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Entry version 78 (08 May 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Protein FAM83C

Gene

Fam83c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in MAPK signaling.By similarity

Caution

It is uncertain whether Met-1 or Met-47 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM83CCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fam83cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918655 Fam83c

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004345661 – 776Protein FAM83CAdd BLAST776

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2ARK0

PRoteomics IDEntifications database

More...
PRIDEi
A2ARK0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2ARK0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2ARK0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000074647 Expressed in 14 organ(s), highest expression level in zone of skin

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with RAF1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000029143

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A2ARK0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM83 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG1F Eukaryota
ENOG4110G08 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160254

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231831

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2ARK0

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITKYHQL

Database of Orthologous Groups

More...
OrthoDBi
421095at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2ARK0

TreeFam database of animal gene trees

More...
TreeFami
TF330777

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012461 FAM83_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07894 FAM83, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2ARK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGCQAGASI FFLIAANPDA NHGASGGLGS RWIRTFSRIA PAGTQGMAGP
60 70 80 90 100
LRSRVEELKR PWWRESSPLV LQHSEAARLA ADALLERGEA AYLQVISEER
110 120 130 140 150
ELPFLSALDV DYMISHVRGV PELSEAQGSE TLGQDLSMLS EVTSGTYFPM
160 170 180 190 200
ASDLDPPDLD LGWPEVPQAT GFSPTQAVVH FQRDKGKSIK DLLRFLFSQA
210 220 230 240 250
QTVVAVVMDV FTDMELLCDL MEASSRRGVP VYLLLAQEHL KYFLEMCYKM
260 270 280 290 300
DLNGGHLVNM RVRSTCGDTY CSKAGRRFTG QALEKFVIID CEQVVAGSYS
310 320 330 340 350
FTWLCSQAHT SMVLQLRGHI VEDFDREFRC LYAESQPVEG FCSNEDPLMP
360 370 380 390 400
QVPRPPPVTL AFGPAVPSAT GSSPSSNSLS SIKHSPLLAR SSYLALPGGG
410 420 430 440 450
GRNDMGMGSS SPGPAYHEAG GQPSLYRQLS DPNHISPPGP YRANLSKLGA
460 470 480 490 500
SPWSQSSPAL NHSSTSPLTL AVGSPLLPSS RPLLHFTRGV PALSRLPENG
510 520 530 540 550
LPASQDPSLP RGRWVPGTAL ETVEEKKVSL SQSHDHLDRL SPFSKAGEAG
560 570 580 590 600
GPNSRVTPDS SSLQHRELAL DDRRLSLSHS HSQLDLLSQG QGVLESGSLR
610 620 630 640 650
PGELSLENRK LSLNHNHGQL DLLPQNPKPQ APKIPSDAYS SAGPSKPSLD
660 670 680 690 700
DRRQTLGHSQ LDLITKFGPF RSEGPGPSCP PEPSPVRMAG VGSADEKRLT
710 720 730 740 750
LGHSKLDLIT KYHQLQGARQ KPEPGIPGAP VSGHQNGSSN DLFAPEKRLT
760 770
LGHSKLDLIT KYNKSKFKQL RSRFES
Length:776
Mass (Da):84,071
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA89B2C7490A469D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI13191 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI13798 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti343S → G in AAI13191 (PubMed:15489334).Curated1
Sequence conflicti343S → G in AAI13798 (PubMed:15489334).Curated1
Sequence conflicti546A → V in AAI13191 (PubMed:15489334).Curated1
Sequence conflicti546A → V in AAI13798 (PubMed:15489334).Curated1
Sequence conflicti566R → G in AAI13191 (PubMed:15489334).Curated1
Sequence conflicti566R → G in AAI13798 (PubMed:15489334).Curated1
Sequence conflicti634I → M in AAI13191 (PubMed:15489334).Curated1
Sequence conflicti634I → M in AAI13798 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL845445 Genomic DNA No translation available.
BC113190 mRNA Translation: AAI13191.1 Different initiation.
BC113797 mRNA Translation: AAI13798.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50770.1

NCBI Reference Sequences

More...
RefSeqi
NP_082064.2, NM_027788.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000029143; ENSMUSP00000029143; ENSMUSG00000074647

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
71405

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:71405

UCSC genome browser

More...
UCSCi
uc008nlm.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845445 Genomic DNA No translation available.
BC113190 mRNA Translation: AAI13191.1 Different initiation.
BC113797 mRNA Translation: AAI13798.1 Different initiation.
CCDSiCCDS50770.1
RefSeqiNP_082064.2, NM_027788.2

3D structure databases

SMRiA2ARK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029143

PTM databases

iPTMnetiA2ARK0
PhosphoSitePlusiA2ARK0

Proteomic databases

PaxDbiA2ARK0
PRIDEiA2ARK0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029143; ENSMUSP00000029143; ENSMUSG00000074647
GeneIDi71405
KEGGimmu:71405
UCSCiuc008nlm.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
128876
MGIiMGI:1918655 Fam83c

Phylogenomic databases

eggNOGiENOG410IG1F Eukaryota
ENOG4110G08 LUCA
GeneTreeiENSGT00940000160254
HOGENOMiHOG000231831
InParanoidiA2ARK0
OMAiITKYHQL
OrthoDBi421095at2759
PhylomeDBiA2ARK0
TreeFamiTF330777

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fam83c mouse

Protein Ontology

More...
PROi
PR:A2ARK0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000074647 Expressed in 14 organ(s), highest expression level in zone of skin

Family and domain databases

InterProiView protein in InterPro
IPR012461 FAM83_N
PfamiView protein in Pfam
PF07894 FAM83, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA83C_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ARK0
Secondary accession number(s): Q14CG2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 11, 2015
Last sequence update: February 20, 2007
Last modified: May 8, 2019
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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