 6790 6800
DSSDMGSYTC VAANVAGSDE CRALLTVQEP PSFVKEPEPL EVLPGKNITF
6810 6820 6830 6840 6850
TSVIRGTPPF KVGWFRGARE LVKGNRCNIY FEDTVAELEL FNIDISQSGE
6860 6870 6880 6890 6900
YTCVVSNNAG QASCTTRLFV KEPATFVKKL SDHSVEPGKS IILEGTYTGT
6910 6920 6930 6940 6950
LPISVTWKKD GVSITPSERC NIVTTEKTCI LEILSSTKGD AGHYSCEIEN
6960 6970 6980 6990 7000
EAGRDACDAL VSTLEPPYFV TELEPLEASV GDSVSLQCQV AGTPEITVSW
7010 7020 7030 7040 7050
FKGDTKLRST PEYRTYFTNN VATLVFNKVS INDSGEYTCM AENSIGTAAS
7060 7070 7080 7090 7100
KTIFRIQERQ LPPSFARQLK DIEQTVGLPV TLTCRLNGSA PIQVCWYRDG
7110 7120 7130 7140 7150
VLLRDDENLQ MSFVDNVATL KILQTDLSHS GQYSCSASNP LGTASSTARL
7160 7170 7180 7190 7200
TAREPKKSPF FDIKPVSIDV IAGESADFEC HVTGAQPMRV TWSKDNKEIR
7210 7220 7230 7240 7250
PGGNYTITCV GNTPHLRILK VGKGDSGQYT CQATNDVGKD MCSAQLSVKE
7260 7270 7280 7290 7300
PPKFIKKLDA SKVAKQGESI QLECKISGSP EIKVVWFRND SELHESWKYN
7310 7320 7330 7340 7350
MSFVNSVALL TINEASAEDT GDYICEAHNG VGDASCSTAL KVKAPPVFTQ
7360 7370 7380 7390 7400
KPPPVGALKG SDVILQCEIS GTPPFEVVWV KDRKQVRSSK KFKITSKNFD
7410 7420 7430 7440 7450
TSLHIFNLEA PDIGEYHCKA TNEVGSDTCA CTVKFKEPPR FVKKLSDAST
7460 7470 7480 7490 7500
LIGDPVELQA VVEGFQPISV VWLKDKGEVI RESENVRISF VDNIATLQLG
7510 7520 7530 7540 7550
SPEASQSGKY VCQIKNDAGM RECSAVLTVL EPATIVEKPE PMTVTTGNPF
7560 7570 7580 7590 7600
TLECVVAGTP ELSAKWFKDG RELSSGSRHH ITFVRNLASL KIPSAEMNDK
7610 7620 7630 7640 7650
GLYTFEVENR VGKSSCTVSV HVSDRVVPPS FVRRLKDTSA TLGASVVLEC
7660 7670 7680 7690 7700
RVSGSAPISV GWFLDGNEII SSPKCQSSFA DNVCTLTLSS LEPSDTGAYT
7710 7720 7730 7740 7750
CVAANVAGQD ESSAVLTVQE PPSFEQTPDS VEVLPGMSLT FTSVIRGTPP
7760 7770 7780 7790 7800
FKVKWFKGSR ELVSGEACTI SLEDFVTELE LLEVEPGQSG DYSCLVTNDA
7810 7820 7830 7840 7850
GSASCTTHLF VKEPATFVKR LADTSVETGS PIVLEATYSG TPPISVSWMK
7860 7870 7880 7890 7900
NEYPLSQSPN CGITTTEKSS ILEILESTIE DYAQYACLIE NEAGQDICEA
7910 7920 7930 7940 7950
LVSVLEPPYF IEPLEHVEAA IGEPITLQCK VDGTPEIRIS WYKEHTKLRS
7960 7970 7980 7990 8000
APAYKMQFKN NVASLVINKV DHSDVGEYTC KAENSVGAVA SSAVLVIKER
8010 8020 8030 8040 8050
KLPPSFARKL KDVHETLGFP VAFECRINGS EPLQVSWYKD GELLKDDANL
8060 8070 8080 8090 8100
QMSFVHHVAT LQILQTDQSH VGQYNCSASN PLGTASSSAK LILSEHEVPP
8110 8120 8130 8140 8150
FFDLKPVSVD LALGESGSFK CHVTGTAPIK ITWAKDNREI RPGGNYKMTL
8160 8170 8180 8190 8200
VENTATLTVL KVAKGDAGQY TCYASNVAGK DSCSAQLGVQ EPPRFIKKLD
8210 8220 8230 8240 8250
QSRIVKQDEY TRYECKIGGS PEIKVLWYKD EVEIQESSKF RMSFEDSVAI
8260 8270 8280 8290 8300
LEMHSLSVED SGDYTCEARN AAGSASSSTS LKVKEPPVFR KKPFPVETLK
8310 8320 8330 8340 8350
GADVHLECEL QGTPPFQVSW HKDKRELRSG KKYKIMSENL LTSIHILNVD
8360 8370 8380 8390 8400
TADIGEYQCK ATNDVGSDTC VGSVTMKAPP QFVKKLTDIS TIIGKEVQLQ
8410 8420 8430 8440 8450
TTIEGAEPIS VAWFKDKGEI VRESDNIWIS YSENIATLQF SRAEPANAGK
8460 8470 8480 8490 8500
YTCQIKNDAG MQECYATLSV LEPAAIVEKP ESIKVTTGDT CTLECTVSGT
8510 8520 8530 8540 8550
PELSTKWFKD GKELTSDNKY KISFFNKVSG LKIINVVPGD SGVYSFEVQN
8560 8570 8580 8590 8600
PVGKDSCKVS IQVSDRIIPP SFTRKLKETN GLSGSSVVME CKVYGSPPIS
8610 8620 8630 8640 8650
VLWFHDGNEI SSGRKYQTTL TDNTCALTVN MLEEADAGDY TCIATNVAGS
8660 8670 8680 8690 8700
DECSAPLTVR EPPSFVQKPD PMDVLTGSNV TFTSIVKGSP PFTVSWFKGS
8710 8720 8730 8740 8750
TELVPGARCN VSLQDSVGEL ELFDVDTSQS GEYTCIVSNE AGRASCTTRL
8760 8770 8780 8790 8800
FVKAPAIFVK RLNDYSIEKG KPLILEGTFS GTPPISVTWK KNGINVIASQ
8810 8820 8830 8840 8850
RCNITTTEKS AILEILSSTV EDSGQYNCYI ENASGKDSCS AQILILEPPY
8860 8870 8880 8890 8900
FVKQLEPVKV TVGDSASLQC QLAGTPEIGV SWYKGDTKLR PTATCKMHFK
8910 8920 8930 8940 8950
NNVATLVFTQ VDSSDSGEYI CRAENSVGEV SSSTFLTVQE QKLPPSFSRQ
8960 8970 8980 8990 9000
LRDVQETVGL PVVFECAVSG SEPISVSWYK DGKPLKDSPN IQTSFLDNIA
9010 9020 9030 9040 9050
TLNIFKTDRS LSGQYSCTAT NPIGSASSGA KLILTEGKNP PFFDIPLAPM
9060 9070 9080 9090 9100
DAVVGESADL ECHVTGTQPI KVTWAKDNRE IRSGGNYQIS YLENSAHLTI
9110 9120 9130 9140 9150
VKVDKGDSGQ YTCYAVNEVG KDSCTAQLNI KERLIPPSFT KKLSETVEET
9160 9170 9180 9190 9200
EGNSFKLEGR VAGSQPITVA WYKNNVEIHP TSNCEIMFKN NALLLQVKRA
9210 9220 9230 9240 9250
SMADAGLYTC KATNDAGSAL CTSSIVIKEP KKPPVFDQHL APVTASEGDS
9260 9270 9280 9290 9300
VQLSCHVQGS EPIRIQWLKA GREVKPSDRC SFSFASGTAM LELKETAKAD
9310 9320 9330 9340 9350
SGDYVCKASN VAGSDTSKCK VTIKEKPAAA PAAKKAAVDG KLFFVSEPQS
9360 9370 9380 9390 9400
IRVVEKTTAT FIAKVGGDPI PNVKWTKGKW RQLNQGGRIL IHQKGDEAKL
9410 9420 9430 9440 9450
EIRDTTKTDS GLYRCVAFNK HGEIESNVNL QVDERKKQEK IEGDLRAMLK
9460 9470 9480 9490 9500
KTPALKKGSG EEEEIDIMEL LKNVDPKEYE KYARMYGITD FRGLLQAFEL
9510 9520 9530 9540 9550
LKQSQEEETH RLEIEELEKS ERDEKEFEEL VAFIQQRLTQ TEPVTLIKDI
9560 9570 9580 9590 9600
ENQTVLKDND AIFEIDIKIN YPEIKLSWYK GTEKLEPSNK YEISIDGDRH
9610 9620 9630 9640 9650
TLRVKNCQPK DQGNYRLVCG PHIASAKLTV IEPAWERHLQ DVTLKEGQTC
9660 9670 9680 9690 9700
TMTCQFSVPN VKSEWFRNGR VLKPQGRVKT EVEHKVHKLT IADVRAEDQG
9710 9720 9730 9740 9750
QYTCKHEDLE TSAELRIEAE PIQFTKRIQN IVVSEHQSAT FECEVSFDDA
9760 9770 9780 9790 9800
IVTWYKGPTE LTESQKYNFR NDGRCHYMTI HNVTPDDEGV YSVIARLEPR
9810 9820 9830 9840 9850
GEARSTAELY LTTKEIKLEM KPPDIPDSRV PIPTMPIRAV PPEEIPPAVA
9860 9870 9880 9890 9900
PSIPLLLPLP EEKKPPAKRI EVTKKGVKKD TKKVVTKPKE EAPPPPVAKK
9910 9920 9930 9940 9950
PPPPTPMIPA KASEIIDVSS KAEEVKITTI TRKKEVHKEK EAVYEREEAV
9960 9970 9980 9990 10000
YEKKVHIEPW EEPYEELETE PYTEPYEEPY YEEPDEDYEE IKVEAKKQVH
10010 10020 10030 10040 10050
EEWEEDFEEG QEYYEREEGY DEGEEEWEEI YHEREIIQVQ KEVHEELHEK
10060 10070 10080 10090 10100
KIPAKVPEKK VPPPKVVKKP VVEKVEKTTR RMEEEKVQVI KVPEVSKKIV
10110 10120 10130 10140 10150
PQKPSRTPVQ EEIIEVKVPA VHTKKMVISE EKMFFASHTE EEVSVSVPEV
10160 10170 10180 10190 10200
QKKTVTEEKI HVAVSKKIEP PPKVPEPPKK PVPEEVVPVP IPKKVEPPAA
10210 10220 10230 10240 10250
KVPEAPKKPV PEEKKPVPIP KKKEPAAPPQ VPEAPKKPAP EEKIPVPVTK
10260 10270 10280 10290 10300
KKEAPPAKVP EVQKKVVTEE KIAIITQREE SPPPAVPEIP KKKVPEEKRP
10310 10320 10330 10340 10350
VPRKEEVPPP KVPVPPKKAV PEAVVPAPIP KKAPPRAEVS KKTVVEEKRF
10360 10370 10380 10390 10400
AAEEKLSVAV PQRVELMRHE EEEWTYSEEE ERVSVSVYRE EERDEEEAEI
10410 10420 10430 10440 10450
TEYEVLEEPE EYVVEEKMHF ISKKVEVEPA KVPEKKIIPK PKVPAKIEEP
10460 10470 10480 10490 10500
PPTKVPEPPK KIVPEKKVPA PAPKKVPPAK APEESKRPVP EKRAPAEEVG
10510 10520 10530 10540 10550
IEEPPPTKVA ERHMKITQEE KVLVAVTKKE APPRARVPEE PKKVAPEERF
10560 10570 10580 10590 10600
PKLKPRREEE PPAKVTEVRK RAVKEEKVSI EVPKREPRPT KEVTVTEEKK
10610 10620 10630 10640 10650
WSYTREEETV SEHREEEYED YEDYEEYKEF EEYEPTEEYD QYDEYAEREV
10660 10670 10680 10690 10700
EHYEEHEEYV TEPKKPVPVK PAQEPVPAKP KAPPPKVLKK AVPEEKAPLP
10710 10720 10730 10740 10750
IQKKLKPLPP KAPEEPKKVV EEKIQISITK REKQQVTEPV AKVPMKPKRV
10760 10770 10780 10790 10800
VPEAKIPAPT KEVAVPVRVP GVPKKRELEE VVVFKEEVEA HEEYIVEEEE
10810 10820 10830 10840 10850
EYVHEEEYVH KEEYVHEEEY VHKEEYIHEE EEHLHEEEET IAEEEVVPVA
10860 10870 10880 10890 10900
PVKVPVVPKK PVPEEKKPVP VPKKKEAPPA KVPEIPKKPE EKVPVPIPKK
10910 10920 10930 10940 10950
EKAPPAKVPE VPKKPVPEEK PPVPVPKKVE PPPAKVPEVP KKPVPEKKVP
10960 10970 10980 10990 11000
APTPKKVEAP PAKVPEVPKK PIPEEKKPTA LLKKMEAPPP KAPKKREVVP
11010 11020 11030 11040 11050
VPVALPREEE EEEVPFEEVP EEEILPEEEV PSEEEAPPEE VPPEEEEVLP
11060 11070 11080 11090 11100
EEEEVLPEEE EVLPEEEEVQ PEEEALPEIK PKVPKPAPVP KKTVPEKKVP
11110 11120 11130 11140 11150
VPVPKKVEPP PPPKVPEIKK KVPEKKVVVP KKEEAPPTKV PEVSKKVEER
11160 11170 11180 11190 11200
RIIPPKEEEV PPAEVYEEAE EPTPEEIPEE PPSIEEEEIV EEEEEEEEVL
11210 11220 11230 11240 11250
PPRAPEVVKK AVPEAPTPVP KKAEAPPAKV PKKIPEEKVP VPVQKKEAPP
11260 11270 11280 11290 11300
AKVPEKKKIP EKKVPVPKKE AVPPAKGKAV FEEKISVAYQ QEELVQERIE
11310 11320 11330 11340 11350
LELVEAKVEE AFEEEEFHEV QEYFEEEEFH EVEEFIRVEE RRFQEEHKVE
11360 11370 11380 11390 11400
EVHRVIEFLE AEEVEVYEKP KIPPKKGPEV SEKVIPPKKP PTKVIPRKEP
11410 11420 11430 11440 11450
PAKVPEVTKK TVVEEKIRAP EEPKVPAPKA PEVPKKITPE EKVREAVPKK
11460 11470 11480 11490 11500
PEVPPPKVPE VPKKIIQEEK LPVVLPEDTE IYMYEASEET VIEEEHVTLP
11510 11520 11530 11540 11550
QKARLKVAKV PAPPQTVVTE EKTYVTIRKT RETLALKESE TTREAFPELK
11560 11570 11580 11590 11600
SYKAVPEIPE PPSPEDLEII EDVLPEKRPP ASKRRKTQLP TAPEAPREMP
11610 11620 11630 11640 11650
PEMNTFEEIS VEPEMLPTQV LDTYQEATVE KKTLRISRKK PELPSDEEVP
11660 11670 11680 11690 11700
EAPREVVAKK KVLPPQVPEV VPVKVPGAPK EVVSERKSLE EPPKKPAVRP
11710 11720 11730 11740 11750
VTVPEEPKEV IPEKKVSLVP PKKPAAPPVT VPEAPEEVFS EDEETLAPPQ
11760 11770 11780 11790 11800
EPEAPPAKVP EAPKEVVPEK KVSVVPPKKP EAPPAKVPEA PKEAAPEKKV
11810 11820 11830 11840 11850
PVAPKKKPEA PPVKVPEAPK KVVPEKKLPV AAPKKPEAPA AEVPEVPKTA
11860 11870 11880 11890 11900
VPQKKIPEAI PPKPESPPLE VPEVPPKEVT PEKKVPAAPP TKPEIPPPKV
11910 11920 11930 11940 11950
PEAPQAAVVE EKTPEALPKK AEAAPVPVPQ VQETVPEKTR PVGPPKKPEA
11960 11970 11980 11990 12000
TTVPVPKVQK TIPEKTRPEA PPKRPEARTV PETVPEKTRP MAPPKKPEAT
12010 12020 12030 12040 12050
TLPVPEVQET VPEKTRPVGP PKKPEATTVP VPEVQETIPE KTRPPKKPEA
12060 12070 12080 12090 12100
TPVPVPEVQE TVPEKTRPVG PPKKPEATTV SVPEVQETIP EKTRPAAPPK
12110 12120 12130 12140 12150
KPEATAVPET IPEKTRPEAP PKRPEATTVP VPEADQAVVP EKKVPRVPPK
12160 12170 12180 12190 12200
KVEAPPITVP EEPKEVIPEK KVSLVPPKKP AAPPVTVPEA PEEVFSEDEE
12210 12220 12230 12240 12250
TLAPPQEPEA PPAKVPEAPK EVVPEKKVSV VPPKKPEAPP AKVPEAPKEA
12260 12270 12280 12290 12300
APEKKVPVAP KKKPEAPPVK VPEAPKKVVP EKKLPVAAPK KPEAPAAEVP
12310 12320 12330 12340 12350
EVPKAAVPQK KIPEAIPPKP ESPPPEVYEE PEEEIVPEEP PEEAVEEPVP
12360 12370 12380 12390 12400
APPPKVTEPP KKPVPEKKAP PAVVKKPEPP PAKVPEVPKE APPEKKVPPK
12410 12420 12430 12440 12450
KPEAPPAKVP EVPKEVVTEK KVAVPKKPEV PPAKVPEVPK KPVIEEKPAI
12460 12470 12480 12490 12500
PVVEKVASPP AEVYEEPEEV TAEEEEPAPA VEEEEYEAPP PPAPVPEEPK
12510 12520 12530 12540 12550
KVVPEKKFPV IKKPEAPPPK VPEVPKKAVP VKKVPVVKKP EPPEAEVPEV
12560 12570 12580 12590 12600
PKKLVPVKKE PVPVTKKTEV LPEKVPEAPK KITPEKKESV PVPEEPEAPP
12610 12620 12630 12640 12650
ASVEETPEET IYEEKATITI GRKETPPVEE REIEKFIQPE EPELEPEPEE
12660 12670 12680 12690 12700
IPVQEPEPEK KVIEKPKLKP RPPARPPSPP KEDVKEKMFQ LKAVSKKKVP
12710 12720 12730 12740 12750
EKPEVVEKVE PAPLKVPTAE KKVRKLLPEP KPQPKEEVVL KSVLRKKPEE
12760 12770 12780 12790 12800
EEPKVEPKKV EKAKKPEEPQ PPPKAVEVEA PPEPTPKERK VPEPAKVPEI
12810 12820 12830 12840 12850
KPAIPLPGPE PKPKPEPEVK TMKAPPIEPA PTPIAAPVTA PVVGKKAEAK
12860 12870 12880 12890 12900
PKDEAAKPKG PIKGVAKKTP SPIEAERKKL RPGSGGEKPP DEAPFTYQLK
12910 12920 12930 12940 12950
AVPLKFVKEI KDIVLTEAES VGSSAIFECL VSPSTAITTW MKDGSNIRES
12960 12970 12980 12990 13000
PKHRFIADGK DRKLHIIDVQ LSDAGEYTCV LRLGNKEKTS TAKLIVEELP
13010 13020 13030 13040 13050
VRFVKTLEEE VTVVKGQPLY LSCELNKERD VVWRKDGKIV VEKPGRIVPG
13060 13070 13080 13090 13100
VIGLMRALTI NDADDTDAGT YTVTVENANN LECSSCVKVV EIIREWLVKP
13110 13120 13130 13140 13150
IRDQHVKPKG TAVFTCDIAK DTPNIKWFKG YDEIPLEPND KTEILKEGNH
13160 13170 13180 13190 13200
LFLKVKNAMP EDIDEYAVEI EGKRYPAKLT LGEREVELLK PIEDVTIYEK
13210 13220 13230 13240 13250
ESASFDAEIS EEDIPGEWKL KGELLRPSPT CEIKAEGGKR FLTLHKVKLD
13260 13270 13280 13290 13300
QAGEVLYQAC NAITTAILTV KEIELDFAVP LKDVTVPEKR QARFECVLTR
13310 13320 13330 13340 13350
EANVIWSKGP DIIKASDKFD IIADGKKHIL VINDSQFDDE GVYTAEVEGK
13360 13370 13380 13390 13400
KTSAQLFVTG IRLKFISPLE DQTVKEGQTA TFVCELSHEK MHVVWFKNDV
13410 13420 13430 13440 13450
KLHTTRTVLM SSEGKTYKLE IRETTLDDIS QIKAQVKNLS STANLKVLEA
13460 13470 13480 13490 13500
DPYFTVKLHD KTGVEKDEII LKCEVSKDVP VKWFKDGEEI VPSPKHSVKT
13510 13520 13530 13540 13550
DGLRRILKIK KAELKDKGEY VCDCGTDTTK ANVTVEARLI KVEKPLYGVE
13560 13570 13580 13590 13600
VFVGETARFE IELSEPDVHG QWKLKGEPLT ASPDCEIIED GKKHVLVLYN
13610 13620 13630 13640 13650
CQLDMTGEIS FQAANAKSAA NLKVKELPLI FITPLSDVKV FEKDEAKFEC
13660 13670 13680 13690 13700
EVSREPKTFR WLKGTQEITG DDRFELIKDG TRHSLVIKSA AFEDEAKYMF
13710 13720 13730 13740 13750
EAEDKRTSGK LIIEGIRLKF LTPLKDVTAK ERENAVFTVE LSHDNIPVSW
13760 13770 13780 13790 13800
FKNDQRLHTS KRVSMHDEGK THSITFKDLS IDDTSQIRVE AMGISSEAKL
13810 13820 13830 13840 13850
TVLEGDPYFT GKLQDYTGVE KDEVILQCEI SKADAPVKWF KDGKEIKPSK
13860 13870 13880 13890 13900
NVVIKADGKK RMLILKKALK SDIGQYTCDC GTDQTSGKLD IEDREIKLVR
13910 13920 13930 13940 13950
PLYSVEVMET ETARFETEIS EDDIHANWKL KGEALLQTPE CEIKEEGKIH
13960 13970 13980 13990 14000
VLILHNCRLD QTGGVDFQAA NVKSSAHLRV KPRVIGLLRP LKDVTVTAGE
14010 14020 14030 14040 14050
TATFDCELSY EDIPVEWYLK GKKLEPNDKV VTRSEGRVHT LTLRDVKLED
14060 14070 14080 14090 14100
AGEVQLTAKD FKTQANLFVK EPPVEFTKPL EDQTVEEEAT AVLECEVSRE
14110 14120 14130 14140 14150
NAKVKWFKNG TEILKSKKYE IVADGRVRKL IIHGCTPEDI KTYTCDAKDF
14160 14170 14180 14190 14200
KTSCNLNVVP PHVEFLRPLT DLQVKEKETA RFECEISKEN EKVQWFKDGA
14210 14220 14230 14240 14250
EIKKGKKYDI ISKGAVRILV INKCLLNDEA EYSCEVRTAR TSGMLTVLEE
14260 14270 14280 14290 14300
EAVFTKNLAN LEVSEGDTIK LVCEVSKPGA EVIWYKGDEE IIETGRFEIL
14310 14320 14330 14340 14350
TDGRKRILII QNAQLEDAGS YNCRLPSSRT DSKVKVHELA AEFISKPQNL
14360 14370 14380 14390 14400
EILEGEKAEF VCTISKESFE VQWKRDDQTL ESGDKYDIIA DGKKRVLVVK
14410 14420 14430 14440 14450
DATLQDMGTY VVMVGAARAA AHLTVIEKLR IIVPLKDTKV KEQQEVVFNC
14460 14470 14480 14490 14500
EVNTEGAKAK WFRNEEAIFD SSKYIILQKD LVYTLRIRDA RLDDQANFNV
14510 14520 14530 14540 14550
SLTNHRGENV KSAANLIVEE EDLRIVEPLK DIETMEKKSV TFWCKVNRLN
14560 14570 14580 14590 14600
VTLKWTKNGE EVAFDNRISY RIDKYKHSLI IKDCGFPDEG EYVVTAGQDK
14610 14620 14630 14640 14650
SVAELLIIEA PTEFVEHLED QTVTEFDDAV FSCQLSREKA NVKWYRNGRE
14660 14670 14680 14690 14700
IKEGKKYKFE KDGSIHRLII KDCRLEDECE YACGVEDRKS RARLFVEEIP
14710 14720 14730 14740 14750
VEIIRPPQDI LEAPGADVIF LAELNKDKVE VQWLRNNMIV VQGDKHQMMS
14760 14770 14780 14790 14800
EGKIHRLQIC DIKPRDQGEY RFIAKDKEAR AKLELAAAPK IKTADQDLVV
14810 14820 14830 14840 14850
DAGQPLTMVV PYDAYPKAEA EWFKENEPLS TKTVDTTAEQ TSFRISEAKK
14860 14870 14880 14890 14900
DDKGRYKIVL QNKHGKAEGF INLQVIDVPG PVRNLEVTET FDGEVSLAWE
14910 14920 14930 14940 14950
EPLTDGGSKI IGYVVERRDI KRKTWVLVTD RADSCEFTVT GLQKGGVEYL
14960 14970 14980 14990 15000
FRVSARNRVG TGEPVETDSP VEARSKYDVP GPPLNVTITD VNRFGVSLTW
15010 15020 15030 15040 15050
EPPEYDGGAE ITNYVIELRD KTSIRWDTAM TVRAEDLSAT VTDVVEGQEY
15060 15070 15080 15090 15100
SFRVRAQNRI GVGKPSAATP FVKVADPIER PSPPVNLNAS EQTQSSVQLT
15110 15120 15130 15140 15150
WEPPLKDGGS PILGYIIERR EEGKDNWIRC NMKPVPELTY KVTGLQKGNK
15160 15170 15180 15190 15200
YLYRVSAENA AGVSDPSEIL GPLTADDAFV EPTMDLSAFK DGLEVIVPNP
15210 15220 15230 15240 15250
IKILVPSTGY PRPKATWTFG DQVLEEGDRV KMKTISAYAE LVISPSERTD
15260 15270 15280 15290 15300
KGIYTLTLEN PVKSISGEIN VNVIAPPSAP KELKFSDITK DSVHLTWEPP
15310 15320 15330 15340 15350
DDDGGSPLTG YVVEKRDMSR KTWTKVMDFV TDLEFTVPDL VQGKEYLFKV
15360 15370 15380 15390 15400
CARNKCGPGE PAYTDEPVNM SAPATVPDPP ENVKWRDRTA NSIFLTWDPP
15410 15420 15430 15440 15450
KNDGGSRIKG YIVEKCPRGS DKWVACGEPV PDTKMEVTGL EEGKWYAYRV
15460 15470 15480 15490 15500
KALNRQGASK PSKPTEEIQA VDTQEAPEIF LDVKLLAGIT VKAGTKIELP
15510 15520 15530 15540 15550
ATVTGKPEPK ITWTKADTLL KPDQRITIEN VPKKSTVTIT DSKRSDTGTY
15560 15570 15580 15590 15600
IIEAVNVCGR ATAVVEVNVL DKPGPPAAFD ITDVTNESCL LTWNPPRDDG
15610 15620 15630 15640 15650
GSKITNYVVE RKATDSDVWH KLSSTVKDTN FKATKLTPNK EYIFRVAAEN
15660 15670 15680 15690 15700
MYGVGEPVQA APIIAKYQFD PPGPPTRLEP SDITKDAVTL TWCEPDDDGG
15710 15720 15730 15740 15750
SPITGYWVER LDPDTDKWVR CNKMPVKDTT YRVKGLTNKK KYRFRVLAEN
15760 15770 15780 15790 15800
LAGPGKPSRS TEPILIKDPI DPPWPPGKPT VKDIGKTSLV LNWTKPEHDG
15810 15820 15830 15840 15850
GAKIESYVIE MLKTGTDEWV RVAEGVPTTE HLLTGLMEGQ EYSFRVRAVN
15860 15870 15880 15890 15900
KAGESEPSEP SDPVLCREKL YPPSPPRWLE VINITKNTAD LKWTVPEKDG
15910 15920 15930 15940 15950
GSPITNYIVE KRDVRRKGWQ TVDTTVKDTK CTVTPLTEGS LYVFRVAAEN
15960 15970 15980 15990 16000
AIGQSDYTEI GDSVLAKDTF TTPGPPYALT VVDVTKRHVD LKWEPPKNDG
16010 16020 16030 16040 16050
GRPIQRYIIE KKEKLGTRWV KAGKTSGPDC NFRVTDVIEG TEVQFQVRAE
16060 16070 16080 16090 16100
NEAGVGHPSE PTEILSIEDP TSPPSPPLDL HVTDAGRKHI AIAWKPPEKN
16110 16120 16130 16140 16150
GGSPIIGYHV EMCPVGTEKW MRVNSRPIKD LKFKVEEGIV PDKEYVLRVR
16160 16170 16180 16190 16200
AVNAVGVSEP SEISENVVAK DPDCKPTIDL ETHDIVVIEG EKLNIPVPFR
16210 16220 16230 16240 16250
AVPVPTVSWH KDGKEVKASD RLTMKNDHIS AHLEVPKSVH ADAGVYTITL
16260 16270 16280 16290 16300
ENKLGSATAS INVKVIGLPG PCKDIKASDI TKSSCKLTWE PPEFDGGSPI
16310 16320 16330 16340 16350
LHYVLERREA GRRTYIPVMS GENKLSWTVK DLIPNGEYFF RVKAVNKIGG
16360 16370 16380 16390 16400
GEYIELKNPV IAQDPKQPPD PPVDVEVHNP TAKAMTITWK PPLYDGGSKI
16410 16420 16430 16440 16450
MGYIIEKITK GEDRWKRCNE HLVPVLTYTA KGLEEGKEYQ FRVRAENAAG
16460 16470 16480 16490 16500
IGEPSRATPP TKAVDPIDAP KVILRTSLEV KRGDEIALDA TISGSPYPTI
16510 16520 16530 16540 16550
TWIKDENVIV PEEIKKRAAP PVRRKKGEAE EEEPFSLPLT ERLSINNSKQ
16560 16570 16580 16590 16600
GESQLRIRDS LRPDHGQYMI KVENDHGVAK APCSVSVLDT PGPPINFVFE
16610 16620 16630 16640 16650
DIRKDSVLCK WEPPLDDGGS EIINYTLEKK DKTKPDSDWI VITSTLRNCK
16660 16670 16680 16690 16700
YSVTKLIEGK EYLFRVRAEN RFGPGPPCVS KPLLAKDPFE PPDAPDKPIV
16710 16720 16730 16740 16750
EDVTSNSMLV KWNEPKDNGS PILGYWLEKR EVNSTHWSRV NKTLLSSLKT
16760 16770 16780 16790 16800
KVDGLLEGLT YVFRVCAENA AGPGKFSPPS DPKTARDPIS PPGPPVPRVA
16810 16820 16830 16840 16850
DTSSTTIELE WEPPAFNGGG EIMGYFVDKQ LVGTNEWSRC TEKMIKVRQF
16860 16870 16880 16890 16900
TVKEIREGAD YKLRVSAVNA AGEGPPGETE PVTVAEPQEP PTVELDVSVK
16910 16920 16930 16940 16950
GGIQIMAGKT LRIPAEVTGR PVPTKVWTIE EGELDKERVI IENVGTKSEL
16960 16970 16980 16990 17000
IIKNALRKDH GRYVITATNS CGSKFAAVRV EVFDVPGPVL DLKPVVTNRK
17010 17020 17030 17040 17050
MCLLNWSDPA DDGGSDITGF IIERKDAKMH TWRQPIETER SKCDITGLIE
17060 17070 17080 17090 17100
GQEYKFRVIA KNKFGCGPPV EIGPILAVDP LGPPTSPERL TYTERTKSTI
17110 17120 17130 17140 17150
TLDWKEPRSD GGSPIQGYII EKRRHDKPDF ERVNKRLCPT TSFLVENLDE
17160 17170 17180 17190 17200
HQMYEFRVKA VNDVGESEPS LPLNVVIQDD EVPPTIKLRL AVRGDTIKVK
17210 17220 17230 17240 17250
AGEPVNIPAD VTGLPMPKIE WSKNEKVIDK PTDTLNITKE EVSRSEAKTE
17260 17270 17280 17290 17300
LSIPKAARED KGTYTITASN RLGSVFRNVH VEVYDRPSPP RNLAVTDIKA
17310 17320 17330 17340 17350
ESCYLTWDAP LDNGGSEITH YIIDKRDASR KKSEWEEVTN TAVERRYGIW
17360 17370 17380 17390 17400
KLIPNGQYEF RVRAVNKYGI SDECKSDKVV IQDPYRLPGP PGKPKVLERT
17410 17420 17430 17440 17450
KGSMLVSWTP PLDNGGSPIT GYWLEKREEG GTYWSRVSRA PITKVGLKGV
17460 17470 17480 17490 17500
EFNVPRLIEG VKYQFRAMAI NAAGIGPPSE PSDPAVAGDP IYPPGPPSCP
17510 17520 17530 17540 17550
EVKDKTKSSI SLAWKPPAKD GGSPIKGYIV EMQEEGTTDW KPVNEPDKLL
17560