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UniProtKB - A2APM1 (A2APM1_MOUSE)
Protein
CD44 antigen
Gene
Cd44
Organism
Mus musculus (Mouse)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- hyaluronic acid binding Source: InterPro
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
Keywordsi
Biological process | Cell adhesionARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: CD44 antigenARBA annotationAlternative name(s): Extracellular matrix receptor IIIARBA annotation GP90 lymphocyte homing/adhesion receptorARBA annotation HUTCH-IARBA annotation Hermes antigenARBA annotation Hyaluronate receptorARBA annotation Phagocytic glycoprotein 1ARBA annotation Phagocytic glycoprotein IARBA annotation |
Gene namesi | Name:Cd44Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88338, Cd44 |
VEuPathDBi | HostDB:ENSMUSG00000005087 |
Subcellular locationi
Other locations
- microvillus ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
- microvillus Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 565 – 586 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membraneARBA annotation, Cell projectionARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5002642320 | 21 – 657 | CD44 antigenSequence analysisAdd BLAST | 637 |
Keywords - PTMi
Disulfide bondARBA annotation, PhosphoproteinARBA annotationProteomic databases
jPOSTi | A2APM1 |
MaxQBi | A2APM1 |
PeptideAtlasi | A2APM1 |
PRIDEi | A2APM1 |
ProteomicsDBi | 324149 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000005087, Expressed in molar tooth and 281 other tissues |
ExpressionAtlasi | A2APM1, baseline and differential |
Genevisiblei | A2APM1, MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 125 | LinkInterPro annotationAdd BLAST | 90 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 229 – 249 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 270 – 470 | DisorderedSequence analysisAdd BLAST | 201 | |
Regioni | 507 – 557 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 270 – 284 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 296 – 364 | Polar residuesSequence analysisAdd BLAST | 69 | |
Compositional biasi | 375 – 403 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 410 – 427 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 528 – 557 | Polar residuesSequence analysisAdd BLAST | 30 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00530000063822 |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR001231, CD44_antigen IPR043210, CD44_antigen-like IPR016187, CTDL_fold IPR000538, Link_dom |
PANTHERi | PTHR10225, PTHR10225, 2 hits PTHR10225:SF6, PTHR10225:SF6, 2 hits |
Pfami | View protein in Pfam PF00193, Xlink, 1 hit |
PRINTSi | PR00658, CD44 PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00445, LINK, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS01241, LINK_1, 1 hit PS50963, LINK_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
A2APM1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKFWWHTAW GLCLLQLSLA HPHQQIDLNV TCRYAGVFHV EKNGRYSISR
60 70 80 90 100
TEAADLCQAF NSTLPTMDQM KLALSKGFET CRYGFIEGNV VIPRIHPNAI
110 120 130 140 150
CAANHTGVYI LVTSNTSHYD TYCFNASAPP EEDCTSVTDL PNSFDGPVTI
160 170 180 190 200
TIVNRDGTRY SKKGEYRTHQ EDIDASNIID DDVSSGSTIE KSTPESYILH
210 220 230 240 250
TYLPTEQPTG DQDDSFFIRS TLATIASTPR VSARTEDNQD WTQWKPNHSN
260 270 280 290 300
PEVLLQTTTR MADIDRISTS AHGENWTPEP QPPFNNHEYQ DEEETPHATS
310 320 330 340 350
TTPNSTAEAA ATQQETWFQN GWQGKNPPTP SEDSHVTEGT TASAHNNHPS
360 370 380 390 400
QRITTQSQED VSWTDFFDPI SHPMGQGHQT ESKDTDSSHS TTLQPTAAPN
410 420 430 440 450
THLVEDLNRT GPLSVTTPQS HSQNFSTLHG EPEEDENHPT TSILPSSTKS
460 470 480 490 500
GAKDARRGGS LPTDTTTSVE GYTFQYPDTM ENGTLFPVTP AKTEVFGETE
510 520 530 540 550
VTLATDSNVN VDGSLPGDRD SSKDSRGSSR TVTHGSELAG HSSANQDSGV
560 570 580 590 600
TTTSGPMRRP QIPEWLIILA SLLALALILA VCIAVNSRRR CGQKKKLVIN
610 620 630 640 650
GGNGTVEDRK PSELNGEASK SQEMVHLVNK EPSETPDQCM TADETRNLQS
VDMKIGV
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP15379 | CD44_MOUSE | CD44 antigen | Cd44 Ly-24 | 778 | Annotation score: | ||
A2APM2 | A2APM2_MOUSE | CD44 antigen | Cd44 | 780 | Annotation score: | ||
A2APM3 | A2APM3_MOUSE | CD44 antigen | Cd44 | 464 | Annotation score: | ||
A2APM4 | A2APM4_MOUSE | CD44 antigen | Cd44 | 498 | Annotation score: | ||
Q3U8S1 | Q3U8S1_MOUSE | CD44 antigen | Cd44 | 365 | Annotation score: | ||
Q80X37 | Q80X37_MOUSE | CD44 antigen | Cd44 | 580 | Annotation score: | ||
A2APM5 | A2APM5_MOUSE | CD44 antigen | Cd44 | 434 | Annotation score: | ||
E9QKM8 | E9QKM8_MOUSE | CD44 antigen | Cd44 | 577 | Annotation score: |
Sequence databases
RefSeqi | NP_001171256.1, NM_001177785.1 |
Genome annotation databases
Ensembli | ENSMUST00000111198; ENSMUSP00000106829; ENSMUSG00000005087 |
GeneIDi | 12505 |
UCSCi | uc008lih.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001171256.1, NM_001177785.1 |
3D structure databases
SMRi | A2APM1 |
ModBasei | Search... |
Proteomic databases
jPOSTi | A2APM1 |
MaxQBi | A2APM1 |
PeptideAtlasi | A2APM1 |
PRIDEi | A2APM1 |
ProteomicsDBi | 324149 |
Protocols and materials databases
Antibodypediai | 804, 5420 antibodies from 58 providers |
DNASUi | 12505 |
Genome annotation databases
Ensembli | ENSMUST00000111198; ENSMUSP00000106829; ENSMUSG00000005087 |
GeneIDi | 12505 |
UCSCi | uc008lih.2, mouse |
Organism-specific databases
CTDi | 960 |
MGIi | MGI:88338, Cd44 |
VEuPathDBi | HostDB:ENSMUSG00000005087 |
Phylogenomic databases
GeneTreei | ENSGT00530000063822 |
Miscellaneous databases
BioGRID-ORCSi | 12505, 1 hit in 65 CRISPR screens |
ChiTaRSi | Cd44, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000005087, Expressed in molar tooth and 281 other tissues |
ExpressionAtlasi | A2APM1, baseline and differential |
Genevisiblei | A2APM1, MM |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR001231, CD44_antigen IPR043210, CD44_antigen-like IPR016187, CTDL_fold IPR000538, Link_dom |
PANTHERi | PTHR10225, PTHR10225, 2 hits PTHR10225:SF6, PTHR10225:SF6, 2 hits |
Pfami | View protein in Pfam PF00193, Xlink, 1 hit |
PRINTSi | PR00658, CD44 PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00445, LINK, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS01241, LINK_1, 1 hit PS50963, LINK_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A2APM1_MOUSE | |
Accessioni | A2APM1Primary (citable) accession number: A2APM1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 20, 2007 |
Last sequence update: | February 20, 2007 | |
Last modified: | January 19, 2022 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |