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UniProtKB - A2ARZ3 (FSIP2_MOUSE)

Entry version 75 (13 Feb 2019)
Sequence version 3 (13 Jul 2010)
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Protein

Fibrous sheath-interacting protein 2

Gene

Fsip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in spermatogenesis.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibrous sheath-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fsip2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2664111 Fsip2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003532121 – 6995Fibrous sheath-interacting protein 2Add BLAST6995

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei430PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2ARZ3

PeptideAtlas

More...PeptideAtlasi		A2ARZ3

PRoteomics IDEntifications database

More...PRIDEi		A2ARZ3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A2ARZ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A2ARZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in testis.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected in testis of 16 day old mice.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000075249 Expressed in 3 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2ARZ3 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with AKAP4.1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000120314

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A2ARZ3

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili665 – 692Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410ISIK Eukaryota
ENOG4112BP1 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00680000100018

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000170878

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG107933

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2ARZ3

Identification of Orthologs from Complete Genome Data

More...OMAi		QHLQPFV

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2ARZ3

TreeFam database of animal gene trees

More...TreeFami		TF342086

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038891 FSIP2
IPR031554 FSIP2_C

The PANTHER Classification System

More...PANTHERi		PTHR21856 PTHR21856, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15783 FSIP2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2ARZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELYLSACSK TANVAANKAA SSTVAEDSQQ CVDGRHKTPI PGVGAAQLLD 
        60         70         80         90        100
LPLGVKLPMI PGTDTVYFTT NISEKLFRPS YGFNLSDPYC RLLETQYKSL 
       110        120        130        140        150
HDPHLRTYYK RKDILRRLKK GGYITSNNKI VCSLRELNKY RQYLTSLKLD 
       160        170        180        190        200
FERNYLREQQ LISKQLHKLQ ETSQLPHCSD VTRFQNWLLQ DNTHSIKDQE 
       210        220        230        240        250
RLLRHRYLDM ISKELEQLER TAEEQRLLRI DRDERRQREY TRKKLTLRRK 
       260        270        280        290        300
IEEEWKTKEM MLLTKIGEDV KREQKIEEQR RKSREESDRK KQAMLEKKMA 
       310        320        330        340        350
YHLQKMQDTG LKDDIGRNGF DYRGQNGTTF ESSSKKRKKQ FDDIKIVYPD 
       360        370        380        390        400
GDQKAYRGTS GQVSATVNQS QSSSKDVTKV SASSVTYPAE VQNSSSEQKR 
       410        420        430        440        450
SEVTKRLSDE RGKNSTDDSA RESIISTQLS PTRNAKLSQI SLDHQKEEKE 
       460        470        480        490        500
MKSTWNGGLS KKSSYAGEPG SPTDAPPQGI FSFPVNSNTQ QNLQHCLKDK 
       510        520        530        540        550
VTSEELNSII QNIMTWVVAT VTSILYPAIT KYEERVQNNT YPVTDDSDLS 
       560        570        580        590        600
SDSSSFCSTC SEGFTYRNYT AKTLPVDPCT FASDMPIKKP PTPLKPPSAH 
       610        620        630        640        650
VERTVIDQTY QRQGQSVPSQ VNYQKTSLDY QFPKIGSSKS DSHLLTSLET 
       660        670        680        690        700
CTKKSKDATT ETESLEISLL YDKKAKAMDQ IKNLKNVFVN FKCHLKGETQ 
       710        720        730        740        750
LILESIFQEI MSDLSQAIPS LSSVTAEVFV DQTETEREEL LSNVDICSVA 
       760        770        780        790        800
SEIVENMLEK LESAVEKRCV QMFSQEDLSV DIKPSLSTSG DYLSSVETKP 
       810        820        830        840        850
SEETLSYTLE PMCDVADDMV HAILEKLMIL ASYKKNDVPP EDTTKHFQQT 
       860        870        880        890        900
KTEPIHKVHQ QTEQKKASFA SDPANQIVKE EIQSLISSIF SQSSLVGYVE 
       910        920        930        940        950
EAISTILGYV QTELNNERLI ASEETVVLLQ LLDDVLTQLH QQPVKAGVKK 
       960        970        980        990       1000
PRRPRVRNLS DPEEKYRVTG TRPFNNLKSK RPFPPVNVPG MVLYSEDDDE 
      1010       1020       1030       1040       1050
EIDNFVQSVL DSSFNDEKSS SQEQVPNYWP KKRDTYFESK RSNKLPTKST 
      1060       1070       1080       1090       1100
FQNKVGSHDW GLKLELSLSS EDIVKTKHCL GQEPSIFSQD QKHQIQKASE 
      1110       1120       1130       1140       1150
NIVKHILTDM LKDMSSDSSS HLGSQTGKGA SAFISEKSQG LSDQEWMEQM 
      1160       1170       1180       1190       1200
FSVSEICAFA HEITDSVINI LHKASMHIPN TIKNAFTSVH PTHVAPFDTA 
      1210       1220       1230       1240       1250
HTSKETPSKM PFKVWFDSEK KMKYLSSLNM EHEKTSQLRS GKCEPKRVND 
      1260       1270       1280       1290       1300
ITDKITNTIF KRLKLFVCPK LQIGNKSSLI EKSLHSQLST YTMKIVNIIL 
      1310       1320       1330       1340       1350
HAIQSELEIN KTKPNLKETD HPKCHKNKGW FTDPNKVVES RVTSVNDDIM 
      1360       1370       1380       1390       1400
ESPLLTCICE MISSTNEDKK NTSTYTDKTL STSICESGNF HKQSILSNKQ 
      1410       1420       1430       1440       1450
DKNSFCQLLA KPCLQHSLAD EKDFKVSSKL EVLDQIGDTL HEMLGKLTGD 
      1460       1470       1480       1490       1500
HPDPQPSCSH QNTETIDKDP PTMSNTQLIS KAILENVLAK LCDVDIDTSI 
      1510       1520       1530       1540       1550
VNSGPKTVPE SLDIDNLSFA STMEEMAKCT NIISNIISKI MKDNKEVTKS 
      1560       1570       1580       1590       1600
KAKNDLPTSS KTEIPKEMCP QNLKNIASDI LNMVFAKLEH FASGSVVNVG 
      1610       1620       1630       1640       1650
NLNDENKKEH TVDWECESNS SPADSHDKSL QSTLYSHAKK VSNGILKAIQ 
      1660       1670       1680       1690       1700
TELNMNPPDC KTDKKRSPEE TQILTNIVDL ILDVVSSDMF AEPESENQSN 
      1710       1720       1730       1740       1750
ENYGYRPTYG NFLPGGAESD SFLDDDTQNK ELIRDATSFN EETRTLSTDQ 
      1760       1770       1780       1790       1800
MGLERTLSKI EVKLKEPHRS PIVPIIRNIL NEIFQSALIN QLNVFSLSRA 
      1810       1820       1830       1840       1850
HFSGMPQNAP TSSTQTSAHF MDQMMGPLVS DTDVSIVVND VVRTVFHKLY 
      1860       1870       1880       1890       1900
SAAMTERHVS ENRGKTIILS ANVSFRECTY GGNAPVSGLN ENVCDLQSSW 
      1910       1920       1930       1940       1950
NVDKQIKINV VEDIVQAILG NLETFAASKV ESLFCPQVKF TVPVTLPVMQ 
      1960       1970       1980       1990       2000
EEGSLSQALS GKDSYSDNQL PCLVDHGNPE QMDSWYQMSL SKLNIYAKDV 
      2010       2020       2030       2040       2050
ARKILQGIKH ELDKEQESPL LTNNIVVSEN IASQVVNKVL DIVSCKSKCD 
      2060       2070       2080       2090       2100
KKSSDKDHYS EQQVGIIEQL VNKREYRKIL EFQIQDTIEG ILCDIYENIL 
      2110       2120       2130       2140       2150
YQNNLSFATP TLKYGIPAKH SEANFEQVVM GTNIIPKVSV PKADVILVSK 
      2160       2170       2180       2190       2200
DIVDIVLHNL TSLVVLAINA KDSAPARVAI YDIFPKPQFQ QPLSITQRTE 
      2210       2220       2230       2240       2250
ETPGHFSHSK NKNLGSPDVY QVPVNGKEDT KELAPDPCKE NANRITQPIF 
      2260       2270       2280       2290       2300
NRLQSFATER INSLMTPAFQ SKGNVFVSPQ FEIGKDDNCI FHEPGQAESD 
      2310       2320       2330       2340       2350
VDVLKLTTRT VTSQELVEPI FTSCRENFGT TPHLSQTNLK DYAAFIASTI 
      2360       2370       2380       2390       2400
LKLIKNDLDL EVQSMHTYSS HILFQKNMIV SEIVNNILKI LPNKEPIKEF 
      2410       2420       2430       2440       2450
FLSSPENSSC SQLTISSEDL VGYKEKEKAT ALPQFTNDSL EENQVTVEKE 
      2460       2470       2480       2490       2500
SQRDVLEEIF MRKGESKPRE KTEILRTVEE VLKKLSQKIM EIIGHVAPFN 
      2510       2520       2530       2540       2550
ESPHTVSKSK SKTAAATQKK FFQSRINNVS NDILENVLSE MHSVVVTSLY 
      2560       2570       2580       2590       2600
RNNKSKREGE MHDSSDSSSV KPSGSRETKP TRKRSSPLRL GVPQMHPHAD 
      2610       2620       2630       2640       2650
NLNALVLENT ILPYSPLQIG KYLVQIVLEN LSNFVSLHLE EGYPPEGSYD 
      2660       2670       2680       2690       2700
DLYLLRLHNA KLSPKNSPRP GGKASLKMRS KINSLSKFKT KPHLGISSTK 
      2710       2720       2730       2740       2750
TKIKNKLSAG EKTPRESRSK TALGLPQTPQ VEDTKTTLKT KLPVAELRLY 
      2760       2770       2780       2790       2800
ATNIITDILQ VILSSLERAA QHRAMFNTKV LASSQILEAS KIVNAVLQEL 
      2810       2820       2830       2840       2850
YATNNDNLAS PINISSLSDR RLSKQNLGAG YPTEQPCFYL ENVSSQLEQI 
      2860       2870       2880       2890       2900
FPKEGILKKM FDKWQTETSD TETEKSKLLT IAENILTEIS IKAKDLEYSL 
      2910       2920       2930       2940       2950
SLLNLPPLEE CENRLYDRFK GVSTRAEDTN AQINMFGREI VEMLFEKLQL 
      2960       2970       2980       2990       3000
CFLSQMPTQD SNGILTSRKE HGTSKSKHGV PTKPILGGIQ TYNSKMADQV 
      3010       3020       3030       3040       3050
SMSPSNQIVH EIVERVLHML ESFVDLKFKH ISKYEFSEIV KMPIDNLFQA 
      3060       3070       3080       3090       3100
QQRQLSKKML PKLPFRKFGD ESKPGTIISK DDGQNTLLQV HLFHSELLTY 
      3110       3120       3130       3140       3150
SVTAVSGMLR IIKNKLDKEI SQMEPSPVSI LKENITASEI IGTLIDQCSH 
      3160       3170       3180       3190       3200
FEESLIKNLP TKHWFQGTEN VYIVNQVEFA TPVKMPPSNT SDTPRTRRSS 
      3210       3220       3230       3240       3250
QGSVSGMGFS SEDDMKEKYS VTSNSSSHIS SCVENTNKSL EPMGRSNSEA 
      3260       3270       3280       3290       3300
MPSGSRHKAH DHGQRKPNFT PFEQVTKTHN FLPQGSVLQK LFKKVNDSTE 
      3310       3320       3330       3340       3350
ESLKQVLSFI ETGKRENPRV FHYETTKSAE PNEIKTTAPP LKICLAAENI 
      3360       3370       3380       3390       3400
VNTVLSSYGF PHQPNTNEST ETMKPFFMSR QIPLSEVCEG QKDTEKTLLK 
      3410       3420       3430       3440       3450
TWYSRKALIQ EEESEGLEAC QEDFSLLHKW KNKKPQMTTE TVEETKTIVF 
      3460       3470       3480       3490       3500
ADHELGPNEM HLVARHVTTS VITHLKNFKT GVSTEKFSHV SSLSKKIDDA 
      3510       3520       3530       3540       3550
NQPLISIYSN SSVCQFCEHL SDAVICYLFL NISDGIKKCS REKAWEIQDA 
      3560       3570       3580       3590       3600
IIDKNVIIHS QLYKTRSISI GDLALSIFEV IVEVLANRNM INADKAHQAS 
      3610       3620       3630       3640       3650
IKAKYMFCPG VTSSDFDDIF QDLLKEVIFV LSKILGINHF ENNVRNKSYP 
      3660       3670       3680       3690       3700
TLKNNLPVFN KVNTIENQIG PRKLESSPPL TDQLAQKNKL NYLARRLNSL 
      3710       3720       3730       3740       3750
VGSLRSRESK EVVNEVFNIV LDLFLPDEIP DGDLSSGKLA KTFSSSNNQP 
      3760       3770       3780       3790       3800
SNRSLANNVG LSPKSIFLLN IVCEKLIRTL LEKCMGGTPF FEDSSLFREI 
      3810       3820       3830       3840       3850
PEECQHVKVL PSVQGGGFDY REAPMDCEQF QGDYMSELLE NLADVDQDLL 
      3860       3870       3880       3890       3900
SSDCILNVIS HSLVKSLMDK LSHGLQQAPF ENKYRNYRTR EMQPFITKAK 
      3910       3920       3930       3940       3950
RQELIEPEET KGHVGFMSYD NNFLTKSLNN TNANSFKKHT QFGKKHAGKS 
      3960       3970       3980       3990       4000
ISLSFSDGKE SRGINTACFH KLCQRGVNGG VFSATFLEEI ISELFYNLST 
      4010       4020       4030       4040       4050
SLWKKNPNIT EAWLNEINTL LINNVVKKLN DAEITVLRYP EERLYFPSAH 
      4060       4070       4080       4090       4100
KGCIAKIVDS IYYDVLQQYE FTVTCGGNLP YDNTPVAKRI SNSILLEVID 
      4110       4120       4130       4140       4150
YQLPSCFKGK LRSNLYHTLN AEIILYKLHN SLKNFNSEPM TSKDYSTMLP 
      4160       4170       4180       4190       4200
HSFLEYVIRR VLAQLISLPI KSSSLEKKYL ASSDFNEMSN CITNKVMSAI 
      4210       4220       4230       4240       4250
SKHKIWLTIY DNQCLYTDKN LQKMVDSVYS NILQMSSSVD SIQKNIISRS 
      4260       4270       4280       4290       4300
PIMIDQIASF IIQEIIENHL QPFLCGERLP RPKTPLDEVS YMVKQVLSDV 
      4310       4320       4330       4340       4350
VESHKSQKPS PFGIYPDKLV GETVTRVLSK IFSPNTNINV ELENVTQKIV 
      4360       4370       4380       4390       4400
SSVHKHLDKA KIPILCHKQP PFPFSNTDIV DELVTSVYKN VLKQHGLDPD 
      4410       4420       4430       4440       4450
IDESVNGEVF VENITKLITA AISDYLLHPL FSGDLPAASC SNSVTDHTVY 
      4460       4470       4480       4490       4500
DILGDINKSS KPNQTLPLYN TLLPYTFLED MIRVLLSKFF PSAPKIDSYK 
      4510       4520       4530       4540       4550
AASKDKEGVN FNEIASNLIS DIRRKISQHE IRFSKDEDKT KSFYSENDVQ 
      4560       4570       4580       4590       4600
HLVDAVFMNI LENYGSPESV EQNITKSNDV FIDQIAGFII KYICEHHLQP 
      4610       4620       4630       4640       4650
FLERKQLSTS SYKYSDDDRQ DLLYGSAYSS TFLEDVVSGV VSKIFHRVIG 
      4660       4670       4680       4690       4700
IVQVNSTINS ENILFDKAEN LIYWITEEFS KAQVTTIENA EERLSLSPVE 
      4710       4720       4730       4740       4750
GNILQKIIDT VYSKILEEHE MEIMPNKDFL NDTKALASQI TEIILSEISY 
      4760       4770       4780       4790       4800
FQIPPDLVAN LPLRLHSKLS QNVLVNKVHY DISKSRFRRQ ASTMYTTMLS 
      4810       4820       4830       4840       4850
HVHLEKIVTQ LMSQINPSDS SVGHSDTYQS ELSNTVVKLI NEIMSIISKH 
      4860       4870       4880       4890       4900
AICIVKHGNE KQSMISEKEM QSMVDSIYAD LSHSNLYQSL TKDKKGLSSI 
      4910       4920       4930       4940       4950
PVSKIANFII KEIFNHHLES FLSGDKSILS ASVAQTCKKK ATTSTKQREL 
      4960       4970       4980       4990       5000
SFIVNSAVFL EEVITELLCK ILQTFIQNSL SMETPERAIA EIMDIVTTLV 
      5010       5020       5030       5040       5050
KSIVFEFTSS EILVAEHLDE SLWFSETYKE MVQKTVNSVY GNIFYEYKSL 
      5060       5070       5080       5090       5100
TQLHRAVQYD TSGFGGKMYH FLLEEMYDYQ VQSLVSGELM PSCYASPQSA 
      5110       5120       5130       5140       5150
NIIKNVLNVI LKDTNALPSC ITVLPCSLIE NMIYKLLENI FPSDDTTNEL 
      5160       5170       5180       5190       5200
KKEEKEEAGP DDVDEFMAAA SKLTDEIIQE ISEHEIRFAN AEDTASMIYE 
      5210       5220       5230       5240       5250
TTENFIDSVC NNILKNSEFQ AEVQKDAHKK GGSFLSKIAG SIIKEIMDHY 
      5260       5270       5280       5290       5300
LQLFLYGEGS HSSKLPHFGG ASVVAKSGKE KAPSSLFSAA FLEDVIVDLA 
      5310       5320       5330       5340       5350
HKFCSFLTLT DDARKKDLPE AEIVSLAIKF ANSLIRDFRK SGIKVLPHAE 
      5360       5370       5380       5390       5400
EIFSFPPIAK ETIDEISNFV YDQFIGKLGA DGIQKDGTGN MVIEMVSSLA 
      5410       5420       5430       5440       5450
QKAISTFKIQ PLFSGDWCST FFSFLDAENI SQRVQLLPKE TSMQISGALK 
      5460       5470       5480       5490       5500
QNQLALSKIT SIKKDDTQDP ILNSIATIMK SNIINLLSGP SAGVTDAKKE 
      5510       5520       5530       5540       5550
DESKVKPATR ETTSPPTSPP ATMKSQGSQV QQLATSPPTS MKSQRIQVQQ 
      5560       5570       5580       5590       5600
SVMSPPTTMK GKGAQVQQFA TSPPTSMKSQ GSQVQQSAMS PPTTMKSRGA 
      5610       5620       5630       5640       5650
QVQESVTSPF TTKESRGAQV QQSAMSPPPS MKDRGAQVQE SSTSPPTTMK 
      5660       5670       5680       5690       5700
SRGAQVQHLS SKYKGNETGK ENLVLVNEQG QILEIFTHFA VAKTVENSPE 
      5710       5720       5730       5740       5750
KEVFISDLKI QNEKKLDVSK SSVKTDDRPM SKDKETMTEK TVLIPQQPVK 
      5760       5770       5780       5790       5800
EERKQSVVKT DTEEEQYSEN ECVENVIENI YDNVFIVSSQ EPLDFSRPIY 
      5810       5820       5830       5840       5850
SRSLTSDKAL VILKDSAQLV PAKDLSSSGH RDIAAKEKAS KETETKIRRD 
      5860       5870       5880       5890       5900
RSETKRSKEM KSKSSMTDHP KPSESKSKIV PAKFLEDVIA ELVNKLVFTF 
      5910       5920       5930       5940       5950
ISDKTTDTNE QKPGELYDTA MRLVNSMTKE LSDAEIKVFR PEKEDEVQAA 
      5960       5970       5980       5990       6000
KEPAPTSPPE VKETVTKEPS PSTNIKNEDQ MSDVQKTPEQ SSPDKLPALE 
      6010       6020       6030       6040       6050
KIPSIEKSIV NKIVHSCVCN IFKECKSQES ICENINSNGE NLAKRLTSTV 
      6060       6070       6080       6090       6100
INEIFQHQLN LIFSDEVPAS ACVPLESKDV EQKVQNVVQT VSKECQTASP 
      6110       6120       6130       6140       6150
YTVQLPYKFL EDVTSGLLAK VFSKLSNVKT KLTPENVLTQ LDFLQSNLVK 
      6160       6170       6180       6190       6200
TIAAEISKNE DLIIQYVESL HPNDDEVIQL VVQTIYNNLL PQFGSQEILQ 
      6210       6220       6230       6240       6250
KCIISGCKLL SKTIVDLVLR EVTGNQLQNY FGGELTPIQC AEVDNVVENI 
      6260       6270       6280       6290       6300
LTNVVLTTPS QPSGPRKLSY NIIETIAVKF LSKLLSVFPK GHPERTKSQE 
      6310       6320       6330       6340       6350
TEMRKITSKI LHSIQEFISK SKIKVVQPVK ESEAVPSADK AAIEKVVNSV 
      6360       6370       6380       6390       6400
YTNLLKHCGS PTSAFEDLMR KSDVISDIIG FSMVKEISNS EFQPQAEEEL 
      6410       6420       6430       6440       6450
SSSELALEAV KIMEKVVKII DELKSQEKPA SITDVMLDSR VLEEALALFL 
      6460       6470       6480       6490       6500
AKLVKTPGPA SKDTTSLTKP ELNKIASQLT KSVTAEISKS NISLVESNHE 
      6510       6520       6530       6540       6550
EQSLDPENIE VISQVVESVY SNVVKQSGTE NELSDIKGTK KAFPKKVASL 
      6560       6570       6580       6590       6600
IVDGVSSVPS CRVITESSYT AAHGDLDTNR IIEKAQKHAA LMSSDSDKDS 
      6610       6620       6630       6640       6650
KKELEDEFPV RIVPHVRNKP LRIDPNIVSD HLAVISMKTQ PLETLQMDCL 
      6660       6670       6680       6690       6700
KRTGCSIAEL RRNSIRGIGP SSTDVSEMGT RQKERRISLD RTGRLDVKPL 
      6710       6720       6730       6740       6750
EAVGRNSFQN VRRPDITRVE LLKDINNKTD LIIRLVAHDI GRKESDSSLS 
      6760       6770       6780       6790       6800
EGMVSDEEEV VLGEVVGDQC LRKISGGRVQ QVKKSAESHV VSSKTATSTS 
      6810       6820       6830       6840       6850
NLKRFLALSK CCQPTSGENI ESIEESGIQI MDPNKAYVKR AAAELDMPSC 
      6860       6870       6880       6890       6900
KSLAEETTSR DKLQYKEEEI LASEPTHYFI HRIMSTSSYN QEDLISGEAE 
      6910       6920       6930       6940       6950
EFLPDAKANA LEESCQEPQE GNSNSLEFVT IYKGSKHIAG SARLSKEHVS 
      6960       6970       6980       6990 
EMPRSSISKQ GSRVLAKVSS TLSKVFSRSS GSIPKSSSPP HQDKR
Length:6,995
Mass (Da):784,857
Last modified:July 13, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC847718F818E457
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZQI5F6ZQI5_MOUSE
Fibrous sheath-interacting protein ...
Fsip2
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BGZ6F7BGZ6_MOUSE
Fibrous sheath-interacting protein ...
Fsip2
1,009Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAM17862 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM17864 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL845500 Genomic DNA Translation: CAM17864.1 Sequence problems.
AL845500 Genomic DNA Translation: CAM17862.3 Sequence problems.

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.302516
Mm.491762

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000143764; ENSMUSP00000120314; ENSMUSG00000075249

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845500 Genomic DNA Translation: CAM17864.1 Sequence problems.
AL845500 Genomic DNA Translation: CAM17862.3 Sequence problems.
UniGeneiMm.302516
Mm.491762

3D structure databases

SMRiA2ARZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120314

PTM databases

iPTMnetiA2ARZ3
PhosphoSitePlusiA2ARZ3

Proteomic databases

PaxDbiA2ARZ3
PeptideAtlasiA2ARZ3
PRIDEiA2ARZ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000143764; ENSMUSP00000120314; ENSMUSG00000075249

Organism-specific databases

MGIiMGI:2664111 Fsip2

Phylogenomic databases

eggNOGiENOG410ISIK Eukaryota
ENOG4112BP1 LUCA
GeneTreeiENSGT00680000100018
HOGENOMiHOG000170878
HOVERGENiHBG107933
InParanoidiA2ARZ3
OMAiQHLQPFV
PhylomeDBiA2ARZ3
TreeFamiTF342086

Miscellaneous databases

Protein Ontology

More...PROi		PR:A2ARZ3

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000075249 Expressed in 3 organ(s), highest expression level in testis
ExpressionAtlasiA2ARZ3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR038891 FSIP2
IPR031554 FSIP2_C
PANTHERiPTHR21856 PTHR21856, 1 hit
PfamiView protein in Pfam
PF15783 FSIP2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFSIP2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ARZ3
Secondary accession number(s): A2ARZ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: July 13, 2010
Last modified: February 13, 2019
This is version 75 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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