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Entry version 94 (02 Jun 2021)
Sequence version 2 (30 Nov 2016)
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Protein
Submitted name:

Vinculin/alpha-catenin family member 1

Gene

Vinac1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Vinculin/alpha-catenin family member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Vinac1Imported
Synonyms:Gm14025Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3649276, Vinac1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A2AP89

PRoteomics IDEntifications database

More...
PRIDEi
A2AP89

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
323037

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000079051, Expressed in spermatid and 50 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000123404

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A2AP89, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A2AP89

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1142 – 1226DisorderedSequence analysisAdd BLAST85

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili41 – 64Sequence analysisAdd BLAST24
Coiled coili850 – 870Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1154 – 1176Polar residuesSequence analysisAdd BLAST23
Compositional biasi1183 – 1210Polar residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3681, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234543

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019046_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A2AP89

Identification of Orthologs from Complete Genome Data

More...
OMAi
EIHRAQQ

Database of Orthologous Groups

More...
OrthoDBi
138192at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR006077, Vinculin/catenin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01044, Vinculin, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47220, SSF47220, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A2AP89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMDSSLGDD FGPTIQNRAM EQIITPMTVQ LCHLLISVER KEVQNKALAS
60 70 80 90 100
LQKVAEQLAN ASEEFVHVAS RLAGDSEEKW LREEMKPVAE SLILSGRNIL
110 120 130 140 150
RVAEKLHLQP ESQRHWEELV ATAQQVLVDT KKVLLLDDAA AVRKTRTAAN
160 170 180 190 200
WCLTCVEALE EAEDTTSLRT SLDDLAAALF RLGGLTARWA WDQHLGRARH
210 220 230 240 250
RLGCCVPALL AAAHGHLRHP RDPQLVASRR RVFALTRQSL EELLDALQPG
260 270 280 290 300
VGVVGTGVLS QNGALARGLC KLRKVLEDPG PGHLLLDAPL AAVVWHCLRL
310 320 330 340 350
AACSAPQERM HLVSRCRQLM QLRPGVHSLP RSSPGTDCEA LRAATDALFR
360 370 380 390 400
AVRAGLLRQI LDTFTDTQSP LETLVQAALA TSTIRFRCDS EALAETVQIL
410 420 430 440 450
LDAFHNQAKQ MIRVAHLVWV CCPQQQTGRD LEAAVAGLQR LVIKVKELFS
460 470 480 490 500
QSPQTLGLDW SPATLQALLE AWARESEHLL SCFDVVLNIP EFLSVSIQEM
510 520 530 540 550
TKHLDLSTIA LRSGASREFS RSVAFLRGRA THIVQVMSRY VGQDPDPIFR
560 570 580 590 600
NGMRVVVQQL AQSSVTLGAA TEGSRAEDSA QDTDVFLTMA KHLIHAAQQV
610 620 630 640 650
REGLDGSNHP DILSPLRVQV QRFDMTKGWS YFILPSPQHP TASEIKYQRV
660 670 680 690 700
PGLWKSGPNT SLLPVEQLSY TVVPGTCIHG WRFPLPAVSK GVTTMENRNH
710 720 730 740 750
QVVTLPCTNT PEQNSTVDTV QETQAGEETL GPERMTGLQE VSTLAPSIID
760 770 780 790 800
LARKEVHSAN TGSEELLRVS FQQSQGTRED RWGLVARAGD WYPLCQQLFC
810 820 830 840 850
HNLETELPGS MAAFVELQQD LALMVQVAAK SGPVNVDKKN PDLMGHPRLL
860 870 880 890 900
LELQDRSEKT EIHAKQLLDQ VLSSDGLQEP TLREENIDNG CLLWAVAVQD
910 920 930 940 950
LMQCMERFSR RQGLFLLPLR QAVKNQQGLQ KGLGQAAEIS QRLQEAAKLS
960 970 980 990 1000
SVLCGDAQVK GEISFLCREV HVLTDALLEV AHILVSSPKP CPSLSTRFEL
1010 1020 1030 1040 1050
LCLELSLRAK ALTDYLTSIN AAYEHMFQDV ISKSSQNRIE GMLSTIQAVQ
1060 1070 1080 1090 1100
GIIAGGQESE TVQKDLLVSL ESILTLTKEV VRKVPVLQEV QSLHTLDWLQ
1110 1120 1130 1140 1150
WEWAAKVHHA VTQLQALEGS HMEAWRLLVQ YLKPRGEQAK PLEEDLVQPP
1160 1170 1180 1190 1200
PHCNEGTAGT TSGVSVDSQG AVPKDTPESS VGTCADEPAT TRTTTADRSM
1210 1220 1230 1240 1250
HQSGSLSLPP AQMDQPAPED SSADSENRIT QITQEMATEV LLMARSLRKS
1260 1270 1280 1290 1300
GQVLTKDQLI ASARKVSASG KDFTRLIHII AKNCIDQRCS QELLCMVEQI
1310 1320 1330 1340 1350
QTMSSQLSII SSVKASLTRS KSSEELLVDN AQRLLQAVSK TVSAVEAACL
1360 1370 1380 1390 1400
RGLRWPSSDP EELEVAAFCT QWKRKLLQHR LQEASNEDCD ELGLRKRSTR
1410
KLPALAALVQ EAL
Length:1,413
Mass (Da):155,824
Last modified:November 30, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i789C36F879F5518B
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_001004454.2, XM_001004454.3
XP_006500577.1, XM_006500514.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000145798; ENSMUSP00000123404; ENSMUSG00000079051

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
668894

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_001004454.2, XM_001004454.3
XP_006500577.1, XM_006500514.2

3D structure databases

SMRiA2AP89
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123404

Proteomic databases

PaxDbiA2AP89
PRIDEiA2AP89
ProteomicsDBi323037

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
668894

Genome annotation databases

EnsembliENSMUST00000145798; ENSMUSP00000123404; ENSMUSG00000079051
GeneIDi668894

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
668894
MGIiMGI:3649276, Vinac1

Phylogenomic databases

eggNOGiKOG3681, Eukaryota
GeneTreeiENSGT01030000234543
HOGENOMiCLU_019046_0_0_1
InParanoidiA2AP89
OMAiEIHRAQQ
OrthoDBi138192at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
668894, 0 hits in 34 CRISPR screens
RNActiA2AP89, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000079051, Expressed in spermatid and 50 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR036723, Alpha-catenin/vinculin-like_sf
IPR006077, Vinculin/catenin
PfamiView protein in Pfam
PF01044, Vinculin, 3 hits
SUPFAMiSSF47220, SSF47220, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2AP89_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2AP89
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: November 30, 2016
Last modified: June 2, 2021
This is version 94 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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