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Entry version 90 (29 Sep 2021)
Sequence version 2 (26 Feb 2008)
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Protein

Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

Gene

Itpripl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920588, Itpripl1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000074825

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 96ExtracellularSequence analysisAdd BLAST74
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 547CytoplasmicSequence analysisAdd BLAST430

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032056723 – 547Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1Add BLAST525

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A2ASA8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2ASA8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2ASA8

PRoteomics IDEntifications database

More...
PRIDEi
A2ASA8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
269076

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2ASA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000074825, Expressed in liver and 85 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2ASA8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2ASA8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000106016

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A2ASA8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili28 – 66Sequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ITPRIP family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RX8U, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00980000198551

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025485_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2ASA8

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLQLEDC

Database of Orthologous Groups

More...
OrthoDBi
1434451at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2ASA8

TreeFam database of animal gene trees

More...
TreeFami
TF332277

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024808, IP3R-int-like_1
IPR026250, ITPRIP_fam
IPR024810, Mab-21_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10656:SF40, PTHR10656:SF40, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03281, Mab-21, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02107, INOS145TPRIP

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01265, Mab-21, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2ASA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVISLMFLA VMYVVHHPLM VSDRMDLDTL ARSRQLEKRM SEEMRQLEME
60 70 80 90 100
FEERSRAAEQ KQKVENFWRG DTSSDQLVLG KKDMGWPFQA GGQDGGPLGW
110 120 130 140 150
ILGNLWNAGL FCLFLIFELL RQSMQHEPAF ESSSEEEEEE IRVVPVSSYT
160 170 180 190 200
RLSDFPSQEA LEAFYKHYIQ NAIRDLPCTC EFVESFVDDL IEACRVLSRR
210 220 230 240 250
EAHPQLEDCL GFGAAFEKWG TLHETQNFDV LVPIVPPQGT MFILEMRDPA
260 270 280 290 300
LGRRCGCVKV DSECMCKHEK LLGDVLCLVH HRDHSAMLSK CTSSIKAALC
310 320 330 340 350
TSSHLDVCKT VQWFRNMVSN AWALVAHKYD FKLTFPPSTT SCKLRLGYRS
360 370 380 390 400
GRSLSISLVL GVQREDTLVY LVSQAPEQEQ LTSVDWPESF AACEHLFLKL
410 420 430 440 450
VGRFAPENTC HLKCLQIVLS LQDHQILPPG ASRPILTSYH FKTALMHLLL
460 470 480 490 500
RLPLTDWQHS MLSLRLQDLL WFLGRGLQQR SLHHFLIGNT YLPLTIPIPK
510 520 530 540
AFRNAEPVNL FQHLVLNPVA HSQAVEEFHN LLAQVKTLPC SPVAGGL
Length:547
Mass (Da):62,217
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0BF812ECBA91CAA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ASB0A2ASB0_MOUSE
Inositol 1,4,5-trisphosphate recept...
Itpripl1
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL928590 Genomic DNA No translation available.
BC130218 mRNA Translation: AAI30219.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50701.1

NCBI Reference Sequences

More...
RefSeqi
NP_001156999.1, NM_001163527.1
NP_001157000.1, NM_001163528.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000110386; ENSMUSP00000106016; ENSMUSG00000074825
ENSMUST00000154021; ENSMUSP00000122289; ENSMUSG00000074825

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
73338

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:73338

UCSC genome browser

More...
UCSCi
uc008meu.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928590 Genomic DNA No translation available.
BC130218 mRNA Translation: AAI30219.1
CCDSiCCDS50701.1
RefSeqiNP_001156999.1, NM_001163527.1
NP_001157000.1, NM_001163528.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106016

PTM databases

PhosphoSitePlusiA2ASA8

Proteomic databases

EPDiA2ASA8
MaxQBiA2ASA8
PaxDbiA2ASA8
PRIDEiA2ASA8
ProteomicsDBi269076

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3069, 106 antibodies

Genome annotation databases

EnsembliENSMUST00000110386; ENSMUSP00000106016; ENSMUSG00000074825
ENSMUST00000154021; ENSMUSP00000122289; ENSMUSG00000074825
GeneIDi73338
KEGGimmu:73338
UCSCiuc008meu.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
150771
MGIiMGI:1920588, Itpripl1
VEuPathDBiHostDB:ENSMUSG00000074825

Phylogenomic databases

eggNOGiENOG502RX8U, Eukaryota
GeneTreeiENSGT00980000198551
HOGENOMiCLU_025485_2_0_1
InParanoidiA2ASA8
OMAiHLQLEDC
OrthoDBi1434451at2759
PhylomeDBiA2ASA8
TreeFamiTF332277

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
73338, 0 hits in 62 CRISPR screens

Protein Ontology

More...
PROi
PR:A2ASA8
RNActiA2ASA8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000074825, Expressed in liver and 85 other tissues
ExpressionAtlasiA2ASA8, baseline and differential
GenevisibleiA2ASA8, MM

Family and domain databases

InterProiView protein in InterPro
IPR024808, IP3R-int-like_1
IPR026250, ITPRIP_fam
IPR024810, Mab-21_dom
PANTHERiPTHR10656:SF40, PTHR10656:SF40, 1 hit
PfamiView protein in Pfam
PF03281, Mab-21, 1 hit
PRINTSiPR02107, INOS145TPRIP
SMARTiView protein in SMART
SM01265, Mab-21, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIPIL1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ASA8
Secondary accession number(s): A1L3P2, B7ZCY2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 29, 2021
This is version 90 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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