Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 101 (16 Jan 2019)
Sequence version 1 (20 Feb 2007)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Mitogen-activated protein kinase kinase kinase 15

Gene

Map3k15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-816, inhibited by phosphorylation at Ser-928 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei685ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei777Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi662 – 670ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase kinase activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • protein kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 15 (EC:2.7.11.25)
Alternative name(s):
MAPK/ERK kinase kinase 15
Short name:
MEK kinase 15
Short name:
MEKK 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Map3k15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2448588 Map3k15

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003076331 – 1331Mitogen-activated protein kinase kinase kinase 15Add BLAST1331

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AQW0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AQW0

PRoteomics IDEntifications database

More...
PRIDEi
A2AQW0

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AQW0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031303 Expressed in 21 organ(s), highest expression level in adult mammalian kidney

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000033665

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A2AQW0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AQW0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini656 – 912Protein kinasePROSITE-ProRule annotationAdd BLAST257

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1216 – 1236Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 86Gly-richSequence analysisAdd BLAST84
Compositional biasi949 – 952Poly-SerSequence analysis4
Compositional biasi1254 – 1257Poly-ProSequence analysis4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4279 Eukaryota
ENOG410XQGS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159562

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293286

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006305

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AQW0

KEGG Orthology (KO)

More...
KOi
K13986

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEYMQPS

Database of Orthologous Groups

More...
OrthoDBi
226722at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105115

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025136 DUF4071
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR013761 SAM/pointed_sf
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13281 DUF4071, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2AQW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGGGGSGGG GGPVPAEAPE EAGEPPQGRL PPGPEGAAGL AEPESTGDAA
60 70 80 90 100
GGEAEGGRGP RRALRAVYVR SESSQGAAAG GGPEAGALKC LLRACEAEGA
110 120 130 140 150
HLTSVPFGEL DFGETAVLDA FYDADVAIVD MSDISRQPSL FYHLGVRESF
160 170 180 190 200
DMANNVILYY DTDADTALSL KDMVTQKNTA SSGNYYFIPY TVTPCADYFC
210 220 230 240 250
CESDAQRRAS EYMQPNWDTI LGPLCMPLVD RFTSLLKDIR VTSCAYYKET
260 270 280 290 300
LLNDIRKARE KYQGDELAKE LTRIKFRMDN IEVLTSDIII NLLLSYRDIQ
310 320 330 340 350
DYDAMVKLVE TLKMLPTCDL ADQHNIKFHY AFALNRRNST GDREKALQVM
360 370 380 390 400
LQVLQSCDHP APDMFCLCGR IYKDIFLDSG CEEDASRDSA IEWYRKGFEL
410 420 430 440 450
QSSLYSGINL AVLLIVSGQQ FETSMELRKI GVRLNSLLGR KGSLEKMNNY
460 470 480 490 500
WDVGQFFTVS MLASDIGKAV QAAERLFKLK PPVWYLRSLV QNLLLIQRFK
510 520 530 540 550
KPITEHSPRQ ERLNFWLDII FEATNEVTNG LRFPVLVIEP TKVYQPSYVS
560 570 580 590 600
INNEAEERTV SLWHVSPTEM KQIHEWNFTA SSIKGISLSK FDERCCFLYV
610 620 630 640 650
HDNSDDFQIY FSTEDQCNRF CSLVKEMLNN GVGSTVELEG EADGDTLEYE
660 670 680 690 700
YDHDANGERV VLGKGSYGIV YAGRDLSNQV RIAIKEIPER DIRYSQPLHE
710 720 730 740 750
EIALHKYLKH RNIVQYLGSV SENGYIKIFM EQVPGGSLSA LLRSKWGPMK
760 770 780 790 800
EPTIKFYTKQ ILEGLKYLHE NQIVHRDIKG DNVLVNTYSG VVKISDFGTS
810 820 830 840 850
KRLAGINPCT ETFTGTLQYM APEIIDQGPR GYGAPADIWS LGCTIIEMAT
860 870 880 890 900
SRPPFHELGE PQAAMFKVGM FKIHPEIPEA LSAEARAFIL SCFEPDPQKR
910 920 930 940 950
VTAADLLQEG FLRQVNKGKK NRIAFKPSEG VRSGTGTLAL PSSGELVGSS
960 970 980 990 1000
SSEHGSISPD SDAQPDAFFE KVQVPKHQLS HLLSVPDESP ALDDRSTALP
1010 1020 1030 1040 1050
PEERDPGLFL LRKDSERRAI LYRILWEEQN QVASNLQECV VQSSEELLLS
1060 1070 1080 1090 1100
VSHIKQIIGI LRDFIRSPEH RVMAATISKL KVDLDFDSSS INQIHLILFG
1110 1120 1130 1140 1150
FQDAVNRILR NHLIRPHWMF AMDNIIRRAV QAAVTILIPE LQAHFEPASE
1160 1170 1180 1190 1200
TEGVDKDTEV EGDYPLVDLL SQEVHVTPRG TRPGSVAIQE GQPHQQDPSL
1210 1220 1230 1240 1250
QLSKLRQETN RLWEHLVQKE REYQNLLRLI LDQKTQELYH LQLQYKSNGG
1260 1270 1280 1290 1300
TENPPPPDGL GTDRELIDWL QLQGVDANTI EKIVEEDYTL SDILNDITKE
1310 1320 1330
DLRCLRLRGG VLCRLWHAVS QHRRQMQESS Q
Length:1,331
Mass (Da):149,327
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BB38F2B8A59B942
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL845167, AL929452 Genomic DNA Translation: CAM22391.1
AL929452, AL845167 Genomic DNA Translation: CAM21674.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53236.1

NCBI Reference Sequences

More...
RefSeqi
NP_001156557.2, NM_001163085.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.386889

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000033665; ENSMUSP00000033665; ENSMUSG00000031303

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
270672

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:270672

UCSC genome browser

More...
UCSCi
uc009utb.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845167, AL929452 Genomic DNA Translation: CAM22391.1
AL929452, AL845167 Genomic DNA Translation: CAM21674.1
CCDSiCCDS53236.1
RefSeqiNP_001156557.2, NM_001163085.2
UniGeneiMm.386889

3D structure databases

ProteinModelPortaliA2AQW0
SMRiA2AQW0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033665

PTM databases

PhosphoSitePlusiA2AQW0

Proteomic databases

MaxQBiA2AQW0
PaxDbiA2AQW0
PRIDEiA2AQW0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033665; ENSMUSP00000033665; ENSMUSG00000031303
GeneIDi270672
KEGGimmu:270672
UCSCiuc009utb.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389840
MGIiMGI:2448588 Map3k15

Phylogenomic databases

eggNOGiKOG4279 Eukaryota
ENOG410XQGS LUCA
GeneTreeiENSGT00940000159562
HOGENOMiHOG000293286
HOVERGENiHBG006305
InParanoidiA2AQW0
KOiK13986
OMAiSEYMQPS
OrthoDBi226722at2759
TreeFamiTF105115

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Map3k15 mouse

Protein Ontology

More...
PROi
PR:A2AQW0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031303 Expressed in 21 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProiView protein in InterPro
IPR025136 DUF4071
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR013761 SAM/pointed_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13281 DUF4071, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM3K15_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AQW0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again