UniProtKB - A2AQC8 (A2AQC8_MOUSE)
Protein
Submitted name:
Nuclear factor of activated T-cells c2 isoform IA-IIL-VIIa
Gene
Nfatc2
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: InterPro
- DNA-binding transcription factor activity Source: InterPro
Keywordsi
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Nuclear factor of activated T-cells c2 isoform IA-IIL-VIIaImportedSubmitted name: Nuclear factor of-activated T-cells, cytoplasmic 2Imported |
Gene namesi | Name:Nfatc2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102463, Nfatc2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027544, Expressed in lumbar subsegment of spinal cord and 251 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 374 – 556 | RHDInterPro annotationAdd BLAST | 183 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 38 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 60 – 94 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 183 – 279 | DisorderedSequence analysisAdd BLAST | 97 | |
Regioni | 302 – 321 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 191 – 206 | PolarSequence analysisAdd BLAST | 16 |
Phylogenomic databases
GeneTreei | ENSGT00940000156230 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR008366, NFAT IPR008967, p53-like_TF_DNA-bd IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 1 hit |
Pfami | View protein in Pfam PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A2AQC8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQRPALRRPG PRQPLRTMGS ADREEPIAHK AISSPSGLAY PDDVLDYGLK
60 70 80 90 100
PCNPLASLSG EPPGRFGEPD SIGFQNFLSP VKPAGASGPS PRIEITPSHE
110 120 130 140 150
LMQAGGALRG RDAGLSPEQP ALALAGVAAS PRFTLPVPGY EGYREPLCLS
160 170 180 190 200
PASSGSSASF ISDTFSPYTS PCVSPNNAGP DDLCPQFQNI PAHYSPRTSP
210 220 230 240 250
IMSPRTSLAE DSCLGRHSPV PRPASRSSSP GAKRRHSCAE ALVAPLPAAS
260 270 280 290 300
PQRSRSPSPQ PSPHVALQDD SIPAGYPPTA GSAVLMDALN TLATDSPCGI
310 320 330 340 350
PSKIWKTSPD PTPVSTAPSK AGLARHIYPT VEFLGPCEQE ERRNSAPESI
360 370 380 390 400
LLVPPTWPKQ LVPAIPICSI PVTASLPPLE WPLSNQSGSY ELRIEVQPKP
410 420 430 440 450
HHRAHYETEG SRGAVKAPTG GHPVVQLHGY MENKPLGLQI FIGTADERIL
460 470 480 490 500
KPHAFYQVHR ITGKTVTTTS YEKIVGNTKV LEIPLEPKNN MRATIDCAGI
510 520 530 540 550
LKLRNADIEL RKGETDIGRK NTRVRLVFRV HVPEPSGRIV SLQAASNPIE
560 570 580 590 600
CSQRSAHELP MVERQDMDSC LVYGGQQMIL TGQNFTAESK VVFMEKTTGP
610 620 630 640 650
AGTCETRPLP ISLISADRLS PWLSRLQRNP PGSVFRCSVL LPAPGSSLVL
LAL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ60591 | NFAC2_MOUSE | Nuclear factor of activated T-cells... | Nfatc2 Nfat1, Nfatp | 927 | Annotation score: | ||
B5B2R5 | B5B2R5_MOUSE | Nuclear factor of activated T-cells... | Nfatc2 | 673 | Annotation score: | ||
Q8C443 | Q8C443_MOUSE | Nuclear factor of activated T-cells... | Nfatc2 | 452 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL840639 Genomic DNA No translation available. AL844575 Genomic DNA No translation available. EU887599 mRNA Translation: ACG55619.1 |
RefSeqi | NP_001278101.1, NM_001291172.1 |
Genome annotation databases
Ensembli | ENSMUST00000137451; ENSMUSP00000118329; ENSMUSG00000027544 |
GeneIDi | 18019 |
UCSCi | uc008oay.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL840639 Genomic DNA No translation available. AL844575 Genomic DNA No translation available. EU887599 mRNA Translation: ACG55619.1 |
RefSeqi | NP_001278101.1, NM_001291172.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 1758, 516 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000137451; ENSMUSP00000118329; ENSMUSG00000027544 |
GeneIDi | 18019 |
UCSCi | uc008oay.2, mouse |
Organism-specific databases
CTDi | 4773 |
MGIi | MGI:102463, Nfatc2 |
Phylogenomic databases
GeneTreei | ENSGT00940000156230 |
Miscellaneous databases
BioGRID-ORCSi | 18019, 4 hits in 17 CRISPR screens |
ChiTaRSi | Nfatc2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027544, Expressed in lumbar subsegment of spinal cord and 251 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR008366, NFAT IPR008967, p53-like_TF_DNA-bd IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR12533, PTHR12533, 1 hit |
Pfami | View protein in Pfam PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01789, NUCFACTORATC |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50254, REL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A2AQC8_MOUSE | |
Accessioni | A2AQC8Primary (citable) accession number: A2AQC8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |