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UniProtKB - A2ART4 (A2ART4_MOUSE)
Protein
Submitted name:
Novel KRAB box and zinc finger, C2H2 type domain containing protein
Gene
Gm2026
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Novel KRAB box and zinc finger, C2H2 type domain containing proteinImportedSubmitted name: Predicted gene 11007Submitted name: Predicted gene 14308Submitted name: Predicted gene 14434Submitted name: Predicted gene 2007Submitted name: Predicted gene 2026Submitted name: Predicted gene 4631Submitted name: Predicted gene 4724 |
Gene namesi | Name:Gm2026 Synonyms:Gm11007, Gm14308, Gm14434, Gm2007, Gm4631, Gm4724 ORF Names:RP23-376N23.4-001Imported, RP24-574J13.1-003Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3779223, Gm11007 MGI:3782921, Gm14308 MGI:3702417, Gm14434 MGI:3780177, Gm2007 MGI:3780195, Gm2026 MGI:3782813, Gm4631 MGI:3782904, Gm4724 |
VEuPathDBi | HostDB:ENSMUSG00000078880 HostDB:ENSMUSG00000078881 HostDB:ENSMUSG00000078886 HostDB:ENSMUSG00000078897 HostDB:ENSMUSG00000078899 HostDB:ENSMUSG00000094475 HostDB:ENSMUSG00000094932 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000078880, Expressed in brain and 63 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 75 | KRABInterPro annotationAdd BLAST | 72 | |
Domaini | 67 – 102 | C2H2-typeInterPro annotationAdd BLAST | 36 | |
Domaini | 103 – 130 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 131 – 158 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 159 – 186 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 187 – 214 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 215 – 242 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 243 – 270 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 271 – 298 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 299 – 326 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 327 – 354 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 355 – 382 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 383 – 410 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 411 – 438 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 439 – 466 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 467 – 494 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Keywords - Domaini
RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154469 |
HOGENOMi | CLU_002678_57_1_1 |
OMAi | CEETCHE |
OrthoDBi | 1318335at2759 |
TreeFami | TF338854 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
A2ART4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLVTYDDVH VNFTQDEWAL LDPSQKSLYK GVMLETYKNL TAIGYIWEEH
60 70 80 90 100
TIEDHFQTSR SHGRHERSCS AEQPSEFIQC GKAFAYESGR QRHQIKHNGE
110 120 130 140 150
KHHDCNQCGK DFRTWNVLQI HKRTHTGEKP YDCKQCGKVF ARSCHLQIHN
160 170 180 190 200
RTHAGEKQYE CNQCGKAFKR RINLQIHKRT HTGEKPYECN QCGKAFASSG
210 220 230 240 250
ELQKHKRTHT GEKPYECKQC GKAFSQSSHL RIHKRTHTGE KPYECNQCGK
260 270 280 290 300
AFARSGDLQK HKRTHTGEKP YECKQCGKAF AHSSHLHKHE RTHTGDKPYE
310 320 330 340 350
CKQCGKAFAV IYTLQMHKRT HTGDKPYECK QCGKAFAVIY TLQMHKRTHT
360 370 380 390 400
GEKPYKCKQC GKAFARSCHL RIHKRTHTGE KPYECNQCGK AFAESSTLQI
410 420 430 440 450
HNRTHTGEKP YECNQCGKAF ITRRVLQIHK RTHTGEKPYE CNQCGKAFAR
460 470 480 490
SCDLQKHKRT HTGEKPYECN HCGKAFAQSS SLRIHKRTYT GERQYECN
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8BHI0 | Q8BHI0_MOUSE | Novel KRAB box and zinc finger, C2H... | Gm14410 Gm11007, Gm14305, Gm14308, Gm14434, Gm2007 | 64 | Annotation score: | ||
F7CEW8 | F7CEW8_MOUSE | Predicted gene 11007 | Gm2007 Gm11007, Gm4631 | 497 | Annotation score: | ||
A2BE23 | A2BE23_MOUSE | Novel KRAB box and zinc finger, C2H... | Gm14305 RP23-376N23.2-001, RP24-574J13.4-001 | 498 | Annotation score: | ||
A2ARW1 | A2ARW1_MOUSE | Predicted gene 14410 | Gm14410 | 370 | Annotation score: | ||
G3UZB7 | G3UZB7_MOUSE | Predicted gene 2026 | Gm2026 | 114 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005149 Genomic DNA Translation: CAM27972.1 BX682537 Genomic DNA Translation: CAM46166.1 |
RefSeqi | NP_001092819.1, NM_001099349.2 NP_001093885.1, NM_001100415.1 NP_001095274.1, NM_001101804.1 NP_001171014.1, NM_001177543.1 NP_001243409.1, NM_001256480.1 XP_017174895.1, XM_017319406.1 XP_017174896.1, XM_017319407.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005149 Genomic DNA Translation: CAM27972.1 BX682537 Genomic DNA Translation: CAM46166.1 |
RefSeqi | NP_001092819.1, NM_001099349.2 NP_001093885.1, NM_001100415.1 NP_001095274.1, NM_001101804.1 NP_001171014.1, NM_001177543.1 NP_001243409.1, NM_001256480.1 XP_017174895.1, XM_017319406.1 XP_017174896.1, XM_017319407.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000104609 |
Genome annotation databases
Organism-specific databases
MGIi | MGI:3779223, Gm11007 MGI:3782921, Gm14308 MGI:3702417, Gm14434 MGI:3780177, Gm2007 MGI:3780195, Gm2026 MGI:3782813, Gm4631 MGI:3782904, Gm4724 |
VEuPathDBi | HostDB:ENSMUSG00000078880 HostDB:ENSMUSG00000078881 HostDB:ENSMUSG00000078886 HostDB:ENSMUSG00000078897 HostDB:ENSMUSG00000078899 HostDB:ENSMUSG00000094475 HostDB:ENSMUSG00000094932 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154469 |
HOGENOMi | CLU_002678_57_1_1 |
OMAi | CEETCHE |
OrthoDBi | 1318335at2759 |
TreeFami | TF338854 |
Miscellaneous databases
BioGRID-ORCSi | 100039060, 2 hits in 26 CRISPR screens 100043381, 2 hits in 22 CRISPR screens 100043915, 4 hits in 24 CRISPR screens 102633156, 0 hits in 1 CRISPR screen 102639653, 0 hits in 1 CRISPR screen 627914, 0 hits in 4 CRISPR screens 668039, 2 hits in 17 CRISPR screens |
ChiTaRSi | Gm11007, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000078880, Expressed in brain and 63 other tissues |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A2ART4_MOUSE | |
Accessioni | A2ART4Primary (citable) accession number: A2ART4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | May 25, 2022 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |