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Entry version 75 (13 Feb 2019)
Sequence version 3 (13 Jul 2010)
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Protein

Fibrous sheath-interacting protein 2

Gene

Fsip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in spermatogenesis.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibrous sheath-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fsip2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2664111 Fsip2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003532121 – 6995Fibrous sheath-interacting protein 2Add BLAST6995

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei430PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2ARZ3

PeptideAtlas

More...
PeptideAtlasi
A2ARZ3

PRoteomics IDEntifications database

More...
PRIDEi
A2ARZ3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2ARZ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2ARZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in testis.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected in testis of 16 day old mice.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000075249 Expressed in 3 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2ARZ3 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with AKAP4.1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000120314

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2ARZ3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili665 – 692Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISIK Eukaryota
ENOG4112BP1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00680000100018

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000170878

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107933

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2ARZ3

Identification of Orthologs from Complete Genome Data

More...
OMAi
QHLQPFV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2ARZ3

TreeFam database of animal gene trees

More...
TreeFami
TF342086

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038891 FSIP2
IPR031554 FSIP2_C

The PANTHER Classification System

More...
PANTHERi
PTHR21856 PTHR21856, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15783 FSIP2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2ARZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELYLSACSK TANVAANKAA SSTVAEDSQQ CVDGRHKTPI PGVGAAQLLD
60 70 80 90 100
LPLGVKLPMI PGTDTVYFTT NISEKLFRPS YGFNLSDPYC RLLETQYKSL
110 120 130 140 150
HDPHLRTYYK RKDILRRLKK GGYITSNNKI VCSLRELNKY RQYLTSLKLD
160 170 180 190 200
FERNYLREQQ LISKQLHKLQ ETSQLPHCSD VTRFQNWLLQ DNTHSIKDQE
210 220 230 240 250
RLLRHRYLDM ISKELEQLER TAEEQRLLRI DRDERRQREY TRKKLTLRRK
260 270 280 290 300
IEEEWKTKEM MLLTKIGEDV KREQKIEEQR RKSREESDRK KQAMLEKKMA
310 320 330 340 350
YHLQKMQDTG LKDDIGRNGF DYRGQNGTTF ESSSKKRKKQ FDDIKIVYPD
360 370 380 390 400
GDQKAYRGTS GQVSATVNQS QSSSKDVTKV SASSVTYPAE VQNSSSEQKR
410 420 430 440 450
SEVTKRLSDE RGKNSTDDSA RESIISTQLS PTRNAKLSQI SLDHQKEEKE
460 470 480 490 500
MKSTWNGGLS KKSSYAGEPG SPTDAPPQGI FSFPVNSNTQ QNLQHCLKDK
510 520 530 540 550
VTSEELNSII QNIMTWVVAT VTSILYPAIT KYEERVQNNT YPVTDDSDLS
560 570 580 590 600
SDSSSFCSTC SEGFTYRNYT AKTLPVDPCT FASDMPIKKP PTPLKPPSAH
610 620 630 640 650
VERTVIDQTY QRQGQSVPSQ VNYQKTSLDY QFPKIGSSKS DSHLLTSLET
660 670 680 690 700
CTKKSKDATT ETESLEISLL YDKKAKAMDQ IKNLKNVFVN FKCHLKGETQ
710 720 730 740 750
LILESIFQEI MSDLSQAIPS LSSVTAEVFV DQTETEREEL LSNVDICSVA
760 770 780 790 800
SEIVENMLEK LESAVEKRCV QMFSQEDLSV DIKPSLSTSG DYLSSVETKP
810 820 830 840 850
SEETLSYTLE PMCDVADDMV HAILEKLMIL ASYKKNDVPP EDTTKHFQQT
860 870 880 890 900
KTEPIHKVHQ QTEQKKASFA SDPANQIVKE EIQSLISSIF SQSSLVGYVE
910 920 930 940 950
EAISTILGYV QTELNNERLI ASEETVVLLQ LLDDVLTQLH QQPVKAGVKK
960 970 980 990 1000
PRRPRVRNLS DPEEKYRVTG TRPFNNLKSK RPFPPVNVPG MVLYSEDDDE
1010 1020 1030 1040 1050
EIDNFVQSVL DSSFNDEKSS SQEQVPNYWP KKRDTYFESK RSNKLPTKST
1060 1070 1080 1090 1100
FQNKVGSHDW GLKLELSLSS EDIVKTKHCL GQEPSIFSQD QKHQIQKASE
1110 1120 1130 1140 1150
NIVKHILTDM LKDMSSDSSS HLGSQTGKGA SAFISEKSQG LSDQEWMEQM
1160 1170 1180 1190 1200
FSVSEICAFA HEITDSVINI LHKASMHIPN TIKNAFTSVH PTHVAPFDTA
1210 1220 1230 1240 1250
HTSKETPSKM PFKVWFDSEK KMKYLSSLNM EHEKTSQLRS GKCEPKRVND
1260 1270 1280 1290 1300
ITDKITNTIF KRLKLFVCPK LQIGNKSSLI EKSLHSQLST YTMKIVNIIL
1310 1320 1330 1340 1350
HAIQSELEIN KTKPNLKETD HPKCHKNKGW FTDPNKVVES RVTSVNDDIM
1360 1370 1380 1390 1400
ESPLLTCICE MISSTNEDKK NTSTYTDKTL STSICESGNF HKQSILSNKQ
1410 1420 1430 1440 1450
DKNSFCQLLA KPCLQHSLAD EKDFKVSSKL EVLDQIGDTL HEMLGKLTGD
1460 1470 1480 1490 1500
HPDPQPSCSH QNTETIDKDP PTMSNTQLIS KAILENVLAK LCDVDIDTSI
1510 1520 1530 1540 1550
VNSGPKTVPE SLDIDNLSFA STMEEMAKCT NIISNIISKI MKDNKEVTKS
1560 1570 1580 1590 1600
KAKNDLPTSS KTEIPKEMCP QNLKNIASDI LNMVFAKLEH FASGSVVNVG
1610 1620 1630 1640 1650
NLNDENKKEH TVDWECESNS SPADSHDKSL QSTLYSHAKK VSNGILKAIQ
1660 1670 1680 1690 1700
TELNMNPPDC KTDKKRSPEE TQILTNIVDL ILDVVSSDMF AEPESENQSN
1710 1720 1730 1740 1750
ENYGYRPTYG NFLPGGAESD SFLDDDTQNK ELIRDATSFN EETRTLSTDQ
1760 1770 1780 1790 1800
MGLERTLSKI EVKLKEPHRS PIVPIIRNIL NEIFQSALIN QLNVFSLSRA
1810 1820 1830 1840 1850
HFSGMPQNAP TSSTQTSAHF MDQMMGPLVS DTDVSIVVND VVRTVFHKLY
1860 1870 1880 1890 1900
SAAMTERHVS ENRGKTIILS ANVSFRECTY GGNAPVSGLN ENVCDLQSSW
1910 1920 1930 1940 1950
NVDKQIKINV VEDIVQAILG NLETFAASKV ESLFCPQVKF TVPVTLPVMQ
1960 1970 1980 1990 2000
EEGSLSQALS GKDSYSDNQL PCLVDHGNPE QMDSWYQMSL SKLNIYAKDV
2010 2020 2030 2040 2050
ARKILQGIKH ELDKEQESPL LTNNIVVSEN IASQVVNKVL DIVSCKSKCD
2060 2070 2080 2090 2100
KKSSDKDHYS EQQVGIIEQL VNKREYRKIL EFQIQDTIEG ILCDIYENIL
2110 2120 2130 2140 2150
YQNNLSFATP TLKYGIPAKH SEANFEQVVM GTNIIPKVSV PKADVILVSK
2160 2170 2180 2190 2200
DIVDIVLHNL TSLVVLAINA KDSAPARVAI YDIFPKPQFQ QPLSITQRTE
2210 2220 2230 2240 2250
ETPGHFSHSK NKNLGSPDVY QVPVNGKEDT KELAPDPCKE NANRITQPIF
2260 2270 2280 2290 2300
NRLQSFATER INSLMTPAFQ SKGNVFVSPQ FEIGKDDNCI FHEPGQAESD
2310 2320 2330 2340 2350
VDVLKLTTRT VTSQELVEPI FTSCRENFGT TPHLSQTNLK DYAAFIASTI
2360 2370 2380 2390 2400
LKLIKNDLDL EVQSMHTYSS HILFQKNMIV SEIVNNILKI LPNKEPIKEF
2410 2420 2430 2440 2450
FLSSPENSSC SQLTISSEDL VGYKEKEKAT ALPQFTNDSL EENQVTVEKE
2460 2470 2480 2490 2500
SQRDVLEEIF MRKGESKPRE KTEILRTVEE VLKKLSQKIM EIIGHVAPFN
2510 2520 2530 2540 2550
ESPHTVSKSK SKTAAATQKK FFQSRINNVS NDILENVLSE MHSVVVTSLY
2560 2570 2580 2590 2600
RNNKSKREGE MHDSSDSSSV KPSGSRETKP TRKRSSPLRL GVPQMHPHAD
2610 2620 2630 2640 2650
NLNALVLENT ILPYSPLQIG KYLVQIVLEN LSNFVSLHLE EGYPPEGSYD
2660 2670 2680 2690 2700
DLYLLRLHNA KLSPKNSPRP GGKASLKMRS KINSLSKFKT KPHLGISSTK
2710 2720 2730 2740 2750
TKIKNKLSAG EKTPRESRSK TALGLPQTPQ VEDTKTTLKT KLPVAELRLY
2760 2770 2780 2790 2800
ATNIITDILQ VILSSLERAA QHRAMFNTKV LASSQILEAS KIVNAVLQEL
2810 2820 2830 2840 2850
YATNNDNLAS PINISSLSDR RLSKQNLGAG YPTEQPCFYL ENVSSQLEQI
2860 2870 2880 2890 2900
FPKEGILKKM FDKWQTETSD TETEKSKLLT IAENILTEIS IKAKDLEYSL
2910 2920 2930 2940 2950
SLLNLPPLEE CENRLYDRFK GVSTRAEDTN AQINMFGREI VEMLFEKLQL
2960 2970 2980 2990 3000
CFLSQMPTQD SNGILTSRKE HGTSKSKHGV PTKPILGGIQ TYNSKMADQV
3010 3020 3030 3040 3050
SMSPSNQIVH EIVERVLHML ESFVDLKFKH ISKYEFSEIV KMPIDNLFQA
3060 3070 3080 3090 3100
QQRQLSKKML PKLPFRKFGD ESKPGTIISK DDGQNTLLQV HLFHSELLTY
3110 3120 3130 3140 3150
SVTAVSGMLR IIKNKLDKEI SQMEPSPVSI LKENITASEI IGTLIDQCSH
3160 3170 3180 3190 3200
FEESLIKNLP TKHWFQGTEN VYIVNQVEFA TPVKMPPSNT SDTPRTRRSS
3210 3220 3230 3240 3250
QGSVSGMGFS SEDDMKEKYS VTSNSSSHIS SCVENTNKSL EPMGRSNSEA
3260 3270 3280 3290 3300
MPSGSRHKAH DHGQRKPNFT PFEQVTKTHN FLPQGSVLQK LFKKVNDSTE
3310 3320 3330 3340 3350
ESLKQVLSFI ETGKRENPRV FHYETTKSAE PNEIKTTAPP LKICLAAENI
3360 3370 3380 3390 3400
VNTVLSSYGF PHQPNTNEST ETMKPFFMSR QIPLSEVCEG QKDTEKTLLK
3410 3420 3430 3440 3450
TWYSRKALIQ EEESEGLEAC QEDFSLLHKW KNKKPQMTTE TVEETKTIVF
3460 3470 3480 3490 3500
ADHELGPNEM HLVARHVTTS VITHLKNFKT GVSTEKFSHV SSLSKKIDDA
3510 3520 3530 3540 3550
NQPLISIYSN SSVCQFCEHL SDAVICYLFL NISDGIKKCS REKAWEIQDA
3560 3570 3580 3590 3600
IIDKNVIIHS QLYKTRSISI GDLALSIFEV IVEVLANRNM INADKAHQAS
3610 3620 3630 3640 3650
IKAKYMFCPG VTSSDFDDIF QDLLKEVIFV LSKILGINHF ENNVRNKSYP
3660 3670 3680 3690 3700
TLKNNLPVFN KVNTIENQIG PRKLESSPPL TDQLAQKNKL NYLARRLNSL
3710 3720 3730 3740 3750
VGSLRSRESK EVVNEVFNIV LDLFLPDEIP DGDLSSGKLA KTFSSSNNQP
3760 3770 3780 3790 3800
SNRSLANNVG LSPKSIFLLN IVCEKLIRTL LEKCMGGTPF FEDSSLFREI
3810 3820 3830 3840 3850
PEECQHVKVL PSVQGGGFDY REAPMDCEQF QGDYMSELLE NLADVDQDLL
3860 3870 3880 3890 3900
SSDCILNVIS HSLVKSLMDK LSHGLQQAPF ENKYRNYRTR EMQPFITKAK
3910 3920 3930 3940 3950
RQELIEPEET KGHVGFMSYD NNFLTKSLNN TNANSFKKHT QFGKKHAGKS
3960 3970 3980 3990 4000
ISLSFSDGKE SRGINTACFH KLCQRGVNGG VFSATFLEEI ISELFYNLST
4010 4020 4030 4040 4050
SLWKKNPNIT EAWLNEINTL LINNVVKKLN DAEITVLRYP EERLYFPSAH
4060 4070 4080 4090 4100
KGCIAKIVDS IYYDVLQQYE FTVTCGGNLP YDNTPVAKRI SNSILLEVID
4110 4120 4130 4140 4150
YQLPSCFKGK LRSNLYHTLN AEIILYKLHN SLKNFNSEPM TSKDYSTMLP
4160 4170 4180 4190 4200
HSFLEYVIRR VLAQLISLPI KSSSLEKKYL ASSDFNEMSN CITNKVMSAI
4210 4220 4230 4240 4250
SKHKIWLTIY DNQCLYTDKN LQKMVDSVYS NILQMSSSVD SIQKNIISRS
4260 4270 4280 4290 4300
PIMIDQIASF IIQEIIENHL QPFLCGERLP RPKTPLDEVS YMVKQVLSDV
4310 4320 4330 4340 4350
VESHKSQKPS PFGIYPDKLV GETVTRVLSK IFSPNTNINV ELENVTQKIV
4360 4370 4380 4390 4400
SSVHKHLDKA KIPILCHKQP PFPFSNTDIV DELVTSVYKN VLKQHGLDPD
4410 4420 4430 4440 4450
IDESVNGEVF VENITKLITA AISDYLLHPL FSGDLPAASC SNSVTDHTVY
4460 4470 4480 4490 4500
DILGDINKSS KPNQTLPLYN TLLPYTFLED MIRVLLSKFF PSAPKIDSYK
4510 4520 4530 4540 4550
AASKDKEGVN FNEIASNLIS DIRRKISQHE IRFSKDEDKT KSFYSENDVQ
4560 4570 4580 4590 4600
HLVDAVFMNI LENYGSPESV EQNITKSNDV FIDQIAGFII KYICEHHLQP
4610 4620 4630 4640 4650
FLERKQLSTS SYKYSDDDRQ DLLYGSAYSS TFLEDVVSGV VSKIFHRVIG
4660 4670 4680 4690 4700
IVQVNSTINS ENILFDKAEN LIYWITEEFS KAQVTTIENA EERLSLSPVE
4710 4720 4730 4740 4750
GNILQKIIDT VYSKILEEHE MEIMPNKDFL NDTKALASQI TEIILSEISY
4760 4770 4780 4790 4800
FQIPPDLVAN LPLRLHSKLS QNVLVNKVHY DISKSRFRRQ ASTMYTTMLS
4810 4820 4830 4840 4850
HVHLEKIVTQ LMSQINPSDS SVGHSDTYQS ELSNTVVKLI NEIMSIISKH
4860 4870 4880 4890 4900
AICIVKHGNE KQSMISEKEM QSMVDSIYAD LSHSNLYQSL TKDKKGLSSI
4910 4920 4930 4940 4950
PVSKIANFII KEIFNHHLES FLSGDKSILS ASVAQTCKKK ATTSTKQREL
4960 4970 4980 4990 5000
SFIVNSAVFL EEVITELLCK ILQTFIQNSL SMETPERAIA EIMDIVTTLV
5010 5020 5030 5040 5050
KSIVFEFTSS EILVAEHLDE SLWFSETYKE MVQKTVNSVY GNIFYEYKSL
5060 5070 5080 5090 5100
TQLHRAVQYD TSGFGGKMYH FLLEEMYDYQ VQSLVSGELM PSCYASPQSA
5110 5120 5130 5140 5150
NIIKNVLNVI LKDTNALPSC ITVLPCSLIE NMIYKLLENI FPSDDTTNEL
5160 5170 5180 5190 5200
KKEEKEEAGP DDVDEFMAAA SKLTDEIIQE ISEHEIRFAN AEDTASMIYE
5210 5220 5230 5240 5250
TTENFIDSVC NNILKNSEFQ AEVQKDAHKK GGSFLSKIAG SIIKEIMDHY
5260 5270 5280 5290 5300
LQLFLYGEGS HSSKLPHFGG ASVVAKSGKE KAPSSLFSAA FLEDVIVDLA
5310 5320 5330 5340 5350
HKFCSFLTLT DDARKKDLPE AEIVSLAIKF ANSLIRDFRK SGIKVLPHAE
5360 5370 5380 5390 5400
EIFSFPPIAK ETIDEISNFV YDQFIGKLGA DGIQKDGTGN MVIEMVSSLA
5410 5420 5430 5440 5450
QKAISTFKIQ PLFSGDWCST FFSFLDAENI SQRVQLLPKE TSMQISGALK
5460 5470 5480 5490 5500
QNQLALSKIT SIKKDDTQDP ILNSIATIMK SNIINLLSGP SAGVTDAKKE
5510 5520 5530 5540 5550
DESKVKPATR ETTSPPTSPP ATMKSQGSQV QQLATSPPTS MKSQRIQVQQ
5560 5570 5580 5590 5600
SVMSPPTTMK GKGAQVQQFA TSPPTSMKSQ GSQVQQSAMS PPTTMKSRGA
5610 5620 5630 5640 5650
QVQESVTSPF TTKESRGAQV QQSAMSPPPS MKDRGAQVQE SSTSPPTTMK
5660 5670 5680 5690 5700
SRGAQVQHLS SKYKGNETGK ENLVLVNEQG QILEIFTHFA VAKTVENSPE
5710 5720 5730 5740 5750
KEVFISDLKI QNEKKLDVSK SSVKTDDRPM SKDKETMTEK TVLIPQQPVK
5760 5770 5780 5790 5800
EERKQSVVKT DTEEEQYSEN ECVENVIENI YDNVFIVSSQ EPLDFSRPIY
5810 5820 5830 5840 5850
SRSLTSDKAL VILKDSAQLV PAKDLSSSGH RDIAAKEKAS KETETKIRRD
5860 5870 5880 5890 5900
RSETKRSKEM KSKSSMTDHP KPSESKSKIV PAKFLEDVIA ELVNKLVFTF
5910 5920 5930 5940 5950
ISDKTTDTNE QKPGELYDTA MRLVNSMTKE LSDAEIKVFR PEKEDEVQAA
5960 5970 5980 5990 6000
KEPAPTSPPE VKETVTKEPS PSTNIKNEDQ MSDVQKTPEQ SSPDKLPALE
6010 6020 6030 6040 6050
KIPSIEKSIV NKIVHSCVCN IFKECKSQES ICENINSNGE NLAKRLTSTV
6060 6070 6080 6090 6100
INEIFQHQLN LIFSDEVPAS ACVPLESKDV EQKVQNVVQT VSKECQTASP
6110 6120 6130 6140 6150
YTVQLPYKFL EDVTSGLLAK VFSKLSNVKT KLTPENVLTQ LDFLQSNLVK
6160 6170 6180 6190 6200
TIAAEISKNE DLIIQYVESL HPNDDEVIQL VVQTIYNNLL PQFGSQEILQ
6210 6220 6230 6240 6250
KCIISGCKLL SKTIVDLVLR EVTGNQLQNY FGGELTPIQC AEVDNVVENI
6260 6270 6280 6290 6300
LTNVVLTTPS QPSGPRKLSY NIIETIAVKF LSKLLSVFPK GHPERTKSQE
6310 6320 6330 6340 6350
TEMRKITSKI LHSIQEFISK SKIKVVQPVK ESEAVPSADK AAIEKVVNSV
6360 6370 6380 6390 6400
YTNLLKHCGS PTSAFEDLMR KSDVISDIIG FSMVKEISNS EFQPQAEEEL
6410 6420 6430 6440 6450
SSSELALEAV KIMEKVVKII DELKSQEKPA SITDVMLDSR VLEEALALFL
6460 6470 6480 6490 6500
AKLVKTPGPA SKDTTSLTKP ELNKIASQLT KSVTAEISKS NISLVESNHE
6510 6520 6530 6540 6550
EQSLDPENIE VISQVVESVY SNVVKQSGTE NELSDIKGTK KAFPKKVASL
6560 6570 6580 6590 6600
IVDGVSSVPS CRVITESSYT AAHGDLDTNR IIEKAQKHAA LMSSDSDKDS
6610 6620 6630 6640 6650
KKELEDEFPV RIVPHVRNKP LRIDPNIVSD HLAVISMKTQ PLETLQMDCL
6660 6670 6680 6690 6700
KRTGCSIAEL RRNSIRGIGP SSTDVSEMGT RQKERRISLD RTGRLDVKPL
6710 6720 6730 6740 6750
EAVGRNSFQN VRRPDITRVE LLKDINNKTD LIIRLVAHDI GRKESDSSLS
6760 6770 6780 6790 6800
EGMVSDEEEV VLGEVVGDQC LRKISGGRVQ QVKKSAESHV VSSKTATSTS
6810 6820 6830 6840 6850
NLKRFLALSK CCQPTSGENI ESIEESGIQI MDPNKAYVKR AAAELDMPSC
6860 6870 6880 6890 6900
KSLAEETTSR DKLQYKEEEI LASEPTHYFI HRIMSTSSYN QEDLISGEAE
6910 6920 6930 6940 6950
EFLPDAKANA LEESCQEPQE GNSNSLEFVT IYKGSKHIAG SARLSKEHVS
6960 6970 6980 6990
EMPRSSISKQ GSRVLAKVSS TLSKVFSRSS GSIPKSSSPP HQDKR
Length:6,995
Mass (Da):784,857
Last modified:July 13, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC847718F818E457
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZQI5F6ZQI5_MOUSE
Fibrous sheath-interacting protein ...
Fsip2
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BGZ6F7BGZ6_MOUSE
Fibrous sheath-interacting protein ...
Fsip2
1,009Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAM17862 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM17864 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL845500 Genomic DNA Translation: CAM17864.1 Sequence problems.
AL845500 Genomic DNA Translation: CAM17862.3 Sequence problems.

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.302516
Mm.491762

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000143764; ENSMUSP00000120314; ENSMUSG00000075249

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845500 Genomic DNA Translation: CAM17864.1 Sequence problems.
AL845500 Genomic DNA Translation: CAM17862.3 Sequence problems.
UniGeneiMm.302516
Mm.491762

3D structure databases

SMRiA2ARZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120314

PTM databases

iPTMnetiA2ARZ3
PhosphoSitePlusiA2ARZ3

Proteomic databases

PaxDbiA2ARZ3
PeptideAtlasiA2ARZ3
PRIDEiA2ARZ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000143764; ENSMUSP00000120314; ENSMUSG00000075249

Organism-specific databases

MGIiMGI:2664111 Fsip2

Phylogenomic databases

eggNOGiENOG410ISIK Eukaryota
ENOG4112BP1 LUCA
GeneTreeiENSGT00680000100018
HOGENOMiHOG000170878
HOVERGENiHBG107933
InParanoidiA2ARZ3
OMAiQHLQPFV
PhylomeDBiA2ARZ3
TreeFamiTF342086

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A2ARZ3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000075249 Expressed in 3 organ(s), highest expression level in testis
ExpressionAtlasiA2ARZ3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR038891 FSIP2
IPR031554 FSIP2_C
PANTHERiPTHR21856 PTHR21856, 1 hit
PfamiView protein in Pfam
PF15783 FSIP2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFSIP2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ARZ3
Secondary accession number(s): A2ARZ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: July 13, 2010
Last modified: February 13, 2019
This is version 75 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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