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Protein
Submitted name:

Dual oxidase 2

Gene

Duox2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi832 – 843PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi868 – 879PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-209968 Thyroxine biosynthesis

Protein family/group databases

PeroxiBasei3341 MmDuOx02-4

Names & Taxonomyi

Protein namesi
Submitted name:
Dual oxidase 2Imported
Gene namesi
Name:Duox2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:3036280 Duox2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei596 – 622HelicalSequence analysisAdd BLAST27
Transmembranei1007 – 1026HelicalSequence analysisAdd BLAST20
Transmembranei1046 – 1068HelicalSequence analysisAdd BLAST23
Transmembranei1148 – 1175HelicalSequence analysisAdd BLAST28
Transmembranei1187 – 1209HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500264273226 – 1517Sequence analysisAdd BLAST1492

Proteomic databases

PaxDbiA2AQ99
PRIDEiA2AQ99

Expressioni

Gene expression databases

BgeeiENSMUSG00000068452 Expressed in 13 organ(s), highest expression level in colon

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050314

Structurei

3D structure databases

ProteinModelPortaliA2AQ99
SMRiA2AQ99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini819 – 854EF-handInterPro annotationAdd BLAST36
Domaini855 – 890EF-handInterPro annotationAdd BLAST36
Domaini899 – 934EF-handInterPro annotationAdd BLAST36
Domaini1236 – 1342FAD-binding FR-typeInterPro annotationAdd BLAST107

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0039 Eukaryota
ENOG410XNZY LUCA
GeneTreeiENSGT00550000074350
HOGENOMiHOG000231774
HOVERGENiHBG080428
InParanoidiA2AQ99
OMAiWPGPKEK
OrthoDBiEOG091G00PO
PhylomeDBiA2AQ99
TreeFamiTF105424

Family and domain databases

CDDicd09820 dual_peroxidase_like, 1 hit
cd00051 EFh, 2 hits
Gene3Di1.10.640.10, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR034818 DUOX2
IPR034821 DUOX_peroxidase
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR013112 FAD-bd_8
IPR017927 FAD-bd_FR_type
IPR013130 Fe3_Rdtase_TM_dom
IPR013121 Fe_red_NAD-bd_6
IPR039261 FNR_nucleotide-bd
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR017938 Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF67 PTHR11972:SF67, 2 hits
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF00036 EF-hand_1, 1 hit
PF13202 EF-hand_5, 1 hit
PF08022 FAD_binding_8, 1 hit
PF01794 Ferric_reduct, 1 hit
PF08030 NAD_binding_6, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48113 SSF48113, 1 hit
SSF52343 SSF52343, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS51384 FAD_FR, 1 hit
PS50292 PEROXIDASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

A2AQ99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPTSPKTLV LLGALLTGPL GPAGGQDAPS LPWEVQRYDG WFNNLKYHQR
60 70 80 90 100
GAAGSRLRRL IPANYADGVY QALEEPLLPN PRRLSDAVAK GKAGLPSVHN
110 120 130 140 150
RTVLGVFFGY HVLSDLVSVE TPGCPAEFLN IYIPRGDPVF DPDKRGNVVL
160 170 180 190 200
PFQRSRWDHN TGQSPSNPRD QSNQVTGWLD GSAIYGSSHS WSDTLRSFSG
210 220 230 240 250
GQLASGPDPA FPRNSQSSLL MWMAPDPSTG RGGPQGVYAF GAQRGNREPF
260 270 280 290 300
LQALGLLWFR YHNLCARKLA QEHPHWGDEE LFQHARKRVI ATYQNIALYQ
310 320 330 340 350
WLPSFLQKTP PEYSGYRPFM DPSISPEFVV ASEQFLSTMV PPGVYMRNSS
360 370 380 390 400
CHFRKFPKEG SDSSPALRVC NSYWIRENPN LKTAQDVDQL LLGMASQISE
410 420 430 440 450
LEDRIVIEDL RDYWPGPERF SRTDYVASSI QRGRDMGLPS YSQALLALGL
460 470 480 490 500
EPPKNWSALN PQVEPQVLEA TAALYNQDLS QLELLLGGLL ESHGDPGPLF
510 520 530 540 550
SNIILDQFVR LRDGDRYWFE NTRNGLFSKE EIAEIRNTTL RDVLVAVSNV
560 570 580 590 600
DPSALQPNVF FWQEGAPCPQ PRQLTTDGLP QCAPVTVIDY FEGSGAGYGV
610 620 630 640 650
TLVAVCCFPL VSLIVAGVVA HFRNREHKML LKKGKESLKK QPASDGVPAM
660 670 680 690 700
EWPGPKEKSY PVTLQLLPDR SLQVLDKRFT VLRTIQLQSP QQVNLILSSN
710 720 730 740 750
SGRRTLLLKI PKEYDLVLMF NSEEDRGAFV RLLQDLCICC TPGLHIAEVD
760 770 780 790 800
EKELLRKAVT KQQRAGILEI FFRQLFAQVL DINQADAGTL PLDSSQQVRE
810 820 830 840 850
ALTCELSRAE FADSLGLKPQ DMFVESMFSL ADKDGNGYIS FREFLDILVV
860 870 880 890 900
FMKGSSEDKS RLMFTMYDLD GNGFLSKDEF FTMMRSFIEI SNNCLSKAQL
910 920 930 940 950
AEVVESMFRE SGFQDKEELT WEDFHFMLRD HDSDLRFTQL CVKGGAGGTK
960 970 980 990 1000
DIFKQSSACR VSFINRTPGN RVMGPSPRLY TEALQEKKQS GFLAQKFKQY
1010 1020 1030 1040 1050
KRFVENYRRH IVCVTIFSAI CIGLFADRAY YYGFASPPTD IEETTYVGII
1060 1070 1080 1090 1100
LSRGTAASIS FMFSYILLTM CRNLITFLRE TFLNRYIPFD AAVDFHRWIA
1110 1120 1130 1140 1150
MAAVVLAVLH SAGHAVNVYI FSVSPLSLMA CVFPNVFVND GSKFPPKYYW
1160 1170 1180 1190 1200
WFFETVPGMT GVLLLLVLAI MYVFASHHFR RHSFRGFWLT HHLYVVLYVL
1210 1220 1230 1240 1250
IIIHGSYALI QLPSFHIYFL VPAIIYGGDK LVSLSRKKVE ISVVKAELLP
1260 1270 1280 1290 1300
SGVTYLQFQR PKTFEYKSGQ WVRIACLDLG TNEYHPFTLT SAPHEDTLSL
1310 1320 1330 1340 1350
HIRAVGPWTT RLREIYSPPV GGTCARYPKL YLDGPFGEGH QEWHKFEVSV
1360 1370 1380 1390 1400
LVGGGIGVTP FASILKDLVF KSSMGSQMLC KKIYFIWVTR TQRQFEWLAD
1410 1420 1430 1440 1450
IIREVEENDC QDLVSVHIYI TQLAEKFDLR TTMLYICERH FQKALNRSLF
1460 1470 1480 1490 1500
TGLRSITHFG RPPFELFFNS LQEVHPQVRK IGVFSCGPPG MTKNVEKACQ
1510
LINRQDRAHF VHHYENF
Length:1,517
Mass (Da):171,626
Last modified:February 20, 2007 - v1
Checksum:iB5AB2345C85FC1DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844566 Genomic DNA No translation available.
RefSeqiNP_808278.2, NM_177610.2
UniGeneiMm.358846

Genome annotation databases

EnsembliENSMUST00000053734; ENSMUSP00000050314; ENSMUSG00000068452
GeneIDi214593
UCSCiuc008mak.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844566 Genomic DNA No translation available.
RefSeqiNP_808278.2, NM_177610.2
UniGeneiMm.358846

3D structure databases

ProteinModelPortaliA2AQ99
SMRiA2AQ99
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050314

Protein family/group databases

PeroxiBasei3341 MmDuOx02-4

Proteomic databases

PaxDbiA2AQ99
PRIDEiA2AQ99

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053734; ENSMUSP00000050314; ENSMUSG00000068452
GeneIDi214593
UCSCiuc008mak.1 mouse

Organism-specific databases

CTDi50506
MGIiMGI:3036280 Duox2

Phylogenomic databases

eggNOGiKOG0039 Eukaryota
ENOG410XNZY LUCA
GeneTreeiENSGT00550000074350
HOGENOMiHOG000231774
HOVERGENiHBG080428
InParanoidiA2AQ99
OMAiWPGPKEK
OrthoDBiEOG091G00PO
PhylomeDBiA2AQ99
TreeFamiTF105424

Enzyme and pathway databases

ReactomeiR-MMU-209968 Thyroxine biosynthesis

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068452 Expressed in 13 organ(s), highest expression level in colon

Family and domain databases

CDDicd09820 dual_peroxidase_like, 1 hit
cd00051 EFh, 2 hits
Gene3Di1.10.640.10, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR034818 DUOX2
IPR034821 DUOX_peroxidase
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR013112 FAD-bd_8
IPR017927 FAD-bd_FR_type
IPR013130 Fe3_Rdtase_TM_dom
IPR013121 Fe_red_NAD-bd_6
IPR039261 FNR_nucleotide-bd
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR017938 Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF67 PTHR11972:SF67, 2 hits
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF00036 EF-hand_1, 1 hit
PF13202 EF-hand_5, 1 hit
PF08022 FAD_binding_8, 1 hit
PF01794 Ferric_reduct, 1 hit
PF08030 NAD_binding_6, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48113 SSF48113, 1 hit
SSF52343 SSF52343, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS51384 FAD_FR, 1 hit
PS50292 PEROXIDASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA2AQ99_MOUSE
AccessioniPrimary (citable) accession number: A2AQ99
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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