UniProtKB - A2AP18 (PLCH2_MOUSE)
Protein
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
Gene
Plch2
Organism
Mus musculus (Mouse)
Status
Functioni
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.2 Publications
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+1 PublicationEC:3.1.4.111 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
Ca2+PROSITE-ProRule annotation
Activity regulationi
Activity is stimulated by GNB1:GNG2.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 415 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 416 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 445 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 447 | Calcium 1; catalyticBy similarity | 1 | |
Active sitei | 459 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 494 | Calcium 1; catalyticBy similarity | 1 | |
Binding sitei | 543 | SubstrateBy similarity | 1 | |
Binding sitei | 545 | SubstrateBy similarity | 1 | |
Binding sitei | 734 | SubstrateBy similarity | 1 | |
Binding sitei | 761 | SubstrateBy similarity | 1 | |
Metal bindingi | 865 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 867 | Calcium 2By similarity | 1 | |
Metal bindingi | 891 | Calcium 2By similarity | 1 | |
Metal bindingi | 920 | Calcium 3By similarity | 1 | |
Metal bindingi | 921 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 922 | Calcium 3By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 256 – 267 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phosphatidylinositol phospholipase C activity Source: GO_Central
- phospholipase C activity Source: MGI
GO - Biological processi
- lipid catabolic process Source: UniProtKB-KW
- phosphatidylinositol-mediated signaling Source: GO_Central
- phosphatidylinositol metabolic process Source: MGI
Keywordsi
Molecular function | Hydrolase, Transducer |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.4.11, 3474 |
Reactomei | R-MMU-1855204, Synthesis of IP3 and IP4 in the cytosol |
Chemistry databases
SwissLipidsi | SLP:000000943 |
Names & Taxonomyi
Protein namesi | Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2Curated (EC:3.1.4.111 Publication)Alternative name(s): Phosphoinositide phospholipase C-eta-2 Phosphoinositide phospholipase C-like 4 Short name: PLC-L4 Short name: Phospholipase C-like protein 4 Phospholipase C-eta-2 Short name: PLC-eta2 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443078, Plch2 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Localized predominantly at the plasma membrane.1 Publication
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 415 | H → A: Inhibition of activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308959 | 1 – 1501 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2Add BLAST | 1501 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 561 | PhosphoserineCombined sources | 1 | |
Modified residuei | 565 | PhosphoserineCombined sources | 1 | |
Modified residuei | 676 | PhosphoserineCombined sources | 1 | |
Modified residuei | 686 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | A2AP18 |
PaxDbi | A2AP18 |
PRIDEi | A2AP18 |
PTM databases
iPTMneti | A2AP18 |
PhosphoSitePlusi | A2AP18 |
SwissPalmi | A2AP18 |
Expressioni
Tissue specificityi
Specifically detected in the brain, with higher level in cerebral cortex, olfactory bulb and hippocampus (at protein level). Expressed in the pyramidal cells of the hippocampus, but also in eye and lung.2 Publications
Developmental stagei
Expressed at 2 weeks after birth but barely detected 1 week after birth. Increased expression during brain development.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000029055, Expressed in habenula and 182 other tissues |
ExpressionAtlasi | A2AP18, baseline and differential |
Genevisiblei | A2AP18, MM |
Interactioni
Protein-protein interaction databases
IntActi | A2AP18, 1 interactor |
MINTi | A2AP18 |
STRINGi | 10090.ENSMUSP00000101256 |
Miscellaneous databases
RNActi | A2AP18, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 121 – 229 | PHPROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 243 – 278 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 279 – 315 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 400 – 545 | PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST | 146 | |
Domaini | 707 – 821 | PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 821 – 950 | C2PROSITE-ProRule annotationAdd BLAST | 130 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 75 – 229 | Necessary for plasma membrane localizationAdd BLAST | 155 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1227 – 1236 | Poly-Ser | 10 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0169, Eukaryota |
GeneTreei | ENSGT00940000158374 |
HOGENOMi | CLU_030679_1_0_1 |
InParanoidi | A2AP18 |
OrthoDBi | 368239at2759 |
PhylomeDBi | A2AP18 |
TreeFami | TF313216 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR028393, PLC-eta2 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF166, PTHR10336:SF166, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF16457, PH_12, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00054, EFh, 2 hits SM00233, PH, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS50003, PH_DOMAIN, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A2AP18-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGGLAWGPSR AAGSSWVNAS GTWEQPLRGF SGLQGGRRRG RGEKGIPEEP
60 70 80 90 100
LCQLTPQLGL SLRVPFGLGD YGLDMPGPQP SAASQTTGAV ACLAEVLLWV
110 120 130 140 150
GGSVVVSPRW QLSLVVERCM SAMQEGTQMV KLRGSSKGLV RFYYLDEHRS
160 170 180 190 200
CLRWRPSRKN EKAKISIDSI QEVSEGRQSE IFQRYPDSSF DPNCCFSIYH
210 220 230 240 250
GSHRESLDLV SPSSEEARTW VTGLRYLMAG ISDEDSLARR QRTRDQWLKQ
260 270 280 290 300
TFDEADKNGD GSLSISEVLQ LLHKLNVNLP RQRVKQMFRE ADTDDHQGTL
310 320 330 340 350
GFEEFCAFYK MMSTRRDLYL LMLTYSNHKD HLDASDLQRF LEVEQKMNGV
360 370 380 390 400
TLESCQNIIE QFEPCLENKS KGMLGIDGFT NYTRSPAGDI FNPEHNRVHQ
410 420 430 440 450
DMTQPLSHYF ITSSHNTYLV GDQLMSQSRV DMYAWVLQAG CRCVEVDCWD
460 470 480 490 500
GPDGEPIVHH GYTLTSKILF KDVIETINKY AFIKNEYPVI LSIENHCSVV
510 520 530 540 550
QQKKMAQYLT DILGDKLDLS SVSSEDATML PSPQMLKGKI LVKGKKLPAN
560 570 580 590 600
ISEDAEEGEV SDEDSADEME DDCKLLNGDA STNRKRVENI AKKKLDSLIK
610 620 630 640 650
ESKIRDCEDP NDFSVSTLSP SGKLGRKAEA KKGQSKVEED VEAGEDSGVS
660 670 680 690 700
RQNSRLFMSS FSKRKKKGSK IKKVASVEEG DETLDSPGSQ SRGTARQKKT
710 720 730 740 750
MKLSRALSDL VKYTKSVGTH DVEIEVVSSW QVSSFSETKA HQILQQKPTQ
760 770 780 790 800
YLRFNQHQLS RIYPSSYRVD SSNYNPQPFW NAGCQMVALN YQSEGRMLQL
810 820 830 840 850
NRAKFSANGD CGYVLKPQCM CQGVFNPNSE DPLPGQLKKQ LALRIISGQQ
860 870 880 890 900
LPKPRDSVLG DRGEIIDPFV EVEVIGLPVD CSKEQTRVVD DNGFNPMWEE
910 920 930 940 950
TLVFTVHMPE IALVRFLVWD HDPIGRDFIG QRTLAFSSIM PGYRHVYLEG
960 970 980 990 1000
MEEASIFVHV AVSDISGKVK QTLGLKGLFL RGTKPGSLDS HAAGQPLPRP
1010 1020 1030 1040 1050
SVSQRLLRRT ASAPTKSQKP SRKGFPELAL GTQDAGSEGA ADDVAPSSPN
1060 1070 1080 1090 1100
PALEAPTQER SGSSSPRDTR LFPLQRPISP LCSLEPIAEE PALGPGLPLQ
1110 1120 1130 1140 1150
AAAPTGPSQE GSQCPVGLGA KVTSSQQTSL GAFGTLQLRI GGGRENEEPP
1160 1170 1180 1190 1200
LRPHNGGISS GPREGTSGRQ TDSKSRSRVP GHLPVVRRAK SEGQVLSELS
1210 1220 1230 1240 1250
PTPAVYSDAT GTDRLWQRLE PGSHRDSVSS SSSMSSNDTV IDLSLPSLGL
1260 1270 1280 1290 1300
CRSRESIPGV SLGRLTSRPC LASAARPDLP PVTKSKSNPN LRVAGGLPTA
1310 1320 1330 1340 1350
PDELQPRPLA PRLTGHHPRP PWHHLTLVGL RDCPVSAKSK SLGDLTADDF
1360 1370 1380 1390 1400
APSFQGSTSS LSCGLGSLGV AHQVLEPGIR RDALTEQLRW LTGFQQAGDI
1410 1420 1430 1440 1450
TSPTSLGPAG DGSVGGPSFL RRSSSRSQSR VRAIASRARQ AQERQQRLRG
1460 1470 1480 1490 1500
QDSRGPPEEE RGTPEGACSV GHEGCVDVPM PAKGAPEQVC GAADGQLLLR
L
Isoform 3 (identifier: A2AP18-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1068-1252: DTRLFPLQRP...LSLPSLGLCR → GKAPGGEATE...ASHALYTWHA
1253-1501: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF7C3A0 | F7C3A0_MOUSE | Phosphoinositide phospholipase C | Plch2 | 1,238 | Annotation score: | ||
H3BIW6 | H3BIW6_MOUSE | Phosphoinositide phospholipase C | Plch2 | 1,137 | Annotation score: | ||
H3BK11 | H3BK11_MOUSE | Phosphoinositide phospholipase C | Plch2 | 1,250 | Annotation score: | ||
A0A087WSR3 | A0A087WSR3_MOUSE | 1-phosphatidylinositol 4,5-bisphosp... | Plch2 | 493 | Annotation score: | ||
F7C512 | F7C512_MOUSE | 1-phosphatidylinositol 4,5-bisphosp... | Plch2 | 199 | Annotation score: | ||
F6UKG4 | F6UKG4_MOUSE | 1-phosphatidylinositol 4,5-bisphosp... | Plch2 | 111 | Annotation score: | ||
A6PWW4 | A6PWW4_MOUSE | 1-phosphatidylinositol 4,5-bisphosp... | Plch2 | 57 | Annotation score: |
Sequence cautioni
The sequence BAC32005 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC37371 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence CAO78007 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAO78129 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 340 | F → L in BAC34011 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 664 – 665 | RK → HR in AAH40465 (PubMed:15489334).Curated | 2 | |
Sequence conflicti | 781 | N → D in BAC32005 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1258 | P → A in BAC32005 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1495 | G → S in BAC32005 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029075 | 1 – 105 | Missing in isoform 4. 1 PublicationAdd BLAST | 105 | |
Alternative sequenceiVSP_029076 | 40 – 115 | Missing in isoform 5. 1 PublicationAdd BLAST | 76 | |
Alternative sequenceiVSP_029077 | 106 – 116 | VSPRWQLSLVV → MDAGAAPQKHM in isoform 4. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_029078 | 580 – 675 | ASTNR…IKKVA → VSGSPGSACREPGVGPQHPR PILSTKGIYLPQRERGQGVR DKDRRWRVREKGKGTREGAR GICPGGRGDKGLPLDREETD RQTWPIGKWWFTNVKK in isoform 5. 1 PublicationAdd BLAST | 96 | |
Alternative sequenceiVSP_029079 | 676 – 1501 | Missing in isoform 5. 1 PublicationAdd BLAST | 826 | |
Alternative sequenceiVSP_029081 | 1068 – 1252 | DTRLF…LGLCR → GKAPGGEATEERTLAQVRSP NAPEGPGPAGMAATCMKCVV GSCAGMDVEGLQREQQPSPG PAGSHMAISHQPRARVDSLG GPCCSPSPRATPGRSKEAPK GPRARRQGPGGGSVSSDSSS PDSPGSPKVAPCQPEGAHRQ QGALQGEMNALFVQKLEEIR SHSPMFSTGKACRSAASHAL YTWHA in isoform 3. 1 PublicationAdd BLAST | 185 | |
Alternative sequenceiVSP_029082 | 1068 – 1238 | DTRLF…MSSND → GKAPGGEATEERTLAQVRSP NAPEGPGPAGMAATCMKCVV GSCAGMDVEGLRREQQPSPG PAGSHMAISHQPRARVDSLG GPCCSPSPRATPGRSKEAPK GPRARRQGPGGGSVSSDSSS PDSPGSPKVAPCQPEGAHRQ QGALQGEMNALFVQKLEEIR SHSPMFSTVRD in isoform 2. 1 PublicationAdd BLAST | 171 | |
Alternative sequenceiVSP_029083 | 1239 – 1501 | Missing in isoform 2. 1 PublicationAdd BLAST | 263 | |
Alternative sequenceiVSP_029084 | 1253 – 1501 | Missing in isoform 3. 1 PublicationAdd BLAST | 249 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ176851 mRNA Translation: ABA12210.1 AL831788, BX004788 Genomic DNA Translation: CAM16344.2 BX004788, AL831788 Genomic DNA Translation: CAM28037.2 AL831788, BX004788 Genomic DNA Translation: CAO78007.1 Sequence problems. BX004788, AL831788 Genomic DNA Translation: CAO78129.1 Sequence problems. AK044619 mRNA Translation: BAC32005.1 Sequence problems. AK049970 mRNA Translation: BAC34011.1 AK078731 mRNA Translation: BAC37371.1 Sequence problems. AY966876 mRNA Translation: AAY33831.1 BC040465 mRNA Translation: AAH40465.1 BC052329 mRNA Translation: AAH52329.1 |
CCDSi | CCDS38990.2 [A2AP18-2] CCDS71533.1 [A2AP18-1] |
RefSeqi | NP_001106831.1, NM_001113360.2 [A2AP18-1] NP_780765.2, NM_175556.4 |
Genome annotation databases
Ensembli | ENSMUST00000105631; ENSMUSP00000101256; ENSMUSG00000029055 [A2AP18-1] ENSMUST00000135665; ENSMUSP00000118292; ENSMUSG00000029055 [A2AP18-4] ENSMUST00000145662; ENSMUSP00000119864; ENSMUSG00000029055 [A2AP18-5] |
GeneIDi | 269615 |
KEGGi | mmu:269615 |
UCSCi | uc008wcq.2, mouse [A2AP18-5] uc056zyr.1, mouse [A2AP18-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ176851 mRNA Translation: ABA12210.1 AL831788, BX004788 Genomic DNA Translation: CAM16344.2 BX004788, AL831788 Genomic DNA Translation: CAM28037.2 AL831788, BX004788 Genomic DNA Translation: CAO78007.1 Sequence problems. BX004788, AL831788 Genomic DNA Translation: CAO78129.1 Sequence problems. AK044619 mRNA Translation: BAC32005.1 Sequence problems. AK049970 mRNA Translation: BAC34011.1 AK078731 mRNA Translation: BAC37371.1 Sequence problems. AY966876 mRNA Translation: AAY33831.1 BC040465 mRNA Translation: AAH40465.1 BC052329 mRNA Translation: AAH52329.1 |
CCDSi | CCDS38990.2 [A2AP18-2] CCDS71533.1 [A2AP18-1] |
RefSeqi | NP_001106831.1, NM_001113360.2 [A2AP18-1] NP_780765.2, NM_175556.4 |
3D structure databases
SMRi | A2AP18 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A2AP18, 1 interactor |
MINTi | A2AP18 |
STRINGi | 10090.ENSMUSP00000101256 |
Chemistry databases
SwissLipidsi | SLP:000000943 |
PTM databases
iPTMneti | A2AP18 |
PhosphoSitePlusi | A2AP18 |
SwissPalmi | A2AP18 |
Proteomic databases
MaxQBi | A2AP18 |
PaxDbi | A2AP18 |
PRIDEi | A2AP18 |
Protocols and materials databases
Antibodypediai | 1163, 21 antibodies |
DNASUi | 269615 |
Genome annotation databases
Ensembli | ENSMUST00000105631; ENSMUSP00000101256; ENSMUSG00000029055 [A2AP18-1] ENSMUST00000135665; ENSMUSP00000118292; ENSMUSG00000029055 [A2AP18-4] ENSMUST00000145662; ENSMUSP00000119864; ENSMUSG00000029055 [A2AP18-5] |
GeneIDi | 269615 |
KEGGi | mmu:269615 |
UCSCi | uc008wcq.2, mouse [A2AP18-5] uc056zyr.1, mouse [A2AP18-1] |
Organism-specific databases
CTDi | 9651 |
MGIi | MGI:2443078, Plch2 |
Phylogenomic databases
eggNOGi | KOG0169, Eukaryota |
GeneTreei | ENSGT00940000158374 |
HOGENOMi | CLU_030679_1_0_1 |
InParanoidi | A2AP18 |
OrthoDBi | 368239at2759 |
PhylomeDBi | A2AP18 |
TreeFami | TF313216 |
Enzyme and pathway databases
BRENDAi | 3.1.4.11, 3474 |
Reactomei | R-MMU-1855204, Synthesis of IP3 and IP4 in the cytosol |
Miscellaneous databases
BioGRID-ORCSi | 269615, 2 hits in 13 CRISPR screens |
ChiTaRSi | Plch2, mouse |
PROi | PR:A2AP18 |
RNActi | A2AP18, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029055, Expressed in habenula and 182 other tissues |
ExpressionAtlasi | A2AP18, baseline and differential |
Genevisiblei | A2AP18, MM |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR028393, PLC-eta2 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF166, PTHR10336:SF166, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF16457, PH_12, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00054, EFh, 2 hits SM00233, PH, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS50003, PH_DOMAIN, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLCH2_MOUSE | |
Accessioni | A2AP18Primary (citable) accession number: A2AP18 Secondary accession number(s): A6PWW5 Q8CFR1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | August 21, 2007 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot