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Protein

Myosin-7B

Gene

Myh7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in muscle contraction.By similarity

Miscellaneous

The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi177 – 184ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-7B
Alternative name(s):
Myosin cardiac muscle beta chain
Myosin heavy chain 7B, cardiac muscle beta isoform
Gene namesi
Name:Myh7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:3710243 Myh7b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003493131 – 1941Myosin-7BAdd BLAST1941

Proteomic databases

EPDiA2AQP0
MaxQBiA2AQP0
PaxDbiA2AQP0
PeptideAtlasiA2AQP0
PRIDEiA2AQP0

PTM databases

iPTMnetiA2AQP0
PhosphoSitePlusiA2AQP0

Expressioni

Gene expression databases

BgeeiENSMUSG00000074652 Expressed in 102 organ(s), highest expression level in diaphragm
GenevisibleiA2AQP0 MM

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090672

Structurei

3D structure databases

ProteinModelPortaliA2AQP0
SMRiA2AQP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 80Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST51
Domaini84 – 785Myosin motorPROSITE-ProRule annotationAdd BLAST702
Domaini788 – 817IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni662 – 684Actin-bindingBy similarityAdd BLAST23
Regioni764 – 778Actin-bindingBy similarityAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili846 – 1935Sequence analysisAdd BLAST1090

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919
HOGENOMiHOG000173959
HOVERGENiHBG004704
InParanoidiA2AQP0
KOiK10352
OMAiKDEECTN
OrthoDBiEOG091G07UM
TreeFamiTF314375

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

A2AQP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDMSELGES ACYLRQGYQE MMKVHTVPWD GKKRVWVPDE QDAYVEAEVK
60 70 80 90 100
TEATGGKVTV ETKDQKVLTV RETEMQPMNP PRFDLLEDMA MMTHLNEAAV
110 120 130 140 150
LHNLRQRYAR WMIYTYSGLF CVTINPYKWL PVYTAAVVAA YKGKRRSEAP
160 170 180 190 200
PHIYAVADNA YNDMLRNREN QSMLITGESG AGKTVNTKRV IQYFAIVAAL
210 220 230 240 250
GDGPGKKAQF LATKTGGTLE DQIIEANPAM EAFGNAKTLR NDNSSRFGKF
260 270 280 290 300
IRIHFGPTGK LASADIDSYL LEKSRVIFQL PGERGYHVYY QILSGKKPEL
310 320 330 340 350
QDMLLLSMNP YDYHFCSQGV TTVDNMDDGE ELIATDHAMD ILGFSVDEKC
360 370 380 390 400
ACYKIVGALL HFGNMKFKQK QREEQAEADG TESADKAAYL MGVSSGDLLK
410 420 430 440 450
GLLHPRVRVG NEYVTKGQSV EQVVFAVGAL AKATYDRLFR WLVSRINQTL
460 470 480 490 500
DTKLPRQFFI GVLDIAGFEI FEFNSFEQLC INFTNEKLQQ FFNQHMFVLE
510 520 530 540 550
QEEYKREGID WVFIDFGLDL QPCIDLIEKP LGILSILEEE CMFPKASDAS
560 570 580 590 600
FRAKLYDNHS GKSPNFQQPR PDKKRKYQAH FEVVHYAGVV PYSIVGWLEK
610 620 630 640 650
NKDPLNETVV PIFQKSQNRL LATLYENYAG SCSTEPPKSG VKEKRKKAAS
660 670 680 690 700
FQTVSQLHKE NLNKLMTNLR ATQPHFVRCI VPNENKTPGV MDSFLVLHQL
710 720 730 740 750
RCNGVLEGIR ICRQGFPNRL LYADFRQRYR ILNPSAIPDD TFVDSRKATE
760 770 780 790 800
KLLGSLDIDH TQYQFGHTKV FFKAGLLGIL EELRDQRLAK VLTLLQARSR
810 820 830 840 850
GRLMRLEYQR MLGGRDALFT IQWNIRAFNA VKNWSWMKLF FKMKPLLRSA
860 870 880 890 900
QAEEELAALR AELRGLRGAL ATAEAKRQEL EETQVSVTQE KNDLALQLQA
910 920 930 940 950
EQDNLADAEE RCHLLIKSKV QLEAKVKELS ERLEDEEEVN ADLAARRRKL
960 970 980 990 1000
EDECTELKKD IDDLELTLAK AEKEKQATEN KVKNLTEEMA ALDEAVVRLT
1010 1020 1030 1040 1050
KEKKALQEAH QQALGDLQAE EDRVSALAKA KIRLEQQVED LECSLEQEKK
1060 1070 1080 1090 1100
LRMDTERAKR KLEGDLKLTQ ETVTDTTQDK QQLEEKLKKK DSELSQLNLR
1110 1120 1130 1140 1150
VEDEQLVGVQ LQKKIKELQA RAEELEEELE AERAARARVE KQRAEAAREL
1160 1170 1180 1190 1200
EELSERLEEA GGASAGQREG CRKREAELGR LRRELEEAVL RHEATVAALR
1210 1220 1230 1240 1250
RKQADSAAEL SEQVDSLQRI RQKLEKEKSE LRMEVDDLGA SVETLARGKA
1260 1270 1280 1290 1300
SAEKLCRTYE DQLSEAKIKV EELQRQLADA STQRGRLQTE NGELGRLLEE
1310 1320 1330 1340 1350
KESMISQLSR GKTSAAQSLE ELRRQLEEES KAKGALAHAV QALRHDCDLL
1360 1370 1380 1390 1400
REQHEEESEA QAELQRLLSK ANAEVAQWRS KYEADAIQRT EELEEAKKKL
1410 1420 1430 1440 1450
ALRLQEAEEG VEAANAKCSS LEKAKLRLQT ESEDVTLELE RATSAAAALD
1460 1470 1480 1490 1500
KKQRHLERAL EERRRQEEEM QRELEAAQRE ARGLGTELFR LRHSHEEALE
1510 1520 1530 1540 1550
ALETLKRENK NLQEEISDLT DQVSLSGKSI QELEKAKKAL EGEKSELQAA
1560 1570 1580 1590 1600
LEEAEGALEL EETKTLRIQL ELSQVKAEVD RKLAEKDEEC TNLRRNHQRA
1610 1620 1630 1640 1650
VESLQASLDA ETRARNEALR LKKKMEGDLN DLELQLGHAT RQAMEAQAAT
1660 1670 1680 1690 1700
RLLQAQLKEE QAGRDEEQRL AAELREQGQA LERRAALLAA ELEELRAALE
1710 1720 1730 1740 1750
QGERSRRLAE QELLEATERL NLLHSQNTGL LNQKKKLEVD LAQLSGEVEE
1760 1770 1780 1790 1800
AAQERREAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KTLEQTVREL
1810 1820 1830 1840 1850
QARLEEAEQA ALRGGKKQVQ KLEAKVRELE AELDAEQKKH AEALKGVRKH
1860 1870 1880 1890 1900
ERRVKELVYQ TEEDRKNLAR MQDLVDKLQS KVKSYKRQFE EAEQQASTNL
1910 1920 1930 1940
AKYRKAQHEL DDAEERADMA ETQANKLRAR SRDALGPKHK E
Length:1,941
Mass (Da):221,497
Last modified:February 20, 2007 - v1
Checksum:i6F1F88B2D563A94E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844852 Genomic DNA No translation available.
CCDSiCCDS50768.1
RefSeqiNP_001078847.1, NM_001085378.2
UniGeneiMm.469980
Mm.489207

Genome annotation databases

EnsembliENSMUST00000092995; ENSMUSP00000090672; ENSMUSG00000074652
GeneIDi668940
KEGGimmu:668940
UCSCiuc008nla.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844852 Genomic DNA No translation available.
CCDSiCCDS50768.1
RefSeqiNP_001078847.1, NM_001085378.2
UniGeneiMm.469980
Mm.489207

3D structure databases

ProteinModelPortaliA2AQP0
SMRiA2AQP0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090672

PTM databases

iPTMnetiA2AQP0
PhosphoSitePlusiA2AQP0

Proteomic databases

EPDiA2AQP0
MaxQBiA2AQP0
PaxDbiA2AQP0
PeptideAtlasiA2AQP0
PRIDEiA2AQP0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092995; ENSMUSP00000090672; ENSMUSG00000074652
GeneIDi668940
KEGGimmu:668940
UCSCiuc008nla.2 mouse

Organism-specific databases

CTDi57644
MGIiMGI:3710243 Myh7b

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919
HOGENOMiHOG000173959
HOVERGENiHBG004704
InParanoidiA2AQP0
KOiK10352
OMAiKDEECTN
OrthoDBiEOG091G07UM
TreeFamiTF314375

Miscellaneous databases

PROiPR:A2AQP0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074652 Expressed in 102 organ(s), highest expression level in diaphragm
GenevisibleiA2AQP0 MM

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYH7B_MOUSE
AccessioniPrimary (citable) accession number: A2AQP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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