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Entry version 84 (08 May 2019)
Sequence version 3 (26 May 2009)
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Protein

Kelch domain-containing protein 7A

Gene

Klhdc7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch domain-containing protein 7A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Klhdc7a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444612 Klhdc7a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 40HelicalSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002850861 – 773Kelch domain-containing protein 7AAdd BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei89PhosphoserineCombined sources1
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei361PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A2APT9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A2APT9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2APT9

PRoteomics IDEntifications database

More...
PRIDEi
A2APT9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2APT9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2APT9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000078234 Expressed in 55 organ(s), highest expression level in brown adipose tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A2APT9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000100648

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati323 – 370Kelch 1Add BLAST48
Repeati488 – 534Kelch 2Add BLAST47
Repeati537 – 585Kelch 3Add BLAST49
Repeati586 – 628Kelch 4Add BLAST43
Repeati631 – 673Kelch 5Add BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi81 – 86Poly-Arg6

Keywords - Domaini

Kelch repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1072 Eukaryota
ENOG4110X8D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162724

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246990

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2APT9

Identification of Orthologs from Complete Genome Data

More...
OMAi
EAAYKVM

Database of Orthologous Groups

More...
OrthoDBi
594274at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2APT9

TreeFam database of animal gene trees

More...
TreeFami
TF328485

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01344 Kelch_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00612 Kelch, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2APT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPTGEGAEG QDWHLDMQLP SKVVLSAAAL LLVTAAYKLY KSRPAPVGQA
60 70 80 90 100
GRNNKDHKAE NETEALGQLA FQEAPPGTLP RGRRRRKASK GAGTSLDYSL
110 120 130 140 150
VDPEDPCILD ISRSEEATRK GSDESQGRQC PDSQQVPPPC GGQEAGTDVR
160 170 180 190 200
GKPNPPHLPH SGCEPTSSSG RLIPGVGGSC VGDKLSPWPD SRPPEETGSG
210 220 230 240 250
DLEAPNGWTD LTLVNGDMNQ SWIFTHMTGV SRGEAGVLQA AADMGLATQQ
260 270 280 290 300
QEGATNASHT FSSVARIRME ENIIQKAEGP GLKGRVYDYF VESTSKADSR
310 320 330 340 350
PVPCPAALAD APSPGPGPEP LVTGAASRDE AANTAGGGAS EAASPQPVAS
360 370 380 390 400
PSAPGFSRKV SLLQIAENPE LQLQPEGFRM PLPAHLDQRA QLSSACSHGE
410 420 430 440 450
PHVQLVAGTN FFHIPLTPAS ALDVRLDLGN CYEMLTLAKR QGLETLKEAA
460 470 480 490 500
YKVLSDNYLQ VLRSPDIYGG LSGAERELIL QRRFRGHKRL VVADMCPQDD
510 520 530 540 550
SGRLCCYDNV QDAWHPLAQL PPEAMSRGCA LCTLFNYLFV VSGCQEPGGQ
560 570 580 590 600
PSNRVFCYNP LTAIWSEVCP LNQARPHCRL VALEGHLYAI GGECLNTVER
610 620 630 640 650
YDPRLDRWTF APPLPNDTFA LAHTATVCAN EIFVTGGSLR YLLLRFSTQE
660 670 680 690 700
QRWWAGPTGG SKDRTAEMVA VNGFLYRFDL NRSLGISVYR CSASTRLWYE
710 720 730 740 750
CATYRLPYPD AFQCAVVDDH IYCVGRRRML CFLADHISPR FVSKELKGFP
760 770
SARGTLLPAV LTLPVPDVPQ TPV
Length:773
Mass (Da):83,590
Last modified:May 26, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i200329BF358AB065
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC35129 differs from that shown. Reason: Frameshift at position 658.Curated
The sequence BAC35129 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14H → I in BAC35129 (PubMed:16141072).Curated1
Sequence conflicti513A → V in BAC35129 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL844480 Genomic DNA No translation available.
AK052747 mRNA Translation: BAC35129.1 Sequence problems.
BC043462 mRNA Translation: AAH43462.1
BC043672 mRNA Translation: AAH43672.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS38935.1

NCBI Reference Sequences

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RefSeqi
NP_775603.2, NM_173427.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000105031; ENSMUSP00000100648; ENSMUSG00000078234

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
242721

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:242721

UCSC genome browser

More...
UCSCi
uc008vmt.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844480 Genomic DNA No translation available.
AK052747 mRNA Translation: BAC35129.1 Sequence problems.
BC043462 mRNA Translation: AAH43462.1
BC043672 mRNA Translation: AAH43672.1
CCDSiCCDS38935.1
RefSeqiNP_775603.2, NM_173427.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100648

PTM databases

iPTMnetiA2APT9
PhosphoSitePlusiA2APT9

Proteomic databases

jPOSTiA2APT9
MaxQBiA2APT9
PaxDbiA2APT9
PRIDEiA2APT9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105031; ENSMUSP00000100648; ENSMUSG00000078234
GeneIDi242721
KEGGimmu:242721
UCSCiuc008vmt.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
127707
MGIiMGI:2444612 Klhdc7a

Phylogenomic databases

eggNOGiKOG1072 Eukaryota
ENOG4110X8D LUCA
GeneTreeiENSGT00940000162724
HOGENOMiHOG000246990
InParanoidiA2APT9
OMAiEAAYKVM
OrthoDBi594274at2759
PhylomeDBiA2APT9
TreeFamiTF328485

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Klhdc7a mouse

Protein Ontology

More...
PROi
PR:A2APT9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000078234 Expressed in 55 organ(s), highest expression level in brown adipose tissue
GenevisibleiA2APT9 MM

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
PfamiView protein in Pfam
PF01344 Kelch_1, 2 hits
SMARTiView protein in SMART
SM00612 Kelch, 2 hits
SUPFAMiSSF117281 SSF117281, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLD7A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2APT9
Secondary accession number(s): Q80SV4, Q8C706
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 26, 2009
Last modified: May 8, 2019
This is version 84 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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