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Protein

Protein PAT1 homolog 2

Gene

Patl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that acts as a translational repressor.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PAT1 homolog 2
Alternative name(s):
PAT1-like protein 2
Protein PAT1 homolog a
Short name:
Pat1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Patl2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914828 Patl2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004045781 – 529Protein PAT1 homolog 2Add BLAST529

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2ARM1

PRoteomics IDEntifications database

More...
PRIDEi
A2ARM1

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
A2ARM1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027233 Expressed in 30 organ(s), highest expression level in oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2ARM1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LSM1.By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2ARM1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2ARM1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PAT1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJI7 Eukaryota
ENOG410YH7J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055649

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231836

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG076566

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2ARM1

Identification of Orthologs from Complete Genome Data

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OMAi
WSQQPDP

Database of Orthologous Groups

More...
OrthoDBi
950451at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2ARM1

TreeFam database of animal gene trees

More...
TreeFami
TF323322

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039900 Pat1-like
IPR019167 PAT1_dom

The PANTHER Classification System

More...
PANTHERi
PTHR21551 PTHR21551, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09770 PAT1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2ARM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKCLEGLHLQ QRPSKFSVSL APEEGLVCAF QLEEEKENED ECVCSDQAPE
60 70 80 90 100
VKEEGCGLGD PAIVSAFQNT QVPQQRGLHS SHRVKVSGAL GMSSASLHFM
110 120 130 140 150
WQSVFPRASS PAHHFGPQQP SPDPFLFYSP LTPWPPKLSL PSHLTQLHPQ
160 170 180 190 200
HQQILQQQQR WRRRRSPTAR SVPAQKPWSR EPAASDAYAN LMTRKEKDWV
210 220 230 240 250
IRVQMVQLQS ENPRLDDYYY QKYYQKLEKR QADKELLGQK TRAESLKLVT
260 270 280 290 300
PYIQKPEVYE SVVRIEGSLG QVAVSTCFSP RRAIDAVSHG TQEQDTGAAS
310 320 330 340 350
SQRLRVLSQI EKMFLQLLKI EEGQNDGLPQ LYHTREQSSQ VEKLFQALKT
360 370 380 390 400
QEQNNLEEAA DNLLQVLSVR KGKVLVARLL PFLPPDQAVS LLLYITYHLP
410 420 430 440 450
LLIQRDMADQ GLHMLFKPLG KYISHLTFHQ LLHAMQGLML LSPGSSERPV
460 470 480 490 500
SVVLQNQFGI SLLYALLSHG EQLVSLDPSL RSSSDCATWT DLVILIAWEI
510 520
AQLPAASLAE PLAFPRNLLP CSAITWTSN
Length:529
Mass (Da):59,639
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4393AB954493943D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB29742 differs from that shown. Reason: Frameshift at positions 226, 231 and 234.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19S → P in AAI45647 (PubMed:15489334).Curated1
Sequence conflicti41E → K in AAI45647 (PubMed:15489334).Curated1
Sequence conflicti86V → A in AAI45647 (PubMed:15489334).Curated1
Sequence conflicti155L → LQ in AAI45647 (PubMed:15489334).Curated1
Sequence conflicti243 – 247AESLK → VEFLQ in BAB29742 (PubMed:16141072).Curated5
Sequence conflicti256P → L in BAB29742 (PubMed:16141072).Curated1
Sequence conflicti343K → E in AAI45647 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK015195 mRNA Translation: BAB29742.1 Frameshift.
AL845457 Genomic DNA No translation available.
BC145646 mRNA Translation: AAI45647.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS16653.1

NCBI Reference Sequences

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RefSeqi
NP_080527.2, NM_026251.2
XP_017174713.1, XM_017319224.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.150462

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000028665; ENSMUSP00000028665; ENSMUSG00000027233

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67578

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67578

UCSC genome browser

More...
UCSCi
uc008mae.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015195 mRNA Translation: BAB29742.1 Frameshift.
AL845457 Genomic DNA No translation available.
BC145646 mRNA Translation: AAI45647.1
CCDSiCCDS16653.1
RefSeqiNP_080527.2, NM_026251.2
XP_017174713.1, XM_017319224.1
UniGeneiMm.150462

3D structure databases

ProteinModelPortaliA2ARM1
SMRiA2ARM1
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiA2ARM1

Proteomic databases

PaxDbiA2ARM1
PRIDEiA2ARM1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028665; ENSMUSP00000028665; ENSMUSG00000027233
GeneIDi67578
KEGGimmu:67578
UCSCiuc008mae.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
197135
MGIiMGI:1914828 Patl2

Phylogenomic databases

eggNOGiENOG410IJI7 Eukaryota
ENOG410YH7J LUCA
GeneTreeiENSGT00520000055649
HOGENOMiHOG000231836
HOVERGENiHBG076566
InParanoidiA2ARM1
OMAiWSQQPDP
OrthoDBi950451at2759
PhylomeDBiA2ARM1
TreeFamiTF323322

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Patl2 mouse

Protein Ontology

More...
PROi
PR:A2ARM1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027233 Expressed in 30 organ(s), highest expression level in oocyte
GenevisibleiA2ARM1 MM

Family and domain databases

InterProiView protein in InterPro
IPR039900 Pat1-like
IPR019167 PAT1_dom
PANTHERiPTHR21551 PTHR21551, 1 hit
PfamiView protein in Pfam
PF09770 PAT1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPATL2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ARM1
Secondary accession number(s): A6H5U9, Q9D5L4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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