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Protein

Cation channel sperm-associated protein 2

Gene

Catsper2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.3 Publications

Activity regulationi

In contrast to the human ortholog, not activated by progesterone.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Developmental protein, Ion channel, Voltage-gated channel
Biological processCalcium transport, Differentiation, Ion transport, Spermatogenesis, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein 2
Short name:
CatSper2
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2387404 Catsper2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 106CytoplasmicSequence analysisAdd BLAST106
Transmembranei107 – 127Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini128 – 149ExtracellularSequence analysisAdd BLAST22
Transmembranei150 – 170Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini171 – 176CytoplasmicSequence analysis6
Transmembranei177 – 197Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini198 – 203ExtracellularSequence analysis6
Transmembranei204 – 224Helical; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini225 – 240CytoplasmicSequence analysisAdd BLAST16
Transmembranei241 – 261Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini262 – 280ExtracellularSequence analysisAdd BLAST19
Intramembranei281 – 301Helical; Pore-formingSequence analysisAdd BLAST21
Topological domaini302 – 318ExtracellularSequence analysisAdd BLAST17
Transmembranei319 – 339Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini340 – 588CytoplasmicSequence analysisAdd BLAST249

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are normal but males are sterile. Male sterility is due to defects in sperm motility unability to fertilize intact eggs. In mice lacking Catsper1, the sperm lacks CatSper2, while in mice lacking CatSper1, the sperm lacks CatSper1, suggesting that stable expression of CatSper1 requires CatSper2 and vice versa.1 Publication

Chemistry databases

GuidetoPHARMACOLOGYi389

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002956771 – 588Cation channel sperm-associated protein 2Add BLAST588

Proteomic databases

PaxDbiA2ARP9
PRIDEiA2ARP9

PTM databases

PhosphoSitePlusiA2ARP9

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Developmental stagei

Present in testis of 8 day-old. Expressed in pachytene spermatocytes.1 Publication

Gene expression databases

CleanExiMM_CATSPER2

Interactioni

Subunit structurei

Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity (By similarity). Component of the CatSper complex.By similarityCurated1 Publication

Protein-protein interaction databases

DIPiDIP-60801N
IntActiA2ARP9, 2 interactors
MINTiA2ARP9
STRINGi10090.ENSMUSP00000037222

Structurei

3D structure databases

ProteinModelPortaliA2ARP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi396 – 430Asp-richAdd BLAST35

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG4111GC6 LUCA
HOGENOMiHOG000007710
HOVERGENiHBG107782
InParanoidiA2ARP9
PhylomeDBiA2ARP9
TreeFamiTF343585

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR028747 CatSper2
IPR005821 Ion_trans_dom
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF189 PTHR10037:SF189, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A2ARP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQEQGHFQL LRADAIRSKL IDTFSLIEHL QGLSQAVPRH TLREILDPSY
60 70 80 90 100
QQKLMSGDQE QLVRFSIKPR RMGHITHSRR LLSRLRVRCS RMPPLSLWAG
110 120 130 140 150
WVLDSSVFSK FIISLIFLNT FVLMVEIELM ESTNTALWPV KLALEVADWF
160 170 180 190 200
ILLSFIVEIL LMWLASFSLF WKDAWNVFDF FVTLLSLLPE LVVLLGVPAH
210 220 230 240 250
SVWLQLLRVC RVLRSLKLFA RFRQIKVILL ALVRALKSMT FLLMLLLIFF
260 270 280 290 300
YIFAVTGVYF FREYSRSTIE GLEYNMFFSD LLNSLVTVFI LFTLDHWYAV
310 320 330 340 350
LQDIWKVPES SRVFSSIYVI LWLLLGSIIF RNIIVAMMVT NFQNIRSELS
360 370 380 390 400
EEMSHLEVQY KADMFKQQII QRRQHSESLR GTSLGKVSED IIETSDASDD
410 420 430 440 450
DDDDDDDDDD DDDDDDDKSD ATESDNEESD SENSESENSE SEKIDPEKDY
460 470 480 490 500
AKKSYPEKSH PEKSYPEKSH PEKSYPEKSH PKKSYDEQAE AEKVKEESKE
510 520 530 540 550
KAYPVSHSIS SHGSTAADTA FLENLDWETL VHENLPGLMD MDQDDRIVWP
560 570 580
RDSLFRYFEL LEKLQYNLEE RKKLQEFAVQ ALMSFEDK
Length:588
Mass (Da):68,572
Last modified:July 24, 2007 - v2
Checksum:i93396326105828DA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQ85A0A0A0MQ85_MOUSE
Cation channel sperm-associated pro...
Catsper2
588Annotation score:
D6RCY8D6RCY8_MOUSE
Cation channel sperm-associated pro...
Catsper2
134Annotation score:

Sequence cautioni

The sequence CAM24230 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49S → A in AAL26489 (PubMed:11675491).Curated1
Sequence conflicti49S → A in AAI32141 (PubMed:15489334).Curated1
Sequence conflicti303D → N in AAL26489 (PubMed:11675491).Curated1
Sequence conflicti335V → I in AAL26489 (PubMed:11675491).Curated1
Sequence conflicti426N → G in AAL26489 (PubMed:11675491).Curated1
Sequence conflicti426N → G in AAI32141 (PubMed:15489334).Curated1
Sequence conflicti482K → E in AAL26489 (PubMed:11675491).Curated1
Sequence conflicti482K → E in AAI32141 (PubMed:15489334).Curated1
Sequence conflicti515T → I in AAL26489 (PubMed:11675491).Curated1
Sequence conflicti515T → I in AAI32141 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411816 mRNA Translation: AAL26489.1
AL845466 Genomic DNA Translation: CAM24230.1 Sequence problems.
BC132140 mRNA Translation: AAI32141.1
UniGeneiMm.384318

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411816 mRNA Translation: AAL26489.1
AL845466 Genomic DNA Translation: CAM24230.1 Sequence problems.
BC132140 mRNA Translation: AAI32141.1
UniGeneiMm.384318

3D structure databases

ProteinModelPortaliA2ARP9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60801N
IntActiA2ARP9, 2 interactors
MINTiA2ARP9
STRINGi10090.ENSMUSP00000037222

Chemistry databases

GuidetoPHARMACOLOGYi389

PTM databases

PhosphoSitePlusiA2ARP9

Proteomic databases

PaxDbiA2ARP9
PRIDEiA2ARP9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2387404 Catsper2

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG4111GC6 LUCA
HOGENOMiHOG000007710
HOVERGENiHBG107782
InParanoidiA2ARP9
PhylomeDBiA2ARP9
TreeFamiTF343585

Miscellaneous databases

PROiPR:A2ARP9
SOURCEiSearch...

Gene expression databases

CleanExiMM_CATSPER2

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR028747 CatSper2
IPR005821 Ion_trans_dom
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF189 PTHR10037:SF189, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTSR2_MOUSE
AccessioniPrimary (citable) accession number: A2ARP9
Secondary accession number(s): A2RSK0, Q91ZP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: November 7, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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