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Protein

Midasin

Gene

Mdn1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • ribosomal large subunit assembly Source: GO_Central
  • rRNA processing Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperoneUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MidasinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mdn1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1926159 Mdn1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A2ANY6

MaxQB - The MaxQuant DataBase

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MaxQBi
A2ANY6

PeptideAtlas

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PeptideAtlasi
A2ANY6

PRoteomics IDEntifications database

More...
PRIDEi
A2ANY6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2ANY6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
A2ANY6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000058006 Expressed in 247 organ(s), highest expression level in embryonic stem cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A2ANY6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A2ANY6, 2 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5377 – 5576VWFAInterPro annotationAdd BLAST200

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4959 – 4985Sequence analysisAdd BLAST27
Coiled coili5177 – 5197Sequence analysisAdd BLAST21
Coiled coili5271 – 5291Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the midasin family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1808 Eukaryota
COG5271 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074802

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231719

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG031706

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2ANY6

Identification of Orthologs from Complete Genome Data

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OMAi
WQPHESG

Database of Orthologous Groups

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OrthoDBi
138219at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
A2ANY6

TreeFam database of animal gene trees

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TreeFami
TF300488

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011704 ATPase_dyneun-rel_AAA
IPR029317 KRBA1_rpt
IPR012099 Midasin
IPR027417 P-loop_NTPase
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF07728 AAA_5, 8 hits

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF010340 Midasin, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00382 AAA, 5 hits
SM01258 KRBA1, 1 hit
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 6 hits
SSF53300 SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A2ANY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHLSVELVS GPLRLIAAKN EKSSGELNRF LAKSVWTPQD RQCILDSLAQ
60 70 80 90 100
LLLDKDYTLL LGRQLRPILL DLLERNAKAI KTGGQVNHDL HERLSVSMSK
110 120 130 140 150
LIGSHPDVLP FALRYFKDTY PVFQRLFLES SDANPVRYGR RRMKLRDLME
160 170 180 190 200
AANIFLQHRQ TVFRELWDWS VCVPLLRSHD ALVRWHTANC LALVTCMNEE
210 220 230 240 250
HKLSFLRKIF SSDELVHFRL RLLEEAQLQD LEKALVLANP EVSLWHKGEE
260 270 280 290 300
PQYIQGHLVS ADLSSSVAAV CGVVLPKLSS SPGEQASDRS SSLEQELALK
310 320 330 340 350
SFVLVESVCK NLQLLAVSVA SQNAVLLEGP IGSGKTSLVE HLAAVTGRTK
360 370 380 390 400
PPQLLKVQLG DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATKGYWILL
410 420 430 440 450
EDIDYAPLDV VSVLIPLLEH GELLIPGHGD CLKVAPTFQL FATRRLLSCG
460 470 480 490 500
GSWYRPMNSH ATMLDKYWTK IHLHNLNKKD LNEVLQSKYP SLLAATDHLL
510 520 530 540 550
DIYIELTGEK HCCPSVAYDK APQEVSEAER ENRRVVLEGR ELSLRDLLNW
560 570 580 590 600
CNRVAHGFDP TSSTALLHIF QEAMDCFTAM LSEQTKKLRM AEVIGSRLNI
610 620 630 640 650
SKKKAEFYCK LYKPEIVINE LDVQVGRVRL LRKQSEVVRI QKEKCTFAAT
660 670 680 690 700
RPSSVLLEQL AVCVSQGEPV LLVGETGTGK TSAVQYLAYA TGQHLRVVNM
710 720 730 740 750
NQQSDTADLL GGFKPVDHKL IWLPLRETFE ELFVQTFSKK QNFTFLGHIQ
760 770 780 790 800
TCYRQKRWHD LLKLMLHVQK SASTKGGEQS QPGLLKEKWE AFGLRLNHAQ
810 820 830 840 850
QQMKMTENAL LFAFVEGTLA QAIKKGEWIL LDEINLAAPE TLECLSGLLE
860 870 880 890 900
GSSGSLVLLD RGDTEPLVRH PDFRLFACMN PATDVGKRNL PPGIRNRFTE
910 920 930 940 950
LYVEELESKE DLQILIVDYL KGLNVSKNTV QGIVNFYTAL RKESGTKLVD
960 970 980 990 1000
GTGHRPHYSL RTLCRALRFA ASNPCGSIQR SLYEGFCLGF LTQLDRASHP
1010 1020 1030 1040 1050
VVQKLICQHI ISGNVKSLLK QPIPEPKGGR LIQVEGYWIS VGDKEPKIDE
1060 1070 1080 1090 1100
TYVLTPSVKL NLRDIARVVS AGTYPVLIQG ETSVGKTSLI RWLAAASGNH
1110 1120 1130 1140 1150
CVRINNHEHT DIQEYIGCYT SDTSGKLVFN EGVLIDAMRK GYWIVLDELN
1160 1170 1180 1190 1200
LAPTDVLEAL NRLLDDNREL LITETQEVVR AHPRFMLFAT QNPPGLYGGR
1210 1220 1230 1240 1250
KVLSRAFRNR FVELHFDELP SSELETILHK RCSLPPSYCS KLVKVMLDLQ
1260 1270 1280 1290 1300
SYRRRSSVFA GKQGFIALRD LFRWAERYRL AEQTQEDYDW LQHLANDGFM
1310 1320 1330 1340 1350
LLAGRVRKQE EADVIQEVLE KHFKKKLCPQ SLFSKENVLK LLGKSSTQTT
1360 1370 1380 1390 1400
VLESKFSHVV WTESMRRLAV LVGRALEFGE PVLLVGDTGC GKTTVCQMFS
1410 1420 1430 1440 1450
ALANQKLYSV NCHLNMETSD FLGGLRPVRQ KPNDKDELDT RLFEWHDGPL
1460 1470 1480 1490 1500
VLAMKEDSFF LLDEISLADD SVLERLNSVL EVEKCLVLAE KGSPESKDNE
1510 1520 1530 1540 1550
VELLTAGKHF RILATMNPGG DFGKKELSPA LRNRFTEIWC PQSTKREDLI
1560 1570 1580 1590 1600
QIINHNLRPG LSLAGVGHKG AGVAEVMLAF ITWLTRQEFG RKCVVSIRDI
1610 1620 1630 1640 1650
LSWVNFMNSM AEDAAVKRPE AISTVTSFVH AACLVYIDGI GSGVTSSGFG
1660 1670 1680 1690 1700
TALLAREECL KFLIKKLSKV VRLTQRQKDE LKIYDRLRHK EFTSIDDFWG
1710 1720 1730 1740 1750
VHPFFIPRGP VLDGHNTGDY ALTAGTTAMN AQRLLRAAKL NKPILLEGSP
1760 1770 1780 1790 1800
GVGKTSLVAA LAKASGNTLV RINLSEQTDI TDLFGADLPV EGGRGGEFAW
1810 1820 1830 1840 1850
CDGPLLAALK AGHWVVLDEL NLASQSILEG LNACFDHRGE IYVPELGMSF
1860 1870 1880 1890 1900
QVQHEKTRIF GCQNPFRQGG GRKGLPKSFL NRFTQVFVDP LTVVDMEFIA
1910 1920 1930 1940 1950
STLFPTIDKD IVKKMVAFNN HIDHEVTVEK KWGQKGGPWE FNLRDLFRWC
1960 1970 1980 1990 2000
QLILVDQSPG CYDPGQHVFL VYGERMRTRE DKEKVVAVFK DVFASNSMPY
2010 2020 2030 2040 2050
IGTRQFHITP YDIQIGYSVL SRSSYVPHPS RRPLSLLHQS FQSLEPIMKC
2060 2070 2080 2090 2100
VQMNWMVILV GPASVGKTSL VQLLAHLTGH TLKIMAMNSA MDTTELLGGF
2110 2120 2130 2140 2150
EQVDIIRPWR LLLEKVERTV RVLLRDSLLI NSVDTEVVLQ AWSHFLLTYK
2160 2170 2180 2190 2200
PKCLGEDGKG VTIEIVNKLE AVLLLMQRLN NKINSYSKAD FAKLVEDFRS
2210 2220 2230 2240 2250
FGVKLLQSAS GRSHGSFEWV DSMLVQALKS GDWLLMDNVN FCNPSVLDRL
2260 2270 2280 2290 2300
NALLEPGGVL TINERGMVDG STCTVTPNPN FRLFLSMDPI HGEISRAMRN
2310 2320 2330 2340 2350
RGLEIYISGE EDGSIQDNLD LKVLLHSLGL VGDSVCNILL ALHTEIQSLV
2360 2370 2380 2390 2400
RGSPASSVST LSHTAILIVQ YLQRGLSLHK AFFEACWEVY VCSQHSAANQ
2410 2420 2430 2440 2450
KLVQDLLESH TASLQARETW GHSILATGLW PDSVPSALFA TEDSRLSVVR
2460 2470 2480 2490 2500
SEGQILAYCL NRMSLKTSSW TRSQPLTLQD LENIMQTCSP DDLTFNAVEV
2510 2520 2530 2540 2550
DTCWVDEPEV LATAVKLLIE RATNQDWMLR VKWLCHLAKN IPQGLESVRV
2560 2570 2580 2590 2600
HLEASATALR KFYSTSLSAG VSNVLKILQT NITDDFVIPL DPRWNMQALD
2610 2620 2630 2640 2650
IIRNSLDFDP QSDQAKQLFA LLESVANKTF IYLDREKRIF TEANLVSVGS
2660 2670 2680 2690 2700
KKLRSSVLRM SFEFHKDPEN YHSPPHEIVA NLAAFFELID GLILLWVQSP
2710 2720 2730 2740 2750
QGVVPDAHIN KILGSVQWRD RFWTVADTVT VDASGLALLA LHWHWVSKHL
2760 2770 2780 2790 2800
IYQIPQLLVN QENKYYKELQ TVSEHIHSCL GSPADSFAGV KKLQAFLGRP
2810 2820 2830 2840 2850
FPFKDKLVVD CFLQLQALNR ALAIGEQLPV FGECGWQEDI NRLQVVASEW
2860 2870 2880 2890 2900
NLKKSLLQAW GLILRANILE DVNLDELKNL VSTQCSELKS RGLSRGFLEK
2910 2920 2930 2940 2950
AHDASSPSQP DLSSLVHLTR RVQLWPAAEY LAMLWQYRVT ADFIAQACLR
2960 2970 2980 2990 3000
RSSKHDQMDE EISHHIAFCL KHTPIAPQKL WNLWSLLHIE MLSAQEVSCL
3010 3020 3030 3040 3050
WSELFTSTFG SSWSSPVTTA PECWLAWSPL PNIQQQEVPR SRWDSTLKGP
3060 3070 3080 3090 3100
GSLCRAVFSK CCFGVLTNSS RASYWDVSGL PLLSSSHVTL GEWVERAQQL
3110 3120 3130 3140 3150
QDISSLLWTN MAVPSVAEFR RTDSRLQGLV LCRYLLGLTE LLPAHQRQEY
3160 3170 3180 3190 3200
MQNCEHLLLG NTQAFHHVDQ TMGNIGGQEA LPKELLCLLL TSLHYFIGEG
3210 3220 3230 3240 3250
EGKQNLPEAA RRGRLWVSLG LLQIQTWLPR ARFDPAVKKA YKLRYAQDEL
3260 3270 3280 3290 3300
RQLQCELKTR NLLSHLQTGR DLEDDIITSH SHPHIKLLPQ RISQLESLVH
3310 3320 3330 3340 3350
SLSKKQAFRP HLPSYETLVQ EIHHYVTSIA KVTAVQDLLM RLLQALHTDG
3360 3370 3380 3390 3400
PKSAQVLQNL LKEEASWQQS HHQFRKRLVE EYALYPDTVA PLLASILQLQ
3410 3420 3430 3440 3450
HGMRLVASEV HASLHSGVLC AENLGALAMA VLAFPSVGPS FPTYHAHADA
3460 3470 3480 3490 3500
LCSVNAAEAL RSLGKLMVKR AARKEEAKSQ QAYPTREQLL MNALLYLRSH
3510 3520 3530 3540 3550
VLCKGELDQR ALLLFRHLCQ EIINEWDEQE RIAQEKAEQE SSLYRYRSRS
3560 3570 3580 3590 3600
GRTALSEEEE EELELRKLFP LHEKDFADIL MEPTLEEKKK VSDGREEEAA
3610 3620 3630 3640 3650
PDPTLLCQSS MQAVMLIHQQ LCLSFARSLW YQQAVPPHEA KHYLSLFLSC
3660 3670 3680 3690 3700
YQTGASLVTH FYPLMGVELN DQLLGSQLLA CTLSSNTLCG EATSDLMMRP
3710 3720 3730 3740 3750
DGPYDFYQHP NVAEARQCQP VLQGFSEAVS QLLQDWPEHP VLQQLLVVMD
3760 3770 3780 3790 3800
RIRGFPLSSP ISKFLNGLEI LLAKAQDWEE NASRVLSLRK HLDLVSQMII
3810 3820 3830 3840 3850
RWRKLELNCW SMSLDNTMIR HTEKSTKHWF SIYQMLEKHM QERTEEQEDD
3860 3870 3880 3890 3900
KQMTLMLLVS TLQAFIEGSS LGEFHVRLQM LLVFHCHVLL MPQVEGKDSL
3910 3920 3930 3940 3950
CSVLWNLYHF YKQFLDPVKA KIMELRSPIE KELKEFVKIS KWNDVSFWSI
3960 3970 3980 3990 4000
KQSVEKTHRT LFKFMKKFEA VLSEPCQSCL VESDKEEQPD CLPKPTEEAT
4010 4020 4030 4040 4050
METSPIQGLN NALRETLLAQ PVEWKPSGTE QCQDASPLSV EGELLRRLPR
4060 4070 4080 4090 4100
LSKRMRKMCL VFMKESPLPH LVESLDQFTG GVISSVSELQ SLKVDPSAEK
4110 4120 4130 4140 4150
EKQHSEAKHI LLQKHRALSD LFKHLANIGL SYRKGLAWAR SKSPQELLHL
4160 4170 4180 4190 4200
HPLDLRSALS IVSSTREADS RLLTEISSLW DGCQKYFYRS LARHTRLTAA
4210 4220 4230 4240 4250
LATPVKEVSM GTIERCKGFS AHLMKLLIRQ RHSLTTLTEQ WIILRNLLSC
4260 4270 4280 4290 4300
VQEIHSRLTG PPVYPVAFPP QDSVQQWTER LQHLAMQSQI LLEQFSWLFQ
4310 4320 4330 4340 4350
CCPSAEPTVG HRDAQVQEHP SASHLENIDF KETIAGVMPD LLSSDLSYPS
4360 4370 4380 4390 4400
PVPTSQLPSA CRMRRQDQLW QQSTAGLTEM LKTIKTMKAG VDKIRQQSCE
4410 4420 4430 4440 4450
TLFHTWEDFE VCSSGLNCLS QVSAHLQGLA SLFILPGIEV EQTDSRMALV
4460 4470 4480 4490 4500
ESLDYLRGEV SKAIDDFTAW KARLFVAHKQ EGNQMVEESF VEDFSEQVET
4510 4520 4530 4540 4550
AIRAILCTIQ NLAERNNKKA EDSAVDKRLQ EEDGGKEEEA SFKSLQPGHL
4560 4570 4580 4590 4600
TKLLEDDFWA SVSTLHVQKI ISSVSELLER LKSCSEDGNT TKHKVFSQSC
4610 4620 4630 4640 4650
GLLVRLIPIL CGFSDLVLFF LTVSLATHRS TAKLLSVLAQ TFTELSQKGF
4660 4670 4680 4690 4700
CLPKELMEDS AGEGATQFHD YEGGGIGDGE GMKDVSDRIE NEEQVEDTFQ
4710 4720 4730 4740 4750
KGQEKDEEDL DSKPDTKGED NAIEMSEDFD GKMHDGELEQ EEDDEKSDSE
4760 4770 4780 4790 4800
DGDLDKQMGN LNGEEADKLD ERLWGDDEEE DEDGDGRAEE TGPGVDEEDS
4810 4820 4830 4840 4850
ELVAKDDSLD AGNLNKNKKH QDEKEDSEPE DVEQGQEKIN EQIDEREYDE
4860 4870 4880 4890 4900
NEVDPYHGNQ EKLPEPEALD LPDDLKLDSE DKSGGEDTDN EEAEEENPLE
4910 4920 4930 4940 4950
IKEKTVDMEE TDHEIEEPGA GQDEGESPHE PEEGPSEDKE NMDMDTGADD
4960 4970 4980 4990 5000
QDRDTSSHAE EHSLEEEAEE EEEKGEKEED KATTDGGGES GVNPVDQGLQ
5010 5020 5030 5040 5050
PQKEEEEEGE QSDAEEQVPE ATERKEHATC GQTGVDNVQS AQAVELAGAA
5060 5070 5080 5090 5100
PEKEQGKEEH GSGAADANQA EGHESNLIAR LSSQQHTNKN TQSFKRRPGQ
5110 5120 5130 5140 5150
ADNERSVGDY NERVRKRLRT VGTDRETEQE PTQAQVEDAD AFEHVKQGSD
5160 5170 5180 5190 5200
AYDAQTYDVA SSEQQQTAKA SGQDQEEEEI EDILMDTEEE LMRAEDTEQL
5210 5220 5230 5240 5250
KPEAVQSETA ATSGSSEMEV DMQTLKTKED QDPRTTTPHQ ETENERPERS
5260 5270 5280 5290 5300
RDSTIHTLRQ FLVDSVFQPI LKDISELRQE MERQLETWQA HDYGNAEEEK
5310 5320 5330 5340 5350
AAAEMWQNYL VLTASLSQQL CEQLRLLLEP TQAAKLRGDY RTGKRLNMRK
5360 5370 5380 5390 5400
IIPYIASQFR KDRIWLRRTK PSKRQYQICL AIDDSSSMVD NHTKQLAFES
5410 5420 5430 5440 5450
LAVIGNALTL LEVGQIAVCS FGESVKLLHP FHEQFNDSSG THILRLCTFQ
5460 5470 5480 5490 5500
QRKTKIAQFL ETVAKMFAAA QKLSQNVSPE TAQLLLIVSD GRGLFLEGKD
5510 5520 5530 5540 5550
RVLAAVQAAQ NANIFVIFVV LDNPNSRDSI LDIKVPIFKG PGEMPEIRSY
5560 5570 5580
MEEFPFPFYI ILRDVNALPE TLSDALRQWF ELVTASDHS
Length:5,589
Mass (Da):630,342
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE58B46C42EA157A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QMC5J3QMC5_MOUSE
Midasin
Mdn1
5,582Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL805973 Genomic DNA No translation available.
AL831774 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
XP_006537539.1, XM_006537476.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.24627

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000071642; ENSMUSP00000071569; ENSMUSG00000058006

Database of genes from NCBI RefSeq genomes

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GeneIDi
100019

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL805973 Genomic DNA No translation available.
AL831774 Genomic DNA No translation available.
RefSeqiXP_006537539.1, XM_006537476.2
UniGeneiMm.24627

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Protein-protein interaction databases

IntActiA2ANY6, 2 interactors

PTM databases

iPTMnetiA2ANY6
PhosphoSitePlusiA2ANY6

Proteomic databases

jPOSTiA2ANY6
MaxQBiA2ANY6
PeptideAtlasiA2ANY6
PRIDEiA2ANY6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071642; ENSMUSP00000071569; ENSMUSG00000058006
GeneIDi100019

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23195
MGIiMGI:1926159 Mdn1

Phylogenomic databases

eggNOGiKOG1808 Eukaryota
COG5271 LUCA
GeneTreeiENSGT00550000074802
HOGENOMiHOG000231719
HOVERGENiHBG031706
InParanoidiA2ANY6
OMAiWQPHESG
OrthoDBi138219at2759
PhylomeDBiA2ANY6
TreeFamiTF300488

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Mdn1 mouse

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000058006 Expressed in 247 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiA2ANY6 baseline and differential

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011704 ATPase_dyneun-rel_AAA
IPR029317 KRBA1_rpt
IPR012099 Midasin
IPR027417 P-loop_NTPase
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF07728 AAA_5, 8 hits
PIRSFiPIRSF010340 Midasin, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 5 hits
SM01258 KRBA1, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF52540 SSF52540, 6 hits
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2ANY6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A2ANY6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: January 16, 2019
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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