Duox2

Functionⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	832 – 843	PROSITE-ProRule annotationAdd BLAST		12
Calcium bindingⁱ	868 – 879	PROSITE-ProRule annotationAdd BLAST		12

GO - Molecular functionⁱ

calcium ion binding Source: MGI
heme binding Source: InterPro
NAD(P)H oxidase activity Source: MGI
peroxidase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenohypophysis morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 17440044
bone mineralization
Source: MGI
Inferred from mutant phenotypeⁱ
- 17440044
cytokine-mediated signaling pathway Source: MGI
fertilization
Source: MGI
Inferred from mutant phenotypeⁱ
- 17440044
hormone metabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 17440044
hydrogen peroxide biosynthetic process Source: InterPro
inner ear development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17440044
multicellular organism growth
Source: MGI
Inferred from mutant phenotypeⁱ
- 17440044
response to cAMP Source: MGI
response to oxidative stress Source: InterPro
response to virus Source: MGI
thyroid gland development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17440044
thyroid hormone metabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 17440044

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	OxidoreductaseSAAS annotation
Ligand	CalciumPROSITE-ProRule annotation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-209968 Thyroxine biosynthesis

Reactomeⁱ

R-MMU-209968 Thyroxine biosynthesis

Protein family/group databases

PeroxiBaseⁱ	3341 MmDuOx02-4

PeroxiBaseⁱ

3341 MmDuOx02-4

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Dual oxidase 2Imported
Gene namesⁱ	Name:Duox2Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:3036280 Duox2

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	596 – 622	HelicalSequence analysisAdd BLAST	27
Transmembraneⁱ	1007 – 1026	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	1046 – 1068	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	1148 – 1175	HelicalSequence analysisAdd BLAST	28
Transmembraneⁱ	1187 – 1209	HelicalSequence analysisAdd BLAST	23

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_5002642732	26 – 1517	Sequence analysisAdd BLAST		1492

Proteomic databases

PaxDbⁱ	A2AQ99
PRIDEⁱ	A2AQ99

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000068452 Expressed in 13 organ(s), highest expression level in colon

Bgeeⁱ

ENSMUSG00000068452 Expressed in 13 organ(s), highest expression level in colon

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000050314

STRINGⁱ

10090.ENSMUSP00000050314

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A2AQ99
SMRⁱ	A2AQ99
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	819 – 854	EF-handInterPro annotationAdd BLAST	36
Domainⁱ	855 – 890	EF-handInterPro annotationAdd BLAST	36
Domainⁱ	899 – 934	EF-handInterPro annotationAdd BLAST	36
Domainⁱ	1236 – 1342	FAD-binding FR-typeInterPro annotationAdd BLAST	107

Keywords - Domainⁱ

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG0039 Eukaryota ENOG410XNZY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074350
HOGENOMⁱ	HOG000231774
HOVERGENⁱ	HBG080428
InParanoidⁱ	A2AQ99
OMAⁱ	WPGPKEK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00PO
PhylomeDBⁱ	A2AQ99
TreeFamⁱ	TF105424

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09820 dual_peroxidase_like, 1 hit cd00051 EFh, 2 hits
Gene3Dⁱ	1.10.640.10, 1 hit 3.40.50.80, 1 hit
InterProⁱ	View protein in InterPro IPR034818 DUOX2 IPR034821 DUOX_peroxidase IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR013112 FAD-bd_8 IPR017927 FAD-bd_FR_type IPR013130 Fe3_Rdtase_TM_dom IPR013121 Fe_red_NAD-bd_6 IPR039261 FNR_nucleotide-bd IPR010255 Haem_peroxidase IPR019791 Haem_peroxidase_animal IPR037120 Haem_peroxidase_sf IPR017938 Riboflavin_synthase-like_b-brl
PANTHERⁱ	PTHR11972:SF67 PTHR11972:SF67, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03098 An_peroxidase, 1 hit PF00036 EF-hand_1, 1 hit PF13202 EF-hand_5, 1 hit PF08022 FAD_binding_8, 1 hit PF01794 Ferric_reduct, 1 hit PF08030 NAD_binding_6, 1 hit
PRINTSⁱ	PR00457 ANPEROXIDASE
SMARTⁱ	View protein in SMART SM00054 EFh, 2 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit SSF48113 SSF48113, 1 hit SSF52343 SSF52343, 1 hit SSF63380 SSF63380, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 3 hits PS51384 FAD_FR, 1 hit PS50292 PEROXIDASE_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A2AQ99-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLPTSPKTLV LLGALLTGPL GPAGGQDAPS LPWEVQRYDG WFNNLKYHQR 
        60         70         80         90        100
GAAGSRLRRL IPANYADGVY QALEEPLLPN PRRLSDAVAK GKAGLPSVHN 
       110        120        130        140        150
RTVLGVFFGY HVLSDLVSVE TPGCPAEFLN IYIPRGDPVF DPDKRGNVVL 
       160        170        180        190        200
PFQRSRWDHN TGQSPSNPRD QSNQVTGWLD GSAIYGSSHS WSDTLRSFSG 
       210        220        230        240        250
GQLASGPDPA FPRNSQSSLL MWMAPDPSTG RGGPQGVYAF GAQRGNREPF 
       260        270        280        290        300
LQALGLLWFR YHNLCARKLA QEHPHWGDEE LFQHARKRVI ATYQNIALYQ 
       310        320        330        340        350
WLPSFLQKTP PEYSGYRPFM DPSISPEFVV ASEQFLSTMV PPGVYMRNSS 
       360        370        380        390        400
CHFRKFPKEG SDSSPALRVC NSYWIRENPN LKTAQDVDQL LLGMASQISE 
       410        420        430        440        450
LEDRIVIEDL RDYWPGPERF SRTDYVASSI QRGRDMGLPS YSQALLALGL 
       460        470        480        490        500
EPPKNWSALN PQVEPQVLEA TAALYNQDLS QLELLLGGLL ESHGDPGPLF 
       510        520        530        540        550
SNIILDQFVR LRDGDRYWFE NTRNGLFSKE EIAEIRNTTL RDVLVAVSNV 
       560        570        580        590        600
DPSALQPNVF FWQEGAPCPQ PRQLTTDGLP QCAPVTVIDY FEGSGAGYGV 
       610        620        630        640        650
TLVAVCCFPL VSLIVAGVVA HFRNREHKML LKKGKESLKK QPASDGVPAM 
       660        670        680        690        700
EWPGPKEKSY PVTLQLLPDR SLQVLDKRFT VLRTIQLQSP QQVNLILSSN 
       710        720        730        740        750
SGRRTLLLKI PKEYDLVLMF NSEEDRGAFV RLLQDLCICC TPGLHIAEVD 
       760        770        780        790        800
EKELLRKAVT KQQRAGILEI FFRQLFAQVL DINQADAGTL PLDSSQQVRE 
       810        820        830        840        850
ALTCELSRAE FADSLGLKPQ DMFVESMFSL ADKDGNGYIS FREFLDILVV 
       860        870        880        890        900
FMKGSSEDKS RLMFTMYDLD GNGFLSKDEF FTMMRSFIEI SNNCLSKAQL 
       910        920        930        940        950
AEVVESMFRE SGFQDKEELT WEDFHFMLRD HDSDLRFTQL CVKGGAGGTK 
       960        970        980        990       1000
DIFKQSSACR VSFINRTPGN RVMGPSPRLY TEALQEKKQS GFLAQKFKQY 
      1010       1020       1030       1040       1050
KRFVENYRRH IVCVTIFSAI CIGLFADRAY YYGFASPPTD IEETTYVGII 
      1060       1070       1080       1090       1100
LSRGTAASIS FMFSYILLTM CRNLITFLRE TFLNRYIPFD AAVDFHRWIA 
      1110       1120       1130       1140       1150
MAAVVLAVLH SAGHAVNVYI FSVSPLSLMA CVFPNVFVND GSKFPPKYYW 
      1160       1170       1180       1190       1200
WFFETVPGMT GVLLLLVLAI MYVFASHHFR RHSFRGFWLT HHLYVVLYVL 
      1210       1220       1230       1240       1250
IIIHGSYALI QLPSFHIYFL VPAIIYGGDK LVSLSRKKVE ISVVKAELLP 
      1260       1270       1280       1290       1300
SGVTYLQFQR PKTFEYKSGQ WVRIACLDLG TNEYHPFTLT SAPHEDTLSL 
      1310       1320       1330       1340       1350
HIRAVGPWTT RLREIYSPPV GGTCARYPKL YLDGPFGEGH QEWHKFEVSV 
      1360       1370       1380       1390       1400
LVGGGIGVTP FASILKDLVF KSSMGSQMLC KKIYFIWVTR TQRQFEWLAD 
      1410       1420       1430       1440       1450
IIREVEENDC QDLVSVHIYI TQLAEKFDLR TTMLYICERH FQKALNRSLF 
      1460       1470       1480       1490       1500
TGLRSITHFG RPPFELFFNS LQEVHPQVRK IGVFSCGPPG MTKNVEKACQ 
      1510 
LINRQDRAHF VHHYENF

Length:1,517

Mass (Da):171,626

Last modified:February 20, 2007 - v1

Checksum:ⁱB5AB2345C85FC1DD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL844566 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_808278.2, NM_177610.2
UniGeneⁱ	Mm.358846

Genome annotation databases

Ensemblⁱ	ENSMUST00000053734; ENSMUSP00000050314; ENSMUSG00000068452
GeneIDⁱ	214593
UCSC genome browser More...UCSCⁱ	uc008mak.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
A2AQ99	Dual oxidase 2		RAT		1517	UniRef90_Q9ES45
UPI000A311815		MUSPA		1517
UPI000A31AFE8		MUSCR		1517
UPI00042AD186		PERMB		1513
Isoform 2 of Dual oxidase 2		RAT		456
+2

Protein	Similar proteins		Species	Score	Length	Source
A2AQ99	Dual oxidase 2		RAT		1517	UniRef50_Q9ES45
Uncharacterized protein		PELSI		1543
Dual oxidase 2		ALLMI		1540
dual oxidase 2		ALLSI		1540
dual oxidase 1		Austrofundulus limnaeus		1528
+91

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL844566 Genomic DNA No translation available.
RefSeqⁱ	NP_808278.2, NM_177610.2
UniGeneⁱ	Mm.358846

3D structure databases

ProteinModelPortalⁱ	A2AQ99
SMRⁱ	A2AQ99
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000050314

STRINGⁱ

10090.ENSMUSP00000050314

Protein family/group databases

PeroxiBaseⁱ	3341 MmDuOx02-4

PeroxiBaseⁱ

3341 MmDuOx02-4

Proteomic databases

PaxDbⁱ	A2AQ99
PRIDEⁱ	A2AQ99

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000053734; ENSMUSP00000050314; ENSMUSG00000068452
GeneIDⁱ	214593
UCSCⁱ	uc008mak.1 mouse

Organism-specific databases

CTDⁱ	50506
MGIⁱ	MGI:3036280 Duox2

Phylogenomic databases

eggNOGⁱ	KOG0039 Eukaryota ENOG410XNZY LUCA
GeneTreeⁱ	ENSGT00550000074350
HOGENOMⁱ	HOG000231774
HOVERGENⁱ	HBG080428
InParanoidⁱ	A2AQ99
OMAⁱ	WPGPKEK
OrthoDBⁱ	EOG091G00PO
PhylomeDBⁱ	A2AQ99
TreeFamⁱ	TF105424

Enzyme and pathway databases

Reactomeⁱ	R-MMU-209968 Thyroxine biosynthesis

Reactomeⁱ

R-MMU-209968 Thyroxine biosynthesis

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000068452 Expressed in 13 organ(s), highest expression level in colon

Bgeeⁱ

ENSMUSG00000068452 Expressed in 13 organ(s), highest expression level in colon

Family and domain databases

CDDⁱ	cd09820 dual_peroxidase_like, 1 hit cd00051 EFh, 2 hits
Gene3Dⁱ	1.10.640.10, 1 hit 3.40.50.80, 1 hit
InterProⁱ	View protein in InterPro IPR034818 DUOX2 IPR034821 DUOX_peroxidase IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR013112 FAD-bd_8 IPR017927 FAD-bd_FR_type IPR013130 Fe3_Rdtase_TM_dom IPR013121 Fe_red_NAD-bd_6 IPR039261 FNR_nucleotide-bd IPR010255 Haem_peroxidase IPR019791 Haem_peroxidase_animal IPR037120 Haem_peroxidase_sf IPR017938 Riboflavin_synthase-like_b-brl
PANTHERⁱ	PTHR11972:SF67 PTHR11972:SF67, 2 hits
Pfamⁱ	View protein in Pfam PF03098 An_peroxidase, 1 hit PF00036 EF-hand_1, 1 hit PF13202 EF-hand_5, 1 hit PF08022 FAD_binding_8, 1 hit PF01794 Ferric_reduct, 1 hit PF08030 NAD_binding_6, 1 hit
PRINTSⁱ	PR00457 ANPEROXIDASE
SMARTⁱ	View protein in SMART SM00054 EFh, 2 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit SSF48113 SSF48113, 1 hit SSF52343 SSF52343, 1 hit SSF63380 SSF63380, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 3 hits PS51384 FAD_FR, 1 hit PS50292 PEROXIDASE_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A2AQ99_MOUSE
Accessionⁱ	A2AQ99Primary (citable) accession number: A2AQ99
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 20, 2007
	Last sequence update:	February 20, 2007
	Last modified:	November 7, 2018
	This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A2AQ99 (A2AQ99_MOUSE)

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Dual oxidase 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ