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UniProtKB - A2ANX9 (ZN711_MOUSE)
Protein
Zinc finger protein 711
Gene
Znf711
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 383 – 408 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 414 – 436 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 476 – 499 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 505 – 527 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 533 – 556 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 562 – 584 | C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 590 – 613 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 619 – 641 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 647 – 670 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 676 – 698 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 704 – 727 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 733 – 755 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 711 |
Gene namesi | Name:Znf711 Synonyms:Zfp711 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3045342, Zfp711 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000399819 | 1 – 761 | Zinc finger protein 711Add BLAST | 761 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 224 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 235 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 296 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MaxQBi | A2ANX9 |
PeptideAtlasi | A2ANX9 |
PRIDEi | A2ANX9 |
ProteomicsDBi | 302142 |
PTM databases
iPTMneti | A2ANX9 |
PhosphoSitePlusi | A2ANX9 |
Interactioni
Subunit structurei
Interacts with PHF8.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000109036 |
Miscellaneous databases
RNActi | A2ANX9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 383 – 408 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 414 – 436 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 476 – 499 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 505 – 527 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 533 – 556 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 562 – 584 | C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 590 – 613 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 619 – 641 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 647 – 670 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 676 – 698 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 704 – 727 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 733 – 755 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | A2ANX9 |
Family and domain databases
InterProi | View protein in InterPro IPR006794, Transcrp_activ_Zfx/Zfy-dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 7 hits PF04704, Zfx_Zfy_act, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A2ANX9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESGGGSLGL HTSDARMAHT MIMQDFVAGM AGTAHIDGDH IVVSVPEAVL
60 70 80 90 100
VSDVVTDDGI TLDHGLAAEV VHGPDIITET DVVTEGVIVP EAVLEADVAI
110 120 130 140 150
EEDLEEDDGD HILTSELITE TVRVPEQVFV ADLVSGPDGH LEHVVQDCVS
160 170 180 190 200
GVDSPTMVSE EVLVTNSDTE TVIQAGGGVP GSTVTIKTEE DDDDDVKSTS
210 220 230 240 250
EDYLMISLDD VGEKLEHMGN TPLKIASDGS QEDVKEDAFG SEVIKVYIFK
260 270 280 290 300
AEAEDDVEIG GTEIVTESEY SSGHSVAGVL DQSRMQREKM VYMAVKDSSQ
310 320 330 340 350
EQDDIRDERR VSRRYEECQA PGNTFDSALE NRNTTAAQYL QICDSMNTNK
360 370 380 390 400
VLKQKIKKRR RGETRQWQTA VIIGPDGQPL TVYPCHICTK KFKSRGFLKR
410 420 430 440 450
HMKNHPDHLM RKKYQCTDCD FTTNKKVSFH NHLESHKLIN KVDKTHEFTE
460 470 480 490 500
YTRRYREASP LSSNKLILRD KEPKMHKCKY CDYETAEQGL LNRHLLAVHS
510 520 530 540 550
KSFPHVCVEC GKGFRHPSEL KKHMRTHTGE KPYQCQYCAF RCADQSNLKT
560 570 580 590 600
HIKSKHGSNL PYKCEHCPQA FGDERELQRH LDLFQGHKTH QCPHCDHKST
610 620 630 640 650
NSSDLKRHII SVHTKDFPHK CEVCDKGFHR PSELKKHSDI HKGRKIHQCR
660 670 680 690 700
HCDFKTSDPF ILSGHILSVH TKDQSLKCKR CKRGFRQQNE LKKHMKTHTG
710 720 730 740 750
RKIYQCEYCE YSTTDASGFK RHVISIHTKD YPHRCEFCKK GFRRPSEKKQ
760
HIMRHHKETL M
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6VDX0 | F6VDX0_MOUSE | Zinc finger protein 711 | Zfp711 | 231 | Annotation score: | ||
E9PUP8 | E9PUP8_MOUSE | Zinc finger protein 711 | Zfp711 | 805 | Annotation score: | ||
F8WGY3 | F8WGY3_MOUSE | Zinc finger protein 711 | Zfp711 | 760 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL831771 Genomic DNA No translation available. |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL831771 Genomic DNA No translation available. |
3D structure databases
SMRi | A2ANX9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000109036 |
PTM databases
iPTMneti | A2ANX9 |
PhosphoSitePlusi | A2ANX9 |
Proteomic databases
MaxQBi | A2ANX9 |
PeptideAtlasi | A2ANX9 |
PRIDEi | A2ANX9 |
ProteomicsDBi | 302142 |
Organism-specific databases
MGIi | MGI:3045342, Zfp711 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | A2ANX9 |
Miscellaneous databases
ChiTaRSi | Zfp711, mouse |
PROi | PR:A2ANX9 |
RNActi | A2ANX9, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR006794, Transcrp_activ_Zfx/Zfy-dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 7 hits PF04704, Zfx_Zfy_act, 2 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN711_MOUSE | |
Accessioni | A2ANX9Primary (citable) accession number: A2ANX9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 5, 2010 |
Last sequence update: | February 20, 2007 | |
Last modified: | April 7, 2021 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families