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UniProtKB - A2AQ99 (A2AQ99_MOUSE)

Entry version 126 (07 Apr 2021)
Sequence version 1 (20 Feb 2007)
Previous versions | rss
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Protein

NAD(P)H oxidase (H(2)O(2)-forming)

Gene

Duox2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.ARBA annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: thyroid hormone biosynthesis

This protein is involved in the pathway thyroid hormone biosynthesis, which is part of Hormone biosynthesis.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway thyroid hormone biosynthesis and in Hormone biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi832 – 843PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi868 – 879PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, PeroxidaseARBA annotation
Biological processThyroid hormones biosynthesisARBA annotation
LigandCalciumPROSITE-ProRule annotation, FADARBA annotation, Flavoprotein, NADPARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-209968, Thyroxine biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00194

Protein family/group databases

PeroxiBase, a peroxidase database

More...PeroxiBasei		3341, MmDuOx02-4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NAD(P)H oxidase (H(2)O(2)-forming)ARBA annotation (EC:1.6.3.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Duox2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:3036280, Duox2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei596 – 622HelicalSequence analysisAdd BLAST27
Transmembranei1007 – 1026HelicalSequence analysisAdd BLAST20
Transmembranei1046 – 1068HelicalSequence analysisAdd BLAST23
Transmembranei1148 – 1175HelicalSequence analysisAdd BLAST28
Transmembranei1187 – 1209HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500264273226 – 1517NAD(P)H oxidase (H(2)O(2)-forming)Sequence analysisAdd BLAST1492

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A2AQ99

PRoteomics IDEntifications database

More...PRIDEi		A2AQ99

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		349677

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000068452, Expressed in ileum and 35 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A2AQ99, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000050314

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A2AQ99, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A2AQ99

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini819 – 854EF-handInterPro annotationAdd BLAST36
Domaini855 – 890EF-handInterPro annotationAdd BLAST36
Domaini899 – 934EF-handInterPro annotationAdd BLAST36
Domaini1236 – 1342FAD-binding FR-typeInterPro annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni153 – 175DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi154 – 175PolarSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the peroxidase family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0039, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160291

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004482_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A2AQ99

Identification of Orthologs from Complete Genome Data

More...OMAi		NVFVWHE

Database of Orthologous Groups

More...OrthoDBi		27424at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A2AQ99

TreeFam database of animal gene trees

More...TreeFami		TF105424

Family and domain databases

Conserved Domains Database

More...CDDi		cd09820, dual_peroxidase_like, 1 hit
cd00051, EFh, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.640.10, 1 hit
3.40.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034818, DUOX2
IPR034821, DUOX_peroxidase
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR017938, Riboflavin_synthase-like_b-brl

The PANTHER Classification System

More...PANTHERi		PTHR11972:SF67, PTHR11972:SF67, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03098, An_peroxidase, 1 hit
PF00036, EF-hand_1, 1 hit
PF13202, EF-hand_5, 1 hit
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00457, ANPEROXIDASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054, EFh, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit
SSF48113, SSF48113, 1 hit
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits
PS51384, FAD_FR, 1 hit
PS50292, PEROXIDASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2AQ99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPTSPKTLV LLGALLTGPL GPAGGQDAPS LPWEVQRYDG WFNNLKYHQR 
        60         70         80         90        100
GAAGSRLRRL IPANYADGVY QALEEPLLPN PRRLSDAVAK GKAGLPSVHN 
       110        120        130        140        150
RTVLGVFFGY HVLSDLVSVE TPGCPAEFLN IYIPRGDPVF DPDKRGNVVL 
       160        170        180        190        200
PFQRSRWDHN TGQSPSNPRD QSNQVTGWLD GSAIYGSSHS WSDTLRSFSG 
       210        220        230        240        250
GQLASGPDPA FPRNSQSSLL MWMAPDPSTG RGGPQGVYAF GAQRGNREPF 
       260        270        280        290        300
LQALGLLWFR YHNLCARKLA QEHPHWGDEE LFQHARKRVI ATYQNIALYQ 
       310        320        330        340        350
WLPSFLQKTP PEYSGYRPFM DPSISPEFVV ASEQFLSTMV PPGVYMRNSS 
       360        370        380        390        400
CHFRKFPKEG SDSSPALRVC NSYWIRENPN LKTAQDVDQL LLGMASQISE 
       410        420        430        440        450
LEDRIVIEDL RDYWPGPERF SRTDYVASSI QRGRDMGLPS YSQALLALGL 
       460        470        480        490        500
EPPKNWSALN PQVEPQVLEA TAALYNQDLS QLELLLGGLL ESHGDPGPLF 
       510        520        530        540        550
SNIILDQFVR LRDGDRYWFE NTRNGLFSKE EIAEIRNTTL RDVLVAVSNV 
       560        570        580        590        600
DPSALQPNVF FWQEGAPCPQ PRQLTTDGLP QCAPVTVIDY FEGSGAGYGV 
       610        620        630        640        650
TLVAVCCFPL VSLIVAGVVA HFRNREHKML LKKGKESLKK QPASDGVPAM 
       660        670        680        690        700
EWPGPKEKSY PVTLQLLPDR SLQVLDKRFT VLRTIQLQSP QQVNLILSSN 
       710        720        730        740        750
SGRRTLLLKI PKEYDLVLMF NSEEDRGAFV RLLQDLCICC TPGLHIAEVD 
       760        770        780        790        800
EKELLRKAVT KQQRAGILEI FFRQLFAQVL DINQADAGTL PLDSSQQVRE 
       810        820        830        840        850
ALTCELSRAE FADSLGLKPQ DMFVESMFSL ADKDGNGYIS FREFLDILVV 
       860        870        880        890        900
FMKGSSEDKS RLMFTMYDLD GNGFLSKDEF FTMMRSFIEI SNNCLSKAQL 
       910        920        930        940        950
AEVVESMFRE SGFQDKEELT WEDFHFMLRD HDSDLRFTQL CVKGGAGGTK 
       960        970        980        990       1000
DIFKQSSACR VSFINRTPGN RVMGPSPRLY TEALQEKKQS GFLAQKFKQY 
      1010       1020       1030       1040       1050
KRFVENYRRH IVCVTIFSAI CIGLFADRAY YYGFASPPTD IEETTYVGII 
      1060       1070       1080       1090       1100
LSRGTAASIS FMFSYILLTM CRNLITFLRE TFLNRYIPFD AAVDFHRWIA 
      1110       1120       1130       1140       1150
MAAVVLAVLH SAGHAVNVYI FSVSPLSLMA CVFPNVFVND GSKFPPKYYW 
      1160       1170       1180       1190       1200
WFFETVPGMT GVLLLLVLAI MYVFASHHFR RHSFRGFWLT HHLYVVLYVL 
      1210       1220       1230       1240       1250
IIIHGSYALI QLPSFHIYFL VPAIIYGGDK LVSLSRKKVE ISVVKAELLP 
      1260       1270       1280       1290       1300
SGVTYLQFQR PKTFEYKSGQ WVRIACLDLG TNEYHPFTLT SAPHEDTLSL 
      1310       1320       1330       1340       1350
HIRAVGPWTT RLREIYSPPV GGTCARYPKL YLDGPFGEGH QEWHKFEVSV 
      1360       1370       1380       1390       1400
LVGGGIGVTP FASILKDLVF KSSMGSQMLC KKIYFIWVTR TQRQFEWLAD 
      1410       1420       1430       1440       1450
IIREVEENDC QDLVSVHIYI TQLAEKFDLR TTMLYICERH FQKALNRSLF 
      1460       1470       1480       1490       1500
TGLRSITHFG RPPFELFFNS LQEVHPQVRK IGVFSCGPPG MTKNVEKACQ 
      1510 
LINRQDRAHF VHHYENF
Length:1,517
Mass (Da):171,626
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5AB2345C85FC1DD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494BAW1A0A494BAW1_MOUSE
NAD(P)H oxidase (H(2)O(2)-forming)
Duox2
1,545Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL844566 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_808278.2, NM_177610.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000053734; ENSMUSP00000050314; ENSMUSG00000068452

UCSC genome browser

More...UCSCi		uc008mak.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844566 Genomic DNA No translation available.
RefSeqiNP_808278.2, NM_177610.2

3D structure databases

SMRiA2AQ99
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050314

Protein family/group databases

PeroxiBasei3341, MmDuOx02-4

Proteomic databases

PaxDbiA2AQ99
PRIDEiA2AQ99
ProteomicsDBi349677

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24313, 173 antibodies

Genome annotation databases

EnsembliENSMUST00000053734; ENSMUSP00000050314; ENSMUSG00000068452
UCSCiuc008mak.1, mouse

Organism-specific databases

MGIiMGI:3036280, Duox2

Phylogenomic databases

eggNOGiKOG0039, Eukaryota
GeneTreeiENSGT00940000160291
HOGENOMiCLU_004482_1_0_1
InParanoidiA2AQ99
OMAiNVFVWHE
OrthoDBi27424at2759
PhylomeDBiA2AQ99
TreeFamiTF105424

Enzyme and pathway databases

UniPathwayiUPA00194
ReactomeiR-MMU-209968, Thyroxine biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		214593, 1 hit in 52 CRISPR screens
RNActiA2AQ99, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000068452, Expressed in ileum and 35 other tissues
ExpressionAtlasiA2AQ99, baseline and differential

Family and domain databases

CDDicd09820, dual_peroxidase_like, 1 hit
cd00051, EFh, 2 hits
Gene3Di1.10.640.10, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR034818, DUOX2
IPR034821, DUOX_peroxidase
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR017938, Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF67, PTHR11972:SF67, 1 hit
PfamiView protein in Pfam
PF03098, An_peroxidase, 1 hit
PF00036, EF-hand_1, 1 hit
PF13202, EF-hand_5, 1 hit
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit
PRINTSiPR00457, ANPEROXIDASE
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SUPFAMiSSF47473, SSF47473, 1 hit
SSF48113, SSF48113, 1 hit
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits
PS51384, FAD_FR, 1 hit
PS50292, PEROXIDASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2AQ99_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AQ99
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 7, 2021
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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