UniProtKB - A2APY7 (NDUF5_MOUSE)
Protein
Arginine-hydroxylase NDUFAF5, mitochondrial
Gene
Ndufaf5
Organism
Mus musculus (Mouse)
Status
Functioni
Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. Acts by mediating hydroxylation of 'Arg-111' of NDUFS7. May also have methyltransferase activity.By similarity
GO - Molecular functioni
- methyltransferase activity Source: UniProtKB-KW
- oxidoreductase activity Source: UniProtKB-KW
GO - Biological processi
- methylation Source: UniProtKB-KW
- mitochondrial respiratory chain complex I assembly Source: UniProtKB
- peptidyl-arginine hydroxylation Source: UniProtKB
Keywordsi
Molecular function | Methyltransferase, Oxidoreductase, Transferase |
Enzyme and pathway databases
Reactomei | R-MMU-6799198, Complex I biogenesis |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Ndufaf5Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916737, Ndufaf5 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity
Note: Peripherally localized on the matrix face of the mitochondrial inner membrane.By similarity
Mitochondrion
- extrinsic component of mitochondrial inner membrane Source: MGI
- mitochondrion Source: MGI
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 29 | MitochondrionSequence analysisAdd BLAST | 29 | |
ChainiPRO_0000307214 | 30 – 343 | Arginine-hydroxylase NDUFAF5, mitochondrialAdd BLAST | 314 |
Proteomic databases
EPDi | A2APY7 |
MaxQBi | A2APY7 |
PaxDbi | A2APY7 |
PeptideAtlasi | A2APY7 |
PRIDEi | A2APY7 |
PTM databases
iPTMneti | A2APY7 |
PhosphoSitePlusi | A2APY7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027384, Expressed in hindlimb stylopod muscle and 275 other tissues |
Genevisiblei | A2APY7, MM |
Interactioni
Subunit structurei
Interacts with NDUFAF8, leading to stabilize NDUFAF5.
Interacts with NDUFS7.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035325 |
Miscellaneous databases
RNActi | A2APY7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the methyltransferase superfamily.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2940, Eukaryota |
GeneTreei | ENSGT00390000014687 |
HOGENOMi | CLU_046586_0_2_1 |
InParanoidi | A2APY7 |
OMAi | IYFVGWK |
OrthoDBi | 691814at2759 |
PhylomeDBi | A2APY7 |
TreeFami | TF315222 |
Family and domain databases
InterProi | View protein in InterPro IPR013216, Methyltransf_11 IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF08241, Methyltransf_11, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: A2APY7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLRKVVLLRL CPLLGRPAVS ASSGSRREVA SGVPPSGSTS PRALNIFDRE
60 70 80 90 100
LKRKQKNWAA RQPDPMKFDY LKEEVGSRIA DRVYDIARDF PLALDIGCGR
110 120 130 140 150
GYIAQHLDKE TVGKIFQTDI AEHALKNSLE TDIPTVNILA DEEFLPFQEN
160 170 180 190 200
TFDLVVSSLS LHWVNDLPRA LEQIHYVLKP DGVFVGAMFG GDTLYELRCS
210 220 230 240 250
LQLAETEREG GFSPHISPFT AVNDLGHLLG RAGFNTLTVD TDEIQVNYPG
260 270 280 290 300
MFELMEDLKG MGESNCSWNR KALLHRDTML AAAAVYREMY RNEDGSIPAT
310 320 330 340
FQIYHMIGWK YHDSQARPAE RGSATVSFGE LAKLNDVMSH EKK
Sequence cautioni
The sequence AAH05630 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028638 | 1 – 187 | Missing in isoform 2. 1 PublicationAdd BLAST | 187 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK009123 mRNA Translation: BAB26088.1 AL844528 Genomic DNA No translation available. BC005630 mRNA Translation: AAH05630.1 Different initiation. |
CCDSi | CCDS16804.2 [A2APY7-1] |
RefSeqi | NP_081369.2, NM_027093.4 [A2APY7-1] |
Genome annotation databases
Ensembli | ENSMUST00000044825; ENSMUSP00000035325; ENSMUSG00000027384 [A2APY7-1] |
GeneIDi | 69487 |
KEGGi | mmu:69487 |
UCSCi | uc008mpo.2, mouse [A2APY7-1] uc008mpp.2, mouse [A2APY7-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK009123 mRNA Translation: BAB26088.1 AL844528 Genomic DNA No translation available. BC005630 mRNA Translation: AAH05630.1 Different initiation. |
CCDSi | CCDS16804.2 [A2APY7-1] |
RefSeqi | NP_081369.2, NM_027093.4 [A2APY7-1] |
3D structure databases
SMRi | A2APY7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035325 |
PTM databases
iPTMneti | A2APY7 |
PhosphoSitePlusi | A2APY7 |
Proteomic databases
EPDi | A2APY7 |
MaxQBi | A2APY7 |
PaxDbi | A2APY7 |
PeptideAtlasi | A2APY7 |
PRIDEi | A2APY7 |
Protocols and materials databases
Antibodypediai | 24277, 119 antibodies |
DNASUi | 69487 |
Genome annotation databases
Ensembli | ENSMUST00000044825; ENSMUSP00000035325; ENSMUSG00000027384 [A2APY7-1] |
GeneIDi | 69487 |
KEGGi | mmu:69487 |
UCSCi | uc008mpo.2, mouse [A2APY7-1] uc008mpp.2, mouse [A2APY7-2] |
Organism-specific databases
CTDi | 79133 |
MGIi | MGI:1916737, Ndufaf5 |
Phylogenomic databases
eggNOGi | KOG2940, Eukaryota |
GeneTreei | ENSGT00390000014687 |
HOGENOMi | CLU_046586_0_2_1 |
InParanoidi | A2APY7 |
OMAi | IYFVGWK |
OrthoDBi | 691814at2759 |
PhylomeDBi | A2APY7 |
TreeFami | TF315222 |
Enzyme and pathway databases
Reactomei | R-MMU-6799198, Complex I biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 69487, 8 hits in 19 CRISPR screens |
PROi | PR:A2APY7 |
RNActi | A2APY7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027384, Expressed in hindlimb stylopod muscle and 275 other tissues |
Genevisiblei | A2APY7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR013216, Methyltransf_11 IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF08241, Methyltransf_11, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NDUF5_MOUSE | |
Accessioni | A2APY7Primary (citable) accession number: A2APY7 Secondary accession number(s): Q9D7L6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families