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Entry version 86 (08 May 2019)
Sequence version 1 (20 Feb 2007)
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Protein

Sickle tail protein

Gene

Skt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal development of intervertebral disks.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sickle tail protein
Alternative name(s):
Enhancer trap locus 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SktImported
Synonyms:Etl4Imported, Kiaa1217Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:95454 Etl4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice display a kinky-tail phenotype in about half of homozygotes with defects in the nucleus pulposus and annulus fibrosus of intertebral disks. Shortening and curving of caudal vertebrae 20-25 is apparent by the age of 2 weeks.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002878981 – 1946Sickle tail proteinAdd BLAST1946

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei169PhosphoserineCombined sources1
Modified residuei244PhosphotyrosineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi357O-linked (GlcNAc) serine1 Publication1
Modified residuei361PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei393PhosphotyrosineBy similarity1
Modified residuei470PhosphothreonineBy similarity1
Modified residuei474PhosphoserineCombined sources1
Modified residuei809PhosphoserineCombined sources1
Modified residuei1032PhosphoserineCombined sources1
Modified residuei1035PhosphoserineCombined sources1
Modified residuei1038PhosphoserineCombined sources1
Modified residuei1049PhosphoserineCombined sources1
Modified residuei1466PhosphoserineCombined sources1
Modified residuei1741PhosphoserineBy similarity1
Modified residuei1843PhosphoserineCombined sources1
Modified residuei1899PhosphoserineCombined sources1
Modified residuei1902PhosphoserineCombined sources1
Modified residuei1905PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2AQ25

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AQ25

PeptideAtlas

More...
PeptideAtlasi
A2AQ25

PRoteomics IDEntifications database

More...
PRIDEi
A2AQ25

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AQ25

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AQ25

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in the notochord and mesonephros during embryogenesis as well as in other areas such as the epithalamus sulcus, lens vesicle, inner retinal layer, heart, hepatic primordial surface, infundibulum, surface ectoderm, hind gut and limb bud mesenchyme. In adults, expressed in a range of tissues including the nucleus pulposus, corpus callosum, kidney, cardiac muscle, Sertoli cells and hair follicles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036617 Expressed in 275 organ(s), highest expression level in epithelium of lens

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2AQ25 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2AQ25 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CPNE4 (via VWFA domain) (PubMed:12522145).1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
228993, 9 interactors

Protein interaction database and analysis system

More...
IntActi
A2AQ25, 9 interactors

Molecular INTeraction database

More...
MINTi
A2AQ25

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000041431

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AQ25

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili557 – 581Sequence analysisAdd BLAST25
Coiled coili644 – 685Sequence analysisAdd BLAST42
Coiled coili962 – 990Sequence analysisAdd BLAST29
Coiled coili1469 – 1495Sequence analysisAdd BLAST27
Coiled coili1659 – 1688Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi298 – 364Pro-richSequence analysisAdd BLAST67
Compositional biasi1050 – 1120Pro-richSequence analysisAdd BLAST71
Compositional biasi1796 – 1908Ser-richSequence analysisAdd BLAST113

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG2A Eukaryota
ENOG410ZC52 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156098

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AQ25

Database of Orthologous Groups

More...
OrthoDBi
840295at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2AQ25

TreeFam database of animal gene trees

More...
TreeFami
TF332255

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022782 AIP3-like_C
IPR026725 Skt

The PANTHER Classification System

More...
PANTHERi
PTHR22741:SF11 PTHR22741:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03915 AIP3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A2AQ25-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEESEGQKCE PNLPPSGDSR QMPQQGRSNL HVTSQEDAAC RRPRERLSNG
60 70 80 90 100
NARAQVSKPA RNIPRRHTLG GPRSSKEILG MQPSEMDRKR EAFLEHLKQK
110 120 130 140 150
YPHHATAIMG HQERLRDQTK SPKLSHSPQP PNLGDPVEHL SETSGDSLEA
160 170 180 190 200
MSEGEVPSPF ARGSRTRASL PVVRSANQTK ERSLGVLYLQ YGDETKQLRM
210 220 230 240 250
PNEVTSTDTI RALFVSAFPQ QLTMKMLESP SVAIYIKDDS RNVYYELNDV
260 270 280 290 300
RNIQDRSLLK VYNKDPSHAF NHMTKAVNGD MRMQREIVYA RGDGLVAPRP
310 320 330 340 350
GSVAHPPHVI PNSPPSTPVP HSLPPSPSRI PYGGSRPMAI PGNATIPRDR
360 370 380 390 400
LSSLPVSRSI SPSPSAILER RDVKPDEDMS SKNLVMFRNE GFYADPYLYH
410 420 430 440 450
EGRMSIASSH GGHPLDVPDH VIAYHRTAIR SASAYCSPSL QAEMHMEQSL
460 470 480 490 500
YRQKSRKYPD SHLPTLGSKT PPASPHRVGD LRMIDLHPHL NTHGPPHTLQ
510 520 530 540 550
PDRASPSRQS FKKEPGTLVY IEKPRNTSGL SSLVDLGPPL VEKQGFAYST
560 570 580 590 600
TTIPKDRETR ERMQAMEKQI ASLTGLVQSA LFKGPITSSS KEASSEKMVK
610 620 630 640 650
ATANRNQADG AGTAHVSAGK VLGSVEFSLP PSQPLPAGTS PIHTSLLDMR
660 670 680 690 700
RNVAELRLQL QQMRQLQLQN QEILRAMMKK AELEISNKVK ETMKRLEDPV
710 720 730 740 750
QRQRTLVEQE RQKYLHEEER IVKKLCELED FVEDLKKDSS STGRVVTLKD
760 770 780 790 800
VEDGAFLLRQ VGEAVATLKG EFPTLQNKMR AVLRIEVEAV RFLKEEPHKL
810 820 830 840 850
DSLLKRVRSM TDVLTMLRRH VTDGLLKGTD ASQAAQYVAM EKATAAEVLK
860 870 880 890 900
HQEETAHAPG QPLHCSTGSP GDVKSEVVPL STMTVHHVQS SPVVMQPSQH
910 920 930 940 950
SSALMNPAQN LPGGTRPHTA SPPAITQEVT SAQSAPGPQS PQTPVNGSSM
960 970 980 990 1000
QSLFIEEIHS VSAKNRAVSI EKAEKKWEEK RQNLEHYNGK EFEKLLEEAQ
1010 1020 1030 1040 1050
ANIMKSIPNL EMPPASSPVS KGDAAGDKLE LSEDSPNSEQ ELDKIGGKSP
1060 1070 1080 1090 1100
PPPPPPPRRS YLPGSGLTTT RSGDVVYTGR SMSKVSSEDP GPTPQTRATK
1110 1120 1130 1140 1150
CPPEEPASAW APSPPPVPAP SSKEEEEEEE EGDKIMAELQ AFQKCSFMDV
1160 1170 1180 1190 1200
NPNSHAEQSR ANSHLKDTRA GATAPPKEKK NLEFYHEDVR KSDVECENGP
1210 1220 1230 1240 1250
QVESQKVTAG ALRPSGPPKW ERVMVDSISD TSRTSECRAD TFTEENATPN
1260 1270 1280 1290 1300
KSLFRDSRNY SQKNVPKVSF SSSGLNSLEG EINKGPNVSG LQCAIPDLEN
1310 1320 1330 1340 1350
QKLNFGKTKE IGQQGQENAD KSHIPLPTRS AEFSIHDVKT QDQDVPVTGY
1360 1370 1380 1390 1400
GQVVLRSKVG RHANMNMNED GESTPSSPSE EHTATDNIAF MITKTAVQVL
1410 1420 1430 1440 1450
SSGEVHDIVS QKGQDVQTVN IDGRKETASQ HEGTEGEEPV VCLDKKPVII
1460 1470 1480 1490 1500
IFDEPMDIRS AYKRLSTIFE ECDEELERML TEEKIEEEEE DENEDSGVRT
1510 1520 1530 1540 1550
SSQMSCEQVD SRSDRMGQKA ETQSQPHVLS AELLTPGVQG VRKAEQRKLS
1560 1570 1580 1590 1600
SADSPDSGNK CGMVDDQFES PKKKFKFKFP KKQLAALTQA IRTGTKTGKK
1610 1620 1630 1640 1650
TLQVVVYEEE EEDGTLKQHK EAKRFEITRS QPEDALKTMA RRQEQLSPEG
1660 1670 1680 1690 1700
TLPASRTDEI RKSTYRTLDS LEQTIKQLEN TISEMSPRAL VDTSCSSNRD
1710 1720 1730 1740 1750
CGASLPHMAQ EVSPRSLLVL DEVPPAPEPP TSISPASRKG SSTTPQTSRM
1760 1770 1780 1790 1800
PVPMTSKNRP GSLDKASKQS KLQDPRQYRQ ANGSAKKAGG DCKPTSPSLP
1810 1820 1830 1840 1850
ASKIPALSPS SGKSSSLPSA SGDSSNLPNA PATKPSIAST PLSPQAGRSA
1860 1870 1880 1890 1900
HSASLIPSVS NGSLKFQSPP HAGKGHHHLS FALQTQNGRA APTTSSSSSP
1910 1920 1930 1940
PSPASPTSLN QGARGIRTIH TPSLASYKAQ NGSSSKATPS TAKETS
Note: Gene prediction based on EST data.Curated
Length:1,946
Mass (Da):213,037
Last modified:February 20, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5D411BD044DC1CB
GO
Isoform 2 (identifier: A2AQ25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.

Note: Gene prediction based on EST data.Curated
Show »
Length:1,629
Mass (Da):177,470
Checksum:i1CA9737BD1115EA6
GO
Isoform 31 Publication (identifier: A2AQ25-3) [UniParc]FASTAAdd to basket
Also known as: Skt-a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     560-594: Missing.
     1181-1739: Missing.

Show »
Length:1,352
Mass (Da):147,228
Checksum:i31F5EB88824A81F6
GO
Isoform 41 Publication (identifier: A2AQ25-4) [UniParc]FASTAAdd to basket
Also known as: Skt-b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     560-594: Missing.
     961-971: Missing.
     1181-1739: Missing.

Show »
Length:1,341
Mass (Da):146,072
Checksum:i6F89DC54769612F8
GO
Isoform 5 (identifier: A2AQ25-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1207-1739: Missing.
     1781-1784: ANGS → VVLP
     1785-1946: Missing.

Note: Gene prediction based on EST data.Curated
Show »
Length:934
Mass (Da):102,599
Checksum:i1739E8A5CB11FC2E
GO
Isoform 6 (identifier: A2AQ25-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1181-1739: Missing.
     1781-1784: ANGS → VVLP
     1785-1946: Missing.

Note: Gene prediction based on EST data.Curated
Show »
Length:908
Mass (Da):99,537
Checksum:i98ADFD53F75B0020
GO
Isoform 72 Publications (identifier: A2AQ25-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-1946: Missing.

Show »
Length:251
Mass (Da):28,239
Checksum:i091D565110CE85B4
GO
Isoform 81 Publication (identifier: A2AQ25-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     560-594: Missing.
     885-1755: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,040
Mass (Da):113,806
Checksum:i400C01C9C7028F95
GO
Isoform 91 Publication (identifier: A2AQ25-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     961-971: Missing.
     1181-1191: NLEFYHEDVRK → VTCGSYTFTIQ
     1192-1946: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:863
Mass (Da):94,616
Checksum:i9E986A826CCC2CA3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QAU4E9QAU4_MOUSE
Enhancer trap locus 4
Etl4
1,997Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z781D3Z781_MOUSE
Enhancer trap locus 4
Etl4
1,347Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BHR1Q8BHR1_MOUSE
Enhancer trap locus 4
Etl4 BC026657
480Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AY49B1AY49_MOUSE
Enhancer trap locus 4
Etl4
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AY50B1AY50_MOUSE
Enhancer trap locus 4
Etl4
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH26657 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC41473 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41R → H in AAH50016 (PubMed:15489334).Curated1
Sequence conflicti119T → R in BAC41473 (PubMed:12465718).Curated1
Sequence conflicti551T → A in BAC41473 (PubMed:12465718).Curated1
Sequence conflicti818R → Q in BAC41473 (PubMed:12465718).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0524161 – 282Missing in isoform 2, isoform 5, isoform 6 and isoform 9. 1 PublicationAdd BLAST282
Alternative sequenceiVSP_052417252 – 1946Missing in isoform 7. 2 PublicationsAdd BLAST1695
Alternative sequenceiVSP_052418560 – 594Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 8 and isoform 9. 4 PublicationsAdd BLAST35
Alternative sequenceiVSP_052419885 – 1755Missing in isoform 8. 1 PublicationAdd BLAST871
Alternative sequenceiVSP_052420961 – 971Missing in isoform 4 and isoform 9. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_0524211181 – 1739Missing in isoform 3, isoform 4 and isoform 6. 2 PublicationsAdd BLAST559
Alternative sequenceiVSP_0524221181 – 1191NLEFYHEDVRK → VTCGSYTFTIQ in isoform 9. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0524231192 – 1946Missing in isoform 9. 1 PublicationAdd BLAST755
Alternative sequenceiVSP_0524241207 – 1739Missing in isoform 5. CuratedAdd BLAST533
Alternative sequenceiVSP_0524251781 – 1784ANGS → VVLP in isoform 5 and isoform 6. Curated4
Alternative sequenceiVSP_0524261785 – 1946Missing in isoform 5 and isoform 6. CuratedAdd BLAST162

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB125594 mRNA Translation: BAD14929.1
AB125595 mRNA Translation: BAD14930.1
AB093289 mRNA Translation: BAC41473.2 Different initiation.
AK052733 mRNA Translation: BAC35121.1
AK054453 mRNA Translation: BAC35783.1
AL844538 Genomic DNA No translation available.
AL929100 Genomic DNA No translation available.
BC026657 mRNA Translation: AAH26657.2 Different initiation.
BC050016 mRNA Translation: AAH50016.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS50510.1 [A2AQ25-4]
CCDS50511.1 [A2AQ25-3]

NCBI Reference Sequences

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RefSeqi
NP_001074475.1, NM_001081006.1
NP_001171101.2, NM_001177630.2
NP_084171.2, NM_029895.4 [A2AQ25-4]
NP_835160.2, NM_178059.5 [A2AQ25-3]
XP_006497478.1, XM_006497415.3 [A2AQ25-1]
XP_006497487.1, XM_006497424.3 [A2AQ25-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000045555; ENSMUSP00000041431; ENSMUSG00000036617 [A2AQ25-3]
ENSMUST00000066509; ENSMUSP00000066170; ENSMUSG00000036617 [A2AQ25-1]
ENSMUST00000114606; ENSMUSP00000110253; ENSMUSG00000036617 [A2AQ25-6]
ENSMUST00000114607; ENSMUSP00000110254; ENSMUSG00000036617 [A2AQ25-5]
ENSMUST00000114608; ENSMUSP00000110255; ENSMUSG00000036617 [A2AQ25-2]
ENSMUST00000114614; ENSMUSP00000110261; ENSMUSG00000036617 [A2AQ25-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
208618

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:208618

UCSC genome browser

More...
UCSCi
uc008imn.1 mouse [A2AQ25-3]
uc008imo.1 mouse [A2AQ25-4]
uc008imp.1 mouse [A2AQ25-7]
uc008imq.1 mouse [A2AQ25-1]
uc008ims.1 mouse [A2AQ25-6]
uc008imt.1 mouse [A2AQ25-9]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB125594 mRNA Translation: BAD14929.1
AB125595 mRNA Translation: BAD14930.1
AB093289 mRNA Translation: BAC41473.2 Different initiation.
AK052733 mRNA Translation: BAC35121.1
AK054453 mRNA Translation: BAC35783.1
AL844538 Genomic DNA No translation available.
AL929100 Genomic DNA No translation available.
BC026657 mRNA Translation: AAH26657.2 Different initiation.
BC050016 mRNA Translation: AAH50016.1
CCDSiCCDS50510.1 [A2AQ25-4]
CCDS50511.1 [A2AQ25-3]
RefSeqiNP_001074475.1, NM_001081006.1
NP_001171101.2, NM_001177630.2
NP_084171.2, NM_029895.4 [A2AQ25-4]
NP_835160.2, NM_178059.5 [A2AQ25-3]
XP_006497478.1, XM_006497415.3 [A2AQ25-1]
XP_006497487.1, XM_006497424.3 [A2AQ25-2]

3D structure databases

SMRiA2AQ25
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228993, 9 interactors
IntActiA2AQ25, 9 interactors
MINTiA2AQ25
STRINGi10090.ENSMUSP00000041431

PTM databases

iPTMnetiA2AQ25
PhosphoSitePlusiA2AQ25

Proteomic databases

MaxQBiA2AQ25
PaxDbiA2AQ25
PeptideAtlasiA2AQ25
PRIDEiA2AQ25

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045555; ENSMUSP00000041431; ENSMUSG00000036617 [A2AQ25-3]
ENSMUST00000066509; ENSMUSP00000066170; ENSMUSG00000036617 [A2AQ25-1]
ENSMUST00000114606; ENSMUSP00000110253; ENSMUSG00000036617 [A2AQ25-6]
ENSMUST00000114607; ENSMUSP00000110254; ENSMUSG00000036617 [A2AQ25-5]
ENSMUST00000114608; ENSMUSP00000110255; ENSMUSG00000036617 [A2AQ25-2]
ENSMUST00000114614; ENSMUSP00000110261; ENSMUSG00000036617 [A2AQ25-4]
GeneIDi208618
KEGGimmu:208618
UCSCiuc008imn.1 mouse [A2AQ25-3]
uc008imo.1 mouse [A2AQ25-4]
uc008imp.1 mouse [A2AQ25-7]
uc008imq.1 mouse [A2AQ25-1]
uc008ims.1 mouse [A2AQ25-6]
uc008imt.1 mouse [A2AQ25-9]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100144434
MGIiMGI:95454 Etl4

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IG2A Eukaryota
ENOG410ZC52 LUCA
GeneTreeiENSGT00940000156098
InParanoidiA2AQ25
OrthoDBi840295at2759
PhylomeDBiA2AQ25
TreeFamiTF332255

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Etl4 mouse

Protein Ontology

More...
PROi
PR:A2AQ25

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036617 Expressed in 275 organ(s), highest expression level in epithelium of lens
ExpressionAtlasiA2AQ25 baseline and differential
GenevisibleiA2AQ25 MM

Family and domain databases

InterProiView protein in InterPro
IPR022782 AIP3-like_C
IPR026725 Skt
PANTHERiPTHR22741:SF11 PTHR22741:SF11, 1 hit
PfamiView protein in Pfam
PF03915 AIP3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKT_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AQ25
Secondary accession number(s): A2AUE9
, A2AUF0, A2AUF1, Q75UV8, Q75UV9, Q80VK2, Q8BHX8, Q8BHY1, Q8CHA8, Q8R0K6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 20, 2007
Last modified: May 8, 2019
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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