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Entry version 118 (29 Sep 2021)
Sequence version 2 (09 Dec 2015)
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Protein
Submitted name:

Low-density lipoprotein receptor-related protein 1B

Gene

Lrp1b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorARBA annotation
Biological processEndocytosisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Low-density lipoprotein receptor-related protein 1BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrp1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2151136, Lrp1b

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000049252

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4444 – 4467HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500589820321 – 4599Sequence analysisAdd BLAST4579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi845 ↔ 857PROSITE-ProRule annotation
Disulfide bondi852 ↔ 870PROSITE-ProRule annotation
Disulfide bondi886 ↔ 898PROSITE-ProRule annotation
Disulfide bondi893 ↔ 911PROSITE-ProRule annotation
Disulfide bondi927 ↔ 939PROSITE-ProRule annotation
Disulfide bondi934 ↔ 952PROSITE-ProRule annotation
Disulfide bondi975 ↔ 993PROSITE-ProRule annotation
Disulfide bondi987 ↔ 1002PROSITE-ProRule annotation
Disulfide bondi1006 ↔ 1018PROSITE-ProRule annotation
Disulfide bondi1013 ↔ 1031PROSITE-ProRule annotation
Disulfide bondi1073 ↔ 1088PROSITE-ProRule annotation
Disulfide bondi1116 ↔ 1131PROSITE-ProRule annotation
Disulfide bondi2518 ↔ 2536PROSITE-ProRule annotation
Disulfide bondi2552 ↔ 2564PROSITE-ProRule annotation
Disulfide bondi2559 ↔ 2577PROSITE-ProRule annotation
Disulfide bondi2571 ↔ 2586PROSITE-ProRule annotation
Disulfide bondi2591 ↔ 2603PROSITE-ProRule annotation
Disulfide bondi2598 ↔ 2616PROSITE-ProRule annotation
Disulfide bondi2610 ↔ 2625PROSITE-ProRule annotation
Disulfide bondi2659 ↔ 2674PROSITE-ProRule annotation
Disulfide bondi2682 ↔ 2694PROSITE-ProRule annotation
Disulfide bondi2689 ↔ 2707PROSITE-ProRule annotation
Disulfide bondi2701 ↔ 2716PROSITE-ProRule annotation
Disulfide bondi2720 ↔ 2732PROSITE-ProRule annotation
Disulfide bondi2727 ↔ 2745PROSITE-ProRule annotation
Disulfide bondi2805 ↔ 2817PROSITE-ProRule annotation
Disulfide bondi2812 ↔ 2830PROSITE-ProRule annotation
Disulfide bondi2845 ↔ 2857PROSITE-ProRule annotation
Disulfide bondi2891 ↔ 2903PROSITE-ProRule annotation
Disulfide bondi2898 ↔ 2916PROSITE-ProRule annotation
Disulfide bondi2910 ↔ 2925PROSITE-ProRule annotation
Disulfide bondi3317 ↔ 3329PROSITE-ProRule annotation
Disulfide bondi3324 ↔ 3342PROSITE-ProRule annotation
Disulfide bondi3357 ↔ 3369PROSITE-ProRule annotation
Disulfide bondi3364 ↔ 3382PROSITE-ProRule annotation
Disulfide bondi3376 ↔ 3391PROSITE-ProRule annotation
Disulfide bondi3416 ↔ 3431PROSITE-ProRule annotation
Disulfide bondi3456 ↔ 3471PROSITE-ProRule annotation
Disulfide bondi3476 ↔ 3488PROSITE-ProRule annotation
Disulfide bondi3483 ↔ 3501PROSITE-ProRule annotation
Disulfide bondi3495 ↔ 3510PROSITE-ProRule annotation
Disulfide bondi3515 ↔ 3527PROSITE-ProRule annotation
Disulfide bondi3522 ↔ 3540PROSITE-ProRule annotation
Disulfide bondi3534 ↔ 3549PROSITE-ProRule annotation
Disulfide bondi3553 ↔ 3565PROSITE-ProRule annotation
Disulfide bondi3560 ↔ 3578PROSITE-ProRule annotation
Disulfide bondi3572 ↔ 3587PROSITE-ProRule annotation
Disulfide bondi3594 ↔ 3606PROSITE-ProRule annotation
Disulfide bondi3601 ↔ 3619PROSITE-ProRule annotation
Disulfide bondi3613 ↔ 3628PROSITE-ProRule annotation
Disulfide bondi3652 ↔ 3667PROSITE-ProRule annotation
Disulfide bondi3674 ↔ 3686PROSITE-ProRule annotation
Disulfide bondi3681 ↔ 3699PROSITE-ProRule annotation
Disulfide bondi3736 ↔ 3751PROSITE-ProRule annotation
Disulfide bondi3762 ↔ 3774PROSITE-ProRule annotation
Disulfide bondi3769 ↔ 3787PROSITE-ProRule annotation
Disulfide bondi3781 ↔ 3796PROSITE-ProRule annotation
Disulfide bondi4217 ↔ 4227PROSITE-ProRule annotation
Disulfide bondi4253 ↔ 4263PROSITE-ProRule annotation
Disulfide bondi4275 ↔ 4284PROSITE-ProRule annotation
Disulfide bondi4289 ↔ 4299PROSITE-ProRule annotation
Disulfide bondi4311 ↔ 4320PROSITE-ProRule annotation
Disulfide bondi4325 ↔ 4335PROSITE-ProRule annotation
Disulfide bondi4347 ↔ 4356PROSITE-ProRule annotation
Disulfide bondi4394 ↔ 4404PROSITE-ProRule annotation
Disulfide bondi4398 ↔ 4415PROSITE-ProRule annotation
Disulfide bondi4417 ↔ 4426PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A2API5

PRoteomics IDEntifications database

More...
PRIDEi
A2API5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
347222

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000049252, Expressed in secondary oocyte and 117 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A2API5, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2API5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati295 – 337LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati338 – 381LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati568 – 610LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati611 – 656LDL-receptor class BPROSITE-ProRule annotationAdd BLAST46
Repeati657 – 706LDL-receptor class BPROSITE-ProRule annotationAdd BLAST50
Repeati707 – 750LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1300 – 1346LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati1347 – 1389LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1390 – 1436LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati1437 – 1481LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati1618 – 1660LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1705 – 1744LDL-receptor class BPROSITE-ProRule annotationAdd BLAST40
Repeati1922 – 1964LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1965 – 2007LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati2008 – 2051LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2052 – 2095LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2330 – 2374LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati2375 – 2417LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati3099 – 3141LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati3142 – 3185LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati4039 – 4082LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4213 – 4246EGF-likeInterPro annotationAdd BLAST34
Domaini4249 – 4285EGF-likeInterPro annotationAdd BLAST37
Domaini4286 – 4321EGF-likeInterPro annotationAdd BLAST36
Domaini4322 – 4357EGF-likeInterPro annotationAdd BLAST36
Domaini4392 – 4427EGF-likeInterPro annotationAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.ARBA annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157521

Identification of Orthologs from Complete Genome Data

More...
OMAi
QCIPAKW

Database of Orthologous Groups

More...
OrthoDBi
1606at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A2API5

TreeFam database of animal gene trees

More...
TreeFami
TF315253

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 30 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 8 hits
4.10.400.10, 32 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR032485, DUF5050
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662, cEGF, 1 hit
PF16472, DUF5050, 1 hit
PF00008, EGF, 1 hit
PF07645, EGF_CA, 2 hits
PF00057, Ldl_recept_a, 31 hits
PF00058, Ldl_recept_b, 10 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 24 hits
SM00179, EGF_CA, 6 hits
SM00192, LDLa, 32 hits
SM00135, LY, 36 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 3 hits
SSF57424, SSF57424, 32 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 4 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 3 hits
PS01209, LDLRA_1, 15 hits
PS50068, LDLRA_2, 32 hits
PS51120, LDLRB, 21 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A2API5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQLLLAILT LSGLLPNAEV LIVGANQDQH LCDPGEFLCH DHVTCVSQSW
60 70 80 90 100
LCDGDPDCPD QSDESLDTCP EEVEIKCPLN HIACHGSSAC VHLSKLCNGV
110 120 130 140 150
VDCPDGFDEG GHCQELLPSC QQLNCQFKCA MVRNATRCYC EDGFEVAEDG
160 170 180 190 200
RSCKDQDECS IYGICSQTCK NTYGSYACSC VEGYIMQSDN RSCKVKHEPT
210 220 230 240 250
DKAPMLLISS LETIELFYIN GSKMTTLSSA NRNEIHTLDF IYSEEMICWI
260 270 280 290 300
ESRESSNQLK CGQITKAGRL TDQRIINSLQ SFQNVEQMAF DWLTRNIYFV
310 320 330 340 350
DHVSDRIFVC NFNGSVCVTL IESELHNPKA IAADPIAGKL FFTDYGNVPK
360 370 380 390 400
IERCDLDGMN RTRIVYSKAE QPSALALDLV NRLVYWVDLY LDYVGVVDYQ
410 420 430 440 450
GKNRHTIVQG RQVKHLYGIT VFEDYLYATS SDNFNIIRIN RFNGTDIHSI
460 470 480 490 500
IKMESARGIR TYQKRTQPTV RSHACEVDAY GMPGGCSHIC LLSSSYKTRT
510 520 530 540 550
CRCRTGFNMG SDGRSCKRPK NELFLFYGKG RPGIVRGMDL NTKIADECMI
560 570 580 590 600
PIENLVNPRA LDFHAEANYI YFADTTSFLI GRQKIDGTER ETILKDDLDN
610 620 630 640 650
VEGIAVDWIG NNLYWTNDGH RKTINVARLE KASQSRKTLL EGGMSHPRAI
660 670 680 690 700
VVDPVNGWMY WTDWKEDKID DSVGRIEKAW MDGVNRQVFV TSKMLWPNGL
710 720 730 740 750
TLDFHTSTLY WCDAYYDHIE KVFLNGTHRK VVYSGKELNH PFGLSHHGNY
760 770 780 790 800
VFWTDYMNGS IFQLDLMTNE VTLLRHERAP LFGLQIYDPR KQQGDNMCRI
810 820 830 840 850
NNGGCGTLCL AIPAGRVCAC ADNQLLDENG TTCTFNPEEI RFHICKPGEF
860 870 880 890 900
RCKNKHCIQA RWKCDGDDDC LDGSDEDSVT CFNHSCPDDQ FKCQNNRCIP
910 920 930 940 950
KRWLCDGAND CGSNEDESNQ TCTARTCQAD QFSCGNGRCI PTAWLCDRED
960 970 980 990 1000
DCGDQTDEVA SCEFPTCEPL TQFICKSGRC ISNKWHCDTD DDCGDRSDEV
1010 1020 1030 1040 1050
GCVHSCLDDQ FRCSSGRCIP GHWACDGDND CGDFSDETHI NCTKEEARSP
1060 1070 1080 1090 1100
AGCIGNEFQC RPDGNCIPDL WRCDGEKDCE DGSDEKGCNG TIRLCDHKTK
1110 1120 1130 1140 1150
FSCRSTGRCI NNAWVCDGDV DCEDQSDEED CDSFLCGPPK YPCANDTSVC
1160 1170 1180 1190 1200
LQPEKLCNGR KDCPDGSDEG DLCDECSLNN GGCSNHCSVV PGRGIVCSCP
1210 1220 1230 1240 1250
EGHQLKKDNR TCEIVDYCAS HLRCSQVCEQ QKHMVKCSCY EGWALGTDGE
1260 1270 1280 1290 1300
SCTSVDSFEA FIIFSIRHEI RRIDLHKGDY SLLVPGLRNT IALDFHFNQS
1310 1320 1330 1340 1350
LLYWTDVVED RIYRGKLSES GGVSAIEVVV EHGLATPEGL TVDWIAGNIY
1360 1370 1380 1390 1400
WIDSNLDQIE VSKLDGSLRA TLIAGAMEHP RAIALDPRYG ILFWTDWDAN
1410 1420 1430 1440 1450
FPRIESASMS GAGRKTIYKD MKTGAWPNGL TVDHFERRIV WTDARSDAIY
1460 1470 1480 1490 1500
SAFYDGTNMI EIIRGHEYLS HPFAVSLYGS EVYWTDWRTN TLAKANKWTG
1510 1520 1530 1540 1550
QNVSVIQKTS AQPFDLQIYH PSRQPQAPNP CAANEGRGPC SHLCLINHNR
1560 1570 1580 1590 1600
SAACACPHLM KLSSDKKTCY EMKKFLLYAR RSEIRGVDID NPYVNFITAF
1610 1620 1630 1640 1650
TVPDIDDVAV IDFDASEERL YWTDIKTQTI TRAFINGTGL ETVISRDIQS
1660 1670 1680 1690 1700
IRGLAVDWVS RNLYWISSEF DETQINVARL DGSLKTSIIH GIDKPQCLAA
1710 1720 1730 1740 1750
HPVRGKLYWT DGNTINMANM DGSNSKILFQ NQKEPVGLSI DYVENKLYWI
1760 1770 1780 1790 1800
SSGNGTINRC NLDGGNLEVI ESMKEELTKA TALTIMDKKL WWADQNLAQL
1810 1820 1830 1840 1850
GTCNKRDGRN PSILRNKTSG VVHMKVYDKE AQQGSNSCQV NNGGCSQLCL
1860 1870 1880 1890 1900
PTSETTRTCM CTVGYYLQKN RMSCQGIESF LMYSVHEGIR GIPLEPRDKV
1910 1920 1930 1940 1950
DALMPISGAA FAVGIDFHAE NDTIYWTDMG LNKISRAKRD QTWKEDVVTN
1960 1970 1980 1990 2000
GLGRVEGIAV DWIAGNIYWT DHGFNLIEVA RLNGSFRYVI ISQGLDQPRS
2010 2020 2030 2040 2050
IAVHPEKGFL FWTEWGQVPC IGKARLDGSE KVMIVSVGIT WPNGISIDYE
2060 2070 2080 2090 2100
ENKLYWCDAR SDKIERIDLD TGANREVLLS GSNVDLFSVA VFGAYIYWSD
2110 2120 2130 2140 2150
RAHANGSVRR GHKNDATETV TMRTGLGVNL KEIKIFNRVR EKGTNVCAKE
2160 2170 2180 2190 2200
NGGCQQLCLY RGNSRRTCAC AHGYLAGDGV TCLRHEGYLL YSGRTILKSI
2210 2220 2230 2240 2250
HLSDETNLNS PVRPYENPNY FKNIIALAFD YNQRREGTNR IFYSDAHFGN
2260 2270 2280 2290 2300
IQLIKDNWED RQVIVENVGS VEGLAYHRAW DTLYWTSSST SSITRHTVDQ
2310 2320 2330 2340 2350
TRPGAIDREA VITMSEDDHP HVLALDECQN LMFWTNWNEQ HPSIMRATLT
2360 2370 2380 2390 2400
GKNAHVVVST DILTPNGLTI DHRAEKLYFS DGSLGKIERC EYDGSQRHVI
2410 2420 2430 2440 2450
VKSGPGTFLS LAVYDSYIFW SDWGRRAILR SNKYTGGETK ILRSDIPHQP
2460 2470 2480 2490 2500
MGIIAVANDT NSCELSPCAL LNGGCHDLCL LTPDGRVNCS CRGDRVLLAN
2510 2520 2530 2540 2550
NRCVTKNSSC NIYSEFECGN GDCVDYVLTC DGIPHCKDKS DEKLLYCENR
2560 2570 2580 2590 2600
SCRSGFKPCY NRRCVPHGKL CDGTNDCGDS SDELDCKVST CSTVEFRCAD
2610 2620 2630 2640 2650
GTCIPRSARC NQNMDCSDAS DEKGCNNTDC THFYKLGVKS TGFIRCNSTS
2660 2670 2680 2690 2700
LCVLPSWICD GSNDCGDYSD ELKCPVQNKH KCEENYFGCP SGRCILNTWV
2710 2720 2730 2740 2750
CDGQKDCEDG LDELHCDSSC SWNQFACSVK KCISKHWICD GEDDCGDSLD
2760 2770 2780 2790 2800
ESDSICGAVT CAADMFSCQG SHACVPQHWL CDGERDCPDG SDELSSAGCA
2810 2820 2830 2840 2850
PNNTCDENAF MCHNKVCIPK QFVCDHDDDC GDGSDEFLQC GYRQCGPEEF
2860 2870 2880 2890 2900
RCADGRCLVN TLWQCDGDFD CPDSSDEAPI NPRCRSAEHS CNSSFFMCKN
2910 2920 2930 2940 2950
GRCIPSDGLC DIRDDCGDGS DETNCHINEC LSKKISGCSQ DCQDLPVSYK
2960 2970 2980 2990 3000
CKCWPGFQLK DDGKTCVDID ECSSGFPCSQ QCINTYGTYK CHCAEGYETQ
3010 3020 3030 3040 3050
PDNPNGCRSL SDEEPFLILA DQHEIRKIST DGSNYTLLKQ GLNNVIALDF
3060 3070 3080 3090 3100
DYREEFIYWI DSSRPNGSRI NRMCLNGSDI KVVHNTAVPN ALAVDWIGKN
3110 3120 3130 3140 3150
LYWSDTEKRI IEVSKLNGLY PTVLVSKRLK FPRDLSLDPR AGNLYWIDCC
3160 3170 3180 3190 3200
EYPHIGRVGM DGTNQSVVIE TKISRPMALT IDYVNHRLYW ADENHIEFSN
3210 3220 3230 3240 3250
MDGSHRHKVP NQDIPGVIAL TLFEDYIYWT DGKTKSLSRV HKTSGADRLS
3260 3270 3280 3290 3300
LINSWHAITD IQVYHSYRQP DVSKHLCTVN NGGCSHLCLL GPGKTHTCAC
3310 3320 3330 3340 3350
PTNFYLAADN RTCLSNCTAS QFRCKTDKCI PFWWKCDTVD DCGDGSDEPD
3360 3370 3380 3390 3400
DCPEFKCQPG RFQCGTGLCA LPAFICDGEN DCGDNSDELN CDTHVCLAGQ
3410 3420 3430 3440 3450
FKCTKNKKCI PVNLRCNGQD DCGDEEDEKD CPENSCSPDY FQCKTTKHCI
3460 3470 3480 3490 3500
SKLWVCDEDP DCADASDEAN CDKKTCGPHE FQCKNNNCIP DHWRCDNQND
3510 3520 3530 3540 3550
CSDNSDEDNC KPQTCTLKDF LCSNGDCVSS RFWCDGEFDC ADGSDEKNCE
3560 3570 3580 3590 3600
TSCSKDQFQC SNGQCLSAKW KCDGHEDCKY GEDEKNCEPA FPVCSSSEYM
3610 3620 3630 3640 3650
CASGGCLSAS LKCNGEPDCV DGSDEMDCVI ECKEDQFQCK NKAYCIPIRW
3660 3670 3680 3690 3700
LCDGIYDCVD GSDEETCGRG GSICRDDEFL CNNSLCKLHF WVCDGEDDCG
3710 3720 3730 3740 3750
DNSDEAPDMC VKFLCPPTRP YRCRNDRICL QLEKICNGIN DCGDNSDEEH
3760 3770 3780 3790 3800
CSGKLSLKSK PCKKDEFTCS NRNCIPMELQ CDSLDDCGDG SDEQGCLKTP
3810 3820 3830 3840 3850
IEHTCENNGN PCGDDAYCNQ IKTSVFCRCK PGFQRNMKGR ECADLNECLL
3860 3870 3880 3890 3900
FGICSHHCLN TRGSYKCVCD QNFQEKNNSC IAKGSEDQAL YIANDTDILG
3910 3920 3930 3940 3950
FVYPFNYSGG HQQISHVEHN SRITGMDVHY QRNVIVWSTQ FNPGGIFYKM
3960 3970 3980 3990 4000
IDAREKRQAN SGLICPEFKR PRDIAVDWVA GNVYWTDHSR MHWFSYYTTH
4010 4020 4030 4040 4050
WTSLRYSINV GQLNGPNCTR LLTNMAGEPY AIAVNPKRGM MYWTVIGDHS
4060 4070 4080 4090 4100
HIEEAAMDGT LRRVLVQKNL QRPTGLTVDH FGERIYWADF ELSIIGSVLY
4110 4120 4130 4140 4150
DGSSPVVSVS SKQGLLHPHR IDVFEDYIYG AGPKNGIFRV QKFGHGSVEV
4160 4170 4180 4190 4200
LALGVDKTKS ILVSHRYKQL NLPNPCLDLS CDFLCLLNPS GATCICPEGK
4210 4220 4230 4240 4250
YMMNGTCHDD SLLDDSCKLT CENGGRCILN EKGDLRCHCW PSYSGGRCEV
4260 4270 4280 4290 4300
NHCSNYCQNG GTCIPSTLGR PTCICALGFT GPNCGKAVCE DSCHNGGSCV
4310 4320 4330 4340 4350
VTAGNQPYCH CQADYTGDRC QYYVCHHYCV NSESCTIGND GSVECVCPTR
4360 4370 4380 4390 4400
YEGPKCEIDK CVRCHGGHCI INKDNEDIFC NCTNGKIASS CQLCDGYCYN
4410 4420 4430 4440 4450
GGTCQLDPET SIPVCVCSTN WSGTQCERPA PKSSKSEHIS TRSIAIIVPL
4460 4470 4480 4490 4500
VLLVTLVTTL VIGLVVCKRK RRTKTIRRQP IINGGINVEI GNPSYNMYEV
4510 4520 4530 4540 4550
DHDHSDGGLL EPSFMIDPVK SRYIGGGSSA FKLPHTAPPI YLNSDLKGPL
4560 4570 4580 4590
TSGPTNYSNP VYAKLYMDGQ NCRNSLASVD ERKELLPKKI EIGIRETVA
Length:4,599
Mass (Da):513,574
Last modified:December 9, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1146308354FFB211
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9JI18LRP1B_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b Lrpdit
4,599Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q202E9Q202_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
3,357Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVX0A0A0N4SVX0_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
781Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YDG9F6YDG9_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
798Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVE4A0A0N4SVE4_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
288Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVC8A0A0N4SVC8_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WPQ4A0A087WPQ4_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SV53A0A0N4SV53_MOUSE
Low-density lipoprotein receptor-re...
Lrp1b
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_443737.2, NM_053011.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000052550; ENSMUSP00000054275; ENSMUSG00000049252

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
94217

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:94217

UCSC genome browser

More...
UCSCi
uc008jon.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_443737.2, NM_053011.2

3D structure databases

SMRiA2API5
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA2API5
PRIDEiA2API5
ProteomicsDBi347222

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33599, 57 antibodies

The DNASU plasmid repository

More...
DNASUi
94217

Genome annotation databases

EnsembliENSMUST00000052550; ENSMUSP00000054275; ENSMUSG00000049252
GeneIDi94217
KEGGimmu:94217
UCSCiuc008jon.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
53353
MGIiMGI:2151136, Lrp1b
VEuPathDBiHostDB:ENSMUSG00000049252

Phylogenomic databases

GeneTreeiENSGT00940000157521
OMAiQCIPAKW
OrthoDBi1606at2759
PhylomeDBiA2API5
TreeFamiTF315253

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
94217, 0 hits in 57 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lrp1b, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000049252, Expressed in secondary oocyte and 117 other tissues
ExpressionAtlasiA2API5, baseline and differential

Family and domain databases

CDDicd00112, LDLa, 30 hits
Gene3Di2.120.10.30, 8 hits
4.10.400.10, 32 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR032485, DUF5050
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF12662, cEGF, 1 hit
PF16472, DUF5050, 1 hit
PF00008, EGF, 1 hit
PF07645, EGF_CA, 2 hits
PF00057, Ldl_recept_a, 31 hits
PF00058, Ldl_recept_b, 10 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 24 hits
SM00179, EGF_CA, 6 hits
SM00192, LDLa, 32 hits
SM00135, LY, 36 hits
SUPFAMiSSF57184, SSF57184, 3 hits
SSF57424, SSF57424, 32 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 4 hits
PS01186, EGF_2, 4 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 3 hits
PS01209, LDLRA_1, 15 hits
PS50068, LDLRA_2, 32 hits
PS51120, LDLRB, 21 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2API5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2API5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: December 9, 2015
Last modified: September 29, 2021
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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