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Protein
Submitted name:

Dual oxidase 1

Gene

Duox1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi828 – 839PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi864 – 875PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-209968 Thyroxine biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Dual oxidase 1Imported
Gene namesi
Name:Duox1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139422 Duox1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei593 – 617HelicalSequence analysisAdd BLAST25
Transmembranei1045 – 1068HelicalSequence analysisAdd BLAST24
Transmembranei1088 – 1109HelicalSequence analysisAdd BLAST22
Transmembranei1152 – 1171HelicalSequence analysisAdd BLAST20
Transmembranei1183 – 1209HelicalSequence analysisAdd BLAST27
Transmembranei1221 – 1243HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500264273022 – 1551Sequence analysisAdd BLAST1530

Proteomic databases

PaxDbiA2AQ92
PRIDEiA2AQ92

PTM databases

iPTMnetiA2AQ92
PhosphoSitePlusiA2AQ92

Expressioni

Gene expression databases

BgeeiENSMUSG00000033268
GenevisibleiA2AQ92 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097060

Structurei

3D structure databases

ProteinModelPortaliA2AQ92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini815 – 850EF-handInterPro annotationAdd BLAST36
Domaini851 – 886EF-handInterPro annotationAdd BLAST36
Domaini895 – 930EF-handInterPro annotationAdd BLAST36
Domaini1270 – 1376FAD-binding FR-typeInterPro annotationAdd BLAST107

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili715 – 735Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0039 Eukaryota
ENOG410XNZY LUCA
GeneTreeiENSGT00550000074350
HOGENOMiHOG000231774
HOVERGENiHBG080428
InParanoidiA2AQ92
KOiK13411
OMAiTHFSHHY
OrthoDBiEOG091G00PO
PhylomeDBiA2AQ92
TreeFamiTF105424

Family and domain databases

CDDicd09820 dual_peroxidase_like, 1 hit
cd00051 EFh, 2 hits
Gene3Di1.10.640.10, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR029595 DUOX1/Duox
IPR034821 DUOX_peroxidase
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR013112 FAD-bd_8
IPR017927 Fd_Rdtase_FAD-bd
IPR013130 Fe3_Rdtase_TM_dom
IPR013121 Fe_red_NAD-bd_6
IPR039261 FNR_nucleotide_bd
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR017938 Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF75 PTHR11972:SF75, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF00036 EF-hand_1, 2 hits
PF08022 FAD_binding_8, 1 hit
PF01794 Ferric_reduct, 1 hit
PF08030 NAD_binding_6, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48113 SSF48113, 1 hit
SSF52343 SSF52343, 1 hit
SSF63380 SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS51384 FAD_FR, 1 hit
PS50292 PEROXIDASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

A2AQ92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFHLALAWI LLVGTLASLG AQNSISWEVQ RFDGWYNNLM EHRWGSKGSR
60 70 80 90 100
LQRLVPASYA DGVYQPLKEP YLPNPRHLSN RVMRGSAGQP SLRNRTVLGV
110 120 130 140 150
FFGYHVLSDL VSVETPGCPA EFLNIYIPHG DPVFDPDKRG NVVLPFQRSR
160 170 180 190 200
WDRNTGQSPS NPRDQSNQVT GWLDGSAIYG SSHSWSDTLR SFSGGQLASG
210 220 230 240 250
PDPAFPSDSQ SSLLMWMAPD PSTGQGGPRG VYAFGAQRGN REPFLQALGL
260 270 280 290 300
LWFRYHNLCA RKLAQEHPHW GDEELFQHAR KRVIATYQNI AMYEWLPSFL
310 320 330 340 350
KQTPPEYPGY RPFLDPSISP EFVVASEQFL STMVPSGVYM RNASCHFQGI
360 370 380 390 400
PSHNSSVSGA LRVCNSYWSR EHPKLQRAED VDALLLGMAS QIAEREDHVV
410 420 430 440 450
VEDMQDFWPG PLKFSRTDYL ASCLQRGRDL GLPSYTKARE ALGLSPISHW
460 470 480 490 500
QDINPALSRS NGTVLEATAA LYNQDLSRLE LLPGGLLESH GDPGPLFSTI
510 520 530 540 550
VLDQFVRLRD GDRYWFENTR NGLFSKEEIA EIRNTSLRDI LVAVTNVDPS
560 570 580 590 600
ALQPNVFFWL AGDPCPQPSQ LSAKGLPACA PLFIRDYFEG SGFGFGLTIG
610 620 630 640 650
TLCCFPLVSL LSAWIVARLR KRNFKRLQRQ DRQSIMSEKL VGGVEALEWQ
660 670 680 690 700
GRNEPCRPVL VHLQPGQIRV VDGRLTVLRT IQLRPPQQVN LILSSNRGRR
710 720 730 740 750
TLLLKIPKEY DLVLLFNMEE ERQALVENVR GALKENGLSF QEWELREQEL
760 770 780 790 800
MRAAVTRQQR GHLLETFFRH LFSQVLDINQ ADAGTLPLDS STKVREALTC
810 820 830 840 850
ELSRAEFADS LGLKPQDMFV ESMFSLADKD GNGYLSFREF LDILVVFMKG
860 870 880 890 900
SPEEKSRLMF RMYDFDGNGL ISKDEFIRML RSFIEISNNC LSKAQLAEVV
910 920 930 940 950
ESMFRESGFQ DKEELTWEDF HFMLRDHDSD LRFTQLCVKG VEVPEVIKNL
960 970 980 990 1000
CRRASYISQE KICPSPRMSA HCARNNMKTA SSPQRLQCPM DTDPPQEIRR
1010 1020 1030 1040 1050
RFGKKVTSFQ PLLFTEAHRE KFQRSRRHQT VQQFKRFIEN YRRHIGCVAV
1060 1070 1080 1090 1100
FYTITGALFL ERAYYYAFAA HHSGITDTTR VGIILSRGTA ASISFMFSYI
1110 1120 1130 1140 1150
LLTMCRNLIT FLRETFLNRY IPFDAAVDFH RLIASTAIIL TVLHSAGHVV
1160 1170 1180 1190 1200
NVYLFSISPL SVLSCLFPGL FHDDGSEFPQ KYYWWFFQTV PGLTGVLLLL
1210 1220 1230 1240 1250
ALAIMYVFAS HHFRRRSFRG FWLTHHLYIF LYILLIIHGS FALIQMPRFH
1260 1270 1280 1290 1300
IFFLVPAIIY VGDKLVSLSR KKVEISVVKA ELLPSGVTHL RFQRPQGFEY
1310 1320 1330 1340 1350
KSGQWVRIAC LALGTTEYHP FTLTSAPHED TLSLHIRAAG PWTTRLREIY
1360 1370 1380 1390 1400
SPPTGDTCAR YPKLYLDGPF GEGHQEWHKF EVSVLVGGGI GVTPFASILK
1410 1420 1430 1440 1450
DLVFKSSVSC QVFCKKIYFI WVTRTQRQFE WLADIIREVE ENDRQDLVSV
1460 1470 1480 1490 1500
HIYITQLAEK FDLRTTMLYI CERHFQKVLN RSLFTGLRSI THFGRPPFEP
1510 1520 1530 1540 1550
FFNSLQEVHP QVRKIGVFSC GPPGMTKNVE KACQLINRQD RTHFSHHYEN

F
Length:1,551
Mass (Da):177,132
Last modified:February 20, 2007 - v1
Checksum:i8B9729E2F23CAF1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844566 Genomic DNA No translation available.
RefSeqiNP_001092767.1, NM_001099297.1
XP_006500550.1, XM_006500487.2
UniGeneiMm.108582

Genome annotation databases

EnsembliENSMUST00000099461; ENSMUSP00000097060; ENSMUSG00000033268
GeneIDi99439
KEGGimmu:99439
UCSCiuc008map.1 mouse

Similar proteinsi

Entry informationi

Entry nameiA2AQ92_MOUSE
AccessioniPrimary (citable) accession number: A2AQ92
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: July 18, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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